Recognition of microbial infection by Toll-like receptors.

Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest (2004) 5.39

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity (2010) 5.12

Toll-like receptor 9-induced type I IFN protects mice from experimental colitis. J Clin Invest (2005) 3.36

Reconstructing immune phylogeny: new perspectives. Nat Rev Immunol (2005) 2.95

Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med (2004) 2.32

Combining radiotherapy and immunotherapy: a revived partnership. Int J Radiat Oncol Biol Phys (2005) 2.29

The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signals. J Biol Chem (2005) 2.21

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A (2005) 2.08

Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Genetics (2008) 1.93

Toll-like receptors in central nervous system glial inflammation and homeostasis. J Neurosci Res (2006) 1.91

MyD88-deficient mice display a profound loss in resistance to Mycobacterium tuberculosis associated with partially impaired Th1 cytokine and nitric oxide synthase 2 expression. Infect Immun (2004) 1.89

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation. J Immunol (2010) 1.77

Invertebrate immune systems--not homogeneous, not simple, not well understood. Immunol Rev (2004) 1.72

Toll-like receptor agonists in cancer therapy. Immunotherapy (2009) 1.58

Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest (2005) 1.52

Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood (2007) 1.48

Toll-like receptor 2 (TLR2) is pivotal for recognition of S. aureus peptidoglycan but not intact bacteria by microglia. Glia (2005) 1.46

TBK1 protects vacuolar integrity during intracellular bacterial infection. PLoS Pathog (2007) 1.43

Enhanced efficacy and reduced toxicity of multifactorial adjuvants compared with unitary adjuvants as cancer vaccines. Blood (2008) 1.43

Mycobacterium tuberculosis lipomannan induces apoptosis and interleukin-12 production in macrophages. Infect Immun (2004) 1.40

Porcine small intestinal epithelial cell line (IPEC-J2) of rotavirus infection as a new model for the study of innate immune responses to rotaviruses and probiotics. Viral Immunol (2010) 1.37

Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol (2009) 1.36

Myd88 is required for an antibody response to retroviral infection. PLoS Pathog (2009) 1.35

Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. Immunol Lett (2007) 1.35

The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology (2006) 1.34

Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol (2010) 1.34

Immunopathogenesis of brain abscess. J Neuroinflammation (2004) 1.32

Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways. J Clin Invest (2005) 1.32

Regulation of apoptotic and inflammatory cell signaling in cerebral ischemia: the complex roles of heat shock protein 70. Anesthesiology (2008) 1.29

Dendritic cells at the oral mucosal interface. J Dent Res (2006) 1.24

From the Th1/Th2 paradigm towards a Toll-like receptor/T-helper bias. Antimicrob Agents Chemother (2005) 1.23

Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun (2005) 1.23

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response. Proc Natl Acad Sci U S A (2012) 1.22

Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Sci Signal (2012) 1.20

Activation of human and chicken toll-like receptors by Campylobacter spp. Infect Immun (2009) 1.20

Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency. J Exp Med (2007) 1.16

Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery. World J Gastroenterol (2005) 1.15

The struggle within: microbial influences on colorectal cancer. Inflamm Bowel Dis (2011) 1.15

Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori. Infect Immun (2007) 1.15

Innate responses to Toxoplasma gondii in mice and humans. Trends Parasitol (2011) 1.15

Central role for MyD88 in the responses of microglia to pathogen-associated molecular patterns. J Immunol (2006) 1.15

The role of Toll-like receptors in CNS response to microbial challenge. J Neurochem (2006) 1.12

A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation. Clin Exp Immunol (2009) 1.12

Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis. Infect Immun (2005) 1.12

Small intestinal bacterial overgrowth in nonalcoholic steatohepatitis: association with toll-like receptor 4 expression and plasma levels of interleukin 8. Dig Dis Sci (2010) 1.11

The absence of Toll-like receptor 4 signaling in C3H/HeJ mice predisposes them to overwhelming rickettsial infection and decreased protective Th1 responses. Infect Immun (2008) 1.10

Mucosal and cellular immune responses elicited by recombinant Lactococcus lactis strains expressing tetanus toxin fragment C. Infect Immun (2004) 1.09

Bacteria in the intestine, helpful residents or enemies from within? Infect Immun (2008) 1.07

Vesicular stomatitis virus M protein mutant stimulates maturation of Toll-like receptor 7 (TLR7)-positive dendritic cells through TLR-dependent and -independent mechanisms. J Virol (2009) 1.07

TLR2 expression in astrocytes is induced by TNF-alpha- and NF-kappa B-dependent pathways. J Immunol (2008) 1.07

Recognition of fungal pathogens by Toll-like receptors. Eur J Clin Microbiol Infect Dis (2004) 1.07

Role of Toll-like receptors in health and diseases of gastrointestinal tract. World J Gastroenterol (2006) 1.06

Development of a clinical assay to evaluate toll-like receptor function. Clin Vaccine Immunol (2006) 1.06

Minocycline modulates neuroinflammation independently of its antimicrobial activity in staphylococcus aureus-induced brain abscess. Am J Pathol (2007) 1.05

TLR2 and TLR4 stimulation differentially induce cytokine secretion in human neonatal, adult, and murine mononuclear cells. J Interferon Cytokine Res (2004) 1.04

Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol (2014) 1.04

TLR2-dependent modulation of osteoclastogenesis by Porphyromonas gingivalis through differential induction of NFATc1 and NF-kappaB. J Biol Chem (2011) 1.03

Caspase-1 activation of interleukin-1β (IL-1β) and IL-18 is dispensable for induction of experimental cerebral malaria. Infect Immun (2011) 1.02

Carbohydrate-mediated targeting of antigen to dendritic cells leads to enhanced presentation of antigen to T cells. Chembiochem (2008) 1.00

Germinal center kinase is required for optimal Jun N-terminal kinase activation by Toll-like receptor agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization. Mol Cell Biol (2004) 0.99

Matrix protein mutant of vesicular stomatitis virus stimulates maturation of myeloid dendritic cells. J Virol (2006) 0.98

Toll-like receptor 4-mediated activation of p38 mitogen-activated protein kinase is a determinant of respiratory virus entry and tropism. J Virol (2010) 0.98

Innate Immunity in the Female Reproductive Tract: Role of Sex Hormones in Regulating Uterine Epithelial Cell Protection Against Pathogens. Curr Womens Health Rev (2008) 0.98

Membrane repair and immunological danger. EMBO Rep (2005) 0.97

Inhaled innate immune ligands to prevent pneumonia. Br J Pharmacol (2011) 0.97

Deciphering mechanisms of staphylococcal biofilm evasion of host immunity. Front Cell Infect Microbiol (2012) 0.97

The non-pathogenic mycobacteria M. smegmatis and M. fortuitum induce rapid host cell apoptosis via a caspase-3 and TNF dependent pathway. BMC Microbiol (2010) 0.96

Expression of Toll-like receptors and their association with cytokine responses in peripheral blood mononuclear cells of children with acute rotavirus diarrhoea. Clin Exp Immunol (2006) 0.95

Role of TLR2-dependent inflammation in metastatic progression. Ann N Y Acad Sci (2011) 0.94

Blimp-1/PRDM1 mediates transcriptional suppression of the NLR gene NLRP12/Monarch-1. J Immunol (2009) 0.93

Recent advances in dendritic cell biology. J Clin Immunol (2005) 0.92

Evasion of antiviral immunity through sequestering of TBK1/IKKε/IRF3 into viral inclusion bodies. J Virol (2013) 0.92

Toll-like receptor triggering in cord blood mesenchymal stem cells. J Cell Mol Med (2009) 0.92

Tumor necrosis factor-alpha (TNF-alpha) regulates Toll-like receptor 2 (TLR2) expression in microglia. J Neurochem (2007) 0.92

The innate immune system in Alzheimer's disease. Int J Cell Biol (2013) 0.92

DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription. BMC Mol Biol (2008) 0.91

Outer membrane protein A (OmpA) of Shigella flexneri 2a links innate and adaptive immunity in a TLR2-dependent manner and involvement of IL-12 and nitric oxide. J Biol Chem (2012) 0.90

Epigenetic regulation of tumor necrosis factor α (TNFα) release in human macrophages by HIV-1 single-stranded RNA (ssRNA) is dependent on TLR8 signaling. J Biol Chem (2012) 0.90

MKP1 regulates the induction of MUC5AC mucin by Streptococcus pneumoniae pneumolysin by inhibiting the PAK4-JNK signaling pathway. J Biol Chem (2008) 0.90

Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development. Mem Inst Oswaldo Cruz (2011) 0.90

Inhaled therapeutics for prevention and treatment of pneumonia. Expert Opin Drug Saf (2009) 0.89

The role and regulation of receptor-like kinases in plant defense. Gene Regul Syst Bio (2007) 0.87

Spontaneous preterm labor is associated with an increase in the proinflammatory signal transducer TLR4 receptor on maternal blood monocytes. BMC Pregnancy Childbirth (2010) 0.87

Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF. Biochem Biophys Res Commun (2007) 0.87

The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway. PLoS One (2013) 0.87

Differential use of TLR2 and TLR9 in the regulation of immune responses during the infection with Trypanosoma cruzi. PLoS One (2013) 0.86

The optimal partnership of radiation and immunotherapy: from preclinical studies to clinical translation. Radiat Res (2014) 0.86

Lactobacillus casei prevents the development of dextran sulphate sodium-induced colitis in Toll-like receptor 4 mutant mice. Clin Exp Immunol (2007) 0.86

Vitamin K3 attenuates lipopolysaccharide-induced acute lung injury through inhibition of nuclear factor-kappaB activation. Clin Exp Immunol (2009) 0.86

Bacterial LPS up-regulated TLR3 expression is critical for antiviral response in human monocytes: evidence for negative regulation by CYLD. Int Immunol (2011) 0.84

Vaccines: all things considered. Clin Vaccine Immunol (2006) 0.84

Interplay of the Gastric Pathogen Helicobacter pylori with Toll-Like Receptors. Biomed Res Int (2015) 0.84

Activation of the TLR/MyD88/NF-κB signal pathway contributes to changes in IL-4 and IL-12 production in piglet lymphocytes infected with porcine circovirus type 2 in vitro. PLoS One (2014) 0.84

Toll-like receptor- and filarial antigen-mediated, mitogen-activated protein kinase- and NF-κB-dependent regulation of angiogenic growth factors in filarial lymphatic pathology. Infect Immun (2012) 0.83

Differential regulation of Streptococcus pneumoniae-induced human MUC5AC mucin expression through distinct MAPK pathways. Am J Transl Res (2009) 0.83

Effect of oestradiol and pathogen-associated molecular patterns on class II-mediated antigen presentation and immunomodulatory molecule expression in the mouse female reproductive tract. Immunology (2012) 0.82

Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling. J Neurovirol (2011) 0.82

Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype. Ann Surg (2007) 0.82

TIFA upregulation after hypoxia-reoxygenation is TLR4- and MyD88-dependent and associated with HMGB1 upregulation and release. Free Radic Biol Med (2013) 0.81

Dendritic cell interactions with Histoplasma and Paracoccidioides. Virulence (2015) 0.81

Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell (2004) 29.32

Innate immune recognition. Annu Rev Immunol (2001) 26.65

Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 19.15

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science (2003) 14.04

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity (2006) 10.61

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat Med (2005) 8.49

Regulation of adaptive immunity by the innate immune system. Science (2010) 8.00

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol (2008) 7.87

Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature (2007) 7.34

Type I interferons in host defense. Immunity (2006) 7.32

Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med (2003) 7.26

IRAK-M is a negative regulator of Toll-like receptor signaling. Cell (2002) 6.79

Regulation of phagosome maturation by signals from toll-like receptors. Science (2004) 6.79

A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol (2008) 6.78

Control of inducible gene expression by signal-dependent transcriptional elongation. Cell (2009) 6.57

Control of B-cell responses by Toll-like receptors. Nature (2005) 6.44

Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell (2006) 6.01

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95

Toll-like receptor signaling pathways. Science (2003) 5.86

Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science (2007) 5.54

Toll-dependent selection of microbial antigens for presentation by dendritic cells. Nature (2006) 5.54

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat Immunol (2005) 4.30

Toll-like receptors and cancer. Nat Rev Cancer (2008) 4.29

The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors. Nature (2002) 4.15

Role of toll-like receptors in spontaneous commensal-dependent colitis. Immunity (2006) 3.98

Pattern recognition receptors and control of adaptive immunity. Immunol Rev (2009) 3.91

Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol (2009) 3.79

MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity. Cell Metab (2009) 3.64

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12

On regulation of phagosome maturation and antigen presentation. Nat Immunol (2006) 3.11

Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology (2011) 2.90

Toll-dependent control mechanisms of CD4 T cell activation. Immunity (2004) 2.88

Toll-like receptors: linking innate and adaptive immunity. Adv Exp Med Biol (2005) 2.85

A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system. Cell Host Microbe (2010) 2.84

Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice. Nat Med (2002) 2.77

p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65

Retroviral delivery of small interfering RNA into primary cells. Proc Natl Acad Sci U S A (2002) 2.43

Toll-like receptors: linking innate and adaptive immunity. Microbes Infect (2004) 2.38

Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. J Immunol (2005) 2.30

Role of tissue protection in lethal respiratory viral-bacterial coinfection. Science (2013) 2.22

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proc Natl Acad Sci U S A (2014) 2.22

Age-associated defect in human TLR-1/2 function. J Immunol (2007) 2.20

NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway. Nat Immunol (2007) 2.11

Triggering TLR signaling in vaccination. Trends Immunol (2005) 2.09

Allergic host defences. Nature (2012) 1.99

Control of adaptive immune responses by Toll-like receptors. Curr Opin Immunol (2002) 1.92

Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells. Immunity (2013) 1.88

Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity (2013) 1.88

Gene-specific control of the TLR-induced inflammatory response. Clin Immunol (2008) 1.80

Toll-like receptors and acquired immunity. Semin Immunol (2004) 1.79

Innate control of adaptive immunity via remodeling of lymph node feed arteriole. Proc Natl Acad Sci U S A (2005) 1.62

Innate immunity--cross-talk with adaptive immunity through pattern recognition receptors and cytokines. Curr Opin Immunol (2006) 1.62

Host defense pathways: role of redundancy and compensation in infectious disease phenotypes. Immunity (2011) 1.57

Prevaccine determination of the expression of costimulatory B7 molecules in activated monocytes predicts influenza vaccine responses in young and older adults. J Infect Dis (2007) 1.56

Targeting of immune signalling networks by bacterial pathogens. Nat Cell Biol (2009) 1.52

The control of adaptive immune responses by the innate immune system. Adv Immunol (2011) 1.48

Influenza virus-induced glucocorticoids compromise innate host defense against a secondary bacterial infection. Cell Host Microbe (2010) 1.47

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J Immunol (2006) 1.44

MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice. Nat Commun (2012) 1.44

Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus. Immunity (2013) 1.40

Antiviral defense: interferons and beyond. J Exp Med (2006) 1.38

Integration of cytokine and heterologous receptor signaling pathways. Nat Immunol (2009) 1.36

Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci (2010) 1.35

Toll-like receptors: balancing host resistance with immune tolerance. Curr Opin Immunol (2003) 1.34

Semaphorin 7A is a negative regulator of T cell responses. Immunity (2006) 1.33

Adjuvants of immunity: harnessing innate immunity to promote adaptive immunity. J Exp Med (2002) 1.33

Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol (2011) 1.31

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence. PLoS Pathog (2008) 1.27

Evolution of inflammatory diseases. Curr Biol (2012) 1.27

Impact of CD1d deficiency on metabolism. PLoS One (2011) 1.21

Learning tolerance while fighting ignorance. Cell (2009) 1.20

Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A (2008) 1.20

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog (2011) 1.14

Immunostimulatory activity of haptenated proteins. Proc Natl Acad Sci U S A (2009) 1.10

Role of basophils in the initiation of Th2 responses. Curr Opin Immunol (2010) 1.10

Regulation of Toll-like receptor 4 expression in the lung following hemorrhagic shock and lipopolysaccharide. J Immunol (2002) 1.10

Airway epithelial MyD88 restores control of Pseudomonas aeruginosa murine infection via an IL-1-dependent pathway. J Immunol (2011) 1.08

Innate sensors of microbial infection. J Clin Immunol (2005) 1.05

Linking Toll-like receptors to IFN-alpha/beta expression. Nat Immunol (2003) 1.05

The human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter. J Exp Med (2013) 1.01

Two modes of ligand recognition by TLRs. Cell (2007) 0.99

Role of caspase-1 in regulation of triglyceride metabolism. Proc Natl Acad Sci U S A (2013) 0.97

Role of ITAM signaling module in signal integration. Curr Opin Immunol (2012) 0.94

Antifungal defense turns 17. Nat Immunol (2007) 0.93

Toll signaling: RIPping off the TNF pathway. Nat Immunol (2004) 0.90

Not so fast: adaptive suppression of innate immunity. Nat Med (2007) 0.89

Pyroptosis: macrophage suicide exposes hidden invaders. Curr Biol (2011) 0.89

A new shield for a cytokine storm. Cell (2011) 0.88

graal: a Drosophila gene coding for several mosaic serine proteases. Insect Biochem Mol Biol (2004) 0.85

Skin antibiotics get in the loop. Nat Med (2002) 0.84

The origins of tumor-promoting inflammation. Cancer Cell (2013) 0.84

Role of the inflammasome in defense against venoms. Proc Natl Acad Sci U S A (2013) 0.82

Fus1/Tusc2 is a novel regulator of mitochondrial calcium handling, Ca2+-coupled mitochondrial processes, and Ca2+-dependent NFAT and NF-κB pathways in CD4+ T cells. Antioxid Redox Signal (2014) 0.82

A plague on host defense. J Exp Med (2002) 0.81

Prostaglandin-secreting cells: a portable first aid kit for tissue repair. J Clin Invest (2007) 0.78

T helper 17 cells get the NOD. Immunity (2007) 0.78

Training the next generation of biomedical investigators in glycosciences. J Clin Invest (2016) 0.76

Honor thy Go(na)ds. Immunol Cell Biol (2013) 0.75

Germs gone wild. Nat Med (2012) 0.75