An endonuclease activity similar to Xenopus PMR1 catalyzes the degradation of normal and nonsense-containing human beta-globin mRNA in erythroid cells.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 1370479)

Published in RNA on September 01, 2003

Authors

Kirsten A Bremer1, Audrey Stevens, Daniel R Schoenberg

Author Affiliations

1: Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

Articles citing this

Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA. Mol Cell Biol (2009) 1.67

A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay. Mol Cell Biol (2007) 1.38

Re-capping the message. Trends Biochem Sci (2009) 1.28

How and where are nonsense mRNAs degraded in mammalian cells? RNA Biol (2010) 1.23

Novel endoribonucleases as central players in various pathways of eukaryotic RNA metabolism. RNA (2010) 1.20

Different nuclease requirements for exosome-mediated degradation of normal and nonstop mRNAs. Proc Natl Acad Sci U S A (2011) 1.18

Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability. Cell Rep (2012) 1.10

Endonuclease-mediated mRNA decay requires tyrosine phosphorylation of polysomal ribonuclease 1 (PMR1) for the targeting and degradation of polyribosome-bound substrate mRNA. J Biol Chem (2004) 1.09

Mechanisms of endonuclease-mediated mRNA decay. Wiley Interdiscip Rev RNA (2011) 1.03

c-Src activates endonuclease-mediated mRNA decay. Mol Cell (2007) 0.99

Approaches for studying PMR1 endonuclease-mediated mRNA decay. Methods Enzymol (2008) 0.89

SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA. PLoS One (2013) 0.87

The 90-kDa heat shock protein stabilizes the polysomal ribonuclease 1 mRNA endonuclease to degradation by the 26S proteasome. Mol Biol Cell (2007) 0.85

KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. BMC Cell Biol (2009) 0.81

Articles cited by this

AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell (2001) 7.79

Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. EMBO J (2002) 6.08

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. Mol Cell Biol (2002) 5.80

A mouse cytoplasmic exoribonuclease (mXRN1p) with preference for G4 tetraplex substrates. J Cell Biol (1997) 4.93

The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO J (2002) 4.13

The hDcp2 protein is a mammalian mRNA decapping enzyme. Proc Natl Acad Sci U S A (2002) 3.97

Unstable beta-globin mRNA in mRNA-deficient beta o thalassemia. Cell (1981) 3.80

Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression. EMBO J (1990) 3.72

Quality control of mRNA function. Cell (2001) 3.44

A strategy for disease gene identification through nonsense-mediated mRNA decay inhibition. Nat Biotechnol (2001) 2.82

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3' UTR and does not involve poly(A) tail shortening. EMBO J (1994) 2.70

Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae. Annu Rev Biochem (2000) 2.66

Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products. Mol Cell Biol (1992) 2.51

An NMD pathway in yeast involving accelerated deadenylation and exosome-mediated 3'-->5' degradation. Mol Cell (2003) 2.41

A novel phosphorylation-dependent RNase activity of GAP-SH3 binding protein: a potential link between signal transduction and RNA stability. Mol Cell Biol (1998) 2.21

Human beta-globin mRNAs that harbor a nonsense codon are degraded in murine erythroid tissues to intermediates lacking regions of exon I or exons I and II that have a cap-like structure at the 5' termini. EMBO J (1992) 2.09

The half-life of c-myc mRNA in growing and serum-stimulated cells: influence of the coding and 3' untranslated regions and role of ribosome translocation. Mol Cell Biol (1994) 1.76

Novel metabolism of several beta zero-thalassemic beta-globin mRNAs in the erythroid tissues of transgenic mice. EMBO J (1989) 1.68

Purification and characterization of an estrogen-regulated Xenopus liver polysomal nuclease involved in the selective destabilization of albumin mRNA. J Biol Chem (1995) 1.62

Nuclease activity associated with mammalian mRNA in its native state: possible basis for selectivity in mRNA decay. Mol Cell Biol (1990) 1.58

beta-globin dominant control region interacts differently with distal and proximal promoter elements. Genes Dev (1990) 1.54

mRNA degradation machines in eukaryotic cells. Biochimie (2002) 1.48

Identification of an erythroid-enriched endoribonuclease activity involved in specific mRNA cleavage. EMBO J (2000) 1.44

Estrogen-induced ribonuclease activity in Xenopus liver. Biochemistry (1991) 1.37

Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon. Proc Natl Acad Sci U S A (2002) 1.33

Coordinate estrogen-regulated instability of serum protein-coding messenger RNAs in Xenopus laevis. Mol Endocrinol (1991) 1.33

Vigilin binding selectively inhibits cleavage of the vitellogenin mRNA 3'-untranslated region by the mRNA endonuclease polysomal ribonuclease 1. Proc Natl Acad Sci U S A (2000) 1.33

A polysomal ribonuclease involved in the destabilization of albumin mRNA is a novel member of the peroxidase gene family. RNA (1998) 1.30

Purification and characterization of a polysome-associated endoribonuclease that degrades c-myc mRNA in vitro. J Biol Chem (1998) 1.22

Cleavage properties of an estrogen-regulated polysomal ribonuclease involved in the destabilization of albumin mRNA. Nucleic Acids Res (1997) 1.20

Characterization of mRNA endonucleases. Methods (1999) 1.16

Induction of Erythroid-Specific Expression in Murine Erythroleukemia (MEL) Cell Lines. Methods Mol Biol (1991) 1.14

Polysomal ribonuclease 1 exists in a latent form on polysomes prior to estrogen activation of mRNA decay. Nucleic Acids Res (2001) 1.12

Identification of in vivo mRNA decay intermediates corresponding to sites of in vitro cleavage by polysomal ribonuclease 1. J Biol Chem (2001) 0.95

Distinct RNA structural domains cooperate to maintain a specific cleavage site in the 3'-UTR of IGF-II mRNAs. J Mol Biol (2000) 0.94

The specific endoribonuclease activity of small nuclear and cytoplasmic alpha-RNPs. FEBS Lett (1999) 0.88

Polysomal ribonuclease 1. Methods Enzymol (2001) 0.78

Articles by these authors

Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci U S A (2008) 5.29

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. J Cell Biol (2005) 2.51

RNA helicase A is necessary for translation of selected messenger RNAs. Nat Struct Mol Biol (2006) 1.83

Identification of a cytoplasmic complex that adds a cap onto 5'-monophosphate RNA. Mol Cell Biol (2009) 1.67

Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci U S A (2011) 1.62

A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay. Mol Cell Biol (2007) 1.38

Beta -Globin mRNA decay in erythroid cells: UG site-preferred endonucleolytic cleavage that is augmented by a premature termination codon. Proc Natl Acad Sci U S A (2002) 1.33

Endonuclease-mediated mRNA decay involves the selective targeting of PMR1 to polyribosome-bound substrate mRNA. Mol Cell (2004) 1.28

Identification of cytoplasmic capping targets reveals a role for cap homeostasis in translation and mRNA stability. Cell Rep (2012) 1.10

Endonuclease-mediated mRNA decay requires tyrosine phosphorylation of polysomal ribonuclease 1 (PMR1) for the targeting and degradation of polyribosome-bound substrate mRNA. J Biol Chem (2004) 1.09

Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies. PLoS One (2013) 1.06

mRNA with a <20-nt poly(A) tail imparted by the poly(A)-limiting element is translated as efficiently in vivo as long poly(A) mRNA. RNA (2005) 1.03

Assays for determining poly(A) tail length and the polarity of mRNA decay in mammalian cells. Methods Enzymol (2008) 1.03

c-Src activates endonuclease-mediated mRNA decay. Mol Cell (2007) 0.99

RNA processing defects associated with diseases of the motor neuron. Muscle Nerve (2010) 0.99

Polysome-bound endonuclease PMR1 is targeted to stress granules via stress-specific binding to TIA-1. Mol Cell Biol (2006) 0.98

Microsomal triglyceride transfer protein promotes the secretion of Xenopus laevis vitellogenin A1. J Biol Chem (2005) 0.90

The poly(A)-limiting element enhances mRNA accumulation by increasing the efficiency of pre-mRNA 3' processing. RNA (2005) 0.90

Approaches for studying PMR1 endonuclease-mediated mRNA decay. Methods Enzymol (2008) 0.89

SMG6 cleavage generates metastable decay intermediates from nonsense-containing β-globin mRNA. PLoS One (2013) 0.87

U2AF modulates poly(A) length control by the poly(A)-limiting element. Nucleic Acids Res (2003) 0.87

The cytoskeleton-associated Ena/VASP proteins are unanticipated partners of the PMR1 mRNA endonuclease. RNA (2009) 0.86

The 90-kDa heat shock protein stabilizes the polysomal ribonuclease 1 mRNA endonuclease to degradation by the 26S proteasome. Mol Biol Cell (2007) 0.85

The end defines the means in bacterial mRNA decay. Nat Chem Biol (2007) 0.84

Identification of the human PMR1 mRNA endonuclease as an alternatively processed product of the gene for peroxidasin-like protein. RNA (2012) 0.83

KSRP-PMR1-exosome association determines parathyroid hormone mRNA levels and stability in transfected cells. BMC Cell Biol (2009) 0.81

In vivo and in vitro analysis of poly(A) length effects on mRNA translation. Methods Mol Biol (2008) 0.81

Application of the Invader RNA assay to the polarity of vertebrate mRNA decay. Methods Mol Biol (2008) 0.80

Application of ligation-mediated reverse transcription polymerase chain reaction to the identification of in vivo endonuclease-generated messenger RNA decay intermediates. Methods Mol Biol (2004) 0.78

Poly(A) polymerase-based poly(A) length assay. Methods Mol Biol (2014) 0.76

Quantitative analysis of deadenylation-independent mRNA decay by a modified MBRACE assay. Methods Mol Biol (2014) 0.75

Corrigendum: Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice. Nat Med (2015) 0.75

Corrigendum: Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice. Nat Med (2015) 0.75