PubRank

Edward M Brown

Author PubWeight™ 108.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 2003 13.33
2 Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor. Nature 2005 5.54
3 Extracellular calcium sensing and signalling. Nat Rev Mol Cell Biol 2003 3.10
4 Acquired hypocalciuric hypercalcemia due to autoantibodies against the calcium-sensing receptor. N Engl J Med 2004 2.98
5 Physiology and pathophysiology of the calcium-sensing receptor in the kidney. Am J Physiol Renal Physiol 2009 2.02
6 Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. J Am Soc Nephrol 2012 1.59
7 Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 2007 1.56
8 Activating autoantibodies against the calcium-sensing receptor detected in two patients with autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab 2009 1.55
9 Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. Hum Mol Genet 2010 1.53
10 Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites. Hum Mol Genet 2012 1.51
11 The calcium-sensing receptor in normal physiology and pathophysiology: a review. Crit Rev Clin Lab Sci 2005 1.48
12 Lysosomal exocytosis is impaired in mucolipidosis type IV. Mol Genet Metab 2006 1.45
13 Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations. Best Pract Res Clin Rheumatol 2008 1.44
14 Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab 2004 1.44
15 The empirical foundations of telemedicine interventions for chronic disease management. Telemed J E Health 2014 1.34
16 The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am J Physiol Endocrinol Metab 2009 1.32
17 pH Sensing by the calcium-sensing receptor. J Biol Chem 2004 1.32
18 Identification and characterization of the single channel function of human mucolipin-1 implicated in mucolipidosis type IV, a disorder affecting the lysosomal pathway. FEBS Lett 2002 1.31
19 Multiple Ca(2+)-binding sites in the extracellular domain of the Ca(2+)-sensing receptor corresponding to cooperative Ca(2+) response. Biochemistry 2009 1.27
20 Taste receptors in the gastrointestinal tract. II. L-amino acid sensing by calcium-sensing receptors: implications for GI physiology. Am J Physiol Gastrointest Liver Physiol 2006 1.26
21 The role of the calcium-sensing receptor in the development and progression of cancer. Endocr Rev 2009 1.23
22 The calcium-sensing receptor (CaR) is involved in strontium ranelate-induced osteoblast proliferation. Biochem Pharmacol 2007 1.23
23 The calcium-sensing receptor regulates mammary gland parathyroid hormone-related protein production and calcium transport. J Clin Invest 2004 1.17
24 Functional links between mucolipin-1 and Ca2+-dependent membrane trafficking in mucolipidosis IV. Biochem Biophys Res Commun 2004 1.16
25 The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. J Biol Chem 2008 1.14
26 Identification and dissection of Ca(2+)-binding sites in the extracellular domain of Ca(2+)-sensing receptor. J Biol Chem 2007 1.13
27 Calcium-sensing receptor in the brain. Cell Calcium 2004 1.12
28 Calcium-sensing receptor activation stimulates parathyroid hormone-related protein secretion in prostate cancer cells: role of epidermal growth factor receptor transactivation. Bone 2004 1.12
29 Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia. J Clin Endocrinol Metab 2002 1.11
30 Extracellular calcium sensing in rat aortic vascular smooth muscle cells. Biochem Biophys Res Commun 2006 1.10
31 A syndrome of hypocalciuric hypercalcemia caused by autoantibodies directed at the calcium-sensing receptor. J Clin Endocrinol Metab 2003 1.08
32 Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function. J Biol Chem 2002 1.08
33 Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts. Endocrinology 2005 1.08
34 Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism. Eur J Endocrinol 2004 1.07
35 Hypercalcemia and diabetes insipidus in a patient previously treated with lithium. Nat Clin Pract Nephrol 2007 1.06
36 Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. Endocrinology 2004 1.04
37 Epithelial Ca2+ entry channels: transcellular Ca2+ transport and beyond. J Physiol 2003 1.02
38 Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations. PLoS Genet 2013 1.02
39 Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. Mol Genet Metab 2006 1.00
40 The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1. J Clin Endocrinol Metab 2007 0.98
41 L-amino acids regulate parathyroid hormone secretion. J Biol Chem 2004 0.97
42 Signaling through the extracellular calcium-sensing receptor (CaSR). Adv Exp Med Biol 2012 0.95
43 Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. Am J Physiol Endocrinol Metab 2012 0.95
44 PTHrP stimulated by the calcium-sensing receptor requires MAP kinase activation. Am J Physiol Endocrinol Metab 2002 0.95
45 Pilot case-control investigation of risk factors for hip fractures in the urban Indian population. BMC Musculoskelet Disord 2010 0.95
46 Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. Endocrinology 2004 0.93
47 Editorial: mutant extracellular calcium-sensing receptors and severity of disease. J Clin Endocrinol Metab 2005 0.92
48 Telestroke: a multi-site, emergency-based telemedicine service in Ontario. J Telemed Telecare 2006 0.90
49 High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells. Growth Factors 2005 0.89
50 Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression. J Biol Chem 2010 0.89
51 The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice. Am J Physiol Endocrinol Metab 2012 0.87
52 PKC, p42/44 MAPK and p38 MAPK regulate hepatocyte growth factor secretion from human astrocytoma cells. Brain Res Mol Brain Res 2002 0.87
53 Apical entry channels in calcium-transporting epithelia. News Physiol Sci 2003 0.87
54 Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism. Mol Endocrinol 2005 0.87
55 Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. Am J Physiol Endocrinol Metab 2006 0.85
56 Elucidation of a novel extracellular calcium-binding site on metabotropic glutamate receptor 1{alpha} (mGluR1{alpha}) that controls receptor activation. J Biol Chem 2010 0.85
57 The extracellular calcium Ca2+o-sensing receptor is expressed in myeloma cells and modulates cell proliferation. Biochem Biophys Res Commun 2002 0.83
58 Role of the cytoskeleton in extracellular calcium-regulated PTH release. Biochem Biophys Res Commun 2006 0.83
59 Identification of an L-phenylalanine binding site enhancing the cooperative responses of the calcium-sensing receptor to calcium. J Biol Chem 2014 0.83
60 The cation channel mucolipin-1 is a bifunctional protein that facilitates membrane remodeling via its serine lipase domain. Exp Cell Res 2011 0.82
61 Calcium-sensing receptor induces messenger ribonucleic acid of human securin, pituitary tumor transforming gene, in rat testicular cancer. Endocrinology 2003 0.82
62 A new method for in vivo analysis of parathyroid hormone-calcium set point in mice. J Bone Miner Res 2002 0.82
63 The calcium-sensing receptor in human disease. Front Biosci 2003 0.82
64 Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice. J Neurosci Res 2008 0.81
65 Mapping of human autoantibody binding sites on the calcium-sensing receptor. J Bone Miner Res 2010 0.81
66 Calcium-corrected intact PTH: a clinically useful parameter for quantifying parathyroid function in patients undergoing hemodialysis. Nephron Clin Pract 2010 0.81
67 Signal transduction in the parathyroid. Curr Opin Nephrol Hypertens 2002 0.81
68 CaSR-mediated interactions between calcium and magnesium homeostasis in mice. Am J Physiol Endocrinol Metab 2013 0.81
69 The calcium-sensing receptor and 25-hydroxyvitamin D-1alpha-hydroxylase interact to modulate skeletal growth and bone turnover. J Bone Miner Res 2010 0.81
70 Decreased expression of caveolin-1 and altered regulation of mitogen-activated protein kinase in cultured bovine parathyroid cells and human parathyroid adenomas. J Clin Endocrinol Metab 2003 0.80
71 Regulation of a Ca2+-activated K+ channel by calcium-sensing receptor involves p38 MAP kinase. J Neurosci Res 2004 0.80
72 m-Calpain colocalizes with the calcium-sensing receptor (CaR) in caveolae in parathyroid cells and participates in degradation of the CaR. J Biol Chem 2003 0.80
73 Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells. Brain Res Mol Brain Res 2004 0.80
74 Identification and functional characterization of loss-of-function mutations of the calcium-sensing receptor in four Italian kindreds with familial hypocalciuric hypercalcemia. Eur J Endocrinol 2008 0.79
75 Calcium-sensing receptor activation induces nitric oxide production in H-500 Leydig cancer cells. Am J Physiol Endocrinol Metab 2005 0.79
76 Primary hyperparathyroidism and familial hypocalciuric hypercalcemia: relationships and clinical implications. Endocr Pract 2012 0.79
77 Calcium-sensing receptor stimulates secretion of an interferon-gamma-induced monokine (CXCL10) and monocyte chemoattractant protein-3 in immortalized GnRH neurons. J Neurosci Res 2007 0.79
78 Extracellular calcium modulates actions of orthosteric and allosteric ligands on metabotropic glutamate receptor 1α. J Biol Chem 2013 0.78
79 A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia. Eur J Endocrinol 2010 0.78
80 1alpha,25(OH)2-vitamin D3 inhibits HGF synthesis and secretion from MG-63 human osteosarcoma cells. Am J Physiol Endocrinol Metab 2002 0.78
81 Use of recombinant human parathyroid hormone in hypocalcemic cardiomyopathy. Eur J Endocrinol 2012 0.78
82 Familial hypocalciuric hypercalcemia caused by an R648stop mutation in the calcium-sensing receptor gene. J Bone Miner Res 2002 0.77
83 Parathyroid hormone ablation alters erythrocyte parameters that are rescued by calcium-sensing receptor gene deletion. Eur J Haematol 2013 0.77
84 First report of anti-calcium-sensing receptor antibodies in a patient with Sjogren's syndrome and primary hypoparathyroidism. Rheumatology (Oxford) 2011 0.76
85 The calcium sensing receptor: from calcium sensing to signaling. Sci China Life Sci 2015 0.76
86 Preface. Best Pract Res Clin Endocrinol Metab 2013 0.75
87 Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor. J Clin Endocrinol Metab 2010 0.75
88 A novel gain-of-function mutation (F821L) in the transmembrane domain of calcium-sensing receptor is a cause of severe sporadic hypoparathyroidism. Eur J Pediatr 2003 0.75
89 Acquired hypocalciuric hypercalcemia in a patient with CKD. Am J Kidney Dis 2013 0.75