Published in FASEB J on March 28, 2003
A review of the mammalian unfolded protein response. Biotechnol Bioeng (2011) 1.83
Sent to destroy: the ubiquitin proteasome system regulates cell signaling and protein quality control in cardiovascular development and disease. Circ Res (2010) 1.78
Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1/CCR2 pathway. Circ Res (2012) 1.51
Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response. J Biol Chem (2009) 1.48
GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell (2007) 1.46
The role of the unfolded protein response in the heart. J Mol Cell Cardiol (2007) 1.39
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy. Scientifica (Cairo) (2012) 1.37
GRP94 in ER quality control and stress responses. Semin Cell Dev Biol (2010) 1.29
O-GlcNAc signaling attenuates ER stress-induced cardiomyocyte death. Am J Physiol Heart Circ Physiol (2009) 1.20
Time course analysis of mechanical ventilation-induced diaphragm contractile muscle dysfunction in the rat. J Physiol (2014) 1.06
Targeted deletion of NF-kappaB p50 diminishes the cardioprotection of histone deacetylase inhibition. Am J Physiol Heart Circ Physiol (2010) 1.06
The peptide-binding activity of GRP94 is regulated by calcium. Biochem J (2007) 1.05
Mechanisms of exercise-induced cardioprotection. Physiology (Bethesda) (2014) 1.05
PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes. PLoS One (2010) 1.04
Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis. J Cell Physiol (2015) 1.04
gp-91 mediates histone deacetylase inhibition-induced cardioprotection. Biochim Biophys Acta (2010) 1.01
Mild exercise training, cardioprotection and stress genes profile. Eur J Appl Physiol (2007) 0.98
Glucose regulated protein 94 is required for muscle differentiation through its control of the autocrine production of insulin-like growth factors. Biochim Biophys Acta (2009) 0.97
New concepts of endoplasmic reticulum function in the heart: programmed to conserve. J Mol Cell Cardiol (2012) 0.95
Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J (2012) 0.95
Role of endoplasmic reticulum stress in atherosclerosis and diabetic macrovascular complications. Biomed Res Int (2014) 0.94
Reactive Oxygen Species, Endoplasmic Reticulum Stress and Mitochondrial Dysfunction: The Link with Cardiac Arrhythmogenesis. Front Physiol (2016) 0.93
Molecular mechanisms in exercise-induced cardioprotection. Cardiol Res Pract (2011) 0.90
Endoplasmic reticulum stress and diabetic cardiomyopathy. Exp Diabetes Res (2011) 0.89
Sparing of muscle mass and function by passive loading in an experimental intensive care unit model. J Physiol (2012) 0.87
Cardioprotective stress response in the human fetal heart. J Thorac Cardiovasc Surg (2005) 0.87
Organellar calcium buffers. Cold Spring Harb Perspect Biol (2011) 0.87
Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias. Int J Mol Sci (2015) 0.84
Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cells. J Cell Mol Med (2010) 0.83
Exercise and the cardiovascular system. Cardiol Res Pract (2012) 0.83
Curcumin counteracts loss of force and atrophy of hindlimb unloaded rat soleus by hampering neuronal nitric oxide synthase untethering from sarcolemma. J Physiol (2014) 0.81
The Myocardial Unfolded Protein Response during Ischemic Cardiovascular Disease. Biochem Res Int (2012) 0.80
The stress protein/chaperone Grp94 counteracts muscle disuse atrophy by stabilizing subsarcolemmal neuronal nitric oxide synthase. Antioxid Redox Signal (2013) 0.78
Unfolded protein response in brain ischemia: A timely update. J Cereb Blood Flow Metab (2016) 0.78
The Endoplasmic Reticulum Chaperone GRP170: From Immunobiology to Cancer Therapeutics. Front Oncol (2015) 0.76
Resveratrol and Omega-3 Fatty Acid: Its Implications in Cardiovascular Diseases. Front Cardiovasc Med (2015) 0.76
Impact of high cholesterol and endoplasmic reticulum stress on metabolic diseases: An updated mini-review. Redox Biol (2017) 0.75
Targeting the unfolded protein response in heart diseases. Expert Opin Ther Targets (2014) 0.75
Tauroursodeoxycholic acid inhibits endoplasmic reticulum stress, blocks mitochondrial permeability transition pore opening, and suppresses reperfusion injury through GSK-3ß in cardiac H9c2 cells. Am J Transl Res (2016) 0.75
In vivo heat shock preconditioning mitigates calcium overload during ischaemia/reperfusion in the isolated, perfused rat heart. Pflugers Arch (2004) 0.75
Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. J Biol Chem (2005) 4.29
The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J (2006) 3.26
Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A (2013) 2.96
A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis. Oncogene (2002) 2.55
Postconditioning and protection from reperfusion injury: where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res (2010) 2.20
Oxidation of myofibrillar proteins in human heart failure. J Am Coll Cardiol (2011) 2.13
Hexokinase II detachment from mitochondria triggers apoptosis through the permeability transition pore independent of voltage-dependent anion channels. PLoS One (2008) 1.87
Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolization. Eur Heart J (2006) 1.87
Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc Res (2005) 1.75
Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. Biochem J (2002) 1.60
Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex. J Biol Chem (2009) 1.58
Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation. J Biol Chem (2008) 1.43
Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice. Circ Res (2005) 1.34
Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload. Circ Res (2009) 1.32
Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway. J Biol Chem (2004) 1.27
The cardioprotective effects elicited by p66(Shc) ablation demonstrate the crucial role of mitochondrial ROS formation in ischemia/reperfusion injury. Biochim Biophys Acta (2009) 1.22
Mitochondrial alterations induced by the p13II protein of human T-cell leukemia virus type 1. Critical role of arginine residues. J Biol Chem (2002) 1.17
The mitochondrial permeability transition from yeast to mammals. FEBS Lett (2010) 1.17
Oxidative stress by monoamine oxidases is causally involved in myofiber damage in muscular dystrophy. Hum Mol Genet (2010) 1.15
Mitochondria and cardioprotection. Heart Fail Rev (2007) 1.14
The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative. J Biol Chem (2006) 1.14
Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury. Biochim Biophys Acta (2010) 1.13
Bupivacaine myotoxicity is mediated by mitochondria. J Biol Chem (2002) 1.10
The effects of idebenone on mitochondrial bioenergetics. Biochim Biophys Acta (2011) 1.10
Mitochondria and reperfusion injury. The role of permeability transition. Basic Res Cardiol (2003) 1.10
Evidence of myofibrillar protein oxidation induced by postischemic reperfusion in isolated rat hearts. Am J Physiol Heart Circ Physiol (2004) 1.10
Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66(Shc) and monoamine oxidase. Basic Res Cardiol (2009) 1.10
Respiratory complex I dysfunction due to mitochondrial DNA mutations shifts the voltage threshold for opening of the permeability transition pore toward resting levels. J Biol Chem (2008) 1.07
Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor). J Biol Chem (2010) 1.06
Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts. Antioxid Redox Signal (2013) 1.04
Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. J Cell Mol Med (2012) 1.01
Mild exercise training, cardioprotection and stress genes profile. Eur J Appl Physiol (2007) 0.98
Mitochondria and vascular pathology. Pharmacol Rep (2009) 0.97
Modulation of mitochondrial K(+) permeability and reactive oxygen species production by the p13 protein of human T-cell leukemia virus type 1. Biochim Biophys Acta (2009) 0.97
A transient antioxidant stress response accompanies the onset of disuse atrophy in human skeletal muscle. J Appl Physiol (1985) (2009) 0.97
Properties of Ca(2+) transport in mitochondria of Drosophila melanogaster. J Biol Chem (2011) 0.94
Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation. Arthritis Res Ther (2010) 0.94
Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation. Am J Physiol Heart Circ Physiol (2010) 0.92
Redox regulation of T-cell turnover by the p13 protein of human T-cell leukemia virus type 1: distinct effects in primary versus transformed cells. Blood (2010) 0.91
Cellular distribution of Hsp70 expression in rat skeletal muscles. Effects of moderate exercise training and chronic hypoxia. Cell Stress Chaperones (2008) 0.90
Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluorene. Proc Natl Acad Sci U S A (2003) 0.90
Mitochondrial energy dissipation by fatty acids. Mechanisms and implications for cell death. Vitam Horm (2002) 0.90
Mitochondrial respiration and membrane potential after low-flow ischemia are not affected by ischemic preconditioning. J Mol Cell Cardiol (2007) 0.89
Effects of fatty acids on mitochondria: implications for cell death. Biochim Biophys Acta (2002) 0.89
Cinnamic anilides as new mitochondrial permeability transition pore inhibitors endowed with ischemia-reperfusion injury protective effect in vivo. J Med Chem (2014) 0.89
Impact of the phosphatidylinositide 3-kinase signaling pathway on the cardioprotection induced by intermittent hypoxia. PLoS One (2013) 0.89
Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells. J Pharmacol Exp Ther (2011) 0.88
Formation of reactive oxygen species at increased contraction frequency in rat cardiomyocytes. Cardiovasc Res (2006) 0.87
Sparing of muscle mass and function by passive loading in an experimental intensive care unit model. J Physiol (2012) 0.87
Cyclosporine before PCI in Acute Myocardial Infarction. N Engl J Med (2016) 0.87
Mitochondrial injury and protection in ischemic pre- and postconditioning. Antioxid Redox Signal (2010) 0.86
Mitochondria are direct targets of the lipoxygenase inhibitor MK886. A strategy for cell killing by combined treatment with MK886 and cyclooxygenase inhibitors. J Biol Chem (2002) 0.86
Troponin I isoform expression in human and experimental atrial fibrillation. Circulation (2004) 0.86
A glutamine synthetase inhibitor increases survival and decreases cytokine response in a mouse model of acute liver failure. Liver Int (2011) 0.85
Grp94 is Tyr-phosphorylated by Fyn in the lumen of the endoplasmic reticulum and translocates to Golgi in differentiating myoblasts. Biochim Biophys Acta (2008) 0.85
PUVA-induced apoptosis involves mitochondrial dysfunction caused by the opening of the permeability transition pore. FEBS Lett (2002) 0.85
Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR. J Biol Chem (2006) 0.84
Gold(I) complexes determine apoptosis with limited oxidative stress in Jurkat T cells. Eur J Pharmacol (2008) 0.84
Grp94 acts as a mediator of curcumin-induced antioxidant defence in myogenic cells. J Cell Mol Med (2010) 0.83
Cell stress response in skeletal muscle myofibers. Ann N Y Acad Sci (2006) 0.83
Cutting edge issues in polymyositis. Clin Rev Allergy Immunol (2011) 0.82
The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide. Biochim Biophys Acta (2011) 0.82
ROTEM®-guided coagulation factor concentrate therapy in trauma: 2-year experience in Venice, Italy. Crit Care (2012) 0.81
Induction of the mitochondrial permeability transition by the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. Sorting cause and consequence of mitochondrial dysfunction. Biochim Biophys Acta (2004) 0.81
Oxidative stress in muscular dystrophy: from generic evidence to specific sources and targets. J Muscle Res Cell Motil (2014) 0.80
Peptide-based carbon nanotubes for mitochondrial targeting. Nanoscale (2013) 0.80
Discrimination between two steps in the mitochondrial permeability transition process. Int J Biochem Cell Biol (2005) 0.79
Effects of inactivity on human muscle glutathione synthesis by a double-tracer and single-biopsy approach. J Physiol (2010) 0.79
4-hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one induces mitochondrial dysfunction and apoptosis upon its intracellular oxidation. J Med Chem (2005) 0.79
Ranolazine protects from doxorubicin-induced oxidative stress and cardiac dysfunction. Eur J Heart Fail (2014) 0.79
The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy. Blood (2007) 0.79
Species-specific modulation of the mitochondrial permeability transition by norbormide. Biochim Biophys Acta (2005) 0.79
Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide. Biochim Biophys Acta (2007) 0.78
The stress protein/chaperone Grp94 counteracts muscle disuse atrophy by stabilizing subsarcolemmal neuronal nitric oxide synthase. Antioxid Redox Signal (2013) 0.78
Rotational thromboelastometry analysis and management of life-threatening haemorrhage in isolated craniofacial injury. Blood Coagul Fibrinolysis (2012) 0.77
The p66ShcA adaptor protein regulates healing after myocardial infarction. Basic Res Cardiol (2015) 0.77
The contribution of stem cell therapy to skeletal muscle remodeling in heart failure. Int J Cardiol (2013) 0.76
A female way to protect the heart: say NO to calcium. Circ Res (2006) 0.75
Re: Gold standards for scientists who are conducting animal-based exercise studies. J Appl Physiol (1985) (2010) 0.75
Homer 2 antagonizes protein degradation in slow-twitch skeletal muscles. Am J Physiol Cell Physiol (2012) 0.75