Published in Eur J Pharmacol on June 20, 2003
Nicotinic agonists, antagonists, and modulators from natural sources. Cell Mol Neurobiol (2005) 1.53
Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein. J Biol Chem (2012) 0.98
Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats. Alcohol (2009) 0.84
Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. Br J Pharmacol (2005) 0.82
CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation. Br J Pharmacol (2013) 0.81
Role of neuronal nicotinic acetylcholine receptors (nAChRs) on learning and memory in zebrafish. Psychopharmacology (Berl) (2013) 0.77
The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors. Psychopharmacology (Berl) (2014) 0.76
Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse. Prog Neuropsychopharmacol Biol Psychiatry (2015) 0.75
Investigating the hydrogen-bond acceptor site of the nicotinic pharmacophore model: a computational and experimental study using epibatidine-related molecular probes. J Comput Aided Mol Des (2013) 0.75
Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med (2002) 4.67
Brain nicotinic acetylcholine receptors: native subtypes and their relevance. Trends Pharmacol Sci (2006) 4.04
Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci (2003) 2.85
Diversity of vertebrate nicotinic acetylcholine receptors. Neuropharmacology (2008) 2.49
alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine. Mol Pharmacol (2006) 2.42
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells. J Exp Med (2008) 2.41
Structural and functional diversity of native brain neuronal nicotinic receptors. Biochem Pharmacol (2009) 2.33
Potentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci U S A (2008) 2.20
Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. J Neurosci (2002) 2.17
Rodent habenulo-interpeduncular pathway expresses a large variety of uncommon nAChR subtypes, but only the alpha3beta4* and alpha3beta3beta4* subtypes mediate acetylcholine release. J Neurosci (2009) 1.76
Expression of nigrostriatal alpha 6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by beta 3 subunit gene deletion. Mol Pharmacol (2005) 1.38
Agonist activation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci U S A (2011) 1.36
Role of lipid microdomains in P/Q-type calcium channel (Cav2.1) clustering and function in presynaptic membranes. J Biol Chem (2003) 1.27
PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism. J Biol Chem (2005) 1.26
Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol Pharmacol (2008) 1.24
Species selectivity of a nicotinic acetylcholine receptor agonist is conferred by two adjacent extracellular beta4 amino acids that are implicated in the coupling of binding to channel gating. Mol Pharmacol (2006) 1.22
Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism. Eur J Pharmacol (2005) 1.13
Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J Pharmacol Exp Ther (2006) 1.10
alpha7 and non-alpha7 nicotinic acetylcholine receptors modulate dopamine release in vitro and in vivo in the rat prefrontal cortex. Eur J Neurosci (2009) 1.10
Regulation of neuronal nicotinic receptor traffic and expression. Brain Res Rev (2007) 1.08
Nicotinic acetylcholine receptor subtypes expression during rat retina development and their regulation by visual experience. Mol Pharmacol (2004) 1.07
Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation. Neurobiol Dis (2006) 1.06
Antiviral activity of benzimidazole derivatives. II. Antiviral activity of 2-phenylbenzimidazole derivatives. Bioorg Med Chem (2010) 1.06
Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA. Mol Pharmacol (2004) 1.05
Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through α4/β2/α5 nicotinic acetylcholine receptors. Neuropsychopharmacology (2010) 1.04
A comparative study of the effects of the intravenous self-administration or subcutaneous minipump infusion of nicotine on the expression of brain neuronal nicotinic receptor subtypes. Mol Pharmacol (2010) 1.03
Absence of alpha7-containing neuronal nicotinic acetylcholine receptors does not prevent nicotine-induced seizures. Brain Res Mol Brain Res (2002) 1.01
Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition. J Neurosci (2003) 1.00
Chaperone protein 14-3-3 and protein kinase A increase the relative abundance of low agonist sensitivity human alpha 4 beta 2 nicotinic acetylcholine receptors in Xenopus oocytes. J Neurochem (2006) 1.00
Biogenesis, trafficking and up-regulation of nicotinic ACh receptors. Biochem Pharmacol (2013) 0.99
Epiboxidine and novel-related analogues: a convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes. Bioorg Med Chem Lett (2008) 0.97
Expression and functional characterisation of a human chimeric nicotinic receptor with alpha6beta4 properties. Eur J Pharmacol (2003) 0.97
Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras. Mol Pharmacol (2004) 0.97
Stable expression and functional characterization of a human nicotinic acetylcholine receptor with α6β2 properties: discovery of selective antagonists. Br J Pharmacol (2011) 0.92
Nicotine-modulated subunit stoichiometry affects stability and trafficking of α3β4 nicotinic receptor. J Neurosci (2013) 0.91
High sensitivity protein assays on microarray silicon slides. Anal Chem (2009) 0.90
The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology (2003) 0.90
Antiviral activity of benzimidazole derivatives. I. Antiviral activity of 1-substituted-2-[(benzotriazol-1/2-yl)methyl]benzimidazoles. Chem Biodivers (2008) 0.90
Transcription factor PHOX2A regulates the human alpha3 nicotinic receptor subunit gene promoter. J Biol Chem (2007) 0.90
IFN-gamma and R-848 dependent activation of human monocyte-derived dendritic cells by Neisseria meningitidis adhesin A. J Immunol (2007) 0.90
PSAB-OFP, a selective alpha 7 nicotinic receptor agonist, is also a potent agonist of the 5-HT3 receptor. Eur J Pharmacol (2002) 0.88
The expression of PHOX2A, PHOX2B and of their target gene dopamine-beta-hydroxylase (DbetaH) is not modified by exposure to extremely-low-frequency electromagnetic field (ELF-EMF) in a human neuronal model. Toxicol In Vitro (2008) 0.88
Organometallic compounds in oncology: implications of novel organotins as antitumor agents. Drug Discov Today (2009) 0.88
Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activities. Farmaco (2003) 0.87
Unique pharmacology of heteromeric α7β2 nicotinic acetylcholine receptors expressed in Xenopus laevis oocytes. Eur J Pharmacol (2014) 0.87
Engineering of α-conotoxin MII-derived peptides with increased selectivity for native α6β2* nicotinic acetylcholine receptors. FASEB J (2011) 0.86
Expression of mutant beta2 nicotinic receptors during development is crucial for epileptogenesis. Hum Mol Genet (2009) 0.86
Localization of synaptic proteins involved in neurosecretion in different membrane microdomains. J Neurochem (2006) 0.86
Expression of the α7 nAChR subunit duplicate form (CHRFAM7A) is down-regulated in the monocytic cell line THP-1 on treatment with LPS. J Neuroimmunol (2011) 0.86
Rapid aggregation and assembly in aqueous solution of A beta (25-35) peptide. J Biosci (2009) 0.85
Visual acuity is reduced in alpha 7 nicotinic receptor knockout mice. Invest Ophthalmol Vis Sci (2012) 0.85
Nicotinic acetylcholine receptor subtypes in the rat sympathetic ganglion: pharmacological characterization, subcellular distribution and effect of pre- and postganglionic nerve crush. J Neuropathol Exp Neurol (2004) 0.85
Stable expression and characterisation of a human alpha 7 nicotinic subunit chimera: a tool for functional high-throughput screening. Eur J Pharmacol (2004) 0.85
The expression of the human neuronal alpha3 Na+,K+-ATPase subunit gene is regulated by the activity of the Sp1 and NF-Y transcription factors. Biochem J (2005) 0.84
Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity. Neurotox Res (2010) 0.84
Adolescent nicotine exposure transiently increases high-affinity nicotinic receptors and modulates inhibitory synaptic transmission in rat medial prefrontal cortex. FASEB J (2012) 0.83
Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. Br J Pharmacol (2005) 0.82
Glutamatergic reinnervation and assembly of glutamatergic synapses in adult rat skeletal muscle occurs at cholinergic endplates. J Neuropathol Exp Neurol (2009) 0.82
CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation. Br J Pharmacol (2013) 0.81
The subtype-selective nicotinic acetylcholine receptor positive allosteric potentiator 2087101 differentially facilitates neurotransmission in the brain. Eur J Pharmacol (2010) 0.81
Structure of neuronal nicotinic receptors. Curr Top Behav Neurosci (2015) 0.81
Alpha7 but not alpha4 AChR subunit expression is regulated by light in developing primary visual cortex. J Comp Neurol (2004) 0.80
Extremely low-frequency electromagnetic field (ELF-EMF) does not affect the expression of alpha3, alpha5 and alpha7 nicotinic receptor subunit genes in SH-SY5Y neuroblastoma cell line. Toxicol Lett (2006) 0.80
Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies. Bioorg Med Chem Lett (2009) 0.80
Novel sigma binding site ligands as inhibitors of cell proliferation in breast cancer. Oncol Res (2003) 0.79
Synthesis and alpha4beta2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers. Bioorg Med Chem Lett (2004) 0.79
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline. Bioorg Med Chem Lett (2008) 0.79
Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes. J Med Chem (2009) 0.79
Antitumor activity of a new orally active organotin compound: a preliminary study in murine tumor models. Anticancer Drugs (2002) 0.78
Chemosensitivity of glioblastoma cells during treatment with the organo-tin compound triethyltin(IV)lupinylsulfide hydrochloride. J Neurooncol (2002) 0.78
Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes. Bioorg Med Chem (2010) 0.78
Partial agonists for α4β2 nicotinic receptors stimulate dopaminergic neuron firing with relatively enhanced maximal effects. Br J Pharmacol (2012) 0.78