Published in Bioorg Med Chem Lett on February 24, 2003
TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature (2008) 8.40
Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1. J Neurophysiol (2008) 2.99
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci (2007) 2.69
Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila. J Neurosci (2004) 2.66
The calcium-activated chloride channel anoctamin 1 acts as a heat sensor in nociceptive neurons. Nat Neurosci (2012) 2.28
Bradykinin-12-lipoxygenase-VR1 signaling pathway for inflammatory hyperalgesia. Proc Natl Acad Sci U S A (2002) 1.94
Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding. J Biol Chem (2003) 1.68
Dynamic modulation of ANO1/TMEM16A HCO3(-) permeability by Ca2+/calmodulin. Proc Natl Acad Sci U S A (2012) 1.63
Peripheral mechanisms of pain and analgesia. Brain Res Rev (2008) 1.55
A tarantula spider toxin, GsMTx4, reduces mechanical and neuropathic pain. Pain (2008) 1.52
Mechanosensitive ion channels in cultured sensory neurons of neonatal rats. J Neurosci (2002) 1.44
Design and synthesis of 3'-fluoropenciclovir analogues as antiviral agents. Arch Pharm Res (2010) 1.38
Novel Polydioxanone Multifilament Scaffold Device for Tissue Regeneration. Dermatol Surg (2016) 1.38
Histamine-induced itch and its relationship with pain. Mol Pain (2008) 1.34
Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons. Neurosci Lett (2004) 1.33
Cartoon distraction alleviates anxiety in children during induction of anesthesia. Anesth Analg (2012) 1.28
Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res (2004) 1.24
A novel mechanosensitive channel identified in sensory neurons. Eur J Neurosci (2006) 1.23
Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCalpha. J Biol Chem (2001) 1.21
Farnesyl pyrophosphate is a novel pain-producing molecule via specific activation of TRPV3. J Biol Chem (2010) 1.17
Anoctamin 1 contributes to inflammatory and nerve-injury induced hypersensitivity. Mol Pain (2014) 1.16
Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci (2007) 1.16
Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J Biol Chem (2002) 1.14
A combination trial of intradermal radiofrequency and hyaluronic acid filler for the treatment of nasolabial fold wrinkles: a pilot study. J Cosmet Laser Ther (2013) 1.11
Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiol Aging (2003) 1.08
A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion. PLoS Pathog (2013) 1.05
Conformationally constrained analogues of diacylglycerol. 24. Asymmetric synthesis of a chiral (R)-DAG-lactone template as a versatile precursor for highly functionalized DAG-lactones. Org Lett (2004) 1.05
Calcium-dependent and independent mechanisms of capsaicin receptor (TRPV1)-mediated cytokine production and cell death in human bronchial epithelial cells. J Biochem Mol Toxicol (2005) 1.05
2-(3-Fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists: structure activity relationships of the 2-oxy pyridine C-region. Eur J Med Chem (2013) 1.05
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Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches. Int J Oncol (2009) 1.04
TRIF-GEFH1-RhoB pathway is involved in MHCII expression on dendritic cells that is critical for CD4 T-cell activation. EMBO J (2006) 1.03
Novel potent antagonists of transient receptor potential channel, vanilloid subfamily member 1: structure-activity relationship of 1,3-diarylalkyl thioureas possessing new vanilloid equivalents. J Med Chem (2005) 1.02
TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery. J Dermatol Sci (2010) 1.01
Different vanilloid agonists cause different patterns of calcium response in CHO cells heterologously expressing rat TRPV1. Life Sci (2005) 1.01
High affinity antagonists of the vanilloid receptor. Mol Pharmacol (2002) 1.00
Synthesis of 6-formyl-pyridine-2-carboxylate derivatives and their telomerase inhibitory activities. Bioorg Med Chem Lett (2003) 1.00
N-(3-acyloxy-2-benzylpropyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues: novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor. J Med Chem (2003) 0.99
Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-N,N-dialkyluronamides as human A3 adenosine receptor antagonists. Bioorg Med Chem Lett (2008) 0.99
Structural insights into transient receptor potential vanilloid type 1 (TRPV1) from homology modeling, flexible docking, and mutational studies. J Comput Aided Mol Des (2011) 0.99
Heme oxygenase 1 mediates anti-inflammatory effects of 2',4',6'-tris(methoxymethoxy) chalcone. Eur J Pharmacol (2006) 0.98
Transient receptor potential vanilloid subtype 1 mediates microglial cell death in vivo and in vitro via Ca2+-mediated mitochondrial damage and cytochrome c release. J Immunol (2006) 0.98
Activation and activators of TRPV1 and their pharmaceutical implication. Curr Pharm Des (2005) 0.98
Painful channels in sensory neurons. Mol Cells (2005) 0.98
Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae). Oncol Res (2002) 0.97
Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. Pain (2011) 0.97
Quantitative analysis of TRP channel genes in mouse organs. Arch Pharm Res (2012) 0.97
Intracellular amyloid-β accumulation in calcium-binding protein-deficient neurons leads to amyloid-β plaque formation in animal model of Alzheimer's disease. J Alzheimers Dis (2012) 0.97
Lipoxygenase inhibitors suppressed carrageenan-induced Fos-expression and inflammatory pain responses in the rat. Mol Cells (2009) 0.96
TRPV1 recapitulates native capsaicin receptor in sensory neurons in association with Fas-associated factor 1. J Neurosci (2006) 0.95
Sensitization of vanilloid receptor involves an increase in the phosphorylated form of the channel. Arch Pharm Res (2005) 0.94
TRPM4b channel suppresses store-operated Ca2+ entry by a novel protein-protein interaction with the TRPC3 channel. Biochem Biophys Res Commun (2008) 0.93
Highly efficient hybrid light-emitting device using complex of CdSe/ZnS quantum dots embedded in co-polymer as an active layer. Opt Express (2010) 0.92
Facial scar treated with an intradermal radiofrequency device. J Cosmet Laser Ther (2013) 0.92
Transient receptor potential vanilloid-1 (TRPV1) is a mediator of lung toxicity for coal fly ash particulate material. Mol Pharmacol (2011) 0.92
Hot channels in airways: pharmacology of the vanilloid receptor. Curr Opin Pharmacol (2002) 0.91
Stereospecific high-affinity TRPV1 antagonists: chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues. J Med Chem (2007) 0.91
High-affinity partial agonists of the vanilloid receptor. Mol Pharmacol (2003) 0.91
Decrease of ceramides with very long-chain fatty acids and downregulation of elongases in a murine atopic dermatitis model. J Invest Dermatol (2011) 0.90
Peroxiredoxin I is a ROS/p38 MAPK-dependent inducible antioxidant that regulates NF-κB-mediated iNOS induction and microglial activation. J Neuroimmunol (2013) 0.90
Characterization of a recombinant Newcastle disease virus vaccine strain. Clin Vaccine Immunol (2008) 0.89
Kinetics of penetration influence the apparent potency of vanilloids on TRPV1. Mol Pharmacol (2006) 0.89
Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging. Bioorg Med Chem (2004) 0.89
Structure-activity relationship of capsaicin analogs and transient receptor potential vanilloid 1-mediated human lung epithelial cell toxicity. J Pharmacol Exp Ther (2011) 0.88
TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain. Pflugers Arch (2014) 0.88
Antipruritic effects of TRPV1 antagonist in murine atopic dermatitis and itching models. J Invest Dermatol (2011) 0.88
Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades. J Neurochem (2010) 0.88
Axonal neuropathy-associated TRPV4 regulates neurotrophic factor-derived axonal growth. J Biol Chem (2011) 0.87
Endogenous lipid-derived ligands for sensory TRP ion channels and their pain modulation. Arch Pharm Res (2010) 0.87
Inhibition of MKK7-JNK by the TOR signaling pathway regulator-like protein contributes to resistance of HCC cells to TRAIL-induced apoptosis. Gastroenterology (2012) 0.87
2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors. Eur J Med Chem (2008) 0.87
The effect of epidermal growth factor (EGF) conjugated with low-molecular-weight protamine (LMWP) on wound healing of the skin. Biomaterials (2012) 0.87
Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem (2011) 0.86
A new 3D reconstituted human corneal epithelium model as an alternative method for the eye irritation test. Toxicol In Vitro (2010) 0.86
Determination of spatial distribution of melamine-cyanuric acid crystals in rat kidney tissue by histology and imaging matrix-assisted laser desorption/ionization quadrupole time-of-flight mass spectrometry. Chem Res Toxicol (2010) 0.86
Conformationally constrained analogues of diacylglycerol. 19. Synthesis and protein kinase C binding affinity of diacylglycerol lactones bearing an N-hydroxylamide side chain. J Med Chem (2003) 0.86
Calcium-activated cationic channel in rat sensory neurons. Eur J Neurosci (2003) 0.86
Differential modulation of agonist and antagonist structure activity relations for rat TRPV1 by cyclosporin A and other protein phosphatase inhibitors. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.86
Ablation of Ca2+ channel beta3 subunit leads to enhanced N-methyl-D-aspartate receptor-dependent long term potentiation and improved long term memory. J Biol Chem (2008) 0.86
Alpha-substituted N-(4-tert-butylbenzyl)-N'-[4-(methylsulfonylamino)benzyl]thiourea analogues as potent and stereospecific TRPV1 antagonists. Bioorg Med Chem (2007) 0.85
Characterization of arginylation branch of N-end rule pathway in G-protein-mediated proliferation and signaling of cardiomyocytes. J Biol Chem (2012) 0.85
Hypoxia-mediated retinal neovascularization and vascular leakage in diabetic retina is suppressed by HIF-1α destabilization by SH-1242 and SH-1280, novel hsp90 inhibitors. J Mol Med (Berl) (2014) 0.85
Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons. Mol Cell Neurosci (2003) 0.84