Published in J Biol Chem on July 28, 2003
Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal (2012) 2.13
Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity. Org Lett (2006) 1.34
Substrate-specifying determinants of the nucleotide pyrophosphatases/phosphodiesterases NPP1 and NPP2. Biochem J (2004) 1.08
Modulation of purinergic signaling by NPP-type ectophosphodiesterases. Purinergic Signal (2006) 1.07
Identification of Mg2+ -dependent neutral sphingomyelinase 1 as a mediator of heat stress-induced ceramide generation and apoptosis. J Biol Chem (2008) 1.00
Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. Biochem J (2006) 0.95
Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity. ChemMedChem (2011) 0.95
Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression. Lipids Health Dis (2010) 0.91
Glycerophospholipid and sphingolipid species and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. PLoS One (2014) 0.91
Functional studies of human intestinal alkaline sphingomyelinase by deglycosylation and mutagenesis. Biochem J (2005) 0.89
Identification of aberrant forms of alkaline sphingomyelinase (NPP7) associated with human liver tumorigenesis. Br J Cancer (2007) 0.89
Crucial role of alkaline sphingomyelinase in sphingomyelin digestion: a study on enzyme knockout mice. J Lipid Res (2010) 0.89
Acid sphingomyelinase deficiency increases susceptibility to fatal alphavirus encephalomyelitis. J Virol (2006) 0.86
Ursolic acid inhibits the formation of aberrant crypt foci and affects colonic sphingomyelin hydrolyzing enzymes in azoxymethane-treated rats. J Cancer Res Clin Oncol (2007) 0.86
Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. J Biol Chem (2014) 0.85
Expression of alkaline sphingomyelinase in yeast cells and anti-inflammatory effects of the expressed enzyme in a rat colitis model. Dig Dis Sci (2008) 0.85
Generating ceramide from sphingomyelin by alkaline sphingomyelinase in the gut enhances sphingomyelin-induced inhibition of cholesterol uptake in Caco-2 cells. Dig Dis Sci (2010) 0.84
Metabolism, physiological role, and clinical implications of sphingolipids in gastrointestinal tract. Biomed Res Int (2013) 0.82
Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem (2013) 0.82
Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface. Mol Pharmacol (2013) 0.82
Intestinal absorption of dietary maize glucosylceramide in lymphatic duct cannulated rats. J Lipid Res (2010) 0.82
Sphingolipids in the DNA damage response. Adv Biol Regul (2014) 0.80
Sphingolipids in colon cancer. Biochim Biophys Acta (2013) 0.80
Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia. FASEB J (2008) 0.79
Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase. Sci Rep (2016) 0.78
Molecular modeling of human alkaline sphingomyelinase. Bioinformation (2011) 0.78
Effect of dietary sphingomyelin on absorption and fractional synthetic rate of cholesterol and serum lipid profile in humans. Lipids Health Dis (2013) 0.77
Mevalonate inhibits acid sphingomyelinase activity, increases sphingomyelin levels and inhibits cell proliferation of HepG2 and Caco-2 cells. Lipids Health Dis (2015) 0.77
Sphingolipid and ceramide homeostasis: potential therapeutic targets. Biochem Res Int (2012) 0.77
Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization. Biochim Biophys Acta (2014) 0.76
Fecal metabolome of the Hadza hunter-gatherers: a host-microbiome integrative view. Sci Rep (2016) 0.76
Changes of activity and isoforms of alkaline sphingomyelinase (nucleotide pyrophosphatase phosphodiesterase 7) in bile from patients undergoing endoscopic retrograde cholangiopancreatography. BMC Gastroenterol (2014) 0.75
Fostering Inflammatory Bowel Disease: Sphingolipid Strategies to Join Forces. Mediators Inflamm (2016) 0.75
Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7. BMC Biochem (2011) 0.75
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 6.45
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy. Nat Genet (2010) 6.10
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell (2006) 5.10
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol (2013) 4.04
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest (2013) 3.25
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem (2006) 3.24
Health effects of the 2003 Southern California wildfires on children. Am J Respir Crit Care Med (2006) 2.81
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res (2012) 2.50
Readers of histone modifications. Cell Res (2011) 2.40
Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol (2009) 2.36
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer (2008) 2.35
Suppression of RNA interference by adenovirus virus-associated RNA. J Virol (2005) 2.29
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Myotube assembly on nanofibrous and micropatterned polymers. Nano Lett (2006) 2.00
Ultrasound-targeted gene delivery induces angiogenesis after a myocardial infarction in mice. JACC Cardiovasc Imaging (2009) 1.94
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem (2008) 1.89
Identification of bacteria and bacteria-associated chemical cues that mediate oviposition site preferences by Aedes aegypti. Proc Natl Acad Sci U S A (2008) 1.88
EBF2 determines and maintains brown adipocyte identity. Cell Metab (2013) 1.85
The status of glycemic control: A cross-sectional study of outpatients with type 2 diabetes mellitus across primary, secondary, and tertiary hospitals in the Jiangsu province of China. Clin Ther (2010) 1.83
Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets. Anesth Analg (2009) 1.82
St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole. Clin Pharmacol Ther (2004) 1.79
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab (2013) 1.76
Actin and hnRNP U cooperate for productive transcription by RNA polymerase II. Nat Struct Mol Biol (2005) 1.75
High mobility group box chromosomal protein 1 (HMGB1) is an antibacterial factor produced by the human adenoid. Pediatr Res (2002) 1.74
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. Blood (2011) 1.74
Cryopreservation of complex systems: the missing link in the regenerative medicine supply chain. Rejuvenation Res (2006) 1.73
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A (2010) 1.71
Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease. Circ Cardiovasc Genet (2011) 1.69
Urinary interleukin 18 for detection of acute kidney injury: a meta-analysis. Am J Kidney Dis (2013) 1.68
The role of erythropoietin in regulating angiogenesis. Dev Biol (2004) 1.66
Four-color DNA sequencing with 3'-O-modified nucleotide reversible terminators and chemically cleavable fluorescent dideoxynucleotides. Proc Natl Acad Sci U S A (2008) 1.64
Antitumor activity of targeting SRC kinases in endothelial and myeloid cell compartments of the tumor microenvironment. Clin Cancer Res (2010) 1.64
Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A (2013) 1.64
MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS One (2009) 1.62
Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure. Circ Res (2005) 1.62
Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.). Genome Biol (2013) 1.59
HTQC: a fast quality control toolkit for Illumina sequencing data. BMC Bioinformatics (2013) 1.58
A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet (2009) 1.56
An adult uterine hemangioblast: evidence for extramedullary self-renewal and clonal bilineage potential. Blood (2010) 1.56
Analyses of differential proteome of human synovial fibroblasts obtained from arthritis. Clin Rheumatol (2008) 1.56
Predictive factors of type 2 diabetes mellitus remission following bariatric surgery: a meta-analysis. Obes Surg (2015) 1.55
Threshold-free high-power methods for the ontological analysis of genome-wide gene-expression studies. Genome Biol (2007) 1.54
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem (2006) 1.53
Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria. Mol Microbiol (2007) 1.53
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol (2012) 1.51
Kupffer cells mediate leptin-induced liver fibrosis. Gastroenterology (2009) 1.48
Mass screening for prostate cancer: a comparative study in Natori, Japan and Changchun, China. Urology (2003) 1.47
Assessing uncertainty in spatial exposure models for air pollution health effects assessment. Environ Health Perspect (2007) 1.45
Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration. J Am Coll Cardiol (2012) 1.42
Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Hum Mol Genet (2005) 1.42
Diethyl 3,3'-(phenyl-methyl-ene)bis-(1H-indole-2-carboxyl-ate). Acta Crystallogr Sect E Struct Rep Online (2012) 1.42
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability. PLoS Genet (2011) 1.41
Myocardial protection of MCI-186 in rabbit ischemia-reperfusion. Life Sci (2002) 1.40
Myometrial cells induce angiogenesis and salvage damaged myocardium. Am J Physiol Heart Circ Physiol (2006) 1.40
An improved elastase-based method to create a saccular aneurysm rabbit model. Br J Neurosurg (2013) 1.40
A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation (2012) 1.39
Pachyonychia congenita with corneal dystrophy. J Dermatol (2013) 1.39
Prospective study of chemotherapy in combination with cytokine-induced killer cells in patients suffering from advanced non-small cell lung cancer. Anticancer Res (2009) 1.38
Clinical study on the treatment of liver fibrosis due to hepatitis B by IFN-alpha(1) and traditional medicine preparation. World J Gastroenterol (1999) 1.38
Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation (2004) 1.36
Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains. PLoS Biol (2013) 1.35
COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis. Clin Cancer Res (2008) 1.34
Nuclear actin is associated with a specific subset of hnRNP A/B-type proteins. Nucleic Acids Res (2002) 1.33
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. J Allergy Clin Immunol (2010) 1.32
Cryopreservation of organs by vitrification: perspectives and recent advances. Cryobiology (2004) 1.31
Observation of the nonlocal spin-orbital effective field. Nat Commun (2013) 1.31
The Magnaporthe oryzae avirulence gene AvrPiz-t encodes a predicted secreted protein that triggers the immunity in rice mediated by the blast resistance gene Piz-t. Mol Plant Microbe Interact (2009) 1.30
Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. Cancer Res (2011) 1.30
Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc Natl Acad Sci U S A (2013) 1.30
Judging egocentric distance on the ground: occlusion and surface integration. Perception (2004) 1.29
Improved vitrification solutions based on the predictability of vitrification solution toxicity. Cryobiology (2004) 1.28
Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer. Cancer Immunol Immunother (2012) 1.27
Network modeling of the transcriptional effects of copy number aberrations in glioblastoma. Mol Syst Biol (2011) 1.26
Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro. Int J Biol Macromol (2009) 1.26
Treatment of advanced gastric cancer by chemotherapy combined with autologous cytokine-induced killer cells. Anticancer Res (2006) 1.25
Intravenously administered bone marrow cells migrate to damaged brain tissue and improve neural function in ischemic rats. Cell Transplant (2008) 1.25
Modeling the concentrations of on-road air pollutants in southern California. Environ Sci Technol (2013) 1.23
Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem (2004) 1.23
Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun (2013) 1.23
Influence of liver cancer on lipid and lipoprotein metabolism. Lipids Health Dis (2006) 1.23
Functional characterization of human PFTK1 as a cyclin-dependent kinase. Proc Natl Acad Sci U S A (2007) 1.22
Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo. J Pharmacol Exp Ther (2009) 1.20
Boswellic acids trigger apoptosis via a pathway dependent on caspase-8 activation but independent on Fas/Fas ligand interaction in colon cancer HT-29 cells. Carcinogenesis (2002) 1.20
A new and sensitive method for the quantification of HBV cccDNA by real-time PCR. Biochem Biophys Res Commun (2002) 1.20
Signature of circulating microRNAs as potential biomarkers in vulnerable coronary artery disease. PLoS One (2013) 1.19
Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Hum Mol Genet (2009) 1.19
Spermidine oxidase-derived H₂O₂ regulates pollen plasma membrane hyperpolarization-activated Ca(2+) -permeable channels and pollen tube growth. Plant J (2010) 1.18
Dimethyl 3,3'-(phenyl-methyl-ene)bis-(1H-indole-2-carboxyl-ate). Acta Crystallogr Sect E Struct Rep Online (2013) 1.18