Published in Zhonghua Er Bi Yan Hou Ke Za Zhi on April 01, 2001
The sequence of the human genome. Science (2001) 101.55
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell (2001) 25.86
The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell (1996) 17.13
Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity (2000) 16.03
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science (1998) 8.36
Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat Med (1998) 7.48
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization. Cell (1996) 5.67
Comparative efficacy of alternative hand-washing agents in reducing nosocomial infections in intensive care units. N Engl J Med (1992) 5.28
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates. J Virol (1995) 5.01
HIV-1 inhibition by a peptide. Nature (1993) 5.01
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science (2001) 4.82
A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell (1998) 4.78
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science (1997) 4.26
Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature (1998) 4.14
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A (2000) 3.95
Smoking cessation with and without assistance: a population-based analysis. Am J Prev Med (2000) 3.92
Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group. J Clin Oncol (2001) 3.92
Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor. Mol Cell Biol (1994) 3.79
Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical ICU patients. Intensive Care Med (1995) 3.75
CD4-Induced conformational changes in the human immunodeficiency virus type 1 gp120 glycoprotein: consequences for virus entry and neutralization. J Virol (1998) 3.60
A universal pattern of mortality decline in the G7 countries. Nature (2000) 3.56
A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature (1997) 3.54
Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell (1994) 3.44
Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem (2000) 3.34
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem (2001) 3.24
Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev (1998) 3.24
Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radic Biol Med (2005) 3.13
Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature (1992) 3.13
The function of GRB2 in linking the insulin receptor to Ras signaling pathways. Science (1993) 3.12
The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma. EMBO J (1990) 3.05
Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells. Proc Natl Acad Sci U S A (1997) 2.97
Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J Biol Chem (1997) 2.95
BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein. Cell (1993) 2.92
Nanostructured high-strength molybdenum alloys with unprecedented tensile ductility. Nat Mater (2013) 2.90
SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. EMBO J (1992) 2.82
Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial. Neurology (2009) 2.76
Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J Exp Med (1997) 2.75
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. J Neurosci (2001) 2.75
High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth (2012) 2.71
The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med (2001) 2.70
Microbiological factors influencing the outcome of nosocomial bloodstream infections: a 6-year validated, population-based model. Clin Infect Dis (1997) 2.67
Worldwide DNA sequence variation in a 10-kilobase noncoding region on human chromosome 22. Proc Natl Acad Sci U S A (2000) 2.67
Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J Clin Invest (1998) 2.64
Proposal of the genera Anaerococcus gen. nov., Peptoniphilus gen. nov. and Gallicola gen. nov. for members of the genus Peptostreptococcus. Int J Syst Evol Microbiol (2001) 2.59
Molecular characterization and transcriptional analysis of type 8 capsule genes in Staphylococcus aureus. J Bacteriol (1997) 2.58
HIV-1 entry and macrophage inflammatory protein-1beta-mediated signaling are independent functions of the chemokine receptor CCR5. J Biol Chem (1997) 2.55
High sex ratios in China's future. Science (1995) 2.53
Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol (1989) 2.50
Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell (1997) 2.46
The nucleotide sequence of a rat liver glutathione S-transferase subunit cDNA clone. J Biol Chem (1984) 2.43
Regulation of the proinflammatory effects of Fas ligand (CD95L). Science (1998) 2.43
The skeletal muscle calcium release channel: coupled O2 sensor and NO signaling functions. Cell (2000) 2.41
The prevalence of extraintestinal diseases in inflammatory bowel disease: a population-based study. Am J Gastroenterol (2001) 2.33
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc Natl Acad Sci U S A (1996) 2.32
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32
Determinants of human immunodeficiency virus type 1 envelope glycoprotein activation by soluble CD4 and monoclonal antibodies. J Virol (1998) 2.28
A tyrosine-rich region in the N terminus of CCR5 is important for human immunodeficiency virus type 1 entry and mediates an association between gp120 and CCR5. J Virol (1998) 2.28
Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition. Clin Exp Allergy (2002) 2.26
Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development (1995) 2.25
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron (1999) 2.25
Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity (1996) 2.24
Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest (1999) 2.21
Chemical mapping of a single molecule by plasmon-enhanced Raman scattering. Nature (2013) 2.19
Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors. Clin Immunol (2001) 2.19
Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. Genomics (1998) 2.17
Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain. J Biol Chem (1995) 2.17
Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice. Hum Mol Genet (2001) 2.13
Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms. J Mol Cell Cardiol (1994) 2.12
Human immunodeficiency virus type 1 Vif protein is an integral component of an mRNP complex of viral RNA and could be involved in the viral RNA folding and packaging process. J Virol (2000) 2.11
Predictors of smoking cessation in U.S. adolescents. Am J Prev Med (1999) 2.09
The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness. Hum Mol Genet (1999) 2.09
A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J Biol Chem (1994) 2.06
Importance of pre-existing co-morbidities for prognosis of septicemia in critically ill patients. Intensive Care Med (1993) 2.05
IMPACT trial results should not change current standard of care of 100 days for cytomegalovirus prophylaxis. Am J Transplant (2010) 2.05
Superparamagnetic gadonanotubes are high-performance MRI contrast agents. Chem Commun (Camb) (2005) 2.05
Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J (1997) 2.02
Further characterization of endometrial integrins during the menstrual cycle and in pregnancy. Fertil Steril (1994) 1.99
A hierarchical approach to color image segmentation using homogeneity. IEEE Trans Image Process (2000) 1.99
Smoking, air pollution, and the high rates of lung cancer in Shenyang, China. J Natl Cancer Inst (1989) 1.99
Schwann cells express motor and sensory phenotypes that regulate axon regeneration. J Neurosci (2006) 1.97
Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc Natl Acad Sci U S A (1999) 1.95
Indoor radon and lung cancer in China. J Natl Cancer Inst (1990) 1.95
Limitations in bonding to dentin and experimental strategies to prevent bond degradation. J Dent Res (2011) 1.92
Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol (2008) 1.92
Pseudomonas aeruginosa ExoS and ExoT. Rev Physiol Biochem Pharmacol (2004) 1.91
Complete nucleotide sequence and molecular characterization of ViaB region encoding Vi antigen in Salmonella typhi. J Bacteriol (1993) 1.91
Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature (1997) 1.90
KCNE1 mutations cause jervell and Lange-Nielsen syndrome. Nat Genet (1997) 1.90
Reverse transcriptase in a clinical strain of Escherichia coli: production of branched RNA-linked msDNA. Science (1989) 1.89
An analysis of relationships among plant community phenology and seasonal metrics of Normalized Difference Vegetation Index in the northern part of the monsoon region of China. Int J Biometeorol (2001) 1.89
Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4. Proc Natl Acad Sci U S A (1997) 1.89
A phospholipid acts as a chaperone in assembly of a membrane transport protein. J Biol Chem (1996) 1.89
Transformation of NIH 3T3 cells by HER3 or HER4 receptors requires the presence of HER1 or HER2. J Biol Chem (1996) 1.87
Effects of pyrethroid insecticides on subjects engaged in packaging pyrethroids. Br J Ind Med (1988) 1.87
Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. J Biol Chem (1995) 1.86
SNARE protein-dependent glutamate release from astrocytes. J Neurosci (2000) 1.86
Molecular analysis of Vibrio cholerae O1, O139, non-O1, and non-O139 strains: clonal relationships between clinical and environmental isolates. Appl Environ Microbiol (2001) 1.86
The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization. RNA (1997) 1.84