Aire regulates negative selection of organ-specific T cells.

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Deletional tolerance mediated by extrathymic Aire-expressing cells. Science (2008) 4.10

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Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med (2005) 4.06

Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J Exp Med (2010) 3.93

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Aire-dependent thymic development of tumor-associated regulatory T cells. Science (2013) 3.23

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity (2006) 3.02

CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med (2004) 2.52

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J Exp Med (2004) 2.43

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Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med (2004) 2.23

The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression. EMBO Rep (2008) 2.22

Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med (2005) 2.08

Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nat Rev Immunol (2008) 1.99

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Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med (2011) 1.87

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Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc Natl Acad Sci U S A (2008) 1.83

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A (2008) 1.83

Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity (2007) 1.83

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GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1. J Invest Dermatol (2011) 1.56

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CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci U S A (2009) 1.52

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice. J Clin Invest (2006) 1.52

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A (2007) 1.51

AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol Cell Biol (2007) 1.49

Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: from pipe dreams to (therapeutic) pipelines. Proc Natl Acad Sci U S A (2004) 1.49

Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc Natl Acad Sci U S A (2006) 1.47

Hypomorphic Rag mutations can cause destructive midline granulomatous disease. Blood (2010) 1.47

The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Res (2009) 1.46

Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest (2008) 1.43

The autoimmune regulator prevents premature reproductive senescence in female mice. Biol Reprod (2012) 1.42

Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A (2012) 1.41

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Control of central and peripheral tolerance by Aire. Immunol Rev (2011) 1.37

Aire and T cell development. Curr Opin Immunol (2010) 1.36

CD4+ T-cell development in a mouse expressing a transgenic TCR derived from a Treg. Eur J Immunol (2009) 1.36

AIRE deficiency in thymus of 2 patients with Omenn syndrome. J Clin Invest (2005) 1.35

Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator. Structure (2009) 1.35

Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc Natl Acad Sci U S A (2007) 1.31

NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathway. J Clin Invest (2006) 1.29

T-cell tolerance: central and peripheral. Cold Spring Harb Perspect Biol (2012) 1.28

Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. J Exp Med (2013) 1.26

Genetic control of programmed cell death during animal development. Annu Rev Genet (2009) 1.24

Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc Natl Acad Sci U S A (2013) 1.21

Treg cells, life history, and diversity. Cold Spring Harb Perspect Biol (2012) 1.19

TH17 cells and regulatory T cells in primary immunodeficiency diseases. J Allergy Clin Immunol (2009) 1.18

AIRE in the thymus and beyond. Curr Opin Immunol (2009) 1.16

Identification of an autoantigen demonstrates a link between interstitial lung disease and a defect in central tolerance. Sci Transl Med (2009) 1.15

Estimating the proportion of microarray probes expressed in an RNA sample. Nucleic Acids Res (2010) 1.14

AIRE regulates T-cell-independent B-cell responses through BAFF. Proc Natl Acad Sci U S A (2008) 1.13

AIRE activated tissue specific genes have histone modifications associated with inactive chromatin. Hum Mol Genet (2009) 1.13

NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses. J Exp Med (2011) 1.13

Guanylyl cyclase C-induced immunotherapeutic responses opposing tumor metastases without autoimmunity. J Natl Cancer Inst (2008) 1.12

Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus. Nat Commun (2012) 1.11

Human skin cells support thymus-independent T cell development. J Clin Invest (2005) 1.11

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. Biochim Biophys Acta (2007) 1.10

The T-cell receptor repertoire of regulatory T cells. Immunology (2008) 1.09

Developmental pathway of CD4+CD8- medullary thymocytes during mouse ontogeny and its defect in Aire-/- mice. Proc Natl Acad Sci U S A (2007) 1.08

Modulation of Aire regulates the expression of tissue-restricted antigens. Mol Immunol (2007) 1.07

Regulatory T cells in human autoimmune diseases. Springer Semin Immunopathol (2006) 1.07

Re-establishing immunological self-tolerance in autoimmune disease. Nat Med (2012) 1.06

Aire deficiency promotes TRP-1-specific immune rejection of melanoma. Cancer Res (2013) 1.06

Listeria-based vaccines can overcome tolerance by expanding low avidity CD8+ T cells capable of eradicating a solid tumor in a transgenic mouse model of cancer. Cancer Immun (2007) 1.06

Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders. Curr Opin Rheumatol (2009) 1.06

Thymus transplantation. Clin Immunol (2010) 1.04

Functional redundancy between thymic CD8α+ and Sirpα+ conventional dendritic cells in presentation of blood-derived lysozyme by MHC class II proteins. J Immunol (2010) 1.04

Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells. Diabetes (2011) 1.04

Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front Immunol (2012) 1.03

A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol (2007) 1.03

Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis. Immunity (2010) 1.03

Enhancement of an anti-tumor immune response by transient blockade of central T cell tolerance. J Exp Med (2014) 1.01

The immunogenetic architecture of autoimmune disease. Cold Spring Harb Perspect Biol (2012) 1.00

The role of AIRE in human autoimmune disease. Nat Rev Endocrinol (2010) 1.00

Aire controls gene expression in the thymic epithelium with ordered stochasticity. Nat Immunol (2015) 0.99

Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1. Proc Natl Acad Sci U S A (2007) 0.98

B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients. Proc Natl Acad Sci U S A (2008) 0.98

Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance. Philos Trans R Soc Lond B Biol Sci (2005) 0.98

Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling. Genome Biol (2007) 0.98

Central tolerance: what have we learned from mice? Semin Immunopathol (2008) 0.97

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity. Clin Exp Immunol (2004) 0.97

Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc Natl Acad Sci U S A (2012) 0.96

The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance. Nat Immunol (2014) 0.96

The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits. Biol Direct (2007) 0.95

CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire. Proc Natl Acad Sci U S A (2012) 0.95

B cells participate in thymic negative selection of murine auto-reactive CD4+ T cells. PLoS One (2010) 0.95

Normal thymocyte negative selection in TRAIL-deficient mice. J Exp Med (2003) 0.94

Affinity-based selection of regulatory T cells occurs independent of agonist-mediated induction of Foxp3 expression. J Immunol (2009) 0.94

T cells in the control of organ-specific autoimmunity. J Clin Invest (2015) 0.93

Functional specialization of islet dendritic cell subsets. J Immunol (2012) 0.92

Update in endocrine autoimmunity. J Clin Endocrinol Metab (2008) 0.92

TSCOT+ thymic epithelial cell-mediated sensitive CD4 tolerance by direct presentation. PLoS Biol (2008) 0.91

Reduced TCR signaling potential impairs negative selection but does not result in autoimmune disease. J Exp Med (2012) 0.90

The role of Aire in clonal selection. Immunol Cell Biol (2010) 0.90

Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73

Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet (2008) 20.66

Large recurrent microdeletions associated with schizophrenia. Nature (2008) 20.25

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nat Genet (2008) 12.32

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet (2009) 12.19

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nat Genet (2008) 12.07

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85

Common variants conferring risk of schizophrenia. Nature (2009) 10.37

Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

Identification of a variant associated with adult-type hypolactasia. Nat Genet (2002) 7.49

Multiple common variants for celiac disease influencing immune gene expression. Nat Genet (2010) 6.90

A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet (2007) 6.87

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Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nat Genet (2010) 6.49

A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature (2005) 6.31

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet (2009) 6.31

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. Lancet (2010) 6.07

Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56

Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32

New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet (2009) 5.12

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97

Classical twin studies and beyond. Nat Rev Genet (2002) 4.81

Disruption of the neurexin 1 gene is associated with schizophrenia. Hum Mol Genet (2008) 4.78

DNA repair is limiting for haematopoietic stem cells during ageing. Nature (2007) 4.71

Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

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Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes (2008) 4.20

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10

Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet (2012) 4.08

Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Arterioscler Thromb Vasc Biol (2010) 4.08

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am J Hum Genet (2002) 4.06

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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91

Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure. Nat Genet (2009) 3.81

Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum (2010) 3.76

Genetic loci influencing kidney function and chronic kidney disease. Nat Genet (2010) 3.75

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68

Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci. Nat Genet (2010) 3.58

Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies. Nat Genet (2006) 3.54

Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci. PLoS Genet (2007) 3.47

Genetic structure of Europeans: a view from the North-East. PLoS One (2009) 3.46

Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity (2003) 3.36

Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature (2007) 3.08

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Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet (2010) 2.30

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29

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Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood (2011) 2.25

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