Published in N Engl J Med on September 04, 2003
Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction. Obesity (Silver Spring) (2011) 1.78
Comparison of glucostatic parameters after hypocaloric diet or bariatric surgery and equivalent weight loss. Obesity (Silver Spring) (2011) 1.14
Impact of atypical antipsychotic therapy on leptin, ghrelin, and adiponectin. Schizophr Res (2008) 1.03
Naltrexone sustained-release/bupropion sustained-release for the management of obesity: review of the data to date. Drug Des Devel Ther (2014) 1.02
Variations in peptide YY and Y2 receptor genes are associated with severe obesity in Pima Indian men. Diabetes (2005) 0.92
Quick fix or long-term cure? Pros and cons of bariatric surgery. F1000 Med Rep (2012) 0.91
Peripheral mechanisms in appetite regulation. Gastroenterology (2014) 0.90
Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo. J Clin Endocrinol Metab (2009) 0.84
Glucose response to an oral glucose tolerance test predicts weight change in non-diabetic subjects. Obesity (Silver Spring) (2007) 0.84
A natural diet versus modern Western diets? A new approach to prevent "well-being syndromes". Dig Dis Sci (2005) 0.83
Comparison of Bariatric Surgical Procedures for Diabetes Remission: Efficacy and Mechanisms. Diabetes Spectr (2012) 0.82
Relation of fasting plasma peptide YY to glucose metabolism and cardiovascular risk factors after restrictive bariatric surgery. Wien Klin Wochenschr (2007) 0.81
Downregulation of leptin and resistin expression in blood following bariatric surgery. Surg Endosc (2010) 0.80
Impact of OSA on biological markers in morbid obesity and metabolic syndrome. J Clin Sleep Med (2014) 0.78
Obesity-promoting factors in Mexican children and adolescents: challenges and opportunities. Glob Health Action (2016) 0.77
Biliopancreatic diversion: the effectiveness of duodenal switch and its limitations. Gastroenterol Res Pract (2013) 0.77
Peptide tyrosine tyrosine levels are increased in patients with urea cycle disorders. Mol Genet Metab (2012) 0.75
Inhibition of food intake by peptide YY3-36. N Engl J Med (2003) 0.75
Relationship between Serum Leptin, Ghrelin and Dietary Macronutrients in Women with Polycystic Ovary Syndrome. Int J Fertil Steril (2015) 0.75
Protracted effects of juvenile stressor exposure are mitigated by access to palatable food. PLoS One (2014) 0.75
Diet-Induced Obesity and Ghrelin Effects on Pituitary Gonadotrophs: Immunohistomorphometric Study in Male Rats. Cell J (2016) 0.75
Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med (2003) 5.83
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44
The long-term stability of the human gut microbiota. Science (2013) 5.15
Human oocytes reprogram somatic cells to a pluripotent state. Nature (2011) 4.03
Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol (2008) 3.49
Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci U S A (2009) 3.43
Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest (2005) 3.10
Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab (2010) 2.79
Low dose leptin administration reverses effects of sustained weight-reduction on energy expenditure and circulating concentrations of thyroid hormones. J Clin Endocrinol Metab (2002) 2.76
Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proc Natl Acad Sci U S A (2010) 2.45
Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest (2008) 2.44
Effects of experimental weight perturbation on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol (2003) 2.28
Is the energy homeostasis system inherently biased toward weight gain? Diabetes (2003) 2.14
Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr (2008) 2.13
11C-dihydrotetrabenazine PET of the pancreas in subjects with long-standing type 1 diabetes and in healthy controls. J Nucl Med (2009) 1.99
Waist Circumference and Cardiometabolic Risk: a Consensus Statement from Shaping America's Health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Obesity (Silver Spring) (2007) 1.87
Responses of gut microbiota to diet composition and weight loss in lean and obese mice. Obesity (Silver Spring) (2011) 1.73
A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children. J Clin Invest (2011) 1.55
Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun (2011) 1.49
Dietary fat is not a major determinant of body fat. Am J Med (2002) 1.46
Determinants of leptin gene expression in fat depots of lean mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.45
Body fat redistribution after weight gain in women with anorexia nervosa. Am J Clin Nutr (2005) 1.34
Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys. Am J Physiol Endocrinol Metab (2006) 1.27
Cut-like homeobox 1 (CUX1) regulates expression of the fat mass and obesity-associated and retinitis pigmentosa GTPase regulator-interacting protein-1-like (RPGRIP1L) genes and coordinates leptin receptor signaling. J Biol Chem (2010) 1.26
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2013) 1.23
Energy intake in weight-reduced humans. Brain Res (2010) 1.21
Challenges and opportunities of defining clinical leptin resistance. Cell Metab (2012) 1.21
Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr (2012) 1.19
β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome. Diabetes (2013) 1.19
Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice. Am J Physiol Regul Integr Comp Physiol (2004) 1.17
Leptin administration does not prevent the bone mineral metabolism changes induced by weight loss. Metabolism (2011) 1.17
Role of vesicular monoamine transporter type 2 in rodent insulin secretion and glucose metabolism revealed by its specific antagonist tetrabenazine. J Endocrinol (2008) 1.13
Absence epilepsy in apathetic, a spontaneous mutant mouse lacking the h channel subunit, HCN2. Neurobiol Dis (2008) 1.12
Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol (2009) 1.12
Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice. PLoS Genet (2008) 1.10
Reproducibility and accuracy of body composition assessments in mice by dual energy x-ray absorptiometry and time domain nuclear magnetic resonance. Int J Body Compos Res (2009) 1.03
Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice. Am J Physiol Regul Integr Comp Physiol (2012) 1.01
Considerations regarding the genetics of obesity. Obesity (Silver Spring) (2008) 1.00
Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4. Arterioscler Thromb Vasc Biol (2004) 1.00
The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. J Clin Invest (2002) 0.97
Effects of weight loss and leptin on skeletal muscle in human subjects. Am J Physiol Regul Integr Comp Physiol (2011) 0.97
Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell (2011) 0.96
Functional consequences of the human leptin receptor (LEPR) Q223R transversion. Obesity (Silver Spring) (2008) 0.96
Respective contributions of maternal insulin resistance and diet to metabolic and hypothalamic phenotypes of progeny. Obesity (Silver Spring) (2010) 0.96
In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J (2009) 0.96
Roles of the placenta in fetal brain development. Proc Natl Acad Sci U S A (2011) 0.93
Mahoganoid and mahogany mutations rectify the obesity of the yellow mouse by effects on endosomal traffic of MC4R protein. J Biol Chem (2011) 0.93
Differentiation of hypothalamic-like neurons from human pluripotent stem cells. J Clin Invest (2015) 0.93
Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro. Mol Endocrinol (2012) 0.89
Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. Hum Hered (2008) 0.89
Molecular physiology of syndromic obesities in humans. Trends Endocrinol Metab (2005) 0.88
TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism. Endocrinology (2012) 0.85
The mahoganoid mutation (Mgrn1md) improves insulin sensitivity in mice with mutations in the melanocortin signaling pathway independently of effects on adiposity. Am J Physiol Endocrinol Metab (2006) 0.84
Fat cell size and adipokine expression in relation to gender, depot, and metabolic risk factors in morbidly obese adolescents. Obesity (Silver Spring) (2013) 0.84
Whole-exome sequencing identifies novel LEPR mutations in individuals with severe early onset obesity. Obesity (Silver Spring) (2013) 0.83
Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study). Front Genet (2011) 0.82
Hypomorphism of Fto and Rpgrip1l causes obesity in mice. J Clin Invest (2016) 0.81
Energy in, energy out, and the effects of obesity-related genes. N Engl J Med (2008) 0.81
Diabetes and oral disease: implications for health professionals. Ann N Y Acad Sci (2012) 0.81
Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring) (2014) 0.80
Location, location, location... Cell Metab (2008) 0.80
Haplotype analysis of the growth hormone releasing hormone receptor locus in three apparently unrelated kindreds from the indian subcontinent with the identical mutation in the GHRH receptor. Am J Med Genet A (2003) 0.80
Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome. J Clin Invest (2016) 0.79
Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice. Obesity (Silver Spring) (2014) 0.78
The links between obesity, leptin, and prostate cancer. Cancer J (2006) 0.78
Does diet composition have structural consequences in the hypothalamus? Mol Metab (2013) 0.77
An apparent role for Alox15 in the pathogenesis of diabetes in the NOD mouse: parsing the supporting genetic data. Diabetes (2008) 0.77
FTO gains function. Nat Genet (2010) 0.76
ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis. PLoS One (2013) 0.76
Brain reorganization following weight loss. Nestle Nutr Inst Workshop Ser (2012) 0.76
Identifying functional relationships among human genes by systematic analysis of biological literature. BMC Bioinformatics (2002) 0.75
iPSC-derived β cells model diabetes due to glucokinase deficiency. J Clin Invest (2017) 0.75
Corrigendum: MC4R-dependent suppression of appetite by bone-derived lipocalin 2. Nature (2017) 0.75
Toward optimal health: the experts discuss advances in diabetes management in women. Interview by Jodi Godfrey. J Womens Health (Larchmt) (2004) 0.75