A neural survival factor is a candidate oncogene in breast cancer.

PubWeight™: 1.41‹?› | Rank: Top 5%

🔗 View Article (PMC 196905)

Published in Proc Natl Acad Sci U S A on September 02, 2003

Authors

Dale Porter1, Stanislawa Weremowicz, Koei Chin, Pankaj Seth, Aparna Keshaviah, Jaana Lahti-Domenici, Young Kyung Bae, Constance L Monitto, Ana Merlos-Suarez, Jennifer Chan, Christine M Hulette, Andrea Richardson, Cynthia C Morton, Jeffrey Marks, Mabel Duyao, Ralph Hruban, Edward Gabrielson, Rebecca Gelman, Kornelia Polyak

Author Affiliations

1: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

Articles citing this

Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. J Cell Biol (2006) 1.62

Clustering analysis of SAGE data using a Poisson approach. Genome Biol (2004) 1.58

Anti-inflammatory peptide regulates the supply of heat shock protein 70 monomers: implications for aging and age-related disease. Rejuvenation Res (2015) 1.39

Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. J Cell Biol (2006) 1.33

Expression of the proteolysis-inducing factor core peptide mRNA is upregulated in both tumour and adjacent normal tissue in gastro-oesophageal malignancy. Br J Cancer (2006) 1.09

Lacritin and other new proteins of the lacrimal functional unit. Exp Eye Res (2008) 1.08

Temporal profiling of the secretome during adipogenesis in humans. J Proteome Res (2010) 1.07

Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues. Br J Cancer (2006) 1.01

SILAC-based quantitative proteomic approach to identify potential biomarkers from the esophageal squamous cell carcinoma secretome. Cancer Biol Ther (2010) 1.00

The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity. J Biol Chem (2008) 0.95

Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism. J Biol Chem (2013) 0.91

HSP70 natively and specifically associates with an N-terminal dermcidin-derived peptide that contains an HLA-A*03 antigenic epitope. J Biol Chem (2011) 0.90

Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity. J Biol Chem (2013) 0.87

Recent developments in sweat analysis and its applications. Int J Anal Chem (2015) 0.87

Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines. Br J Cancer (2008) 0.87

Statistical analysis and significance testing of serial analysis of gene expression data using a Poisson mixture model. BMC Bioinformatics (2007) 0.85

A nine-gene signature predicting clinical outcome in cutaneous melanoma. J Cancer Res Clin Oncol (2012) 0.84

A cleavage-potentiated fragment of tear lacritin is bactericidal. J Biol Chem (2014) 0.84

The Control of Stress Induced Type I Diabetes Mellitus in Humans through the Hepatic Synthesis of Insulin by the Stimulation of Nitric Oxide Production. Int J Biomed Sci (2012) 0.83

Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK. PLoS One (2014) 0.81

Dermcidin expression is associated with disease progression and survival among breast cancer patients. Breast Cancer Res Treat (2014) 0.76

Genome instability in blood cells of a BRCA1+ breast cancer family. BMC Cancer (2014) 0.76

The presence of the proteolysis-inducing factor in urine does not predict the malignancy of a pancreatic tumour. BMC Gastroenterol (2005) 0.76

Secretome of Olfactory Mucosa Mesenchymal Stem Cell, a Multiple Potential Stem Cell. Stem Cells Int (2016) 0.75

Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling. BMC Cancer (2015) 0.75

Expression of dermcidin in human sinonasal secretions. Int Forum Allergy Rhinol (2016) 0.75

The in Vitro Immune-Modulating Properties of a Sweat Gland-Derived Antimicrobial Peptide Dermcidin. Shock (2016) 0.75

hSAGEing: an improved SAGE-based software for identification of human tissue-specific or common tumor markers and suppressors. PLoS One (2010) 0.75

Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide. BMC Res Notes (2014) 0.75

Effect of purified fractions from cell culture supernate of high-density pre-B acute lymphoblastic leukemia cells (ALL3) on the growth of ALL3 cells at low density. Electrophoresis (2016) 0.75

Articles cited by this

Molecular portraits of human breast tumours. Nature (2000) 94.14

Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A (2001) 71.82

Gene expression profiling predicts clinical outcome of breast cancer. Nature (2002) 71.36

Serial analysis of gene expression. Science (1995) 60.15

Prediction of complete gene structures in human genomic DNA. J Mol Biol (1997) 58.76

A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med (2002) 58.15

Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med (1998) 25.41

High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays. Nat Genet (1998) 21.52

Cancer statistics, 2000. CA Cancer J Clin (2000) 12.32

Genes expressed in human tumor endothelium. Science (2000) 10.75

A public database for gene expression in human cancers. Cancer Res (1999) 8.81

Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 6.99

The kit ligand: a cell surface molecule altered in steel mutant fibroblasts. Cell (1990) 4.43

Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res (2003) 2.55

Characterization of a cancer cachectic factor. Nature (1996) 2.46

Dermcidin: a novel human antibiotic peptide secreted by sweat glands. Nat Immunol (2001) 2.29

Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Ann N Y Acad Sci (2000) 2.25

A SAGE (serial analysis of gene expression) view of breast tumor progression. Cancer Res (2001) 2.22

Induction of cachexia in mice by a product isolated from the urine of cachectic cancer patients. Br J Cancer (1997) 1.95

HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. Proc Natl Acad Sci U S A (2001) 1.89

Rapid brain autopsy. The Joseph and Kathleen Bryan Alzheimer's Disease Research Center experience. Arch Pathol Lab Med (1997) 1.46

cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. J Mol Biol (2001) 1.44

Induction of muscle protein degradation and weight loss by a tumor product. Cancer Res (1996) 1.29

Formation of brainstem (nor)adrenergic centers and first-order relay visceral sensory neurons is dependent on homeodomain protein Rnx/Tlx3. Genes Dev (2001) 1.28

Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin. J Neurosci (1998) 1.20

Identification of the human cDNA for new survival/evasion peptide (DSEP): studies in vitro and in vivo of overexpression by neural cells. Exp Neurol (2002) 1.09

Gene discovery using the serial analysis of gene expression technique: implications for cancer research. J Clin Oncol (2001) 1.08

Interphase cytogenetic analysis of single cell suspensions prepared from previously formalin-fixed and paraffin-embedded tissues. Mod Pathol (1995) 0.92

Tumour-associated hypoglycaemia in a murine cachexia model. Br J Cancer (1992) 0.92

Articles by these authors

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38

A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell (2006) 27.36

Replicating genotype-phenotype associations. Nature (2007) 16.11

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20

A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med (2005) 12.99

Molecular definition of breast tumor heterogeneity. Cancer Cell (2007) 12.67

Prepublication data sharing. Nature (2009) 12.24

Multiple-laboratory comparison of microarray platforms. Nat Methods (2005) 11.74

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07

Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41

Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01

Derivation of embryonic stem-cell lines from human blastocysts. N Engl J Med (2004) 8.89

An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays. Cancer Res (2004) 8.86

Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96

Sequence analysis of mutations and translocations across breast cancer subtypes. Nature (2012) 7.76

End-sequence profiling: sequence-based analysis of aberrant genomes. Proc Natl Acad Sci U S A (2003) 7.70

Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell (2007) 7.60

Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98. J Clin Oncol (2007) 7.45

Retracted Genomic signatures to guide the use of chemotherapeutics. Nat Med (2006) 7.45

Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer (2012) 6.82

Ductal carcinoma in situ of the breast. N Engl J Med (2004) 6.63

Tumor heterogeneity: causes and consequences. Biochim Biophys Acta (2009) 5.90

DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med (2008) 5.87

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med (2006) 5.80

Retracted An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. J Clin Oncol (2007) 5.77

Profiling critical cancer gene mutations in clinical tumor samples. PLoS One (2009) 5.63

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53

A genomic screen for genes upregulated by demethylation and histone deacetylase inhibition in human colorectal cancer. Nat Genet (2002) 5.38

Tissue-specific genetic control of splicing: implications for the study of complex traits. PLoS Biol (2008) 5.08

Disruption of neurexin 1 associated with autism spectrum disorder. Am J Hum Genet (2008) 5.04

Central nervous system metastases in women who receive trastuzumab-based therapy for metastatic breast carcinoma. Cancer (2003) 4.47

Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46

An anatomy of normal and malignant gene expression. Proc Natl Acad Sci U S A (2002) 4.45

The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. J Clin Invest (2011) 4.41

Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet (2005) 4.33

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell (2009) 4.30

Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29

Cellular and genetic diversity in the progression of in situ human breast carcinomas to an invasive phenotype. J Clin Invest (2010) 4.22

A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors. Cancer Res (2011) 4.22

Mutation of perinatal myosin heavy chain associated with a Carney complex variant. N Engl J Med (2004) 4.22

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol (2012) 3.77

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer. J Clin Invest (2002) 3.36

Breast tumor copy number aberration phenotypes and genomic instability. BMC Cancer (2006) 3.34

Prospective study of wide excision alone for ductal carcinoma in situ of the breast. J Clin Oncol (2006) 3.33

No evidence of clonal somatic genetic alterations in cancer-associated fibroblasts from human breast and ovarian carcinomas. Nat Genet (2008) 3.32

A double-blind randomized controlled trial of augmentation and switch strategies for refractory social anxiety disorder. Am J Psychiatry (2014) 3.27

Triple-negative breast cancer: risk factors to potential targets. Clin Cancer Res (2008) 3.25

Sequencing chromosomal abnormalities reveals neurodevelopmental loci that confer risk across diagnostic boundaries. Cell (2012) 3.21

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res (2004) 3.20

A cross-study comparison of gene expression studies for the molecular classification of lung cancer. Clin Cancer Res (2004) 3.20

Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res (2010) 3.19

Contribution of bone marrow-derived endothelial cells to human tumor vasculature. Nat Med (2005) 3.19

Phase II trial of lapatinib for brain metastases in patients with human epidermal growth factor receptor 2-positive breast cancer. J Clin Oncol (2008) 3.08

Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin Cancer Res (2007) 3.08

Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors. J Clin Oncol (2008) 3.04

Human chromosome 7: DNA sequence and biology. Science (2003) 3.02

Breast tumor heterogeneity: cancer stem cells or clonal evolution? Cell Cycle (2007) 3.01

Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A (2008) 2.99

A novel human disease with abnormal prion protein sensitive to protease. Ann Neurol (2008) 2.95

Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder. Am J Hum Genet (2011) 2.85

Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med (2005) 2.82

Tumor-associated endothelial cells with cytogenetic abnormalities. Cancer Res (2004) 2.78

Complicated grief and related bereavement issues for DSM-5. Depress Anxiety (2011) 2.77

Chemotherapy response and recurrence-free survival in neoadjuvant breast cancer depends on biomarker profiles: results from the I-SPY 1 TRIAL (CALGB 150007/150012; ACRIN 6657). Breast Cancer Res Treat (2011) 2.73

Development of a multimarker assay for early detection of ovarian cancer. J Clin Oncol (2010) 2.71

A novel cerebral microangiopathy with endothelial cell atypia and multifocal white matter lesions: a direct mycoplasmal infection? J Neuropathol Exp Neurol (2007) 2.69

Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas. J Thorac Oncol (2013) 2.68

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell (2006) 2.61

The impact of race as a risk factor for symptom severity and age at diagnosis of uterine leiomyomata among affected sisters. Am J Obstet Gynecol (2008) 2.60

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci U S A (2008) 2.59

Cellular heterogeneity and molecular evolution in cancer. Annu Rev Pathol (2012) 2.56

Integrating data on DNA copy number with gene expression levels and drug sensitivities in the NCI-60 cell line panel. Mol Cancer Ther (2006) 2.55

Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res (2003) 2.55

Comparison of clinical and neuropathologic diagnoses of Alzheimer's disease in 3 epidemiologic samples. Alzheimers Dement (2006) 2.51

Gene expression profiling to identify the histogenetic origin of metastatic adenocarcinomas of unknown primary. J Clin Oncol (2008) 2.49

Complex reorganization and predominant non-homologous repair following chromosomal breakage in karyotypically balanced germline rearrangements and transgenic integration. Nat Genet (2012) 2.45

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res (2008) 2.45

LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther (2009) 2.43

Modeling precision treatment of breast cancer. Genome Biol (2013) 2.42

Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes. Am J Pathol (2011) 2.41