Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers.

PubWeight™: 1.79‹?› | Rank: Top 3%

🔗 View Article (PMC 228472)

Published in J Virol on October 01, 2003

Authors

Kate Middleton1, Woei Peh, Shirley Southern, Heather Griffin, Karl Sotlar, Tomomi Nakahara, Amira El-Sherif, Lesley Morris, Rashmi Seth, Merilyn Hibma, David Jenkins, Paul Lambert, Nicholas Coleman, John Doorbar

Author Affiliations

1: National Institute for Medical Research, Mill Hill, London.

Articles citing this

Papillomavirus genome structure, expression, and post-transcriptional regulation. Front Biosci (2006) 2.56

Persistence of human papillomavirus infection: keys to malignant progression. Trends Microbiol (2010) 1.96

Seroprevalence of 34 human papillomavirus types in the German general population. PLoS Pathog (2008) 1.44

Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta (2011) 1.40

Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology. BMC Genomics (2016) 1.38

Detection of human papillomavirus DNA in urine. A review of the literature. Eur J Clin Microbiol Infect Dis (2011) 1.36

Presence of E6 and E7 mRNA from human papillomavirus types 16, 18, 31, 33, and 45 in the majority of cervical carcinomas. J Clin Microbiol (2006) 1.36

Human papillomavirus type 16 E1circumflexE4 contributes to multiple facets of the papillomavirus life cycle. J Virol (2005) 1.32

Control of the papillomavirus early-to-late switch by differentially expressed SRp20. J Virol (2008) 1.20

The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo. J Virol (2004) 1.18

Interactions with pocket proteins contribute to the role of human papillomavirus type 16 E7 in the papillomavirus life cycle. J Virol (2005) 1.16

Role of the E1--E4 protein in the differentiation-dependent life cycle of human papillomavirus type 31. J Virol (2005) 1.16

Construction of a full transcription map of human papillomavirus type 18 during productive viral infection. J Virol (2011) 1.11

Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization. J Virol (2004) 1.10

Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes. J Virol (2005) 1.10

Human papillomavirus molecular biology and disease association. Rev Med Virol (2015) 1.09

Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia. Viruses (2015) 1.06

Differential methylation of the HPV 16 upstream regulatory region during epithelial differentiation and neoplastic transformation. PLoS One (2011) 1.04

Loss of HPV16 E2 Protein Expression Without Disruption of the E2 ORF Correlates with Carcinogenic Progression. Open Virol J (2012) 1.04

E1 empty set E4 protein of human papillomavirus type 16 associates with mitochondria. J Virol (2004) 0.99

Prevalence and type distribution of human papillomavirus infection in women from North Sardinia, Italy. BMC Public Health (2011) 0.96

Human papillomavirus type 8 interferes with a novel C/EBPβ-mediated mechanism of keratinocyte CCL20 chemokine expression and Langerhans cell migration. PLoS Pathog (2012) 0.96

Reconstruction of human papillomavirus type 16-mediated early-stage neoplasia implicates E6/E7 deregulation and the loss of contact inhibition in neoplastic progression. J Virol (2012) 0.95

Expression pattern and subcellular localization of human papillomavirus minor capsid protein L2. Am J Pathol (2008) 0.92

Phosphorylation of the human papillomavirus type 16 E1--E4 protein at T57 by ERK triggers a structural change that enhances keratin binding and protein stability. J Virol (2009) 0.91

Induction of promyelocytic leukemia (PML) oncogenic domains (PODs) by papillomavirus. Virology (2007) 0.91

E6/E7 expression of human papillomavirus type 20 (HPV-20) and HPV-27 influences proliferation and differentiation of the skin in UV-irradiated SKH-hr1 transgenic mice. J Virol (2006) 0.91

The E7 open reading frame acts in cis and in trans to mediate differentiation-dependent activities in the human papillomavirus type 16 life cycle. J Virol (2011) 0.90

Human papillomavirus: gene expression, regulation and prospects for novel diagnostic methods and antiviral therapies. Future Microbiol (2010) 0.90

Evolutionary ecology of human papillomavirus: trade-offs, coexistence, and origins of high-risk and low-risk types. J Infect Dis (2011) 0.89

Structural analysis reveals an amyloid form of the human papillomavirus type 16 E1--E4 protein and provides a molecular basis for its accumulation. J Virol (2008) 0.88

Nucleic acid sequence-based amplification assay for human papillomavirus mRNA detection and typing: evidence for DNA amplification. J Clin Microbiol (2010) 0.87

Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia. World J Clin Oncol (2014) 0.87

E1--E4-mediated keratin phosphorylation and ubiquitylation: a mechanism for keratin depletion in HPV16-infected epithelium. J Cell Sci (2010) 0.87

Reduced expression of multiple gap junction proteins is a feature of cervical dysplasia. Mol Cancer (2005) 0.85

Productive infection of bovine papillomavirus type 2 in the urothelial cells of naturally occurring urinary bladder tumors in cattle and water buffaloes. PLoS One (2013) 0.85

Immunohistochemical detection of human papillomavirus capsid proteins L1 and L2 in squamous intraepithelial lesions: potential utility in diagnosis and management. Mod Pathol (2012) 0.85

The viral E8^E2C repressor limits productive replication of human papillomavirus 16. J Virol (2013) 0.82

HPV status is associated with altered PIWI-interacting RNA expression pattern in head and neck cancer. Oral Oncol (2016) 0.81

Stratification of HPV-induced cervical pathology using the virally encoded molecular marker E4 in combination with p16 or MCM. Mod Pathol (2015) 0.80

Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue. Virology (2013) 0.80

Regulation of bovine papillomavirus type 1 gene expression by RNA processing. Front Biosci (Landmark Ed) (2009) 0.80

Virus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes. J Pathol (2014) 0.80

Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus. Virology (2013) 0.80

A humanized mouse model of HPV-associated pathology driven by E7 expression. PLoS One (2012) 0.80

Human papillomaviruses: a growing field. Genes Dev (2009) 0.79

The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs. J Virol (2013) 0.79

E4 antibodies facilitate detection and type-assignment of active HPV infection in cervical disease. PLoS One (2012) 0.79

Regulation of inflammatory pathways in cancer and infectious disease of the cervix. Scientifica (Cairo) (2012) 0.79

Clinicopathological implications of human papilloma virus (HPV) L1 capsid protein immunoreactivity in HPV16-positive cervical cytology. Int J Med Sci (2013) 0.79

The ecology of human papillomavirus-induced epithelial lesions and the role of somatic evolution in their progression. J Infect Dis (2013) 0.78

Control of human papillomavirus gene expression by alternative splicing. Virus Res (2016) 0.78

[HPV-associated squamous cell carcinogenesis]. Pathologe (2011) 0.78

Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer. Infect Agent Cancer (2014) 0.77

[Molecular pathogenesis of cervical cancer and its first steps]. Pathologe (2005) 0.77

Expression of the h19 oncofetal gene in premalignant lesions of cervical cancer: a potential targeting approach for development of nonsurgical treatment of high-risk lesions. ISRN Obstet Gynecol (2013) 0.77

Construction of a Transcription Map for Papillomaviruses using RACE, RNase Protection, and Primer Extension Assays. Curr Protoc Microbiol (2016) 0.77

[Human papillomavirus infection. Pathology and molecular pathology]. Pathologe (2008) 0.76

Position paper--HPV and the primary prevention of cancer; improving vaccine uptake by paediatricians. Eur J Pediatr (2010) 0.76

Evidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women. Sci Rep (2016) 0.76

Keratinocyte Differentiation-Dependent Human Papillomavirus Gene Regulation. Viruses (2017) 0.75

HPV16 and 18 genome amplification show different E4-dependence, with 16E4 enhancing E1 nuclear accumulation and replicative efficiency via its cell cycle arrest and kinase activation functions. PLoS Pathog (2017) 0.75

Vaginal cells of smokers are more resistant to human papillomavirus infection than that of non-smokers. Exp Mol Pathol (2012) 0.75

Human papillomavirus infection a favorable prognostic factor in laryngeal squamous cell carcinoma is associated with the expression of proliferating cell nuclear antigen. Pak J Med Sci (2013) 0.75

Validation of Serological Antibody Profiles Against Human Papillomavirus Type 16 Antigens as Markers for Early Detection of Cervical Cancer. Medicine (Baltimore) (2016) 0.75

Assessing the detection of human papillomavirus late mRNA in liquid base cytology samples for risk stratification of cervical disease. J Med Virol (2013) 0.75

Molecular mechanisms of HPV mediated neoplastic progression. Infect Agent Cancer (2016) 0.75

AKT1 loss correlates with episomal HPV16 in vulval intraepithelial neoplasia. PLoS One (2012) 0.75

Investigating Diagnostic Problems of CIN1 and CIN2 Associated With High-risk HPV by Combining the Novel Molecular Biomarker PanHPVE4 With P16INK4a. Am J Surg Pathol (2015) 0.75

Modulation of Basal Cell Fate During Productive and Transforming HPV16 Infection is Mediated by Progressive E6-Driven Depletion of Notch. J Pathol (2017) 0.75

Articles cited by this

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol (1999) 40.46

Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med (2003) 31.67

Human papillomavirus infection of the cervix: relative risk associations of 15 common anogenital types. Obstet Gynecol (1992) 7.14

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol (1995) 6.26

Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. Am J Pathol (1985) 6.18

The use of general primers in the polymerase chain reaction permits the detection of a broad spectrum of human papillomavirus genotypes. J Gen Virol (1990) 4.09

Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer (2001) 3.61

Integration of human papillomavirus type 16 into the human genome correlates with a selective growth advantage of cells. J Virol (1995) 3.57

Human papillomavirus infection requires cell surface heparan sulfate. J Virol (2001) 3.32

The L1 major capsid protein of human papillomavirus type 11 recombinant virus-like particles interacts with heparin and cell-surface glycosaminoglycans on human keratinocytes. J Biol Chem (1999) 3.16

Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm. J Virol (1991) 3.10

Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: implications for cervical carcinogenesis. Proc Natl Acad Sci U S A (1995) 2.79

p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol (2002) 2.73

Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol (1998) 2.62

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. Proc Natl Acad Sci U S A (1998) 2.61

Identification of the alpha6 integrin as a candidate receptor for papillomaviruses. J Virol (1997) 2.58

Human papillomavirus types 6 and 11 mRNAs from genital condylomata acuminata. J Virol (1987) 2.57

Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. Clin Cancer Res (1999) 2.49

Cervical intraepithelial neoplasia. Pathol Annu (1973) 2.41

Identification of the human papilloma virus-1a E4 gene products. EMBO J (1986) 2.21

The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J Virol (2000) 2.05

Analysis of the infectious entry pathway of human papillomavirus type 33 pseudovirions. Virology (2002) 2.04

Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique. J Clin Microbiol (2002) 2.03

Identification of proteins encoded by the L1 and L2 open reading frames of human papillomavirus 1a. J Virol (1987) 2.01

Establishment of the human papillomavirus type 16 (HPV-16) life cycle in an immortalized human foreskin keratinocyte cell line. Virology (1999) 1.96

Identification of a differentiation-inducible promoter in the E7 open reading frame of human papillomavirus type 16 (HPV-16) in raft cultures of a new cell line containing high copy numbers of episomal HPV-16 DNA. J Virol (1996) 1.91

Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol (2001) 1.89

Characterization of late gene transcripts expressed during vegetative replication of human papillomavirus type 31b. J Virol (1997) 1.82

Identification of human papillomavirus type 18 E6 polypeptide in cells derived from human cervical carcinomas. J Gen Virol (1987) 1.78

Integration of human papillomavirus type 16 into cellular DNA of cervical carcinoma: preferential deletion of the E2 gene and invariable retention of the long control region and the E6/E7 open reading frames. Virology (1987) 1.73

Induction of proliferating cell nuclear antigen in differentiated keratinocytes of human papillomavirus-infected lesions. Hum Pathol (1994) 1.72

Detection and typing of human papillomavirus DNA in penile carcinoma: evidence for multiple independent pathways of penile carcinogenesis. Am J Pathol (2001) 1.67

Life cycle heterogeneity in animal models of human papillomavirus-associated disease. J Virol (2002) 1.66

Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis. Cancer Res (2000) 1.60

A C-terminal helicase domain of the human papillomavirus E1 protein binds E2 and the DNA polymerase alpha-primase p68 subunit. J Virol (1998) 1.59

Production and characterisation of a monoclonal antibody to human papillomavirus type 16 using recombinant vaccinia virus. J Clin Pathol (1990) 1.57

Human papillomavirus type 31b late gene expression is regulated through protein kinase C-mediated changes in RNA processing. J Virol (1995) 1.57

Characterization of events during the late stages of HPV16 infection in vivo using high-affinity synthetic Fabs to E4. Virology (1997) 1.56

Biotinyl-tyramide-based in situ hybridization signal patterns distinguish human papillomavirus type and grade of cervical intraepithelial neoplasia. Mod Pathol (2002) 1.51

Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments. J Natl Cancer Inst (2002) 1.48

Identification and mapping of human papillomavirus type 1 RNA transcripts recovered from plantar warts and infected epithelial cell cultures. J Virol (1987) 1.44

Stability of the replicative Mcm3 protein in proliferating and differentiating human cells. Exp Cell Res (1998) 1.43

Viral and histopathologic correlates of MN and MIB-1 expression in cervical intraepithelial neoplasia. Hum Pathol (1996) 1.41

Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F. Oncogene (1999) 1.39

Quantitation of papova virus particles in human warts. J Natl Cancer Inst (1962) 1.34

Human papillomavirus type 31b E1 and E2 transcript expression correlates with vegetative viral genome amplification. Virology (1998) 1.28

Association of human papillomavirus type 16 integration in the E2 gene with poor disease-free survival from cervical cancer. Int J Cancer (1997) 1.28

Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool. Lancet (2002) 1.24

Essential role of E2F recognition sites in regulation of the proliferating cell nuclear antigen gene promoter during Drosophila development. J Biol Chem (1995) 1.21

Identification of a G(2) arrest domain in the E1 wedge E4 protein of human papillomavirus type 16. J Virol (2002) 1.21

Bovine papillomaviral gene expression in equine sarcoid tumours. Virus Res (1999) 1.19

Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility. Clin Cancer Res (2002) 1.19

Sequence divergence yet conserved physical characteristics among the E4 proteins of cutaneous human papillomaviruses. Virology (1989) 1.18

Oestrogen stimulates differential transcription of human papillomavirus type 16 in SiHa cervical carcinoma cells. J Gen Virol (1989) 1.18

Risk factors for cervical intraepithelial neoplasia: differences between low- and high-grade lesions. Am J Epidemiol (1994) 1.17

Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia. J Am Acad Dermatol (2002) 1.14

Translational approaches to improving cervical screening. Nat Rev Cancer (2003) 1.10

Physical status of the E2 human papilloma virus 16 viral gene in cervical preneoplastic and neoplastic lesions. J Clin Virol (2001) 1.09

Modulation of the cell division cycle by human papillomavirus type 18 E4. J Virol (2002) 1.09

DNA damage induced p53 mediated transcription is inhibited by human papillomavirus type 18 E6. Oncogene (1994) 1.07

p21cip1 Degradation in differentiated keratinocytes is abrogated by costabilization with cyclin E induced by human papillomavirus E7. J Virol (2001) 1.04

Surrogate biomarkers of HPV infection in cervical neoplasia screening and diagnosis. Adv Anat Pathol (2001) 1.04

Inverse relationship between the expression of the human papillomavirus type 16 transcription factor E2 and virus DNA copy number during the progression of cervical intraepithelial neoplasia. J Gen Virol (2000) 1.04

Positive and negative regulation of cell proliferation by E2F-1: influence of protein level and human papillomavirus oncoproteins. Mol Cell Biol (1994) 1.03

HPV16 and HPV18 in genital tumors: Significantly different levels of viral integration and correlation to tumor invasiveness. J Med Virol (2002) 1.03

Regulation of cell growth and HPV genes by exogenous estrogen in cervical cancer cells. Int J Gynecol Cancer (2000) 1.02

Coexpression of the human papillomavirus type 16 E4 and L1 open reading frames in early cervical neoplasia. Virology (1990) 1.01

The interaction between human papillomavirus type 16 E1 and E2 proteins is blocked by an antibody to the N-terminal region of E2. Eur J Biochem (1995) 1.00

Human papillomavirus type 16 E6 proteins with glycine substitution for cysteine in the metal-binding motif. Virology (1991) 0.99

Detection of S-phase cells in tissue sections by in situ DNA replication. Nat Cell Biol (2000) 0.94

Differential effects of progestins and estrogens on long control regions of human papillomavirus types 16 and 18. Biochem Biophys Res Commun (1996) 0.93

The human papillomavirus type 16 E7 protein is associated with the nucleolus in mammalian and yeast cells. Oncogene (1997) 0.92

Transformation zone location and intraepithelial neoplasia of the cervix uteri. Br J Cancer (1996) 0.91

Association of p27Kip1, cyclin E and c-myc expression with progression and prognosis in HPV-positive cervical neoplasms. Anticancer Res (1999) 0.91

In vivo structure of two divergent promoters at the human PCNA locus. Synthesis of antisense RNA and S phase-dependent binding of E2F complexes in intron 1. J Biol Chem (1999) 0.91

Expression of the proliferating cell nuclear antigen in cervical neoplasia. Int J Gynecol Pathol (1994) 0.87

Expression of cyclin E and p27(KIP1) in cervical carcinoma. Cancer Lett (2000) 0.87

Regulation of human papillomavirus type 18 in vivo: effects of estrogen and progesterone in transgenic mice. Gynecol Oncol (1997) 0.86

Human papillomaviruses, expression of p16, and early endocervical glandular neoplasia. Hum Pathol (2002) 0.85

Human Papillomavirus. Introduction. Semin Cancer Biol (1999) 0.85

Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix. Br J Cancer (2001) 0.84

Human papilloma virus (HPV)-E6/E7 and epidermal growth factor receptor (EGF-R) protein levels in cervical cancer and cervical intraepithelial neoplasia (CIN). Am J Reprod Immunol (2001) 0.83

Oestrogen increases S-phase fraction and oestrogen and progesterone receptors in human cervical cancer in vivo. Br J Cancer (1997) 0.81

E7 proteins of four groups of human papillomaviruses, irrespective of their tissue tropism or cancer association, possess the ability to transactivate transcriptional promoters E2F site dependently. Virus Genes (1996) 0.78

Human papillomavirus DNA and virus-encoded antigens in cervical carcinoma. Med J Malaysia (1997) 0.77

Egg yolk antibodies against the E7 oncogenic protein of human papillomavirus type 16. Arch Virol (2001) 0.76

Articles by these authors

Efficacy of a prophylactic adjuvanted bivalent L1 virus-like-particle vaccine against infection with human papillomavirus types 16 and 18 in young women: an interim analysis of a phase III double-blind, randomised controlled trial. Lancet (2007) 8.55

Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet (2004) 8.09

Sustained efficacy up to 4.5 years of a bivalent L1 virus-like particle vaccine against human papillomavirus types 16 and 18: follow-up from a randomised control trial. Lancet (2006) 7.83

Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J Leukoc Biol (2002) 2.93

Persistent human papillomavirus infection and cervical neoplasia: a systematic review and meta-analysis. Am J Epidemiol (2008) 2.91

Contemporary consensus proposal on criteria and classification of eosinophilic disorders and related syndromes. J Allergy Clin Immunol (2012) 2.78

p16INK4a immunohistochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Pathol (2002) 2.73

Randomised controlled trial of the impact of guidelines, prioritized review criteria and feedback on implementation of recommendations for angina and asthma. Br J Gen Pract (2003) 2.40

Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS. Gastroenterology (2003) 2.39

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients. Blood (2006) 2.38

Progression-specific genes identified by expression profiling of matched ductal carcinomas in situ and invasive breast tumors, combining laser capture microdissection and oligonucleotide microarray analysis. Cancer Res (2006) 2.36

Circulatory arrest versus cerebral perfusion during pulmonary endarterectomy surgery (PEACOG): a randomised controlled trial. Lancet (2011) 2.27

Histological changes in HCV antibody-positive, HCV RNA-negative subjects suggest persistent virus infection. Hepatology (2008) 2.21

Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatology (2005) 2.04

Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome. Am J Gastroenterol (2003) 1.92

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies. J Neurosci (2008) 1.79

Determination of HER2 status using both serum HER2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER2 negative or of unknown HER2 status. Breast Cancer Res (2007) 1.78

Acute lung injury and cell death: how many ways can cells die? Am J Physiol Lung Cell Mol Physiol (2008) 1.69

Tumour lymphocytic infiltrate and recurrence of hepatocellular carcinoma following liver transplantation. J Hepatol (2006) 1.69

One virus, one lesion--individual components of CIN lesions contain a specific HPV type. J Pathol (2012) 1.67

Surgical management and outcome of patients with chronic thromboembolic pulmonary hypertension: results from an international prospective registry. J Thorac Cardiovasc Surg (2011) 1.66

Life cycle heterogeneity in animal models of human papillomavirus-associated disease. J Virol (2002) 1.66

Mastocytosis: state of the art. Pathobiology (2007) 1.64

Colorectal cancer screening: prospects for molecular stool analysis. Nat Rev Cancer (2005) 1.64

Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal. Int Arch Allergy Immunol (2011) 1.63

Mastocytosis: pathology, genetics, and current options for therapy. Leuk Lymphoma (2005) 1.61

Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. Cancer Res (2010) 1.59

Aberrant expression of CD30 in aggressive systemic mastocytosis and mast cell leukemia: a differential diagnosis to consider in aggressive hematopoietic CD30-positive neoplasms. Leuk Lymphoma (2011) 1.59

Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes. Cancer Res (2004) 1.56

FUS/ERG gene fusions in Ewing's tumors. Cancer Res (2003) 1.50

Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes Dev (2006) 1.49

Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe. Int J Cancer (2012) 1.48

Oncogenic human papillomavirus-infected immature metaplastic cells and cervical neoplasia. Am J Surg Pathol (2014) 1.46

Simultaneous adrenal and extra-adrenal myelolipoma - an uncommon incident: case report and review of the literature. World J Surg Oncol (2008) 1.46

Quantification of tumor cell burden by analysis of single cell lymph node disaggregates in metastatic prostate cancer. Prostate (2010) 1.45

Tumor recurrence following liver transplantation for hepatocellular carcinoma: role of tumor proliferation status. Liver Transpl (2010) 1.44

Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology. J Pathol (2005) 1.44

Control of DNA replication and its potential clinical exploitation. Nat Rev Cancer (2005) 1.42

Reversing LRP5-dependent osteoporosis and SOST deficiency-induced sclerosing bone disorders by altering WNT signaling activity. J Bone Miner Res (2014) 1.42

A novel immunohistochemical method to estimate cell-cycle phase distribution in archival tissue: implications for the prediction of outcome in colorectal cancer. J Pathol (2003) 1.40

G2/M cell cycle arrest in the life cycle of viruses. Virology (2007) 1.39

The Value of Endocervical Curettage in Addition to Biopsies in Women Referred to Colposcopy. J Low Genit Tract Dis (2015) 1.39

[Aleukemic mast cell leukemia (formerly: "malignant mastocytosis"): an extremely rare form of leukemia. A case report and simultaneously a contribution to revised classification of mastocytosis]. Wien Klin Wochenschr (2002) 1.38

Can the Kattan nomogram still accurately predict prognosis in renal cell carcinoma using the revised 2010 tumor-nodes-metastasis reclassification? Int J Urol (2012) 1.38

Relation between hepatocyte G1 arrest, impaired hepatic regeneration, and fibrosis in chronic hepatitis C virus infection. Gastroenterology (2005) 1.38

Geminin predicts adverse clinical outcome in breast cancer by reflecting cell-cycle progression. J Pathol (2004) 1.37

Reorganization of nuclear domain 10 induced by papillomavirus capsid protein l2. Virology (2002) 1.36

Comprehensive mutational profiling in advanced systemic mastocytosis. Blood (2013) 1.35

Changes in cervical keratinocyte gene expression associated with integration of human papillomavirus 16. Cancer Res (2002) 1.34

Human papillomavirus type 16 E1circumflexE4 contributes to multiple facets of the papillomavirus life cycle. J Virol (2005) 1.32

Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response. Proc Natl Acad Sci U S A (2006) 1.31

Persistence of viral DNA in the epithelial basal layer suggests a model for papillomavirus latency following immune regression. Virology (2011) 1.30

Clinician's guide to human papillomavirus immunology: knowns and unknowns. Lancet Infect Dis (2009) 1.29

The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. J Virol (2007) 1.29

Surface expression of minichromosome maintenance proteins provides a novel method for detecting patients at risk for developing adenocarcinoma in Barrett's esophagus. Clin Cancer Res (2003) 1.26

A prospective study on the natural course of low-grade squamous intraepithelial lesions and the presence of HPV16 E2-, E6- and E7-specific T-cell responses. Int J Cancer (2010) 1.25

The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. PLoS One (2010) 1.24

Minichromosome maintenance protein 2 is a strong independent prognostic marker in breast cancer. J Clin Oncol (2003) 1.24

Analysis of minichromosome maintenance proteins as a novel method for detection of colorectal cancer in stool. Lancet (2002) 1.24

The occasional role of low-risk human papillomaviruses 6, 11, 42, 44, and 70 in anogenital carcinoma defined by laser capture microdissection/PCR methodology: results from a global study. Am J Surg Pathol (2013) 1.21

Identification of a G(2) arrest domain in the E1 wedge E4 protein of human papillomavirus type 16. J Virol (2002) 1.21

Human immunodeficiency virus type 1 Nef binds to tumor suppressor p53 and protects cells against p53-mediated apoptosis. J Virol (2002) 1.21

Minichromosome maintenance protein 2 expression in normal kidney and renal cell carcinomas: relationship to tumor dormancy and potential clinical utility. Clin Cancer Res (2002) 1.19

Identification of microRNAs From the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. Am J Clin Pathol (2011) 1.19

The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo. J Virol (2004) 1.18

Characterization of naturally occurring HPV16 integration sites isolated from cervical keratinocytes under noncompetitive conditions. Cancer Res (2008) 1.17

The early responses of VEGF and its receptors during acute lung injury: implication of VEGF in alveolar epithelial cell survival. Crit Care (2006) 1.17

Interactions with pocket proteins contribute to the role of human papillomavirus type 16 E7 in the papillomavirus life cycle. J Virol (2005) 1.16

Fatal parvovirus B19-associated myocarditis clinically mimicking ischemic heart disease: an endothelial cell-mediated disease. Hum Pathol (2003) 1.15

Pathogenesis and classification of eosinophil disorders: a review of recent developments in the field. Expert Rev Hematol (2012) 1.15

Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18. Cancer Causes Control (2009) 1.14

Using an immortalized cell line to study the HPV life cycle in organotypic "raft" cultures. Methods Mol Med (2005) 1.13

Polyphosphate kinase from activated sludge performing enhanced biological phosphorus removal. Appl Environ Microbiol (2002) 1.13

Chromatin remodeling and modification during HIV-1 Tat-activated transcription. Curr HIV Res (2003) 1.12

Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia. Clin Cancer Res (2003) 1.12

Interferon-beta treatment of cervical keratinocytes naturally infected with human papillomavirus 16 episomes promotes rapid reduction in episome numbers and emergence of latent integrants. Carcinogenesis (2006) 1.11

Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous clearance from the murine gastric mucosa. Infect Immun (2003) 1.11

In vitro progression of human papillomavirus 16 episome-associated cervical neoplasia displays fundamental similarities to integrant-associated carcinogenesis. Cancer Res (2010) 1.10

Translational approaches to improving cervical screening. Nat Rev Cancer (2003) 1.10

Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization. J Virol (2004) 1.10

Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes. J Virol (2005) 1.10

Mastocytosis: a disease of the hematopoietic stem cell. Dtsch Arztebl Int (2008) 1.09

Human papillomavirus molecular biology and disease association. Rev Med Virol (2015) 1.09

Intestinal ischemia-reperfusion-induced acute lung injury and oncotic cell death in multiple organs. Shock (2007) 1.08

In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line. Am J Gastroenterol (2004) 1.07

Functional evidence that Drosha overexpression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles. J Pathol (2011) 1.07

C-terminal Tensin-like (CTEN) is an oncogene which alters cell motility possibly through repression of E-cadherin in colorectal cancer. J Pathol (2009) 1.07

Excitation of rat colonic afferent fibres by 5-HT(3) receptors. J Physiol (2002) 1.07

Breast cancer proteomics reveals correlation between estrogen receptor status and differential phosphorylation of PGRMC1. Breast Cancer Res (2008) 1.07

Quick-multiplex-consensus (QMC)-PCR followed by high-resolution melting: a simple and robust method for mutation detection in formalin-fixed paraffin-embedded tissue. J Clin Pathol (2010) 1.06

CARM1 is an important determinant of ERα-dependent breast cancer cell differentiation and proliferation in breast cancer cells. Cancer Res (2011) 1.06

The Papworth experience with the Levitronix CentriMag ventricular assist device. J Heart Lung Transplant (2008) 1.05

Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial design. Contemp Clin Trials (2006) 1.05