Published in Circulation on June 23, 2003
Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials. PLoS Med (2010) 4.79
Circulating omega-6 polyunsaturated fatty acids and total and cause-specific mortality: the Cardiovascular Health Study. Circulation (2014) 2.63
Dietary fat types and 4-year cognitive change in community-dwelling older women. Ann Neurol (2012) 2.29
Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies. Arthritis Rheum (2009) 2.19
Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. Circulation (2008) 2.01
Dietary intake of trans fatty acids and systemic inflammation in women. Am J Clin Nutr (2004) 1.88
Depressive symptoms, omega-6:omega-3 fatty acids, and inflammation in older adults. Psychosom Med (2007) 1.54
Inflammation, the metabolic syndrome, and risk of coronary heart disease in women and men. Atherosclerosis (2007) 1.50
Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia. Am J Clin Nutr (2010) 1.47
Fish consumption and risk of major chronic disease in men. Am J Clin Nutr (2008) 1.47
Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. Ann Behav Med (2012) 1.44
Fibroblast growth factor 23, cardiovascular disease risk factors, and phosphorus intake in the health professionals follow-up study. Clin J Am Soc Nephrol (2011) 1.36
Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge. Psychosom Med (2010) 1.22
Inverse association of erythrocyte n-3 fatty acid levels with inflammatory biomarkers in patients with stable coronary artery disease: The Heart and Soul Study. Atherosclerosis (2008) 1.22
Inflammation and early-life abuse in women. Am J Prev Med (2012) 1.20
Associations of dietary long-chain n-3 polyunsaturated fatty acids and fish with biomarkers of inflammation and endothelial activation (from the Multi-Ethnic Study of Atherosclerosis [MESA]). Am J Cardiol (2009) 1.20
Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids. Eur J Clin Nutr (2011) 1.19
Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun (2011) 1.17
Associations of very high intakes of eicosapentaenoic and docosahexaenoic acids with biomarkers of chronic disease risk among Yup'ik Eskimos. Am J Clin Nutr (2010) 1.17
Fatty acid consumption and risk of fracture in the Women's Health Initiative. Am J Clin Nutr (2010) 1.16
A prospective study of plasma inflammatory markers and risk of colorectal cancer in men. Br J Cancer (2013) 1.15
Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. J Am Heart Assoc (2013) 1.14
Omega-3 supplementation lowers inflammation in healthy middle-aged and older adults: a randomized controlled trial. Brain Behav Immun (2012) 1.14
Changes in erythrocyte membrane trans and marine fatty acids between 1999 and 2006 in older Americans. J Nutr (2012) 1.13
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DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men. J Nutr (2009) 1.06
Ethnicity, plasma phospholipid fatty acid composition and inflammatory/endothelial activation biomarkers in the Multi-Ethnic Study of Atherosclerosis (MESA). Eur J Clin Nutr (2012) 1.02
Dietary fat quality and risk of sudden cardiac death in women. Am J Clin Nutr (2012) 1.02
Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions. Arterioscler Thromb Vasc Biol (2012) 0.97
Serum metabolomics reveals higher levels of polyunsaturated fatty acids in lepromatous leprosy: potential markers for susceptibility and pathogenesis. PLoS Negl Trop Dis (2011) 0.96
Relation of omega-3 fatty acid and dietary fish intake with brachial artery flow-mediated vasodilation in the Multi-Ethnic Study of Atherosclerosis. Am J Clin Nutr (2010) 0.96
UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health. Br J Nutr (2007) 0.95
The relationship between dietary fatty acids and inflammatory genes on the obese phenotype and serum lipids. Nutrients (2013) 0.93
Metabolic and endocrine effects of long-chain versus essential omega-3 polyunsaturated fatty acids in polycystic ovary syndrome. Metabolism (2011) 0.92
Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons. Am J Clin Nutr (2004) 0.92
Estimation of the contribution of biomarkers of different metabolic pathways to risk of type 2 diabetes. Eur J Epidemiol (2010) 0.91
Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? Expert Rev Neurother (2012) 0.89
In vitro fatty acid enrichment of macrophages alters inflammatory response and net cholesterol accumulation. Br J Nutr (2009) 0.88
Membrane omega-3 Fatty Acid deficiency as a preventable risk factor for comorbid coronary heart disease in major depressive disorder. Cardiovasc Psychiatry Neurol (2009) 0.87
Hemoglobin a1c is associated with increased risk of incident coronary heart disease among apparently healthy, nondiabetic men and women. J Am Heart Assoc (2013) 0.87
Coordinated defects in hepatic long chain fatty acid metabolism and triglyceride accumulation contribute to insulin resistance in non-human primates. PLoS One (2011) 0.87
Secondhand smoke exposure and inflammatory markers in nonsmokers in the trucking industry. Environ Health Perspect (2011) 0.86
Inflammatory plasma markers and pancreatic cancer risk: a prospective study of five U.S. cohorts. Cancer Epidemiol Biomarkers Prev (2013) 0.86
Effects of supplemental long-chain omega-3 fatty acids and erythrocyte membrane fatty acid content on circulating inflammatory markers in a randomized controlled trial of healthy adults. Prostaglandins Leukot Essent Fatty Acids (2014) 0.85
Obesity modifies the association between plasma phospholipid polyunsaturated fatty acids and markers of inflammation: the Multi-Ethnic Study of Atherosclerosis. Int J Obes (Lond) (2011) 0.84
Nutrition and Inflammation in Older Individuals: Focus on Vitamin D, n-3 Polyunsaturated Fatty Acids and Whey Proteins. Nutrients (2016) 0.83
The effect of two iso-caloric meals containing equal amounts of fats with a different fat composition on the inflammatory and metabolic markers in apparently healthy volunteers. J Inflamm (Lond) (2013) 0.83
Nutrition and depression at the forefront of progress. J Med Life (2012) 0.83
New evidences for C-reactive protein (CRP) deposits in the arterial intima as a cardiovascular risk factor. Clin Interv Aging (2008) 0.83
High habitual dietary alpha-linolenic acid intake is associated with decreased plasma soluble interleukin-6 receptor concentrations in male twins. Am J Clin Nutr (2010) 0.83
The evidence for α-linolenic acid and cardiovascular disease benefits: Comparisons with eicosapentaenoic acid and docosahexaenoic acid. Adv Nutr (2014) 0.83
Effects of the n-6/n-3 polyunsaturated fatty acids ratio on postprandial metabolism in hypertriacylglycerolemia patients. Lipids Health Dis (2013) 0.83
Polyunsaturated fatty acids and their effects on cardiovascular disease. Exp Clin Cardiol (2003) 0.82
Association between nutrient intake and peripheral artery disease: results from the InCHIANTI study. Atherosclerosis (2005) 0.81
Effect of omega-3 polyunsaturated fatty acid supplementation on central arterial stiffness and arterial wave reflections in young and older healthy adults. Physiol Rep (2015) 0.81
Leukotriene A4 hydrolase haplotype, diet and atherosclerosis: a twin study. Atherosclerosis (2012) 0.80
Associations of plasma phospholipid omega-6 and omega-3 polyunsaturated Fatty Acid levels and MRI measures of cardiovascular structure and function: the multiethnic study of atherosclerosis. J Nutr Metab (2011) 0.80
C-reactive protein, interleukin-6, soluble tumor necrosis factor α receptor 2 and incident clinical depression. J Affect Disord (2014) 0.80
Effect of fish or soybean oil-rich diets on bradykinin, kallikrein, nitric oxide, leptin, corticosterone and macrophages in carrageenan stimulated rats. Inflammation (2005) 0.80
Higher Plasma Phospholipid n-3 PUFAs, but Lower n-6 PUFAs, Are Associated with Lower Pulse Wave Velocity among Older Adults. J Nutr (2015) 0.80
First-episode bipolar disorder is associated with erythrocyte membrane docosahexaenoic acid deficits: Dissociation from clinical response to lithium or quetiapine. Psychiatry Res (2015) 0.80
Psychoneuroimmunology: Psychology's Gateway to the Biomedical Future. Perspect Psychol Sci (2009) 0.79
Red blood cell fatty acids and biomarkers of inflammation: a cross-sectional study in a community-based cohort. Atherosclerosis (2015) 0.79
Metabolic Inflammation-Differential Modulation by Dietary Constituents. Nutrients (2016) 0.78
Associations between nut consumption and inflammatory biomarkers. Am J Clin Nutr (2016) 0.78
Erythrocyte linoleic acid, but not oleic acid, is associated with improvements in body composition in men and women. Mol Nutr Food Res (2016) 0.77
Cardioprotective effects of ω -3 PUFAs in chronic kidney disease. Biomed Res Int (2013) 0.77
Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. Nutr Cancer (2013) 0.77
Nutraceuticals and Bioactive Components from Fish for Dyslipidemia and Cardiovascular Risk Reduction. Mar Drugs (2016) 0.77
Metabolic syndrome and inflammation: a critical review of in vitro and clinical approaches for benefit assessment of plant food supplements. Evid Based Complement Alternat Med (2013) 0.77
Plasma n-3 and n-6 fatty acids and inflammatory markers in Chinese vegetarians. Lipids Health Dis (2014) 0.77
Omega-3 fatty acids and stress-induced immune dysregulation: implications for wound healing. Mil Med (2014) 0.76
Markers of inflammation, endothelial activation and autoimmunity in adolescent female gymnasts. J Sports Sci Med (2010) 0.76
Leukotriene haplotype × diet interaction on carotid artery hypertrophy and atherosclerosis in American Indians: the Strong Heart Family Study. Atherosclerosis (2014) 0.76
Investigation of the effects of a high fish diet on inflammatory cytokines, blood pressure, and lipids in healthy older Australians. Food Nutr Res (2014) 0.76
Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer. World J Gastroenterol (2016) 0.76
Cancer Risk and Eicosanoid Production: Interaction between the Protective Effect of Long Chain Omega-3 Polyunsaturated Fatty Acid Intake and Genotype. J Clin Med (2016) 0.76
Metabolic markers in Ossabaw pigs fed high fat diets enriched in regular or low α-linolenic acid soy oil. Nutr Metab (Lond) (2013) 0.75
Consumption of Red Meat, but Not Cooking Oils High in Polyunsaturated Fat, Is Associated with Higher Arachidonic Acid Status in Singapore Chinese Adults. Nutrients (2017) 0.75
Evening primrose oil ameliorates platelet aggregation and improves cardiac recovery in myocardial-infarct hypercholesterolemic rats. Int J Physiol Pathophysiol Pharmacol (2014) 0.75
Bipolar disorder moderates associations between linoleic acid and markers of inflammation. J Psychiatr Res (2016) 0.75
Effects of the Dietary ω3:ω6 Fatty Acid Ratio on Body Fat and Inflammation in Zebrafish (Danio rerio). Comp Med (2015) 0.75
Supplementation of arachidonic acid plus docosahexaenoic acid in cirrhotic patients awaiting liver transplantation: a preliminary study. JPEN J Parenter Enteral Nutr (2007) 0.75
Mitigation of Inflammation-Induced Mood Dysregulation by Long-Chain Omega-3 Fatty Acids. J Am Coll Nutr (2015) 0.75
Effects of dietary milled seed mixture on fatty acid status and inflammatory markers in patients on hemodialysis. ScientificWorldJournal (2014) 0.75
Flaxseed oil increases aortic reactivity to phenylephrine through reactive oxygen species and the cyclooxygenase-2 pathway in rats. Lipids Health Dis (2014) 0.75
Dietary fatty acids and inflammatory markers in patients with coronary artery disease. Adv Biomed Res (2014) 0.75
Whole-blood fatty acids and inflammation in European children: the IDEFICS Study. Eur J Clin Nutr (2016) 0.75
Association between serum fatty acid composition and innate immune markers in healthy adults. Nutr Res Pract (2016) 0.75
Using high-dose omega-3 fatty acid supplements to lower triglyceride levels in 10- to 19-year-olds. Clin Pediatr (Phila) (2014) 0.75
The profile of polyunsaturated fatty acids in juvenile idiopathic arthritis and association with disease activity. Clin Rheumatol (2017) 0.75
N-3 fatty acid supplementation to routine statin treatment inhibits platelet function, decreases patients' daytime blood pressure, and improves inflammatory status. Eur J Clin Pharmacol (2012) 0.75
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
A central role for JNK in obesity and insulin resistance. Nature (2002) 17.27
Inflammation, stress, and diabetes. J Clin Invest (2005) 17.11
Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med (2002) 16.23
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA (2007) 15.32
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91
Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34
Changes in diet and lifestyle and long-term weight gain in women and men. N Engl J Med (2011) 12.29
Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women. JAMA (2004) 11.69
Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr (2006) 10.95
Television watching and other sedentary behaviors in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA (2003) 10.05
Inflammatory mechanisms in obesity. Annu Rev Immunol (2011) 9.83
Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA (2007) 9.68
C-reactive protein levels and outcomes after statin therapy. N Engl J Med (2005) 9.47
Fruit and vegetable intake and risk of major chronic disease. J Natl Cancer Inst (2004) 8.77
Adiposity as compared with physical activity in predicting mortality among women. N Engl J Med (2004) 8.63
Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care (2010) 8.52
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39
The Nurses' Health Study: lifestyle and health among women. Nat Rev Cancer (2005) 8.19
25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med (2008) 8.03
Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA (2006) 7.73
Long-term colorectal-cancer incidence and mortality after lower endoscopy. N Engl J Med (2013) 7.72
The public health and economic benefits of taxing sugar-sweetened beverages. N Engl J Med (2009) 7.48
Plasma adiponectin levels and risk of myocardial infarction in men. JAMA (2004) 7.46
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell (2008) 7.37
C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men. Circulation (2008) 7.33
Blood levels of long-chain n-3 fatty acids and the risk of sudden death. N Engl J Med (2002) 7.32
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Optimal diets for prevention of coronary heart disease. JAMA (2002) 7.24
Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst (2006) 7.19
C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation (2003) 6.99
Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension (2007) 6.99
Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr (2002) 6.96
Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease. Epidemiology (2008) 6.87
A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med (2012) 6.85
Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr (2005) 6.67
Trans fatty acids and cardiovascular disease. N Engl J Med (2006) 6.67
Effect of Vitamin D on falls: a meta-analysis. JAMA (2004) 6.64
Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation (2003) 6.62
Body-mass index and mortality among adults with incident type 2 diabetes. N Engl J Med (2014) 6.51
Insulin-like growth factors and neoplasia. Nat Rev Cancer (2004) 6.29
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 6.15
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol (2004) 6.08
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
Hemoglobin A1c predicts diabetes but not cardiovascular disease in nondiabetic women. Am J Med (2007) 5.95
Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med (2003) 5.95
Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA (2005) 5.95
Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med (2004) 5.86
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82
Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies. Am J Clin Nutr (2009) 5.79
Performance of common genetic variants in breast-cancer risk models. N Engl J Med (2010) 5.79
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. Nat Rev Drug Discov (2008) 5.78
C-reactive protein and the risk of developing hypertension. JAMA (2003) 5.75
Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA (2005) 5.74
Coffee consumption and risk for type 2 diabetes mellitus. Ann Intern Med (2004) 5.67
Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Intern Med (2009) 5.63
Alternative dietary indices both strongly predict risk of chronic disease. J Nutr (2012) 5.60
Dairy consumption and risk of type 2 diabetes mellitus in men: a prospective study. Arch Intern Med (2005) 5.59
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
C-reactive protein and the risk of incident colorectal cancer. JAMA (2004) 4.94
Serum aldosterone and the incidence of hypertension in nonhypertensive persons. N Engl J Med (2004) 4.92
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature (2011) 4.78
Red meat consumption and mortality: results from 2 prospective cohort studies. Arch Intern Med (2012) 4.72
Exercise type and intensity in relation to coronary heart disease in men. JAMA (2002) 4.69
Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes (2004) 4.67
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
Vitamin D and calcium intake in relation to type 2 diabetes in women. Diabetes Care (2006) 4.62
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature (2007) 4.59
Prevalence of the metabolic syndrome in American adolescents: findings from the Third National Health and Nutrition Examination Survey. Circulation (2004) 4.58
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation. PLoS Genet (2008) 4.57
Risk factors for breast cancer according to estrogen and progesterone receptor status. J Natl Cancer Inst (2004) 4.57
Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst (2010) 4.54
Aspirin intake and survival after breast cancer. J Clin Oncol (2010) 4.50
Dietary fat and meat intake in relation to risk of type 2 diabetes in men. Diabetes Care (2002) 4.48