Published in Age Ageing on March 01, 2003
National Dementia Strategy: well intentioned--but how well founded and how well directed? Br J Gen Pract (2010) 3.92
Systemic inflammation and delirium: important co-factors in the progression of dementia. Biochem Soc Trans (2011) 1.36
Blood-based biomarkers of Alzheimer's disease: challenging but feasible. Biomark Med (2010) 1.12
Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease. J Neurol (2008) 1.11
Memory clinics. Postgrad Med J (2006) 1.08
The CERAD Neuropsychologic Battery Total Score and the progression of Alzheimer disease. Alzheimer Dis Assoc Disord (2010) 0.99
Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research. Alzheimers Res Ther (2015) 0.97
The predictive validity of the 10/66 dementia diagnosis in Chennai, India: a 3-year follow-up study of cases identified at baseline. Alzheimer Dis Assoc Disord (2010) 0.93
Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation. J Neurol Neurosurg Psychiatry (2005) 0.91
Predicting the outcome of cholinesterase inhibitor treatment in Alzheimer's disease. J Neurol Neurosurg Psychiatry (2005) 0.86
Galantamine treatment in Alzheimer's disease: response and long-term outcome in a routine clinical setting. Neuropsychiatr Dis Treat (2011) 0.81
High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer's disease. Alzheimers Res Ther (2016) 0.75
Risk Factors for Progression of Alzheimer Disease in a Canadian Population: The Canadian Outcomes Study in Dementia (COSID). Can J Psychiatry (2015) 0.75
Long-term effect of galantamine on cognitive function in patients with Alzheimer's disease versus a simulated disease trajectory: an observational study in the clinical setting. Neuropsychiatr Dis Treat (2017) 0.75
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet (2009) 15.15
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet (2011) 9.23
Protective variant for hippocampal atrophy identified by whole exome sequencing. Ann Neurol (2015) 5.10
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Arch Neurol (2007) 5.09
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry (2010) 3.64
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biol (2012) 3.31
The GSK3 hypothesis of Alzheimer's disease. J Neurochem (2007) 3.16
The South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLAM BRC) case register: development and descriptive data. BMC Psychiatry (2009) 3.15
Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Hum Mol Genet (2007) 2.73
Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. PLoS One (2010) 2.57
Is MCI really just early dementia? A systematic review of conversion studies. Int Psychogeriatr (2004) 2.54
The dementias. Lancet (2002) 2.42
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am J Hum Genet (2005) 2.04
Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proc Natl Acad Sci U S A (2004) 1.95
Alzheimer's disease-do tauists and baptists finally shake hands? Trends Neurosci (2002) 1.83
Full genome screen for Alzheimer disease: stage II analysis. Am J Med Genet (2002) 1.77
Glycogen synthase kinase-3beta and tau genes interact in Alzheimer's disease. Ann Neurol (2008) 1.74
Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals. J Alzheimers Dis (2010) 1.73
DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Hum Mol Genet (2006) 1.73
The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder. Eur J Hum Genet (2012) 1.71
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. PLoS Genet (2010) 1.58
Glycogen synthase kinase-3 inhibition is integral to long-term potentiation. Eur J Neurosci (2007) 1.50
SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiol Dis (2007) 1.49
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet (2012) 1.46
Multivariate analysis of MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls. Neuroimage (2010) 1.44
The AddNeuroMed framework for multi-centre MRI assessment of Alzheimer's disease: experience from the first 24 months. Int J Geriatr Psychiatry (2011) 1.35
Automated hippocampal shape analysis predicts the onset of dementia in mild cognitive impairment. Neuroimage (2011) 1.34
Do antidepressants regulate how cortisol affects the brain? Psychoneuroendocrinology (2004) 1.32
Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment. Neuroimage (2011) 1.30
Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study. J Alzheimers Dis (2014) 1.29
Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice. Biochem Biophys Res Commun (2009) 1.28
MRI measures of Alzheimer's disease and the AddNeuroMed study. Ann N Y Acad Sci (2009) 1.28
Biomarkers for Alzheimer's disease therapeutic trials. Prog Neurobiol (2010) 1.26
Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease. Neuromolecular Med (2004) 1.26
AddNeuroMed and ADNI: similar patterns of Alzheimer's atrophy and automated MRI classification accuracy in Europe and North America. Neuroimage (2011) 1.24
Risk of developing dementia in people with diabetes and mild cognitive impairment. Br J Psychiatry (2010) 1.24
Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. PLoS Genet (2010) 1.23
Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet (2005) 1.22
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Hum Mol Genet (2007) 1.16
Four components describe behavioral symptoms in 1,120 individuals with late-onset Alzheimer's disease. J Am Geriatr Soc (2006) 1.15
Effect of APOE ε4 allele on cortical thicknesses and volumes: the AddNeuroMed study. J Alzheimers Dis (2010) 1.12
Blood-based biomarkers of Alzheimer's disease: challenging but feasible. Biomark Med (2010) 1.12
Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease. Neurobiol Aging (2013) 1.12
Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system. Eur J Neurosci (2008) 1.12
Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. J Alzheimers Dis (2012) 1.11
Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease. J Neurol (2008) 1.11
Sensitivity and specificity of medial temporal lobe visual ratings and multivariate regional MRI classification in Alzheimer's disease. PLoS One (2011) 1.10
Combination analysis of neuropsychological tests and structural MRI measures in differentiating AD, MCI and control groups--the AddNeuroMed study. Neurobiol Aging (2009) 1.09
Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study. Neurosci Lett (2004) 1.09
p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells. Neurosci Lett (2007) 1.08
Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease. Neurobiol Aging (2010) 1.08
A comprehensive testing protocol for MRI neuroanatomical segmentation techniques: Evaluation of a novel lateral ventricle segmentation method. Neuroimage (2011) 1.06
Plasma biomarkers of brain atrophy in Alzheimer's disease. PLoS One (2011) 1.06
The importance of tau phosphorylation for neurodegenerative diseases. Front Neurol (2013) 1.05
A blood gene expression marker of early Alzheimer's disease. J Alzheimers Dis (2013) 1.05
Different multivariate techniques for automated classification of MRI data in Alzheimer's disease and mild cognitive impairment. Psychiatry Res (2013) 1.05
A feasibility and tolerability study of lithium in Alzheimer's disease. Int J Geriatr Psychiatry (2008) 1.04
Glycogen synthase kinase-3 is increased in white cells early in Alzheimer's disease. Neurosci Lett (2005) 1.04
Complement activation as a biomarker for Alzheimer's disease. Immunobiology (2011) 1.04
Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Hum Mol Genet (2007) 1.03
Alzheimer risk variant CLU and brain function during aging. Biol Psychiatry (2012) 1.02
The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. J Alzheimers Dis (2012) 1.02
Identification of cis-regulatory variation influencing protein abundance levels in human plasma. Hum Mol Genet (2012) 1.02
The antidepressant clomipramine regulates cortisol intracellular concentrations and glucocorticoid receptor expression in fibroblasts and rat primary neurones. Neuropsychopharmacology (2003) 1.01
Entorhinal cortex thickness predicts cognitive decline in Alzheimer's disease. J Alzheimers Dis (2013) 1.01
APOE ε2 allele is associated with larger regional cortical thicknesses and volumes. Dement Geriatr Cogn Disord (2010) 1.00
Education increases reserve against Alzheimer's disease--evidence from structural MRI analysis. Neuroradiology (2012) 0.99
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions. Neurobiol Dis (2005) 0.99
Plasma transthyretin as a candidate marker for Alzheimer's disease. J Alzheimers Dis (2012) 0.99
Plasma based markers of [11C] PiB-PET brain amyloid burden. PLoS One (2012) 0.98
Magnetic resonance imaging and magnetic resonance spectroscopy for detection of early Alzheimer's disease. J Alzheimers Dis (2011) 0.98
GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt. Eur J Neurosci (2006) 0.97
Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Ann Neurol (2006) 0.97
A proposed metabolic strategy for monitoring disease progression in Alzheimer's disease. Electrophoresis (2009) 0.96
Diagnosing Alzheimer's disease--non-clinicians and computerised algorithms together are as accurate as the best clinical practice. Int J Geriatr Psychiatry (2007) 0.94
Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci. Am J Med Genet B Neuropsychiatr Genet (2007) 0.93
OPCRIT+: an electronic system for psychiatric diagnosis and data collection in clinical and research settings. Br J Psychiatry (2011) 0.92
Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. Am J Med Genet B Neuropsychiatr Genet (2005) 0.92
Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiol Aging (2012) 0.92
Plasma gelsolin is decreased and correlates with rate of decline in Alzheimer's disease. J Alzheimers Dis (2010) 0.92
Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. Am J Med Genet B Neuropsychiatr Genet (2005) 0.92
TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones. J Neurochem (2006) 0.91
Combinatorial markers of mild cognitive impairment conversion to Alzheimer's disease--cytokines and MRI measures together predict disease progression. J Alzheimers Dis (2011) 0.91
No evidence that extended tracts of homozygosity are associated with Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet (2011) 0.91
Combining MRI and MRS to distinguish between Alzheimer's disease and healthy controls. J Alzheimers Dis (2010) 0.91
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Lett (2006) 0.91
Sequence variation in the CHAT locus shows no association with late-onset Alzheimer's disease. Hum Genet (2003) 0.91
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Hum Mutat (2005) 0.90
Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil. J Clin Psychopharmacol (2009) 0.90
Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4. Biol Psychiatry (2007) 0.89
The NEO-FFI is a reliable measure of premorbid personality in patients with probable Alzheimer's disease. Int J Geriatr Psychiatry (2006) 0.89
Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia. Neurobiol Aging (2010) 0.88
Truncated apoE forms tangle-like structures in a neuronal cell line. Neuroreport (2002) 0.88
TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism. Neurosci Lett (2006) 0.88
Plasma biomarkers for Alzheimer's disease: much needed but tough to find. Biomark Med (2012) 0.88
Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation. Neurobiol Aging (2012) 0.88
Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing. Neurosci Lett (2005) 0.88
Wnt3a induces exosome secretion from primary cultured rat microglia. BMC Neurosci (2012) 0.87
Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging (2011) 0.87
Ageing increases vulnerability to aβ42 toxicity in Drosophila. PLoS One (2012) 0.87