Published in Biochemistry on May 13, 2003
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem (2007) 1.06
An iron 13S-lipoxygenase with an α-linolenic acid specific hydroperoxidase activity from Fusarium oxysporum. PLoS One (2013) 0.96
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 0.94
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. Biochemistry (2009) 0.93
Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation. J Lipid Res (2012) 0.91
Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. Biochemistry (2009) 0.86
Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1. Bioorg Med Chem Lett (2008) 0.82
Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy. PLoS One (2013) 0.77
Analysis of Hydrogen Tunneling in an Enzyme Active Site using von Neumann Measurements. J Chem Theory Comput (2010) 0.76
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Org Biomol Chem (2008) 0.75
Synthesis of Site-Specifically (13)C Labeled Linoleic Acids. Tetrahedron Lett (2016) 0.75
ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. Biochemistry (2014) 0.75
Hydrogen-Deuterium Exchange of Lipoxygenase Uncovers a Relationship between Distal, Solvent Exposed Protein Motions and the Thermal Activation Barrier for Catalytic Proton-Coupled Electron Tunneling. ACS Cent Sci (2017) 0.75
Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction. Diabetologia (2014) 1.49
Novel human lipoxygenase inhibitors discovered using virtual screening with homology models. J Med Chem (2006) 1.36
Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res (2008) 1.34
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases. Bioorg Med Chem (2006) 1.29
Structure-activity relationship studies of nordihydroguaiaretic acid inhibitors toward soybean, 12-human, and 15-human lipoxygenase. J Med Chem (2002) 1.25
Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases. J Nat Prod (2003) 1.17
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Mol Cell Endocrinol (2012) 1.10
Accelerating the discovery of biologically active small molecules using a high-throughput yeast halo assay. J Nat Prod (2007) 1.10
Spectroscopic characterization of soybean lipoxygenase-1 mutants: the role of second coordination sphere residues in the regulation of enzyme activity. Biochemistry (2003) 1.06
Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg Med Chem (2007) 1.06
Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol (2012) 1.05
Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase. J Med Chem (2011) 1.03
Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Biochemistry (2005) 1.02
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod (2009) 1.02
Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. J Med Chem (2010) 1.01
Reactions of NO with Mn(II) and Mn(III) centers coordinated to carboxamido nitrogen: synthesis of a manganese nitrosyl with photolabile NO. Inorg Chem (2004) 1.00
Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2. Bioorg Med Chem (2007) 1.00
Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: archetypes for a unique class of selective and recyclable inhibitors. J Am Chem Soc (2004) 0.98
Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation. Biochemistry (2008) 0.96
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 0.94
Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem (2004) 0.94
Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. Biochemistry (2009) 0.93
A Re(V)-catalyzed C-N bond-forming route to human lipoxygenase inhibitors. Org Lett (2005) 0.92
Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation. Mol Pharmacol (2011) 0.92
Investigations of human platelet-type 12-lipoxygenase: role of lipoxygenase products in platelet activation. J Lipid Res (2012) 0.91
Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem (2014) 0.89
Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1. Biochemistry (2004) 0.89
Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem (2014) 0.89
Pinpointing pseurotins from a marine-derived Aspergillus as tools for chemical genetics using a synthetic lethality yeast screen. J Nat Prod (2007) 0.88
Measurement of the heme affinity for yeast dap1p, and its importance in cellular function. Biochemistry (2007) 0.87
Stopped-flow kinetic investigations of the activation of soybean lipoxygenase-1 and the influence of inhibitors on the allosteric site. Biochemistry (2003) 0.87
Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. Biochemistry (2009) 0.86
Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity. J Nat Prod (2007) 0.86
Kinetic and structural investigations into the allosteric and pH effect on the substrate specificity of human epithelial 15-lipoxygenase-2. Biochemistry (2013) 0.86
Kinetic and spectroscopic studies of N694C lipoxygenase: a probe of the substrate activation mechanism of a nonheme ferric enzyme. J Am Chem Soc (2007) 0.84
Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J (2012) 0.83
An analysis of phakellin and oroidin structures stimulated by further study of an Agelas sponge. J Nat Prod (2004) 0.83
Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis. Bioorg Med Chem (2005) 0.83
Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina. Planta Med (2004) 0.83
Kinetic, spectroscopic, and structural investigations of the soybean lipoxygenase-1 first-coordination sphere mutant, Asn694Gly. Biochemistry (2006) 0.83
Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases. Bioorg Med Chem (2013) 0.82
Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease. J Vis Exp (2014) 0.80
The potential of 12/15-lipoxygenase inhibitors in stroke therapy. Future Med Chem (2014) 0.79
Geometric structure determination of N694C lipoxygenase: a comparative near-edge X-ray absorption spectroscopy and extended X-ray absorption fine structure study. Inorg Chem (2008) 0.78
Evidence for downregulation of calcium signaling proteins in advanced mouse adenocarcinoma. Prostate (2005) 0.78
Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy. PLoS One (2013) 0.77
Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Org Biomol Chem (2008) 0.75
Substrate specificity effects of lipoxygenase products and inhibitors on soybean lipoxygenase-1. Bioorg Med Chem (2009) 0.75
ATP allosterically activates the human 5-lipoxygenase molecular mechanism of arachidonic acid and 5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid. Biochemistry (2014) 0.75