Published in Nature on July 24, 2003
Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism. Proc Natl Acad Sci U S A (2005) 3.34
Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. Neuro Oncol (2007) 2.99
Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion. J Virol (2006) 2.45
Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain. Proc Natl Acad Sci U S A (2004) 2.19
Integrin alphavbeta3 is a coreceptor for human cytomegalovirus. Nat Med (2005) 2.15
Human cytomegalovirus infection induces rapamycin-insensitive phosphorylation of downstream effectors of mTOR kinase. J Virol (2004) 2.08
Isolation of human monoclonal antibodies that potently neutralize human cytomegalovirus infection by targeting different epitopes on the gH/gL/UL128-131A complex. J Virol (2009) 1.92
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Human cytomegalovirus glycoproteins gB and gH/gL mediate epithelial cell-cell fusion when expressed either in cis or in trans. J Virol (2008) 1.64
High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med (2007) 1.63
Maternal antibodies enhance or prevent cytomegalovirus infection in the placenta by neonatal Fc receptor-mediated transcytosis. Am J Pathol (2006) 1.59
Characterization of human cytomegalovirus glycoprotein-induced cell-cell fusion. J Virol (2005) 1.56
Activation of EGFR on monocytes is required for human cytomegalovirus entry and mediates cellular motility. Proc Natl Acad Sci U S A (2009) 1.51
Antiviral chemotherapy facilitates control of poxvirus infections through inhibition of cellular signal transduction. J Clin Invest (2005) 1.50
Human cytomegalovirus UL130 protein promotes endothelial cell infection through a producer cell modification of the virion. J Virol (2005) 1.43
Coiled-coil domains in glycoproteins B and H are involved in human cytomegalovirus membrane fusion. J Virol (2004) 1.43
HCMV spread and cell tropism are determined by distinct virus populations. PLoS Pathog (2011) 1.40
Essential roles for soluble virion-associated heparan sulfonated proteoglycans and growth factors in human papillomavirus infections. PLoS Pathog (2012) 1.36
Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling. EMBO J (2007) 1.32
Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach. J Clin Invest (2007) 1.31
Murine gammaherpesvirus-68 glycoprotein B presents a difficult neutralization target to monoclonal antibodies derived from infected mice. J Gen Virol (2006) 1.26
Lipid rafts in plants. Planta (2005) 1.26
Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress. J Virol (2009) 1.26
Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrins. Proc Natl Acad Sci U S A (2008) 1.25
Human cytomegalovirus glycoprotein gO complexes with gH/gL, promoting interference with viral entry into human fibroblasts but not entry into epithelial cells. J Virol (2011) 1.23
Epidermal growth factor receptor is not required for human cytomegalovirus entry or signaling. J Virol (2007) 1.21
Characterization of murine gammaherpesvirus 68 glycoprotein B. J Virol (2004) 1.19
Roles of phosphatidylinositol 3-kinase and NF-kappaB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistence. J Virol (2007) 1.18
B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies. PLoS Pathog (2011) 1.16
Human cytomegalovirus persistence. Cell Microbiol (2012) 1.16
Cross-regulation between herpesviruses and the TNF superfamily members. Nat Rev Immunol (2008) 1.15
Efficacy of cetuximab in the treatment of Menetrier's disease. Sci Transl Med (2009) 1.14
Human cytomegalovirus entry into dendritic cells occurs via a macropinocytosis-like pathway in a pH-independent and cholesterol-dependent manner. PLoS One (2012) 1.14
Two gamma interferon-activated site-like elements in the human cytomegalovirus major immediate-early promoter/enhancer are important for viral replication. J Virol (2005) 1.13
Human cytomegalovirus entry into cells. Curr Opin Virol (2012) 1.12
MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation. Am J Respir Cell Mol Biol (2011) 1.12
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii. Schizophr Bull (2008) 1.10
PDGF receptor-α does not promote HCMV entry into epithelial and endothelial cells but increased quantities stimulate entry by an abnormal pathway. PLoS Pathog (2012) 1.10
Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell Cycle (2010) 1.10
Annexin A2 and S100A10 regulate human papillomavirus type 16 entry and intracellular trafficking in human keratinocytes. J Virol (2013) 1.08
Cytomegalovirus UL131-128 products promote gB conformational transition and gB-gH interaction during entry into endothelial cells. J Virol (2007) 1.07
Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines. Neurosurg Rev (2008) 1.06
The Chlamydia pneumoniae invasin protein Pmp21 recruits the EGF receptor for host cell entry. PLoS Pathog (2013) 1.06
Synergistic inhibition of human cytomegalovirus replication by interferon-alpha/beta and interferon-gamma. Virol J (2005) 1.04
Human cytomegalovirus activation of ERK and myeloid cell leukemia-1 protein correlates with survival of latently infected cells. Proc Natl Acad Sci U S A (2011) 1.03
Developmental regulation of human cytomegalovirus receptors in cytotrophoblasts correlates with distinct replication sites in the placenta. J Virol (2007) 1.02
Postattachment events associated with viral entry are necessary for induction of interferon-stimulated genes by human cytomegalovirus. J Virol (2004) 1.02
HCMV gB shares structural and functional properties with gB proteins from other herpesviruses. Virology (2012) 1.01
The glycoprotein B disintegrin-like domain binds beta 1 integrin to mediate cytomegalovirus entry. J Virol (2010) 1.01
The chemokine receptor homologue encoded by US27 of human cytomegalovirus is heavily glycosylated and is present in infected human foreskin fibroblasts and enveloped virus particles. Virus Res (2006) 1.01
Human herpesvirus 6 glycoprotein complex formation is required for folding and trafficking of the gH/gL/gQ1/gQ2 complex and its cellular receptor binding. J Virol (2011) 1.00
Human cytomegalovirus blocks tumor necrosis factor alpha- and interleukin-1beta-mediated NF-kappaB signaling. J Virol (2006) 1.00
Human cytomegalovirus (HCMV) glycoprotein gB promotes virus entry in trans acting as the viral fusion protein rather than as a receptor-binding protein. MBio (2013) 0.98
Impact of sequence variation in the UL128 locus on production of human cytomegalovirus in fibroblast and epithelial cells. J Virol (2013) 0.97
The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes. PLoS Pathog (2013) 0.95
Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entry. J Virol (2010) 0.95
Human cytomegalovirus induction of a unique signalsome during viral entry into monocytes mediates distinct functional changes: a strategy for viral dissemination. J Leukoc Biol (2012) 0.94
The human cytomegalovirus virion possesses an activated casein kinase II that allows for the rapid phosphorylation of the inhibitor of NF-kappaB, IkappaBalpha. J Virol (2007) 0.94
Human cytomegalovirus regulates bioactive sphingolipids. J Biol Chem (2008) 0.93
Cytomegalovirus impairs cytotrophoblast-induced lymphangiogenesis and vascular remodeling in an in vivo human placentation model. Am J Pathol (2012) 0.93
Deletion of gpUL132, a structural component of human cytomegalovirus, results in impaired virus replication in fibroblasts. J Virol (2005) 0.91
Activation of epidermal growth factor receptor is required for NTHi-induced NF-κB-dependent inflammation. PLoS One (2011) 0.90
ERBBs in the gastrointestinal tract: recent progress and new perspectives. Exp Cell Res (2008) 0.89
HCMV infection of human trophoblast progenitor cells of the placenta is neutralized by a human monoclonal antibody to glycoprotein B and not by antibodies to the pentamer complex. Viruses (2014) 0.89
Novel chemical class of pUL97 protein kinase-specific inhibitors with strong anticytomegaloviral activity. Antimicrob Agents Chemother (2004) 0.88
Interplay between human cytomegalovirus and intrinsic/innate host responses: a complex bidirectional relationship. Mediators Inflamm (2012) 0.87
Structural basis for the recognition of human cytomegalovirus glycoprotein B by a neutralizing human antibody. PLoS Pathog (2014) 0.86
Epidermal growth factor receptor-PI3K signaling controls cofilin activity to facilitate herpes simplex virus 1 entry into neuronal cells. MBio (2014) 0.86
Human Cytomegalovirus Latency: Approaching the Gordian Knot. Annu Rev Virol (2016) 0.86
Onset of human cytomegalovirus replication in fibroblasts requires the presence of an intact vimentin cytoskeleton. J Virol (2009) 0.86
Exploring kinase inhibitors as therapies for human arenavirus infections. Future Virol (2008) 0.85
Zika Fetal Neuropathogenesis: Etiology of a Viral Syndrome. PLoS Negl Trop Dis (2016) 0.84
Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. PLoS One (2011) 0.84
Chronic viral infection and primary central nervous system malignancy. J Neuroimmune Pharmacol (2010) 0.84
Immunobiology of herpes simplex virus and cytomegalovirus infections of the fetus and newborn. Curr Immunol Rev (2010) 0.83
Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection. J Virol (2013) 0.83
HCMV activates the IL-6-JAK-STAT3 axis in HepG2 cells and primary human hepatocytes. PLoS One (2013) 0.82
Immunological visibility: posttranscriptional regulation of human NKG2D ligands by the EGF receptor pathway. Sci Transl Med (2014) 0.82
DSTP-27 prevents entry of human cytomegalovirus. Antimicrob Agents Chemother (2014) 0.82
Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1 entry. J Virol (2014) 0.81
Characterization of a discontinuous neutralizing epitope on glycoprotein B of human cytomegalovirus. J Virol (2013) 0.81
Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II. J Cell Mol Med (2016) 0.81
Peptide inhibition of human cytomegalovirus infection. Virol J (2011) 0.81
Amplification of autoimmune disease by infection. Arthritis Res Ther (2005) 0.81
THY-1 Cell Surface Antigen (CD90) Has an Important Role in the Initial Stage of Human Cytomegalovirus Infection. PLoS Pathog (2015) 0.81
New cell-signaling pathways for controlling cytomegalovirus replication. Am J Transplant (2014) 0.81
Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol (2012) 0.80
Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer. Nat Microbiol (2016) 0.80
Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors. Front Pharmacol (2015) 0.80
Lack of EGF receptor contributes to drug sensitivity of human germline cells. Br J Cancer (2005) 0.80
Herpesvirus 6 glycoproteins B (gB), gH, gL, and gQ are necessary and sufficient for cell-to-cell fusion. J Virol (2013) 0.79
Expression of the human cytomegalovirus UL11 glycoprotein in viral infection and evaluation of its effect on virus-specific CD8 T cells. J Virol (2014) 0.78
Detection of human cytomegalovirus in different histopathological types of glioma in Iraqi patients. Biomed Res Int (2015) 0.78
Human Cytomegalovirus Stimulates the Synthesis of Select Akt-Dependent Antiapoptotic Proteins during Viral Entry To Promote Survival of Infected Monocytes. J Virol (2016) 0.78
Proteomic analysis of membrane proteins of vero cells: exploration of potential proteins responsible for virus entry. DNA Cell Biol (2013) 0.77
Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog (2006) 4.80
Human tumor virus utilizes exosomes for intercellular communication. Proc Natl Acad Sci U S A (2010) 2.34
Infectious agents and cancer: criteria for a causal relation. Semin Cancer Biol (2004) 2.20
Integrin alphavbeta3 is a coreceptor for human cytomegalovirus. Nat Med (2005) 2.15
Microvesicles and viral infection. J Virol (2011) 2.10
Reactivation of latent Epstein-Barr virus by methotrexate: a potential contributor to methotrexate-associated lymphomas. J Natl Cancer Inst (2004) 1.80
EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching. J Immunol (2003) 1.70
Epstein-Barr virus quantitation by real-time PCR targeting multiple gene segments: a novel approach to screen for the virus in paraffin-embedded tissue and plasma. J Mol Diagn (2004) 1.64
Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma. Cancer Res (2003) 1.60
Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Res (2002) 1.53
Epstein-Barr virus BART microRNAs are produced from a large intron prior to splicing. J Virol (2008) 1.51
Epstein-Barr virus latent membrane protein 1 CTAR1 mediates rodent and human fibroblast transformation through activation of PI3K. Oncogene (2005) 1.47
EBV latent membrane protein 1 activates Akt, NFkappaB, and Stat3 in B cell lymphomas. PLoS Pathog (2007) 1.46
The Epstein-Barr Virus BART microRNAs target the pro-apoptotic protein Bim. Virology (2011) 1.45
Compartmentalization and transmission of multiple epstein-barr virus strains in asymptomatic carriers. J Virol (2003) 1.45
Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma. Cancer Res (2004) 1.37
LMP1 strain variants: biological and molecular properties. J Virol (2006) 1.35
Potential selection of LMP1 variants in nasopharyngeal carcinoma. J Virol (2004) 1.34
Antiviral activity of artesunate towards wild-type, recombinant, and ganciclovir-resistant human cytomegaloviruses. J Mol Med (Berl) (2001) 1.33
Epstein-Barr virus LMP1 activates EGFR, STAT3, and ERK through effects on PKCdelta. J Virol (2011) 1.28
Induction of Id1 and Id3 by latent membrane protein 1 of Epstein-Barr virus and regulation of p27/Kip and cyclin-dependent kinase 2 in rodent fibroblast transformation. J Virol (2004) 1.25
Epstein-Barr Virus (EBV) DNA in plasma is not encapsidated in patients with EBV-related malignancies. Diagn Mol Pathol (2004) 1.22
I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways. Mol Cell Biol (2002) 1.20
Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling. J Virol (2005) 1.19
EBV latent membrane protein 1 effects on plakoglobin, cell growth, and migration. Cancer Res (2008) 1.19
Infection of Epstein-Barr virus in a gastric carcinoma cell line induces anchorage independence and global changes in gene expression. Proc Natl Acad Sci U S A (2012) 1.18
Modulation of B-cell exosome proteins by gamma herpesvirus infection. Proc Natl Acad Sci U S A (2013) 1.14
Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells. J Virol (2004) 1.13
Unique signaling properties of CTAR1 in LMP1-mediated transformation. J Virol (2007) 1.12
Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor through effects on Bcl-3 and STAT3. J Virol (2008) 1.09
The role of miRNAs and EBV BARTs in NPC. Semin Cancer Biol (2011) 1.06
Multiple Epstein-Barr virus strains in patients with infectious mononucleosis: comparison of ex vivo samples with in vitro isolates by use of heteroduplex tracking assays. J Infect Dis (2005) 1.04
Human cytomegalovirus-inhibitory flavonoids: studies on antiviral activity and mechanism of action. Antiviral Res (2005) 1.04
New associations of human papillomavirus, Simian virus 40, and Epstein-Barr virus with human cancer. J Natl Cancer Inst (2002) 1.03
Expression profile of microRNAs in Epstein-Barr virus-infected AGS gastric carcinoma cells. J Virol (2013) 1.02
Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice. PLoS Pathog (2012) 1.00
TRAF interactions with raft-like buoyant complexes, better than TRAF rates of degradation, differentiate signaling by CD40 and EBV latent membrane protein 1. Int J Cancer (2005) 1.00
The need and challenges for development of an Epstein-Barr virus vaccine. Vaccine (2013) 0.98
Identification of Epstein-Barr virus strain variants in hairy leukoplakia and peripheral blood by use of a heteroduplex tracking assay. J Virol (2002) 0.97
Interactions between human cytomegalovirus IE1-72 and cellular p107: functional domains and mechanisms of up-regulation of cyclin E/cdk2 kinase activity. J Virol (2003) 0.96
Epstein-Barr virus LMP1 modulates lipid raft microdomains and the vimentin cytoskeleton for signal transduction and transformation. J Virol (2012) 0.95
Use of adenovirus vectors expressing Epstein-Barr virus (EBV) immediate-early protein BZLF1 or BRLF1 to treat EBV-positive tumors. J Virol (2002) 0.95
Human cytomegalovirus IE1-72 protein interacts with p53 and inhibits p53-dependent transactivation by a mechanism different from that of IE2-86 protein. J Virol (2009) 0.94
Clonal evolution of lymphoblastoid cell lines. Lab Invest (2006) 0.93
Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) and LMP2A function cooperatively to promote carcinoma development in a mouse carcinogenesis model. J Virol (2012) 0.93
Inhibition of human cytomegalovirus signaling and replication by the immunosuppressant FK778. Antiviral Res (2005) 0.92
Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch. Cancer Res (2009) 0.92
3,4',5-Trihydroxy-trans-stilbene (resveratrol) inhibits human cytomegalovirus replication and virus-induced cellular signaling. Antiviral Res (2004) 0.91
Biology of Epstein-Barr virus during infectious mononucleosis. J Infect Dis (2004) 0.90
Cellular stress and signal transduction responses to human cytomegalovirus infection. Microbes Infect (2004) 0.90
Epstein-Barr virus latent membrane protein-2A induces ITAM/Syk- and Akt-dependent epithelial migration through αv-integrin membrane translocation. J Virol (2012) 0.90
Tousled-like kinases modulate reactivation of gammaherpesviruses from latency. Cell Host Microbe (2013) 0.89
Post-transplantation lymphoproliferative disease: Epstein-Barr virus DNA levels, HLA-A3, and survival. Am J Respir Crit Care Med (2008) 0.89
The ID proteins contribute to the growth of rodent fibroblasts during LMP1-mediated transformation. Virology (2008) 0.89
Identification of Epstein-Barr virus RK-BARF0-interacting proteins and characterization of expression pattern. J Virol (2004) 0.88
Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradation. J Virol (2006) 0.87
Transcriptional downregulation of p27KIP1 through regulation of E2F function during LMP1-mediated transformation. J Virol (2009) 0.84
Transcriptome changes induced by Epstein-Barr virus LMP1 and LMP2A in transgenic lymphocytes and lymphoma. MBio (2012) 0.84
Epstein-Barr virus latent membrane protein 2 effects on epithelial acinus development reveal distinct requirements for the PY and YEEA motifs. J Virol (2013) 0.82
Ribonucleotide reductase inhibitors enhance cidofovir-induced apoptosis in EBV-positive nasopharyngeal carcinoma xenografts. Int J Cancer (2005) 0.81
Synthesis and antiviral activity of helioxanthin analogues. J Med Chem (2005) 0.81
Human cytomegalovirus hyperimmune globulin not only neutralizes HCMV infectivity, but also inhibits HCMV-induced intracellular NF-kappaB, Sp1, and PI3-K signaling pathways. J Med Virol (2002) 0.81
Rhesus lymphocryptovirus latent membrane protein 2A activates beta-catenin signaling and inhibits differentiation in epithelial cells. Virology (2008) 0.78
17-allylamino-17-(demethoxy)geldanamycin (17-AAG) is a potent and effective inhibitor of human cytomegalovirus replication in primary fibroblast cells. Arch Virol (2012) 0.77
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