Published in Histochem Cell Biol on April 12, 2003
Cell death in health and disease. J Cell Mol Med (2007) 1.27
Integration of transcriptomics, proteomics, and microRNA analyses reveals novel microRNA regulation of targets in the mammalian inner ear. PLoS One (2011) 1.15
A hierarchy of proliferative cells exists in mouse lens epithelium: implications for lens maintenance. Invest Ophthalmol Vis Sci (2006) 1.09
Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure. Am J Physiol Cell Physiol (2009) 0.95
Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter. PLoS One (2012) 0.88
The significance of autoantibodies to DFS70/LEDGFp75 in health and disease: integrating basic science with clinical understanding. Clin Exp Med (2015) 0.83
Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens. J Cell Mol Med (2013) 0.81
LEDGF(1-326) decreases P23H and wild type rhodopsin aggregates and P23H rhodopsin mediated cell damage in human retinal pigment epithelial cells. PLoS One (2011) 0.79
Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells. J Cell Mol Med (2012) 0.78
FGF2 antagonizes aberrant TGFβ regulation of tropomyosin: role for posterior capsule opacity. J Cell Mol Med (2016) 0.75
PSIP1/LEDGF: a new gene likely involved in sensorineural progressive hearing loss. Sci Rep (2015) 0.75
The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication. J Mol Biol (2016) 0.75
Innovative techniques and applications in histochemistry and cell biology. Histochem Cell Biol (2003) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Social controls on cell survival and cell death. Nature (1992) 9.81
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat Cell Biol (2000) 5.24
Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol (2000) 4.89
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev (1995) 4.87
Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature (1997) 4.82
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution. Genes Dev (1995) 4.19
Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation (1981) 3.65
Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol (2000) 3.05
Genomic imprinting of p57KIP2, a cyclin-dependent kinase inhibitor, in mouse. Nat Genet (1995) 2.24
Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation. EMBO J (1998) 2.04
A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc Natl Acad Sci U S A (1994) 1.95
Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration. Development (1989) 1.80
A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Mol Cell (1998) 1.61
Coincident loss of mitochondria and nuclei during lens fiber cell differentiation. Dev Dyn (1992) 1.52
A role for caspases in lens fiber differentiation. J Cell Biol (1998) 1.47
LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes. Biochem Biophys Res Commun (2001) 1.44
Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death. J Biol Chem (1997) 1.40
Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol (2000) 1.34
Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. Gene (2000) 1.32
Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. J Biol Chem (2001) 1.26
Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts. Biochem Biophys Res Commun (2000) 1.25
Control of lens epithelial cell survival. J Cell Biol (1993) 1.24
Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats. Invest Ophthalmol Vis Sci (2001) 1.20
Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders. Cell Death Differ (2002) 1.15
Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses. Invest Ophthalmol Vis Sci (1999) 1.11
Activation of LEDGF gene by thermal-and oxidative-stresses. Biochem Biophys Res Commun (2000) 1.09
Pituitary adenylate cyclase activating polypeptide anti-mitogenic signaling in cerebral cortical progenitors is regulated by p57Kip2-dependent CDK2 activity. J Neurosci (2002) 1.05
Effects of growth factors on proliferation and differentiation in human lens epithelial cells in early subculture. Invest Ophthalmol Vis Sci (1995) 1.03
Evidence that fibroblast growth factor promotes lens fibre differentiation. Curr Eye Res (1987) 1.03
Lens fibre cell differentiation - A link with apoptosis? Ophthalmic Res (1999) 1.01
Induction of lens fibre differentiation by acidic and basic fibroblast growth factor (FGF). Growth Factors (1989) 1.00
Structural analysis of lens epithelial explants induced to differentiate into fibres by fibroblast growth factor (FGF). Exp Eye Res (1989) 1.00
Spatial and temporal expression of p57(KIP2) during murine lens development. Mech Dev (1999) 0.99
Changes in the nucleolar and coiled body compartments precede lamina and chromatin reorganization during fibre cell denucleation in the bovine lens. Eur J Cell Biol (1998) 0.97
Minireview: apoptosis as seen through a lens. Apoptosis (2000) 0.97
Basonuclin in murine corneal and lens epithelia correlates with cellular maturation and proliferative ability. Differentiation (1999) 0.97
Lens epithelium-derived growth factor: increased survival and decreased DNA breakage of human RPE cells induced by oxidative stress. Invest Ophthalmol Vis Sci (2001) 0.95
Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1. Exp Eye Res (1998) 0.95
LEDGF: survival of embryonic chick retinal photoreceptor cells. Invest Ophthalmol Vis Sci (2000) 0.95
Nuclear localization of basonuclin in human keratinocytes and the role of phosphorylation. Proc Natl Acad Sci U S A (1997) 0.93
Overexpression of FGF-2 modulates fiber cell differentiation and survival in the mouse lens. Development (1997) 0.89
Heparin's roles in stabilizing, potentiating, and transporting LEDGF into the nucleus. Invest Ophthalmol Vis Sci (2000) 0.88
Up-regulation of aFGF expression in quiescent cells is related to cell survival. J Cell Physiol (1994) 0.87
Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF). J Mol Biol (2002) 0.86
Caspase-3 is actively involved in okadaic acid-induced lens epithelial cell apoptosis. Exp Cell Res (2001) 0.85
Nuclear degeneration in the developing lens and its regulation by TNFalpha. Exp Eye Res (1998) 0.83
Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells. Cell Growth Differ (1995) 0.82
Noncontact specular microscopy of human lens epithelium. Invest Ophthalmol Vis Sci (2000) 0.80
The effects of insulin and basic fibroblast growth factor on fibre differentiation in rat lens epithelial explants. Growth Factors (1991) 0.80
Differentiation of human lens epithelial cells in tissue culture. Exp Eye Res (1988) 0.77
Enhancement of differentiation of human lens epithelium in tissue culture by changes in cell-substrate adhesion. Invest Ophthalmol Vis Sci (1990) 0.77
Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet (2003) 1.91
Weight status, abdominal adiposity, diabetes, and early age-related lens opacities. Am J Clin Nutr (2003) 1.68
Dietary glycemic index and carbohydrate in relation to early age-related macular degeneration. Am J Clin Nutr (2006) 1.61
Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress. Proc Natl Acad Sci U S A (2004) 1.48
LEDGF, a survival factor, activates stress-related genes. Prog Retin Eye Res (2002) 1.41
The unfolded protein response in lens epithelial cells from galactosemic rat lenses. Invest Ophthalmol Vis Sci (2006) 1.37
TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am J Physiol Cell Physiol (2008) 1.27
SOD2 protects against oxidation-induced apoptosis in mouse retinal pigment epithelium: implications for age-related macular degeneration. Invest Ophthalmol Vis Sci (2005) 1.22
Role of the unfolded protein response (UPR) in cataract formation. Exp Eye Res (2006) 1.21
Ubiquitin-dependent lysosomal degradation of the HNE-modified proteins in lens epithelial cells. FASEB J (2004) 1.18
HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA. PLoS One (2011) 1.13
Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation. Curr Eye Res (2006) 1.12
Growth factor induced activation of Rho and Rac GTPases and actin cytoskeletal reorganization in human lens epithelial cells. Mol Vis (2003) 1.07
Clinical application of the lens opacities classification system III in the performance of phacoemulsification. J Cataract Refract Surg (2003) 1.06
Cdk5 regulates activation and localization of Src during corneal epithelial wound closure. J Cell Sci (2004) 1.06
Topical ocular hypotensive medication and lens opacification: evidence from the ocular hypertension treatment study. Am J Ophthalmol (2006) 1.05
Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage. BMC Neurosci (2010) 1.04
Involvement of metabotropic glutamate receptor 5, AKT/PI3K signaling and NF-κB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes. J Neuroinflammation (2012) 1.02
Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Hum Mol Genet (2004) 1.01
CDK5 regulates cell adhesion and migration in corneal epithelial cells. Mol Cancer Res (2002) 1.01
Long-term intake of vitamins and carotenoids and odds of early age-related cortical and posterior subcapsular lens opacities. Am J Clin Nutr (2002) 1.00
Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathway. Oncogene (2002) 0.99
The effects of GPX-1 knockout on membrane transport and intracellular homeostasis in the lens. J Membr Biol (2008) 0.99
The effect of up- and downregulation of MnSOD enzyme on oxidative stress in human lens epithelial cells. Invest Ophthalmol Vis Sci (2003) 0.98
PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. Free Radic Res (2009) 0.98
Sigma receptor ligands protect human retinal cells against oxidative stress. Neuroreport (2006) 0.97
Cdk5 regulates cell-matrix and cell-cell adhesion in lens epithelial cells. J Cell Sci (2002) 0.96
Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats. Mol Vis (2007) 0.96
Spectrum and range of oxidative stress responses of human lens epithelial cells to H2O2 insult. Invest Ophthalmol Vis Sci (2003) 0.96
Age-related cataracts: homocysteine coupled endoplasmic reticulum stress and suppression of Nrf2-dependent antioxidant protection. Chem Biol Interact (2012) 0.95
Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure. Am J Physiol Cell Physiol (2009) 0.95
UVA light in vivo reaches the nucleus of the guinea pig lens and produces deleterious, oxidative effects. Exp Eye Res (2002) 0.94
Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells. J Biol Chem (2003) 0.94
Protein-protein interactions between lens vimentin and alphaB-crystallin using FRET acceptor photobleaching. Mol Vis (2008) 0.94
Synergistic cooperation between methamphetamine and HIV-1 gsp120 through the P13K/Akt pathway induces IL-6 but not IL-8 expression in astrocytes. PLoS One (2012) 0.94
TAT-mediated peroxiredoxin 5 and 6 protein transduction protects against high-glucose-induced cytotoxicity in retinal pericytes. Life Sci (2009) 0.93
Polyol pathway-dependent osmotic and oxidative stresses in aldose reductase-mediated apoptosis in human lens epithelial cells: role of AOP2. Biochem Biophys Res Commun (2004) 0.93
Long-term nutrient intake and 5-year change in nuclear lens opacities. Arch Ophthalmol (2005) 0.92
Development- and age-associated expression pattern of peroxiredoxin 6, and its regulation in murine ocular lens. Mech Ageing Dev (2006) 0.91
Overall adherence to the dietary guidelines for americans is associated with reduced prevalence of early age-related nuclear lens opacities in women. J Nutr (2004) 0.91
Curcumin abates hypoxia-induced oxidative stress based-ER stress-mediated cell death in mouse hippocampal cells (HT22) by controlling Prdx6 and NF-κB regulation. Am J Physiol Cell Physiol (2013) 0.91
HIV-1 envelope protein gp120 up regulates CCL5 production in astrocytes which can be circumvented by inhibitors of NF-κB pathway. Biochem Biophys Res Commun (2011) 0.90
Dietary fat intake and early age-related lens opacities. Am J Clin Nutr (2005) 0.90
Regulation of heavy subunit chain of gamma-glutamylcysteine synthetase by tumor necrosis factor-alpha in lens epithelial cells: role of LEDGF/p75. Am J Physiol Cell Physiol (2006) 0.90
Carbohydrate intake and glycemic index in relation to the odds of early cortical and nuclear lens opacities. Am J Clin Nutr (2005) 0.89
LEDGF regulation of alcohol and aldehyde dehydrogenases in lens epithelial cells: stimulation of retinoic acid production and protection from ethanol toxicity. Am J Physiol Cell Physiol (2004) 0.89
Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis. Am J Physiol Cell Physiol (2011) 0.89
Detection of cytotoxic anti-LEDGF autoantibodies in atopic dermatitis. Autoimmunity (2002) 0.89
Promoter demethylation of Keap1 gene in human diabetic cataractous lenses. Biochem Biophys Res Commun (2012) 0.88
Transcriptional protein Sp1 regulates LEDGF transcription by directly interacting with its cis-elements in GC-rich region of TATA-less gene promoter. PLoS One (2012) 0.88
LEDGF activation of PKC gamma and gap junction disassembly in lens epithelial cells. Exp Eye Res (2003) 0.88
Differential activity of kaempferol and quercetin in attenuating tumor necrosis factor receptor family signaling in bone cells. Biochem Pharmacol (2006) 0.87
Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation. J Biol Chem (2004) 0.87
Loss of NF-kappaB control and repression of Prdx6 gene transcription by reactive oxygen species-driven SMAD3-mediated transforming growth factor beta signaling. J Biol Chem (2009) 0.86
Moderate alcoholic beverage intake and early nuclear and cortical lens opacities. Ophthalmic Epidemiol (2004) 0.86
PKC putative phosphorylation site Ser235 is required for MIP/AQP0 translocation to the plasma membrane. Mol Vis (2008) 0.85
Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci (2009) 0.85
Activation of metallothioneins and alpha-crystallin/sHSPs in human lens epithelial cells by specific metals and the metal content of aging clear human lenses. Invest Ophthalmol Vis Sci (2003) 0.84
Inhibitory effects of Arg-Gly-Asp (RGD) peptide on cell attachment and migration in a human lens epithelial cell line. Ophthalmic Res (2005) 0.84
Ocular safety of fluticasone furoate nasal spray in patients with perennial allergic rhinitis: a 2-year study. Ann Allergy Asthma Immunol (2013) 0.83
Proteomic and transcriptomic analyses of retinal pigment epithelial cells exposed to REF-1/TFPI-2. Invest Ophthalmol Vis Sci (2007) 0.83
LEDGF/DFS70, a major autoantigen of atopic dermatitis, is a component of keratohyalin granules. J Invest Dermatol (2006) 0.82
Dynamic and differential regulation in the microRNA expression in the developing and mature cataractous rat lens. J Cell Mol Med (2013) 0.81
Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells. PLoS One (2010) 0.81
Cholesterol-derived bile acids enhance the chaperone activity of α-crystallins. Cell Stress Chaperones (2011) 0.81
Epigenetic repression of LEDGF during UVB exposure by recruitment of SUV39H1 and HDAC1 to the Sp1-responsive elements within LEDGF promoter CpG island. Epigenetics (2013) 0.80
DNA barcoding of gobiid fishes (Perciformes, Gobioidei). Mitochondrial DNA (2013) 0.80
Intake of zinc and antioxidant micronutrients and early age-related maculopathy lesions. Ophthalmic Epidemiol (2007) 0.79
Differential evolution of cell-associated virus in blood and genital tract of HIV-infected females undergoing HAART. Virology (2005) 0.79
Expression and regulation in the brain of the chemokine CCL27 gene locus. J Neuroimmunol (2010) 0.79
LEDGF(1-326) decreases P23H and wild type rhodopsin aggregates and P23H rhodopsin mediated cell damage in human retinal pigment epithelial cells. PLoS One (2011) 0.79
Elevated tropomyosin expression is associated with epithelial-mesenchymal transition of lens epithelial cells. J Cell Mol Med (2012) 0.78
Long-term efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol. Allergy Asthma Proc (2014) 0.78
Dietary linolenic acid intake is positively associated with five-year change in eye lens nuclear density. J Am Coll Nutr (2007) 0.78
Lens epithelium-derived growth factor: neuroprotection on rat retinal damage induced by N-methyl-D-aspartate. Brain Res (2003) 0.77
Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription. FEBS J (2014) 0.77
Neuroactive steroids protect retinal pigment epithelium against oxidative stress. Neuroreport (2005) 0.77