Published in Gene on January 30, 2003
Immune pathways and defence mechanisms in honey bees Apis mellifera. Insect Mol Biol (2006) 3.98
A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults. Genome Biol (2004) 3.21
Comparative genomic analysis of the Tribolium immune system. Genome Biol (2007) 1.74
Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes. Genome Res (2007) 1.71
New lives for old: evolution of pseudoenzyme function illustrated by iRhoms. Nat Rev Mol Cell Biol (2012) 1.58
Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll. Nat Immunol (2008) 1.54
Prophenoloxidase activation is not required for survival to microbial infections in Drosophila. EMBO Rep (2006) 1.49
Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph. Insect Biochem Mol Biol (2005) 1.41
A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway. Proc Natl Acad Sci U S A (2009) 1.38
Comparative analysis of serine protease-related genes in the honey bee genome: possible involvement in embryonic development and innate immunity. Insect Mol Biol (2006) 1.37
Genetic changes accompanying the evolution of host specialization in Drosophila sechellia. Genetics (2008) 1.29
A genomic analysis of rat proteases and protease inhibitors. Genome Res (2004) 1.27
Identification of plasma proteases inhibited by Manduca sexta serpin-4 and serpin-5 and their association with components of the prophenol oxidase activation pathway. J Biol Chem (2005) 1.25
Functions of Manduca sexta hemolymph proteinases HP6 and HP8 in two innate immune pathways. J Biol Chem (2009) 1.19
Gene expression in a Drosophila model of mitochondrial disease. PLoS One (2010) 1.16
Adaptive gene expression divergence inferred from population genomics. PLoS Genet (2007) 1.13
Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster. Genetics (2008) 1.11
Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Genetics (2009) 1.09
Evolutionary rate covariation identifies new members of a protein network required for Drosophila melanogaster female post-mating responses. PLoS Genet (2014) 1.08
Inducible defenses stay up late: temporal patterns of immune gene expression in Tenebrio molitor. G3 (Bethesda) (2013) 1.06
Gene duplication and adaptive evolution of digestive proteases in Drosophila arizonae female reproductive tracts. PLoS Genet (2007) 1.06
Reconstitution of a branch of the Manduca sexta prophenoloxidase activation cascade in vitro: snake-like hemolymph proteinase 21 (HP21) cleaved by HP14 activates prophenoloxidase-activating proteinase-2 precursor. Insect Biochem Mol Biol (2007) 1.04
Polyserase-I, a human polyprotease with the ability to generate independent serine protease domains from a single translation product. Proc Natl Acad Sci U S A (2003) 1.04
Identification and function of proteolysis regulators in seminal fluid. Mol Reprod Dev (2012) 1.02
Genome-wide identification and expression analysis of serine proteases and homologs in the silkworm Bombyx mori. BMC Genomics (2010) 1.02
Structure of a serine protease poised to resynthesize a peptide bond. Proc Natl Acad Sci U S A (2009) 1.01
Bimodal protein targeting through activation of cryptic mitochondrial targeting signals by an inducible cytosolic endoprotease. Mol Cell (2008) 0.99
Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Dev Biol (2010) 0.97
Insect prophenoloxidase: the view beyond immunity. Front Physiol (2014) 0.96
Modelling the correlation between the activities of adjacent genes in Drosophila. BMC Bioinformatics (2005) 0.96
Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster. BMC Genomics (2007) 0.96
Genetic evidence of a redox-dependent systemic wound response via Hayan protease-phenoloxidase system in Drosophila. EMBO J (2012) 0.96
Expression of Manduca sexta serine proteinase homolog precursors in insect cells and their proteolytic activation. Insect Biochem Mol Biol (2007) 0.95
Identification of natural target proteins indicates functions of a serralysin-type metalloprotease, PrtA, in anti-immune mechanisms. Appl Environ Microbiol (2009) 0.95
Sequence conservation, phylogenetic relationships, and expression profiles of nondigestive serine proteases and serine protease homologs in Manduca sexta. Insect Biochem Mol Biol (2014) 0.92
Identification, RNAi knockdown, and functional analysis of an ejaculate protein that mediates a postmating, prezygotic phenotype in a cricket. PLoS One (2009) 0.92
Identification and characterization of human polyserase-3, a novel protein with tandem serine-protease domains in the same polypeptide chain. BMC Biochem (2006) 0.90
Microarray analyses reveal distinct roles for Rel proteins in the Drosophila immune response. Dev Comp Immunol (2007) 0.90
Spn1 regulates the GNBP3-dependent Toll signaling pathway in Drosophila melanogaster. Mol Cell Biol (2011) 0.90
Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts. Mol Biol Evol (2009) 0.89
Identification of unannotated exons of low abundance transcripts in Drosophila melanogaster and cloning of a new serine protease gene upregulated upon injury. BMC Genomics (2007) 0.88
Immune challenge induces N-terminal cleavage of the Drosophila serpin Necrotic. Insect Biochem Mol Biol (2005) 0.88
Bacteria- and IMD pathway-independent immune defenses against Plasmodium falciparum in Anopheles gambiae. PLoS One (2013) 0.88
Manduca sexta prophenoloxidase activating proteinase-1 (PAP-1) gene: organization, expression, and regulation by immune and hormonal signals. Insect Biochem Mol Biol (2005) 0.88
The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families. Biochem J (2007) 0.88
Identification of immunity-related genes in Ostrinia furnacalis against entomopathogenic fungi by RNA-seq analysis. PLoS One (2014) 0.87
Oh, the places they'll go: Female sperm storage and sperm precedence in Drosophila melanogaster. Spermatogenesis (2012) 0.86
Serine protease MP2 activates prophenoloxidase in the melanization immune response of Drosophila melanogaster. PLoS One (2013) 0.84
Clip-domain serine proteases as immune factors in insect hemolymph. Curr Opin Insect Sci (2015) 0.84
Identification, expression and target gene analyses of Micrornas in Spodoptera litura. PLoS One (2012) 0.83
Conformational dynamics of threonine 195 and the S1 subsite in functional trypsin variants. J Mol Model (2012) 0.83
Genomic insights into the serine protease gene family and expression profile analysis in the planthopper, Nilaparvata lugens. BMC Genomics (2014) 0.83
Genome-Wide Gene Expression in relation to Age in Large Laboratory Cohorts of Drosophila melanogaster. Genet Res Int (2015) 0.82
Mutagenesis of the cysteine-rich clip domain in the Drosophila patterning protease, Snake. Arch Biochem Biophys (2008) 0.82
Evolutionary analysis of novel serine proteases in the venom gland transcriptome of Bitis gabonica rhinoceros. PLoS One (2011) 0.82
Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. Mol Ecol (2011) 0.81
Gene structure and expression profile of Manduca sexta prophenoloxidase-activating proteinase-3 (PAP-3), an immune protein containing two clip domains. Insect Mol Biol (2005) 0.81
Temporally variable selection on proteolysis-related reproductive tract proteins in Drosophila. Mol Biol Evol (2011) 0.80
Identification and characterization of a novel serine protease, VvpS, that contains two functional domains and is essential for autolysis of Vibrio vulnificus. J Bacteriol (2011) 0.80
Molecular characterization and evolution of a gene family encoding both female- and male-specific reproductive proteins in Drosophila. Mol Biol Evol (2014) 0.80
High throughput profiling of the cotton bollworm Helicoverpa armigera immunotranscriptome during the fungal and bacterial infections. BMC Genomics (2015) 0.79
Transcriptomic Analysis of Musca domestica to Reveal Key Genes of the Prophenoloxidase-Activating System. G3 (Bethesda) (2015) 0.79
Genome-wide identification and expression profiling of serine proteases and homologs in the diamondback moth, Plutella xylostella (L.). BMC Genomics (2015) 0.79
Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells. Self Nonself (2011) 0.78
Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs. PLoS One (2014) 0.78
Repression of liver colorectal metastasis by the serpin Spn4A a naturally occurring inhibitor of the constitutive secretory proprotein convertases. Oncotarget (2014) 0.78
A snapshot of the Ixodes scapularis degradome. Gene (2011) 0.78
Sequence and phylogenetic analysis of viper venom serine proteases. Bioinformation (2012) 0.77
Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages. Fly (Austin) (2011) 0.77
In search of a function of Manduca sexta hemolymph protease-1 in the innate immune system. Insect Biochem Mol Biol (2016) 0.76
Regulation of a serine protease homolog by the JNK pathway during thoracic development of Drosophila melanogaster. FEBS Open Bio (2015) 0.76
Protein Discovery: Combined Transcriptomic and Proteomic Analyses of Venom from the Endoparasitoid Cotesia chilonis (Hymenoptera: Braconidae). Toxins (Basel) (2017) 0.75
Characterization of Bactrocera dorsalis serine proteases and evidence for their indirect role in insecticide tolerance. Int J Mol Sci (2014) 0.75
Characterization and expression profiling of serine protease inhibitors in the diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae). BMC Genomics (2017) 0.75
Drosophila melanogaster positive transcriptional elongation factors regulate metabolic and sex-biased expression in adults. BMC Genomics (2017) 0.75
The venom gland transcriptome of the parasitoid wasp Nasonia vitripennis highlights the importance of novel genes in venom function. BMC Genomics (2016) 0.75
Tsetse fly tolerance to T. brucei infection: transcriptome analysis of trypanosome-associated changes in the tsetse fly salivary gland. BMC Genomics (2016) 0.75
Characterization and expression analysis of chymotrypsin after bacterial challenge in the mud crab, Scylla paramamosain. Genet Mol Biol (2014) 0.75
Serine protease SP105 activates prophenoloxidase in Asian corn borer melanization, and is regulated by serpin-3. Sci Rep (2017) 0.75
The Entomopathogenic Fungi Isaria fumosorosea Plays a Vital Role in Suppressing the Immune System of Plutella xylostella: RNA-Seq and DGE Analysis of Immunity-Related Genes. Front Microbiol (2017) 0.75
Serine protease-related proteins in the malaria mosquito, Anopheles gambiae. Insect Biochem Mol Biol (2017) 0.75
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16
The genome of the model beetle and pest Tribolium castaneum. Nature (2008) 6.50
Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment. Blood (2009) 5.21
Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Science (2007) 4.03
Priming of naive T cells inside tumors leads to eradication of established tumors. Nat Immunol (2004) 3.95
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell (2012) 3.91
Activity and connectivity of brain mood regulating circuit in depression: a functional magnetic resonance study. Biol Psychiatry (2005) 3.85
Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins. Proc Natl Acad Sci U S A (2008) 3.68
The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. Cancer Cell (2010) 3.52
Innate immune responses of a lepidopteran insect, Manduca sexta. Immunol Rev (2004) 3.19
A Staphylococcus aureus pore-forming toxin subverts the activity of ADAM10 to cause lethal infection in mice. Nat Med (2011) 3.17
Evidence that low-level viremias during effective highly active antiretroviral therapy result from two processes: expression of archival virus and replication of virus. J Virol (2005) 2.82
Evolution, substrate specificity and subfamily classification of glycoside hydrolase family 5 (GH5). BMC Evol Biol (2012) 2.54
RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. J Insect Physiol (2010) 2.47
A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis. Nat Med (2006) 2.36
Neointimal hyperplasia in early arteriovenous fistula failure. Am J Kidney Dis (2007) 2.34
Multiple viral genetic analyses detect low-level human immunodeficiency virus type 1 replication during effective highly active antiretroviral therapy. J Virol (2003) 2.31
Local electronic properties of graphene on a BN substrate via scanning tunneling microscopy. Nano Lett (2011) 2.30
A serpin mutant links Toll activation to melanization in the host defence of Drosophila. EMBO J (2002) 2.22
Prognostic value of coronary CT angiography and calcium score for major adverse cardiac events in outpatients. JACC Cardiovasc Imaging (2012) 2.17
Barriers to accessing TB diagnosis for rural-to-urban migrants with chronic cough in Chongqing, China: a mixed methods study. BMC Health Serv Res (2008) 2.17
Antidepressant effect on connectivity of the mood-regulating circuit: an FMRI study. Neuropsychopharmacology (2005) 2.16
Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res (2009) 2.08
Laccase 2 is the phenoloxidase gene required for beetle cuticle tanning. Proc Natl Acad Sci U S A (2005) 2.04
Cyclophilin A/Cluster of Differentiation 147 Interactions Participate in Early Brain Injury After Subarachnoid Hemorrhage in Rats. Crit Care Med (2015) 2.01
DNA methylation in inflammatory genes among children with obstructive sleep apnea. Am J Respir Crit Care Med (2011) 1.92
Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs. Insect Biochem Mol Biol (2003) 1.89
Peripheral nociception associated with surgical incision elicits remote nonischemic cardioprotection via neurogenic activation of protein kinase C signaling. Circulation (2009) 1.86
Nonproteolytic serine proteinase homologs are involved in prophenoloxidase activation in the tobacco hornworm, Manduca sexta. Insect Biochem Mol Biol (2003) 1.85
Lymphotoxin pathway directs thymic Aire expression. Nat Immunol (2003) 1.79
Management for postoperative complications of breast augmentation by injected polyacrylamide hydrogel. Aesthetic Plast Surg (2005) 1.78
The LRP5 high-bone-mass G171V mutation disrupts LRP5 interaction with Mesd. Mol Cell Biol (2004) 1.77
Comparative genomic analysis of the Tribolium immune system. Genome Biol (2007) 1.74
Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J Clin Invest (2004) 1.71
Antibacterial drug leads targeting isoprenoid biosynthesis. Proc Natl Acad Sci U S A (2012) 1.69
MicroRNA-127 modulates fetal lung development. Physiol Genomics (2009) 1.68
Deep sequencing of small RNA libraries reveals dynamic regulation of conserved and novel microRNAs and microRNA-stars during silkworm development. BMC Genomics (2010) 1.68
Malignant liver tumors: treatment with percutaneous microwave ablation--complications among cohort of 1136 patients. Radiology (2009) 1.68
Direct observation and adherence to tuberculosis treatment in Chongqing, China: a descriptive study. Health Policy Plan (2008) 1.68
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover. Mol Biol Cell (2010) 1.65
CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J (2012) 1.65
Prophenoloxidase-activating proteinase-2 from hemolymph of Manduca sexta. A bacteria-inducible serine proteinase containing two clip domains. J Biol Chem (2002) 1.65
Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases. J Immunol (2007) 1.60
Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation (2005) 1.60
Patient-specific modeling and quantification of the aortic and mitral valves from 4-D cardiac CT and TEE. IEEE Trans Med Imaging (2010) 1.59
Presence and dissemination of the multiresistance gene cfr in Gram-positive and Gram-negative bacteria. J Antimicrob Chemother (2013) 1.59
Anatomic configuration affects the flow rate and diameter of porcine arteriovenous fistulae. Kidney Int (2012) 1.58
Out of Tibet: Pliocene woolly rhino suggests high-plateau origin of Ice Age megaherbivores. Science (2011) 1.58
Chemical vapour deposition growth of large single crystals of monolayer and bilayer graphene. Nat Commun (2013) 1.57
Hypertension prevalence, awareness, treatment, and control in 115 rural and urban communities involving 47 000 people from China. J Hypertens (2016) 1.57
ADAM10 mediates vascular injury induced by Staphylococcus aureus α-hemolysin. J Infect Dis (2012) 1.56
Efficient Constrained Local Model Fitting for Non-Rigid Face Alignment. Image Vis Comput (2009) 1.55
Manduca sexta serpin-3 regulates prophenoloxidase activation in response to infection by inhibiting prophenoloxidase-activating proteinases. J Biol Chem (2003) 1.55
Severe venous neointimal hyperplasia prior to dialysis access surgery. Nephrol Dial Transplant (2011) 1.54
Antibiotic-conjugated polyacrylate nanoparticles: new opportunities for development of anti-MRSA agents. Bioorg Med Chem Lett (2006) 1.53
Aberrant expression of TSC2 gene in the newly diagnosed acute leukemia. Leuk Res (2009) 1.52
microRNA-143, down-regulated in osteosarcoma, promotes apoptosis and suppresses tumorigenicity by targeting Bcl-2. Oncol Rep (2010) 1.51
Photoinstability of S-nitrosothiols during sampling of whole blood: a likely source of error and variability in S-nitrosothiol measurements. Clin Chem (2008) 1.48
Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. Eur J Pharm Biopharm (2006) 1.48
Flexible, stretchable, transparent carbon nanotube thin film loudspeakers. Nano Lett (2008) 1.47
High Caesarean section rate in rural China: is it related to health insurance (New Co-operative Medical Scheme)? Soc Sci Med (2012) 1.47
Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol (2008) 1.46
Automated quantification of mitral inflow and aortic outflow stroke volumes by three-dimensional real-time volume color-flow Doppler transthoracic echocardiography: comparison with pulsed-wave Doppler and cardiac magnetic resonance imaging. J Am Soc Echocardiogr (2011) 1.46
CIP2A is overexpressed in non-small cell lung cancer and correlates with poor prognosis. Ann Surg Oncol (2010) 1.45
Pyrosequence analysis of expressed sequence tags for Manduca sexta hemolymph proteins involved in immune responses. Insect Biochem Mol Biol (2008) 1.45
T1DBase, a community web-based resource for type 1 diabetes research. Nucleic Acids Res (2005) 1.44
Vertically stacked multi-heterostructures of layered materials for logic transistors and complementary inverters. Nat Mater (2012) 1.44
Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum. Proc Natl Acad Sci U S A (2006) 1.43
Role of type I and type II interferon responses in recovery from infection with an encephalitic flavivirus. J Gen Virol (2003) 1.43
Immunity in lepidopteran insects. Adv Exp Med Biol (2010) 1.43
Partial differential equation transform - Variational formulation and Fourier analysis. Int J Numer Method Biomed Eng (2011) 1.43
Collective odor source estimation and search in time-variant airflow environments using mobile robots. Sensors (Basel) (2011) 1.43
NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. Blood (2005) 1.43
Decrease of plasma N-terminal pro beta-type natriuretic peptide as a predictor of clinical improvement after cardiac resynchronization therapy for heart failure. Chin Med J (Engl) (2009) 1.42
Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an FMRI study. J Neuropsychiatry Clin Neurosci (2007) 1.42
Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection. J Invest Dermatol (2012) 1.41
The involvement of AMPA-ERK1/2-BDNF pathway in the mechanism of new antidepressant action of prokinetic meranzin hydrate. Amino Acids (2012) 1.41
Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph. Insect Biochem Mol Biol (2005) 1.41
The proteomics of lipid droplets: structure, dynamics, and functions of the organelle conserved from bacteria to humans. J Lipid Res (2012) 1.40
Prognostic factors for survival in patients with hepatocellular carcinoma after percutaneous microwave ablation. Radiology (2005) 1.40
Characterization of cDNAs encoding putative laccase-like multicopper oxidases and developmental expression in the tobacco hornworm, Manduca sexta, and the malaria mosquito, Anopheles gambiae. Insect Biochem Mol Biol (2004) 1.39
Comparative analysis of serine protease-related genes in the honey bee genome: possible involvement in embryonic development and innate immunity. Insect Mol Biol (2006) 1.37
Four base recognition by triplex-forming oligonucleotides at physiological pH. Nucleic Acids Res (2005) 1.37
MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy. J Biol Chem (2011) 1.36
Sleep fragmentation induces cognitive deficits via nicotinamide adenine dinucleotide phosphate oxidase-dependent pathways in mouse. Am J Respir Crit Care Med (2011) 1.36
Signaling via LTbetaR on the lamina propria stromal cells of the gut is required for IgA production. Nat Immunol (2002) 1.36
MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1. Bone (2013) 1.36
Unusual hydrogen bonding in water-filled carbon nanotubes. J Am Chem Soc (2006) 1.35
Tuberculosis patient expenditure on drugs and tests in subsidised, public services in China: a descriptive study. Trop Med Int Health (2009) 1.35