Published in Proc Natl Acad Sci U S A on February 06, 2003
Nanomechanical measurements of the sequence-dependent folding landscapes of single nucleic acid hairpins. Proc Natl Acad Sci U S A (2006) 3.56
Comparison of the measured phase diagrams in the force-temperature plane for the unzipping of two different natural DNA sequences. Eur Phys J E Soft Matter (2006) 2.03
Real-time observation of bacteriophage T4 gp41 helicase reveals an unwinding mechanism. Proc Natl Acad Sci U S A (2007) 1.76
Mechanical unfolding of RNA hairpins. Proc Natl Acad Sci U S A (2005) 1.57
Single-molecule derivation of salt dependent base-pair free energies in DNA. Proc Natl Acad Sci U S A (2010) 1.53
Single molecule detection of direct, homologous, DNA/DNA pairing. Proc Natl Acad Sci U S A (2009) 1.27
The structure of DNA overstretched from the 5'5' ends differs from the structure of DNA overstretched from the 3'3' ends. Proc Natl Acad Sci U S A (2009) 1.26
Dynamics of molecular motors and polymer translocation with sequence heterogeneity. Biophys J (2004) 1.19
Impediment of E. coli UvrD by DNA-destabilizing force reveals a strained-inchworm mechanism of DNA unwinding. EMBO J (2008) 1.16
Quantifying DNA melting transitions using single-molecule force spectroscopy. J Phys Condens Matter (2009) 1.15
DNA mechanics as a tool to probe helicase and translocase activity. Nucleic Acids Res (2006) 1.13
Pause point spectra in DNA constant-force unzipping. Biophys J (2005) 1.12
Single-molecule studies of the stringency factors and rates governing the polymerization of RecA on double-stranded DNA. Nucleic Acids Res (2011) 0.94
RecA homology search is promoted by mechanical stress along the scanned duplex DNA. Nucleic Acids Res (2011) 0.93
Dynamics of the DNA duplex formation studied by single molecule force measurements. Biophys J (2004) 0.89
Using nonequilibrium measurements to determine macromolecule free-energy differences. Proc Natl Acad Sci U S A (2003) 0.87
Statistical theory of force-induced unzipping of DNA. Eur Phys J E Soft Matter (2005) 0.87
Measurement of the salt-dependent stabilization of partially open DNA by Escherichia coli SSB protein. Nucleic Acids Res (2007) 0.85
THE MELTING MECHANISM OF DNA TETHERED TO A SURFACE. Int J Numer Anal Model (2009) 0.84
Microfluidic force spectroscopy for characterization of biomolecular interactions with piconewton resolution. Appl Phys Lett (2010) 0.84
Changes in the tension in dsDNA alter the conformation of RecA bound to dsDNA-RecA filaments. Nucleic Acids Res (2011) 0.81
Theoretical study of sequence-dependent nanopore unzipping of DNA. Biophys J (2008) 0.81
Biophysics of protein-DNA interactions and chromosome organization. Physica A (2015) 0.81
Can we model DNA at the mesoscale? J Biol Phys (2005) 0.79
DNA as a programmable viscoelastic nanoelement. Biophys J (2005) 0.78
RNA unwinding by NS3 helicase: a statistical approach. PLoS One (2009) 0.78
Thermal fluctuation spectroscopy of DNA thermal denaturation. Biophys J (2010) 0.77
Free-energy landscape and characteristic forces for the initiation of DNA unzipping. Biophys J (2015) 0.77
Temperature and chemical denaturant dependence of forced unfolding of titin I27. J Phys Chem B (2009) 0.77
Extended abstract: plateaus and jumps in single-molecule DNA unzipping experiments. J Biol Phys (2005) 0.75
Inverse Temperature Dependence of Nuclear Quantum Effects in DNA Base Pairs. J Phys Chem Lett (2016) 0.75
Reconstruction and identification of DNA sequence landscapes from unzipping experiments at equilibrium. Biophys J (2014) 0.75
Understanding the physics of DNA using nanoscale single-molecule manipulation. Front Phys (2012) 0.75
An AT-barrier mechanically controls DNA reannealing under tension. Nucleic Acids Res (2016) 0.75
Thermal and inertial resonances in DNA unzipping. Eur Phys J E Soft Matter (2015) 0.75
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Steered molecular dynamics and mechanical functions of proteins. Curr Opin Struct Biol (2001) 5.97
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Magnetic tweezers: micromanipulation and force measurement at the molecular level. Biophys J (2002) 4.49
Single-molecule studies of DNA mechanics. Curr Opin Struct Biol (2000) 4.39
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Force-induced melting of the DNA double helix 1. Thermodynamic analysis. Biophys J (2001) 3.03
Grabbing the cat by the tail: manipulating molecules one by one. Nat Rev Mol Cell Biol (2000) 2.91
Single-molecule analysis of DNA uncoiling by a type II topoisomerase. Nature (2000) 2.78
The thermal stability of immunoglobulin: unfolding and aggregation of a multi-domain protein. Biophys J (2000) 2.37
Unzipping DNA with optical tweezers: high sequence sensitivity and force flips. Biophys J (2002) 2.26
Single molecule statistics and the polynucleotide unzipping transition. Phys Rev E Stat Nonlin Soft Matter Phys (2002) 1.94
Rotational drag on DNA: a single molecule experiment. Phys Rev Lett (2002) 1.68
Force and kinetic barriers to unzipping of the DNA double helix. Proc Natl Acad Sci U S A (2001) 1.65
Pulling pinned polymers and unzipping DNA. Phys Rev Lett (2000) 1.57
DNA replication origins: from sequence specificity to epigenetics. Nat Rev Genet (2001) 1.56
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Force and kinetic barriers to initiation of DNA unzipping. Phys Rev E Stat Nonlin Soft Matter Phys (2002) 1.13
Dynamical scaling of the DNA unzipping transition. Phys Rev Lett (2001) 0.98
Pulling a polymer out of a potential well and the mechanical unzipping of DNA. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics (2000) 0.95
Random walkers in one-dimensional random environments: exact renormalization group analysis. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics (1999) 0.87
The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science (2007) 11.15
Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med (2014) 9.45
Daclatasvir plus sofosbuvir for previously treated or untreated chronic HCV infection. N Engl J Med (2014) 9.25
An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology (2011) 8.95
Sofosbuvir for hepatitis C genotype 2 or 3 in patients without treatment options. N Engl J Med (2013) 8.49
The Physcomitrella genome reveals evolutionary insights into the conquest of land by plants. Science (2007) 8.12
Response-guided telaprevir combination treatment for hepatitis C virus infection. N Engl J Med (2011) 6.31
Treatment of HCV with ABT-450/r-ombitasvir and dasabuvir with ribavirin. N Engl J Med (2014) 5.29
The Ectocarpus genome and the independent evolution of multicellularity in brown algae. Nature (2010) 3.60
Unzipping kinetics of double-stranded DNA in a nanopore. Phys Rev Lett (2003) 3.32
Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial. Lancet Infect Dis (2013) 3.30
An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection. Hepatology (2004) 3.18
Genetic drift at expanding frontiers promotes gene segregation. Proc Natl Acad Sci U S A (2007) 3.14
The Selaginella genome identifies genetic changes associated with the evolution of vascular plants. Science (2011) 3.10
Orientation discrimination of single-stranded DNA inside the alpha-hemolysin membrane channel. Proc Natl Acad Sci U S A (2005) 3.06
The African coelacanth genome provides insights into tetrapod evolution. Nature (2013) 2.78
Virus shapes and buckling transitions in spherical shells. Phys Rev E Stat Nonlin Soft Matter Phys (2003) 2.74
Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1. N Engl J Med (2014) 2.54
Sources of variability on the estimate of treatment effect in the PROWESS trial: implications for the design and conduct of future studies in severe sepsis. Crit Care Med (2004) 2.48
Genomic analysis of detoxification genes in the mosquito Aedes aegypti. Insect Biochem Mol Biol (2007) 2.38
Gene expression associated with interferon alfa antiviral activity in an HCV replicon cell line. Hepatology (2003) 2.35
The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion. PLoS Genet (2009) 2.29
An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23
Direct visualization of dislocation dynamics in grain-boundary scars. Nat Mater (2005) 2.22
Nanomagnetic actuation of receptor-mediated signal transduction. Nat Nanotechnol (2007) 2.22
Identifying hepatitis C virus genotype 2/3 patients who can receive a 16-week abbreviated course of peginterferon alfa-2a (40KD) plus ribavirin. Hepatology (2010) 2.20
Gene surfing in expanding populations. Theor Popul Biol (2007) 2.19
Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure. Crit Care Med (2005) 2.12
Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing. J Mol Biol (2006) 2.05
Is worsening multiple organ failure the cause of death in patients with severe sepsis? Crit Care Med (2011) 2.04
Effect of cigarette smoking on levels of seminal oxidative stress in infertile men: a prospective study. Fertil Steril (2002) 1.97
Foldable structures and the natural design of pollen grains. Proc Natl Acad Sci U S A (2010) 1.97
Single molecule statistics and the polynucleotide unzipping transition. Phys Rev E Stat Nonlin Soft Matter Phys (2002) 1.94
Four-dimensional imaging of E. coli nucleoid organization and dynamics in living cells. Cell (2013) 1.89
Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation. Liver Transpl (2006) 1.86
PHOENIX: A randomized controlled trial of peginterferon alfa-2a plus ribavirin as a prophylactic treatment after liver transplantation for hepatitis C virus. Liver Transpl (2011) 1.85
C-reactive protein, arterial endothelial activation, and development of transplant coronary artery disease: a prospective study. Lancet (2002) 1.80
Sexual dysfunction in men undergoing infertility evaluation: a cohort observational study. Fertil Steril (2003) 1.76
Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system. Gastroenterology (2007) 1.75
Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial. Crit Care Med (2004) 1.73
Dynamic control of liquid-core/liquid-cladding optical waveguides. Proc Natl Acad Sci U S A (2004) 1.68
Dissociation of ligand-receptor complexes using magnetic tweezers. Anal Chem (2005) 1.67
Improved outcomes in patients with hepatitis C with difficult-to-treat characteristics: randomized study of higher doses of peginterferon alpha-2a and ribavirin. Hepatology (2008) 1.66
Negative effects of increased sperm DNA damage in relation to seminal oxidative stress in men with idiopathic and male factor infertility. Fertil Steril (2003) 1.66
Effects of ribavirin dose reduction vs erythropoietin for boceprevir-related anemia in patients with chronic hepatitis C virus genotype 1 infection--a randomized trial. Gastroenterology (2013) 1.63
Quantifying colorimetric assays in paper-based microfluidic devices by measuring the transmission of light through paper. Anal Chem (2009) 1.61
Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.). Genome Biol (2013) 1.59
Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis. Clin J Am Soc Nephrol (2006) 1.59
Severe protein C deficiency predicts early death in severe sepsis. Crit Care Med (2004) 1.58
Clinical pharmacogenetics implementation: approaches, successes, and challenges. Am J Med Genet C Semin Med Genet (2014) 1.57
The 2008 update of the Aspergillus nidulans genome annotation: a community effort. Fungal Genet Biol (2008) 1.56
Life at the front of an expanding population. Evolution (2009) 1.56
An allosteric model of circadian KaiC phosphorylation. Proc Natl Acad Sci U S A (2007) 1.53
Pyrosequencing the transcriptome of the greenhouse whitefly, Trialeurodes vaporariorum reveals multiple transcripts encoding insecticide targets and detoxifying enzymes. BMC Genomics (2011) 1.53
Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochem Biophys Res Commun (2003) 1.52
Impact of implementation of the MELD scoring system on the prevalence and incidence of chronic renal disease following liver transplantation. Liver Transpl (2006) 1.49
Development of an inexpensive artificial vagina for semen collection from rabbits. J Androl (2003) 1.47
Genetic demixing and evolution in linear stepping stone models. Rev Mod Phys (2010) 1.46
CC genotype donors for the interleukin-28B single nucleotide polymorphism are associated with better outcomes in hepatitis C after liver transplant. Liver Int (2012) 1.46
Novel type I interferon IL-28A suppresses hepatitis C viral RNA replication. Virol J (2005) 1.46
Non-immunologic vascular failure of the transplanted heart. J Heart Lung Transplant (2003) 1.40
Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish. BMC Genomics (2010) 1.37
Magnetic resonance imaging-based cartilage loss in painful contralateral knees with and without radiographic joint space narrowing: Data from the Osteoarthritis Initiative. Arthritis Rheum (2009) 1.34
Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated). Clin Infect Dis (2003) 1.33
Selective sweeps in growing microbial colonies. Phys Biol (2012) 1.31
Genome sequence of the model medicinal mushroom Ganoderma lucidum. Nat Commun (2012) 1.30
Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: a randomized, 28-day, dose-ranging trial. J Hepatol (2012) 1.28
Early hepatic stellate cell activation is associated with advanced fibrosis after liver transplantation in recipients with hepatitis C. Liver Transpl (2005) 1.27
The structure of DNA overstretched from the 5'5' ends differs from the structure of DNA overstretched from the 3'3' ends. Proc Natl Acad Sci U S A (2009) 1.26
Genetic drift opposes mutualism during spatial population expansion. Proc Natl Acad Sci U S A (2014) 1.23
Kinase inhibitor Sorafenib modulates immunosuppressive cell populations in a murine liver cancer model. Lab Invest (2011) 1.22
Density-based diamagnetic separation: devices for detecting binding events and for collecting unlabeled diamagnetic particles in paramagnetic solutions. Anal Chem (2007) 1.22
Identification and characterization of a repeat-in-toxin gene cluster in Vibrio anguillarum. Infect Immun (2008) 1.22
Protein C concentrations in severe sepsis: an early directional change in plasma levels predicts outcome. Crit Care (2006) 1.21
Robust circadian clocks from coupled protein-modification and transcription-translation cycles. Proc Natl Acad Sci U S A (2010) 1.21
The cytochrome P450 (CYP) gene superfamily in Daphnia pulex. BMC Genomics (2009) 1.21
Regulation of Vibrio anguillarum empA metalloprotease expression and its role in virulence. Appl Environ Microbiol (2004) 1.20
Elastic instability of a crystal growing on a curved surface. Science (2014) 1.19
Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease. Hepatology (2004) 1.19
Identification and characterization of a hemolysin gene cluster in Vibrio anguillarum. Infect Immun (2006) 1.19
Dynamics of molecular motors and polymer translocation with sequence heterogeneity. Biophys J (2004) 1.19
Genome landscapes and bacteriophage codon usage. PLoS Comput Biol (2008) 1.18
Orientation-dependent interactions of DNA with an alpha-hemolysin channel. Phys Rev E Stat Nonlin Soft Matter Phys (2008) 1.14
Institutional profile: University of Florida and Shands Hospital Personalized Medicine Program: clinical implementation of pharmacogenetics. Pharmacogenomics (2013) 1.14
Magnetically-guided self-assembly of fibrin matrices with ordered nano-scale structure for tissue engineering. Tissue Eng (2006) 1.13
A randomized, open-label study to evaluate the safety and pharmacokinetics of human hepatitis C immune globulin (Civacir) in liver transplant recipients. Liver Transpl (2005) 1.13
Elastic platonic shells. Phys Rev Lett (2013) 1.12
A quantitative test of population genetics using spatiogenetic patterns in bacterial colonies. Am Nat (2011) 1.11
CD8+ T-cell interaction with HCV replicon cells: evidence for both cytokine- and cell-mediated antiviral activity. Hepatology (2003) 1.10
Production of target-specific recombinant human polyclonal antibodies in mammalian cells. Biotechnol Bioeng (2006) 1.10
Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway. Crit Care Med (2004) 1.09
The CYPome (Cytochrome P450 complement) of Aspergillus nidulans. Fungal Genet Biol (2008) 1.08
Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment. Genome Biol (2014) 1.08
Effects of drotrecogin alfa (activated) in human endotoxemia. Shock (2004) 1.07
One-year protocol liver biopsy can stratify fibrosis progression in liver transplant recipients with recurrent hepatitis C infection. Liver Transpl (2004) 1.07