Published in Drugs Today (Barc) on October 01, 1999
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Cytochrome P-450 3A enzymes are responsible for biotransformation of FK506 and rapamycin in man and rat. Drug Metab Dispos (1992) 1.59
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Metabolism of the immunosuppressant tacrolimus in the small intestine: cytochrome P450, drug interactions, and interindividual variability. Drug Metab Dispos (1995) 1.39
The effect of cimetidine on inpatients with duodenal ulcer -- a double blind trial. Acta Gastroenterol Belg (1979) 1.37
Helicobacter pylori causes DNA damage in gastric epithelial cells. Carcinogenesis (2000) 1.34
Effect of substituted benzimidazoles on acid secretion in isolated and enriched guinea pig parietal cells. Gut (1983) 1.29
Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. J Chromatogr B Biomed Sci Appl (2000) 1.18
Interaction of Helicobacter pylori and its fatty acids with parietal cells and gastric H+/K(+)-ATPase. Gut (1994) 1.06
Inhibition of partially purified K+/H+-ATPase from guinea-pig isolated and enriched parietal cells by substituted benzimidazoles. Br J Pharmacol (1984) 1.03
Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry. Clin Chem (1996) 1.02
Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. J Pharmacol Exp Ther (1998) 1.00
Comparative study with ranitidine and cimetidine on gastric secretion in normal volunteers. Gut (1980) 0.99
High-performance liquid chromatographic analysis of phospholipids from different sources with combined fluorescence and ultraviolet detection. Anal Biochem (1994) 0.99
Cyclosporin metabolism in transplant patients. Pharmacol Ther (1993) 0.99
Drug metabolism in hepatocyte sandwich cultures of rats and humans. Biochem Pharmacol (1997) 0.98
Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos (1999) 0.98
Effects of EP-receptor subtype specific agonists and other prostanoids on adenylate cyclase activity of duodenal epithelial cells. Prostaglandins (1992) 0.98
Specific and sensitive measurement of FK506 and its metabolites in blood and urine of liver-graft recipients. Clin Chem (1992) 0.97
Ca2+-dependent and -independent secretagogue action on gastric mucus secretion in rabbit mucosal explants. Am J Physiol (1989) 0.96
Calcium channel antagonists verapamil and gallopamil are powerful inhibitors of acid secretion in isolated and enriched guinea pig parietal cells. Pharmacology (1983) 0.96
Composition of phospholipid classes and phosphatidylcholine molecular species of gastric mucosa and mucus. Biochim Biophys Acta (1995) 0.94
Helicobacter pylori reduces intracellular glutathione in gastric epithelial cells. Dig Dis Sci (2000) 0.92
Effects of flavonoids on parietal cell acid secretion, gastric mucosal prostaglandin production and Helicobacter pylori growth. Arzneimittelforschung (1995) 0.92
Influence of atropine, metiamide and vagotomy on cAMP of resting and stimulated gastric mucosa. Eur J Pharmacol (1975) 0.92
Alternative cyclosporine metabolic pathways and toxicity. Clin Biochem (1995) 0.90
Human gastric mucosal adenylate cyclase: activation by histamine-H2-receptor stimulation and inhibition by cimetidine in vitro and in peptic ulcer patients. Eur J Clin Pharmacol (1979) 0.90
Mechanism of gastric antisecretory effect of SCH 28080. Br J Pharmacol (1986) 0.90
3-D coculture of hepatic sinusoidal cells with primary hepatocytes-design of an organotypical model. Exp Cell Res (1996) 0.89
Indometacin-induced gastrointestinal lesions in relation to tissue concentration, food intake and bacterial invasion in the rat. Pharmacology (1985) 0.89
Does burimamide inhibit gastric acid secretion by a release of catecholamines? Naunyn Schmiedebergs Arch Pharmacol (1973) 0.89
Elevated plasma beta-endorphin levels in pregnant women and their neonates. Life Sci (1979) 0.88
Metabolism of the macrolide immunosuppressant, tacrolimus, by the pig gut mucosa in the Ussing chamber. Br J Pharmacol (1996) 0.87
Effects of endogenous and exogenous prostaglandins on glycoprotein synthesis and secretion in isolated rabbit gastric mucosa. Gastroenterology (1988) 0.87
Porcine pituitary peptides with opiate-like activity: partial purification and effects in the rat after intraventricular injection. Naunyn Schmiedebergs Arch Pharmacol (1976) 0.86
Diltiazem increases blood concentrations of cyclized cyclosporine metabolites resulting in different cyclosporine metabolite patterns in stable male and female renal allograft recipients. Br J Clin Pharmacol (1996) 0.85
Isolation of two immunosuppressive metabolites after in vitro metabolism of rapamycin. Drug Metab Dispos (1992) 0.85
Effect of cimetidine on gastric mucosal histamine and histidine decarboxylase activity in rats. Digestion (1977) 0.85
Omeprazole, SCH 28080 and doxepin differ in their characteristics to inhibit H+/K+-ATPase driven proton accumulation by parietal cell membrane vesicles. Biochem Pharmacol (1988) 0.85
Pitfalls in monitoring tacrolimus (FK 506). Ther Drug Monit (1997) 0.85
Opioids modulate intestinal peristalsis at a site of action additional to that modulating acetylcholine release. J Pharmacol Exp Ther (1982) 0.84
Release of immunoreactive-dynorphin from the isolated guinea-pig small intestine is reduced during peristaltic activity. Neurosci Lett (1981) 0.84
Bismuth subcitrate and omeprazole inhibit Helicobacter pyloriF1-ATPase. Pharmacology (1995) 0.84
Single dose pharmacokinetics of ciclosporin and its main metabolites after oral ciclosporin as oily solution or capsule. Arzneimittelforschung (1990) 0.84
Methylation of histamine in the gastric mucosa. Digestion (1977) 0.84
Clinical relevance of monitoring tacrolimus: comparison of microparticle enzyme immunoassay, enzyme-linked immunosorbent assay, and liquid chromatography mass spectrometry in renal transplant recipients converted from cyclosporine to tacrolimus. Transplant Proc (1996) 0.84
Identification of drugs inhibiting the in vitro metabolism of tacrolimus by human liver microsomes. Br J Clin Pharmacol (1996) 0.84
Anticholinergic effects of pirenzepine on the guinea-pig isolated atrium. Pharmacology (1979) 0.84
LC/ESI-MS allows simultaneous and specific quantification of SDZ RAD and cyclosporine, including groups of their metabolites in human blood. Ther Drug Monit (1999) 0.84
Opioids modulate periodicity rather than efficacy of peristaltic waves in the guinea pig ileum in vitro. Life Sci (1980) 0.83
Opiate tolerance/dependence in the isolated guinea pig ileum is associated with an increased sensitivity to acetylcholine. Pharmacology (1982) 0.83
[The effect of suxamethonium on extraocular muscles and intraocular pressure in cats]. Albrecht Von Graefes Arch Klin Exp Ophthalmol (1969) 0.83
Binding of 3H-iloprost to rat gastric mucosa: a pitfall in performing radioligand binding assays. Res Commun Chem Pathol Pharmacol (1985) 0.83
Ultrastructural and functional differentiation of hepatocytes under long-term culture conditions. Anat Rec (1995) 0.83
Use of organotypical cultures of primary hepatocytes to analyse drug biotransformation in man and animals. Xenobiotica (1994) 0.83
Rat gastric mucosal cAMP following cholinergic and histamine stimulation. Eur J Pharmacol (1974) 0.83
Role of vacA and cagA in Helicobacter pylori inhibition of mucin synthesis in gastric mucous cells. J Clin Microbiol (2000) 0.83
Role of carbonic anhydrase in basal and stimulated bicarbonate secretion by the guinea pig duodenum. Dig Dis Sci (1994) 0.83
Histamine uptake and metabolism in intact isolated parietal cells. Agents Actions (1981) 0.83
Stimulation of pepsinogen release from chief cells by Helicobacter pylori: evidence for a role of calcium and calmodulin. Microb Pathog (1998) 0.83
Isolation, identification and quantitative evaluation of specific cell types from the mammalian gastric mucosa. Cell Tissue Res (1993) 0.82
Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. J Pharmacol Exp Ther (1999) 0.82
The effect of submaximal doses of pentagastrin on gastric acid secretion, histamine and histidine decarboxylase in rats. J Pharm Pharmacol (1973) 0.82
Incorporation of N-acetyl-[14C]D-glucosamine and [3H]L-leucine by isolated pig gastric mucosal cells. Digestion (1989) 0.82
Induction of IL-15 mRNA and protein in A549 cells by pro-inflammatory cytokines. Immunobiology (1998) 0.81
Helicobacter pylori augments the acid inhibitory effect of omeprazole on parietal cells and gastric H(+)/K(+)-ATPase. Gut (2001) 0.81
Additive and synergistic effects of cyclosporine metabolites on glomerular mesangial cells. Kidney Int (1991) 0.81
Enrichment and characterization of specific [3H]PGE2 binding sites in the porcine gastric mucosa. Eur J Pharmacol (1988) 0.81
Simultaneous on-line extraction and analysis of sirolimus (rapamycin) and ciclosporin in blood by liquid chromatography-electrospray mass spectrometry. J Chromatogr B Biomed Sci Appl (1999) 0.81
Measurement of blood concentrations of FK506 (tacrolimus) and its metabolites in seven liver graft patients after the first dose by h.p.l.c.-MS and microparticle enzyme immunoassay (MEIA). Br J Clin Pharmacol (1994) 0.81
Helicobacter pylori fatty acid cis 9,10-methyleneoctadecanoic acid increases [Ca2+]i, activates protein kinase C and stimulates acid secretion in parietal cells. Prostaglandins Leukot Essent Fatty Acids (1998) 0.80
Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes. Drug Metab Dispos (1996) 0.80
The adenylate cyclase-cyclic AMP-protein kinase system in different cell populations of the guinea pig gastric mucosa. Life Sci (1985) 0.80
Adenylate cyclase in human gastric mucosa: its activation by histamine in morphologically different biopsy specimens. Klin Wochenschr (1979) 0.80
The effect of SC-15396, atropine and mepyramine on gastrin-, bethanechol- and histamine-stimulated gastric acid secretion in rats and guinea-pigs. J Pharm Pharmacol (1969) 0.80
Effect of histamine H2-receptor and beta-receptor blockade on histamine-, orciprenaline- and prostaglandin-stimulated frequency of the isolated guinea-pig atrium. Agents Actions (1975) 0.80
Proceedings: Effect of histamine H2-receptor antagonists on gastric secretion, circulation, and acid-base-balance in cats. Naunyn Schmiedebergs Arch Pharmacol (1974) 0.80
Protein kinase C and parietal cell function. Biochem Biophys Res Commun (1987) 0.80
Effect of gastrin I and caerulein on gastric acid secretion in rats. J Pharm Pharmacol (1969) 0.79
The effect of histamine-H2-receptor-antagonists on gastric acid secretion, gastric mucosal blood flow and acid base balance in cats. Naunyn Schmiedebergs Arch Pharmacol (1974) 0.79
Tacrolimus (FK506) metabolite patterns in blood from liver and kidney transplant patients. Clin Chem (1996) 0.79
Comparative study with ranitidine and cimetidine on gastric secretion. Scand J Gastroenterol Suppl (1981) 0.79
Effect of burimamide on gastric acid secretion and gastric mucosal blood flow in cats. Agents Actions (1973) 0.79
Pantoprazole: a novel H+/K(+)-ATPase inhibitor with an improved pH stability. Eur J Pharmacol (1992) 0.79
Determination of histamine and its metabolic products in the pig gastric mucosa. Pharmacology (1979) 0.79
The effect of brocresine (NSD-1055) on the histidine decarboxylase activity in the rat gastric mucosa. J Pharm Pharmacol (1971) 0.79
Regional distribution of an opioid mechanism in the guinea-pig isolated intestine. J Pharm Pharmacol (1981) 0.78
[In vitro inhibition of oxidative N-demethylation with carbon disulfide]. Arzneimittelforschung (1976) 0.78
Peristalsis in the isolated guinea-pig ileum during opiate withdrawal. Naunyn Schmiedebergs Arch Pharmacol (1980) 0.78
Inhibition of acid formation in rabbit parietal cells by prostaglandins is mediated by the prostaglandin E2 receptor. Gastroenterology (1989) 0.78
Reconstruction of liver tissue in vitro: geometry of characteristic flat bed, hollow fiber, and spouted bed bioreactors with reference to the in vivo liver. Artif Organs (1995) 0.78
Interaction of ranitidine and famotidine with guinea pig-isolated parietal cells. Pharmacology (1986) 0.78
Structural elucidation by electrospray mass spectrometry: an approach to the in vitro metabolism of the macrolide immunosuppressant SDZ RAD. J Am Soc Mass Spectrom (1998) 0.78
Liquid-chromatographic measurement of cyclosporin A and its metabolites in blood, bile, and urine. Clin Chem (1988) 0.78
In vitro evidence for the participation of intestinal opioids in the control of peristalsis in the guinea pig small intestine. Naunyn Schmiedebergs Arch Pharmacol (1979) 0.78
Adenylate cyclase of the dog gastric mucosa: stimulation by histamine and inhibition by metiamide. Naunyn Schmiedebergs Arch Pharmacol (1976) 0.78
Contribution of cyclosporin metabolites to immunosuppression in liver-transplanted patients with severe graft dysfunction. Transpl Int (1991) 0.78
Comparative activities of agonists of active duodenal bicarbonate secretion in the guinea pig. Digestion (1994) 0.78
Stimulation of glycoprotein and protein synthesis in isolated pig gastric mucosal cells by prostaglandins. Gut (1990) 0.78