Published in Curr Biol on July 01, 2003
Human RAS superfamily proteins and related GTPases. Sci STKE (2004) 3.80
p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev (2006) 2.89
Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6. Nat Cell Biol (2010) 2.58
p53 and its mutants in tumor cell migration and invasion. J Cell Biol (2011) 2.49
Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling. Neuron (2011) 2.42
Rho protein crosstalk: another social network? Trends Cell Biol (2011) 2.19
14-3-3 proteins interact with a hybrid prenyl-phosphorylation motif to inhibit G proteins. Cell (2013) 1.90
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol (2015) 1.62
Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain. J Biol Chem (2007) 1.61
RhoE function is regulated by ROCK I-mediated phosphorylation. EMBO J (2005) 1.59
Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. Mol Biol Cell (2006) 1.54
RhoE inhibits cell cycle progression and Ras-induced transformation. Mol Cell Biol (2004) 1.41
The RGK family of GTP-binding proteins: regulators of voltage-dependent calcium channels and cytoskeleton remodeling. Cell Signal (2007) 1.40
Coordination of Rho and Rac GTPase function via p190B RhoGAP. Curr Biol (2008) 1.36
Different requirement for Rnd GTPases of R-Ras GAP activity of Plexin-C1 and Plexin-D1. J Biol Chem (2009) 1.28
The role of Rho GTPase proteins in CNS neuronal migration. Dev Neurobiol (2011) 1.28
Rho GTPases in PC-3 prostate cancer cell morphology, invasion and tumor cell diapedesis. Clin Exp Metastasis (2008) 1.27
Mechanism of multi-site phosphorylation from a ROCK-I:RhoE complex structure. EMBO J (2008) 1.27
Rnd3 regulation of the actin cytoskeleton promotes melanoma migration and invasive outgrowth in three dimensions. Cancer Res (2009) 1.21
B-RAF regulation of Rnd3 participates in actin cytoskeletal and focal adhesion organization. Mol Biol Cell (2007) 1.15
Rho GTPases: masters of cell migration. Small GTPases (2014) 1.14
C3 exoenzymes, novel insights into structure and action of Rho-ADP-ribosylating toxins. Naunyn Schmiedebergs Arch Pharmacol (2006) 1.11
Effects of structure of Rho GTPase-activating protein DLC-1 on cell morphology and migration. J Biol Chem (2008) 1.05
FOXD3 regulates migration properties and Rnd3 expression in melanoma cells. Mol Cancer Res (2011) 1.05
RhoE deficiency produces postnatal lethality, profound motor deficits and neurodevelopmental delay in mice. PLoS One (2011) 1.05
A protocadherin-cadherin-FLRT3 complex controls cell adhesion and morphogenesis. PLoS One (2009) 1.05
Gem associates with Ezrin and acts via the Rho-GAP protein Gmip to down-regulate the Rho pathway. Mol Biol Cell (2007) 1.04
A genome-wide screen of CREB occupancy identifies the RhoA inhibitors Par6C and Rnd3 as regulators of BDNF-induced synaptogenesis. PLoS One (2013) 1.01
Rho GTPases in collective cell migration. Small GTPases (2014) 0.96
An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration. Nat Commun (2014) 0.95
Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. PLoS One (2010) 0.93
RhoE inhibits 4E-BP1 phosphorylation and eIF4E function impairing cap-dependent translation. J Biol Chem (2009) 0.91
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol (2014) 0.90
RhoA GTPase inhibition organizes contraction during epithelial morphogenesis. J Cell Biol (2016) 0.88
The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain. PLoS One (2010) 0.87
Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment? Curr Drug Targets (2010) 0.87
Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. J Cell Sci (2010) 0.86
PKCdelta influences p190 phosphorylation and activity: events independent of PKCdelta-mediated regulation of endothelial cell stress fiber and focal adhesion formation and barrier function. Biochim Biophys Acta (2009) 0.86
Rnd1 and Rnd3 targeting to lipid raft is required for p190 RhoGAP activation. Mol Biol Cell (2012) 0.85
Rnd3 induces stress fibres in endothelial cells through RhoB. Biol Open (2012) 0.85
A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing. Proc Natl Acad Sci U S A (2016) 0.85
Function and regulation of Rnd proteins in cortical projection neuron migration. Front Neurosci (2015) 0.85
The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression. J Biol Chem (2013) 0.83
Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res (2014) 0.83
Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure. Cell Death Dis (2014) 0.82
The F-BAR protein Rapostlin regulates dendritic spine formation in hippocampal neurons. J Biol Chem (2011) 0.81
Dual role for RhoA in suppression and induction of cytokines in the human neutrophil. Blood (2006) 0.81
The GTPase-deficient Rnd proteins are stabilized by their effectors. J Biol Chem (2012) 0.81
The role of semaphorins and their receptors in gliomas. J Signal Transduct (2012) 0.79
A switch in RND3-RHOA signaling is critical for melanoma cell invasion following mutant-BRAF inhibition. Mol Cancer (2011) 0.79
Downregulation of RND3/RhoE in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity. Cancer Med (2015) 0.79
Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state. J Biol Chem (2015) 0.79
Analysis of transcriptional responses in the mouse dorsal striatum following acute 3,4-methylenedioxymethamphetamine (ecstasy): identification of extracellular signal-regulated kinase-controlled genes. Neuroscience (2005) 0.79
The human papillomavirus E7 proteins associate with p190RhoGAP and alter its function. J Virol (2014) 0.78
Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis. Hypertension (2016) 0.78
Rho GTPases: Regulation and roles in cancer cell biology. Small GTPases (2016) 0.78
κB-Ras proteins regulate both NF-κB-dependent inflammation and Ral-dependent proliferation. Cell Rep (2014) 0.77
Pathophysiological Functions of Rnd3/RhoE. Compr Physiol (2015) 0.77
Rnd3 as a Novel Target to Ameliorate Microvascular Leakage. J Am Heart Assoc (2016) 0.76
Cancer-associated mutations in the protrusion-targeting region of p190RhoGAP impact tumor cell migration. J Cell Biol (2016) 0.76
Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS. J Biol Chem (2016) 0.76
Rp58 and p27(kip1) coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex. Neural Dev (2017) 0.75
Rnd3-induced cell rounding requires interaction with Plexin-B2. J Cell Sci (2016) 0.75
The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity. Mol Biol Cell (2016) 0.75
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N Engl J Med (2010) 36.78
Cell migration: integrating signals from front to back. Science (2003) 29.13
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol (2009) 15.23
Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer (2007) 14.84
Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med (2008) 13.54
Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science (2004) 11.58
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol (2005) 10.44
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol (2008) 9.43
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A (2007) 8.23
Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib. Proc Natl Acad Sci U S A (2005) 6.82
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res (2008) 6.71
Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine. EMBO Mol Med (2010) 6.38
Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res (2008) 6.05
Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci U S A (2006) 5.23
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07
The Ras superfamily at a glance. J Cell Sci (2005) 4.83
EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov (2012) 4.72
Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes Dev (2002) 4.30
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24
p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. Cell (2006) 4.24
Oncogene addiction: setting the stage for molecularly targeted cancer therapy. Genes Dev (2007) 4.11
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell (2006) 3.78
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature (2011) 3.69
Acquired resistance to tyrosine kinase inhibitors during cancer therapy. Curr Opin Genet Dev (2008) 3.67
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2005) 3.64
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer (2010) 3.59
Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models. Cancer Cell (2012) 3.39
Modulation of Rho GTPase signaling regulates a switch between adipogenesis and myogenesis. Cell (2003) 3.36
Rho-family GTPases: it's not only Rac and Rho (and I like it). J Cell Sci (2004) 3.27
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci Signal (2010) 3.25
Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell (2005) 3.17
Integrin signaling to the actin cytoskeleton. Curr Opin Cell Biol (2003) 3.11
Recruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesion. J Cell Biol (2002) 2.99
Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation. Cancer Res (2007) 2.78
Androgen deprivation causes epithelial-mesenchymal transition in the prostate: implications for androgen-deprivation therapy. Cancer Res (2011) 2.71
Personalized medicine in non-small-cell lung cancer: is KRAS a useful marker in selecting patients for epidermal growth factor receptor-targeted therapy? J Clin Oncol (2010) 2.70
Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol (2008) 2.69
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration. J Immunol (2007) 2.66
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. Nat Cell Biol (2010) 2.61
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr Biol (2006) 2.61
The dark side of Ras: regulation of apoptosis. Oncogene (2003) 2.60
Signaling interplay in Ras superfamily function. Curr Biol (2005) 2.59
The T790M "gatekeeper" mutation in EGFR mediates resistance to low concentrations of an irreversible EGFR inhibitor. Mol Cancer Ther (2008) 2.58
Analysis of activated GAPs and GEFs in cell lysates. Methods Enzymol (2006) 2.45
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol (2011) 2.45
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem (2003) 2.44
The 'invisible hand': regulation of RHO GTPases by RHOGDIs. Nat Rev Mol Cell Biol (2011) 2.39
Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition. Am J Physiol Renal Physiol (2002) 2.36
STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis. Cancer Res (2011) 2.35
RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol (2003) 2.34
Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis? Trends Cell Biol (2004) 2.32
Epidermal growth factor receptor mutants from human lung cancers exhibit enhanced catalytic activity and increased sensitivity to gefitinib. Cancer Res (2007) 2.30
"Oncogenic shock": explaining oncogene addiction through differential signal attenuation. Clin Cancer Res (2006) 2.30
Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem (2003) 2.28
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling. Cancer Res (2007) 2.26
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J Biol Chem (2008) 2.22
KRAS/BRAF mutation status and ERK1/2 activation as biomarkers for MEK1/2 inhibitor therapy in colorectal cancer. Mol Cancer Ther (2009) 2.22
GAP control: regulating the regulators of small GTPases. Trends Cell Biol (2004) 2.21
Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. J Clin Invest (2011) 2.20
Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases. J Biol Chem (2007) 2.20
Rho protein crosstalk: another social network? Trends Cell Biol (2011) 2.19
Ras history: The saga continues. Small GTPases (2010) 2.18
RhoA and ROCK promote migration by limiting membrane protrusions. J Biol Chem (2003) 2.17
Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2009) 2.17
Ligand-dependent dynamics and intramolecular signaling in a PDZ domain. J Mol Biol (2004) 2.17
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. Nat Struct Biol (2002) 2.14
Inhibition of Ras for cancer treatment: the search continues. Future Med Chem (2011) 2.14
Simultaneous stretching and contraction of stress fibers in vivo. Mol Biol Cell (2004) 2.12
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism. Nat Cell Biol (2002) 2.12
RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells. Mol Cell (2009) 2.11
Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migration. J Biol Chem (2006) 2.07
New regulators of Wnt/beta-catenin signaling revealed by integrative molecular screening. Sci Signal (2008) 1.88
Rap1 GTPase inhibits leukocyte transmigration by promoting endothelial barrier function. J Biol Chem (2005) 1.84
Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Mol Cell (2006) 1.81
Catching a GEF by its tail. Trends Cell Biol (2006) 1.79
Modeling oncogene addiction using RNA interference. Proc Natl Acad Sci U S A (2008) 1.79
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. J Biol Chem (2002) 1.78
VEGF-induced Rac1 activation in endothelial cells is regulated by the guanine nucleotide exchange factor Vav2. Exp Cell Res (2007) 1.76
Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res (2004) 1.75
The complexity of targeting EGFR signalling in cancer: from expression to turnover. Biochim Biophys Acta (2006) 1.75
Ras family signaling: therapeutic targeting. Cancer Biol Ther (2003) 1.74
RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J Cell Biol (2007) 1.71
RhoG signals in parallel with Rac1 and Cdc42. J Biol Chem (2002) 1.70
The regulation of vascular endothelial growth factor-induced microvascular permeability requires Rac and reactive oxygen species. J Biol Chem (2009) 1.69
The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity. J Cell Biol (2009) 1.68
Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons. Curr Biol (2004) 1.68
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67
Opinion: Searching for the elusive targets of farnesyltransferase inhibitors. Nat Rev Cancer (2003) 1.67
TORC1 suppression predicts responsiveness to RAF and MEK inhibition in BRAF-mutant melanoma. Sci Transl Med (2013) 1.67
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation. Oncogene (2004) 1.66
Hyperosmotic stress activates Rho: differential involvement in Rho kinase-dependent MLC phosphorylation and NKCC activation. Am J Physiol Cell Physiol (2003) 1.64
Regulation of Rho family GTPases by cell-cell and cell-matrix adhesion. Biol Res (2002) 1.63