Published in J Immunol on August 15, 2003
Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol (2009) 4.31
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neurons. J Alzheimers Dis (2010) 1.84
Akt-mediated foxo1 inhibition is required for liver regeneration. Hepatology (2015) 1.46
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev (2007) 1.43
Effects of FOXO genotypes on longevity: a biodemographic analysis. J Gerontol A Biol Sci Med Sci (2010) 1.38
FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms. PLoS Pathog (2012) 1.22
CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice. J Exp Med (2004) 1.20
Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen. J Immunol (2008) 1.11
The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts. FASEB J (2008) 1.09
FOXO1 plays an essential role in apoptosis of retinal pericytes. Mol Vis (2010) 1.04
Resveratrol enhances antitumor activity of TRAIL in prostate cancer xenografts through activation of FOXO transcription factor. PLoS One (2010) 1.04
Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells. Infect Immun (2008) 1.02
Apoptosis in gingival overgrowth tissues. J Dent Res (2007) 1.01
Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells. Nat Immunol (2009) 1.01
Caenorhabditis is a metazoan host for Legionella. Cell Microbiol (2009) 1.00
Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation. Lab Invest (2009) 0.99
Foxo1, a novel regulator of osteoblast differentiation and skeletogenesis. J Biol Chem (2010) 0.99
FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. J Immunol (2011) 0.98
Tumor suppressor FOXO3 mediates signals from the EGF receptor to regulate proliferation of colonic cells. Am J Physiol Gastrointest Liver Physiol (2010) 0.94
Altered fibroblast proliferation and apoptosis in diabetic gingival wounds. J Dent Res (2010) 0.93
Foxo3-/- mice demonstrate reduced numbers of pre-B and recirculating B cells but normal splenic B cell sub-population distribution. Int Immunol (2009) 0.93
Altered FOXO1 transcript levels in peripheral blood mononuclear cells of systemic lupus erythematosus and rheumatoid arthritis patients. Mol Med (2007) 0.93
Toxicity of neurons treated with herbicides and neuroprotection by mitochondria-targeted antioxidant SS31. Int J Environ Res Public Health (2011) 0.92
FOXO3 regulates the CD8 T cell response to a chronic viral infection. J Virol (2012) 0.91
Epstein-Barr virus encoded miR-BART11 promotes inflammation-induced carcinogenesis by targeting FOXP1. Oncotarget (2016) 0.89
Fork head transcription factor is required for ovarian mature in the brown planthopper, Nilaparvata lugens (Stål). BMC Mol Biol (2011) 0.89
Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener (2011) 0.88
The transmembrane adaptor protein SIT inhibits TCR-mediated signaling. PLoS One (2011) 0.86
Targeting PI3K in neuroblastoma. J Cancer Res Clin Oncol (2010) 0.83
Foxo3a: an integrator of immune dysfunction during HIV infection. Cytokine Growth Factor Rev (2012) 0.81
Tumor suppressive effect of PARP1 and FOXO3A in gastric cancers and its clinical implications. Oncotarget (2015) 0.81
Genetic variants in PI3K/AKT pathway are associated with severe radiation pneumonitis in lung cancer patients treated with radiation therapy. Cancer Med (2015) 0.80
The FOX transcription factors regulate vascular pathology, diabetes and Tregs. Front Biosci (Schol Ed) (2009) 0.79
Forkhead family transcription factor FoxO and neural differentiation. Neurogenetics (2012) 0.79
Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. PLoS One (2014) 0.79
Staying alive in adversity: transcriptome dynamics in the stress-resistant dauer larva. Funct Integr Genomics (2006) 0.78
Retinoic acid receptor α promotes autophagy to alleviate liver ischemia and reperfusion injury. World J Gastroenterol (2015) 0.76
Human IDO-competent, long-lived immunoregulatory dendritic cells induced by intracellular pathogen, and their fate in humanized mice. Sci Rep (2017) 0.75
FOXO1 Up-Regulates Human L-selectin Expression Through Binding to a Consensus FOXO1 Motif. Gene Regul Syst Bio (2012) 0.75
FOXO3 rs12212067: T > G Association with Active Tuberculosis in Han Chinese Population. Inflammation (2016) 0.75
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature (2002) 7.88
The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J Immunol (2002) 4.85
FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol (2003) 4.31
FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines. J Biol Chem (2003) 3.41
FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol (2002) 2.86
Control of cell cycle exit and entry by protein kinase B-regulated forkhead transcription factors. Mol Cell Biol (2002) 2.84
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood (2009) 2.49
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity. Immunity (2013) 2.05
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem (2009) 2.05
Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. Immunity (2013) 1.75
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol (2012) 1.63
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism. Mol Cell Biol (2004) 1.63
Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy. Blood (2012) 1.61
MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol (2009) 1.60
The role of the PI3K-PKB signaling module in regulation of hematopoiesis. Cell Cycle (2009) 1.55
HMG-CoA reductase inhibition induces IL-1beta release through Rac1/PI3K/PKB-dependent caspase-1 activation. Blood (2008) 1.54
FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol (2004) 1.51
The extending network of FOXO transcriptional target genes. Antioxid Redox Signal (2010) 1.49
FOXO3a induces differentiation of Bcr-Abl-transformed cells through transcriptional down-regulation of Id1. J Biol Chem (2006) 1.40
Respiratory syncytial virus inhibits granulocyte apoptosis through a phosphatidylinositol 3-kinase and NF-kappaB-dependent mechanism. J Immunol (2006) 1.40
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex. Mol Biol Cell (2004) 1.39
The ins and outs of syntenin, a multifunctional intracellular adaptor protein. J Cell Sci (2008) 1.38
Rapid temporal control of Foxp3 protein degradation by sirtuin-1. PLoS One (2011) 1.31
Rapamycin specifically interferes with GM-CSF signaling in human dendritic cells, leading to apoptosis via increased p27KIP1 expression. Blood (2002) 1.26
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells. Blood (2011) 1.24
Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS. Oncogene (2005) 1.23
Statin synergizes with LPS to induce IL-1beta release by THP-1 cells through activation of caspase-1. Mol Immunol (2008) 1.22
Molecular mechanisms underlying FIP1L1-PDGFRA-mediated myeloproliferation. Cancer Res (2007) 1.15
Defects in mitochondrial clearance predispose human monocytes to interleukin-1β hypersecretion. J Biol Chem (2013) 1.15
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. Blood (2005) 1.13
Canonical Wnt signaling negatively modulates regulatory T cell function. Immunity (2013) 1.13
Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesis. Blood (2007) 1.11
Chronic protein kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation. Cancer Res (2006) 1.10
Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Blood (2005) 1.07
Signal transducer and activator of transcription 5a (STAT5a) is required for eosinophil differentiation of human cord blood-derived CD34+ cells. Blood (2002) 1.06
Signal inhibitory receptor on leukocytes-1 is a novel functional inhibitory immune receptor expressed on human phagocytes. J Immunol (2010) 1.01
Src kinases regulate PKB activation and modulate cytokine and chemoattractant-controlled neutrophil functioning. J Leukoc Biol (2002) 1.01
Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes. J Immunol (2004) 1.00
Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors. Blood (2009) 1.00
Differential expression of leukocyte-associated Ig-like receptor-1 during neutrophil differentiation and activation. J Leukoc Biol (2006) 1.00
SOX4 mediates TGF-β-induced expression of mesenchymal markers during mammary cell epithelial to mesenchymal transition. PLoS One (2013) 1.00
Signal transducer and activator of transcription 5 (STAT5). Int J Biochem Cell Biol (2004) 0.96
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60. Nat Commun (2013) 0.94
Stressed marrow: FoxOs stem tumour growth. Nat Cell Biol (2007) 0.94
Role of Ca2+/calmodulin regulated signaling pathways in chemoattractant induced neutrophil effector functions. Comparison with the role of phosphotidylinositol-3 kinase. Eur J Biochem (2002) 0.93
Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum (2009) 0.92
p38 MAP kinase inhibits neutrophil development through phosphorylation of C/EBPalpha on serine 21. Stem Cells (2009) 0.92
Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes. Eur J Immunol (2013) 0.92
IL-5-mediated eosinophil survival requires inhibition of GSK-3 and correlates with beta-catenin relocalization. J Leukoc Biol (2006) 0.91
PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function. Blood (2012) 0.91
STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass. PLoS One (2012) 0.91
The reduced GM-CSF priming of ROS production in granulocytes from patients with myelodysplasia is associated with an impaired lipid raft formation. J Leukoc Biol (2006) 0.88
Glutamine metabolism links growth factor signaling to the regulation of autophagy. Autophagy (2012) 0.86
The serine/threonine phosphatase PPM1B (PP2Cβ) selectively modulates PPARγ activity. Biochem J (2013) 0.85
Regulation of autophagy by Forkhead box (FOX) O transcription factors. Adv Biol Regul (2012) 0.84
Histone deacetylase inhibition modulates cell fate decisions during myeloid differentiation. Haematologica (2010) 0.83
Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling. J Immunol (2010) 0.83
A nonredundant role for canonical NF-κB in human myeloid dendritic cell development and function. J Immunol (2010) 0.83
Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties. Blood (2010) 0.83
Cytokine mediated suppression of TF-1 apoptosis requires PI3K activation and inhibition of Bim expression. FEBS Lett (2005) 0.82
Mammalian target of rapamycin activity is required for expansion of CD34+ hematopoietic progenitor cells. Haematologica (2009) 0.81
Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. Blood (2009) 0.81
Tight control of STAT5 activity determines human CD34-derived interstitial dendritic cell and langerhans cell development. J Immunol (2011) 0.80
Survival, but not maturation, is affected in neutrophil progenitors from GSD-1b patients. J Inherit Metab Dis (2011) 0.80
Hepatic autophagy is differentially regulated in periportal and pericentral zones - a general mechanism relevant for other tissues? Cell Commun Signal (2013) 0.78
Ectopic expression of C/EBPalpha and ID1 is sufficient to restore defective neutrophil development in low-risk myelodysplasia. Haematologica (2009) 0.78
Transcriptional regulation of lymphocyte quiescence: as cunning as a FOX. Trends Immunol (2003) 0.78
c-Jun activating binding protein 1 binds to the IgA receptor and modulates protein levels of FcalphaRI and FcRgamma-chain. Eur J Immunol (2010) 0.76
Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts. Haematologica (2010) 0.76
Functional analysis of the interleukin-5 receptor antagonist peptide, AF18748. Cytokine (2004) 0.75
Valproic acid treatment is associated with altered leukocyte subset development. J Clin Psychopharmacol (2012) 0.75