Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.

PubWeight™: 47.46‹?› | Rank: Top 0.01% | All-Time Top 1000

🔗 View Article (PMID 1303622)

Published in Chest on June 01, 1992


R C Bone1, R A Balk, F B Cerra, R P Dellinger, A M Fein, W A Knaus, R M Schein, W J Sibbald

Author Affiliations

1: Rush-Presbyterian St. Luke's Medical Center, Chicago 60612.

Articles citing this

(truncated to the top 100)

A randomized trial of protocol-based care for early septic shock. N Engl J Med (2014) 16.05

Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med (2007) 8.33

Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA (2010) 8.09

Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med (1999) 7.62

Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA (2011) 7.10

Harmful molecular mechanisms in sepsis. Nat Rev Immunol (2008) 6.03

Reduced cortisol metabolism during critical illness. N Engl J Med (2013) 6.01

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA (2016) 4.87

Incidence and predictors of severe obstetric morbidity: case-control study. BMJ (2001) 4.75

Post-randomisation exclusions: the intention to treat principle and excluding patients from analysis. BMJ (2002) 4.70

BTS Guidelines for the Management of Community Acquired Pneumonia in Adults. Thorax (2001) 4.68

Prospective external validation of the clinical effectiveness of an emergency department-based early goal-directed therapy protocol for severe sepsis and septic shock. Chest (2007) 4.60

The ACCP-SCCM consensus conference on sepsis and organ failure. Chest (1992) 4.35

The enigma of sepsis. J Clin Invest (2003) 4.32

Design, conduct, analysis and reporting of a multi-national placebo-controlled trial of activated protein C for persistent septic shock. Intensive Care Med (2008) 4.21

Two decades of mortality trends among patients with severe sepsis: a comparative meta-analysis*. Crit Care Med (2014) 3.82

Association between timing of antibiotic administration and mortality from septic shock in patients treated with a quantitative resuscitation protocol. Crit Care Med (2011) 3.82

Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care (2007) 3.80

The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysis. Crit Care Med (2008) 3.73

Transfusion-related acute lung injury in the critically ill: prospective nested case-control study. Am J Respir Crit Care Med (2007) 3.69

Identifying patients with severe sepsis using administrative claims: patient-level validation of the angus implementation of the international consensus conference definition of severe sepsis. Med Care (2014) 3.51

Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39

Impact of sepsis on risk of postoperative arterial and venous thromboses: large prospective cohort study. BMJ (2014) 3.34

Association between cell-free hemoglobin, acetaminophen, and mortality in patients with sepsis: an observational study. Crit Care Med (2013) 3.30

Mechanisms of cardiac and renal dysfunction in patients dying of sepsis. Am J Respir Crit Care Med (2013) 3.25

Factors associated with nonadherence to early goal-directed therapy in the ED. Chest (2010) 3.23

Pathophysiology of sepsis. Am J Pathol (2007) 3.19

The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*. Crit Care Med (2014) 3.17

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study. Lancet Respir Med (2014) 3.02

Accurate characterization of extravascular lung water in acute respiratory distress syndrome. Crit Care Med (2008) 2.94

The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation. Crit Care Med (2009) 2.92

High-dose, extended-interval colistin administration in critically ill patients: is this the right dosing strategy? A preliminary study. Clin Infect Dis (2012) 2.92

The era of molecular and other non-culture-based methods in diagnosis of sepsis. Clin Microbiol Rev (2010) 2.90

The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection. Gut (2005) 2.82

A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J Exp Med (2004) 2.80

Population burden of long-term survivorship after severe sepsis in older Americans. J Am Geriatr Soc (2012) 2.78

Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest (2004) 2.72

Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care (2008) 2.65

Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis. Am J Respir Crit Care Med (2008) 2.64

Bundled care for septic shock: an analysis of clinical trials. Crit Care Med (2010) 2.57

Determinants of skeletal muscle catabolism after severe burn. Ann Surg (2000) 2.56

Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models. Am J Pathol (1995) 2.55

The pathogenesis of sepsis. Annu Rev Pathol (2011) 2.55

Commonly used surrogates for baseline renal function affect the classification and prognosis of acute kidney injury. Kidney Int (2009) 2.53

Incidence and Prognostic Value of the Systemic Inflammatory Response Syndrome and Organ Dysfunctions in Ward Patients. Am J Respir Crit Care Med (2015) 2.53

Severe sepsis cohorts derived from claims-based strategies appear to be biased toward a more severely ill patient population. Crit Care Med (2013) 2.48

Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages. J Leukoc Biol (2009) 2.45

Prehospital statin and aspirin use and the prevalence of severe sepsis and acute lung injury/acute respiratory distress syndrome. Crit Care Med (2011) 2.40

Increased fluid administration in the first three hours of sepsis resuscitation is associated with reduced mortality: a retrospective cohort study. Chest (2014) 2.39

Isolation of imipenem-resistant Enterobacter species: emergence of KPC-2 carbapenemase, molecular characterization, epidemiology, and outcomes. Antimicrob Agents Chemother (2008) 2.38

Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock (2007) 2.37

Increased circulating regulatory T cells (CD4(+)CD25 (+)CD127 (-)) contribute to lymphocyte anergy in septic shock patients. Intensive Care Med (2008) 2.34

Corticosteroids and transition to delirium in patients with acute lung injury. Crit Care Med (2014) 2.33

Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med (2008) 2.32

Polymorphisms in the mannose binding lectin-2 gene and acute respiratory distress syndrome. Crit Care Med (2007) 2.31

Reliability of the identification of the systemic inflammatory response syndrome in critically ill infants and children. Pediatr Crit Care Med (2012) 2.29

PCR and blood culture for detection of Escherichia coli bacteremia in rats. J Clin Microbiol (1999) 2.28

Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice. J Leukoc Biol (2009) 2.27

Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care (2004) 2.25

An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med (2013) 2.23

The role of infection and comorbidity: Factors that influence disparities in sepsis. Crit Care Med (2006) 2.21

The epidemiology of severe sepsis in England, Wales and Northern Ireland, 1996 to 2004: secondary analysis of a high quality clinical database, the ICNARC Case Mix Programme Database. Crit Care (2006) 2.21

Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock. Chest (2013) 2.20

alpha+-Thalassemia protects children against disease caused by other infections as well as malaria. Proc Natl Acad Sci U S A (1997) 2.19

Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population. PLoS One (2009) 2.09

Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome. Crit Care Med (2016) 2.08

ABO blood type A is associated with increased risk of ARDS in whites following both major trauma and severe sepsis. Chest (2014) 2.07

Delirium epidemiology in critical care (DECCA): an international study. Crit Care (2010) 2.07

IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity. PLoS One (2009) 2.04

Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol (2009) 2.03

Association of body temperature and antipyretic treatments with mortality of critically ill patients with and without sepsis: multi-centered prospective observational study. Crit Care (2012) 2.02

New approaches to sepsis: molecular diagnostics and biomarkers. Clin Microbiol Rev (2012) 2.01

Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure. Crit Care Med (2008) 1.97

MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis. PLoS One (2009) 1.97

Maternal sepsis: a Scottish population-based case-control study. BJOG (2012) 1.95

Blood purification and mortality in sepsis: a meta-analysis of randomized trials. Crit Care Med (2013) 1.94

Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club. Gut (2005) 1.93

Changes in incidence and antifungal drug resistance in candidemia: results from population-based laboratory surveillance in Atlanta and Baltimore, 2008-2011. Clin Infect Dis (2012) 1.91

Outcomes of patients undergoing early sepsis resuscitation for cryptic shock compared with overt shock. Resuscitation (2011) 1.87

Resuscitation fluid use in critically ill adults: an international cross-sectional study in 391 intensive care units. Crit Care (2010) 1.87

Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care (2010) 1.86

Oliguria as predictive biomarker of acute kidney injury in critically ill patients. Crit Care (2011) 1.86

Extravascular lung water in patients with severe sepsis: a prospective cohort study. Crit Care (2005) 1.86

Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Crit Care (2011) 1.84

Randomised controlled trial of intravenous antibiotic treatment for cellulitis at home compared with hospital. BMJ (2004) 1.82

Admission angiopoietin levels in children with septic shock. Shock (2007) 1.82

Safety and feasibility of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: a multicenter phase II trial (JCOG 0703). Gastric Cancer (2010) 1.81

Comparison of procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of sepsis and MODS. Crit Care (1999) 1.81

Effectiveness of polymyxin B-immobilized fiber column in sepsis: a systematic review. Crit Care (2007) 1.80

Streptococcus suis, an important cause of adult bacterial meningitis in northern Vietnam. PLoS One (2009) 1.79

Infection-associated clinical outcomes in hospitalized medical evacuees after traumatic injury: trauma infectious disease outcome study. J Trauma (2011) 1.77

The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit Care (2011) 1.77

The incidence and outcome of septic shock patients in the absence of early-goal directed therapy. Crit Care (2006) 1.77

Increasing incidence of nosocomial Chryseobacterium indologenes infections in Taiwan. Eur J Clin Microbiol Infect Dis (1997) 1.75

Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock: an observational study. Acad Emerg Med (2013) 1.75

Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria. Infect Immun (2003) 1.75

Clinical review: Myocardial depression in sepsis and septic shock. Crit Care (2002) 1.74

Assessing available information on the burden of sepsis: global estimates of incidence, prevalence and mortality. J Glob Health (2012) 1.74

Inhibition of MAP kinase/NF-kB mediated signaling and attenuation of lipopolysaccharide induced severe sepsis by cerium oxide nanoparticles. Biomaterials (2015) 1.74

The selective alpha7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol Med (2009) 1.73

Articles by these authors

APACHE II: a severity of disease classification system. Crit Care Med (1985) 69.83

The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators. JAMA (1996) 17.62

Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med (1995) 10.29

Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N Engl J Med (1991) 9.99

APACHE-acute physiology and chronic health evaluation: a physiologically based classification system. Crit Care Med (1981) 9.14

Outcomes following acute exacerbation of severe chronic obstructive lung disease. The SUPPORT investigators (Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments) Am J Respir Crit Care Med (1996) 5.82

Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome. Ann Intern Med (1993) 5.46

An evaluation of outcome from intensive care in major medical centers. Ann Intern Med (1986) 5.41

Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study Group. N Engl J Med (1996) 5.25

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA (1994) 5.24

Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit Care Med (1997) 4.86

Influence of patient preferences and local health system characteristics on the place of death. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Risks and Outcomes of Treatment. J Am Geriatr Soc (1998) 4.45

The performance of intensive care units: does good management make a difference? Med Care (1994) 4.41

The ACCP-SCCM consensus conference on sepsis and organ failure. Chest (1992) 4.35

Do formal advance directives affect resuscitation decisions and the use of resources for seriously ill patients? SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. J Clin Ethics (1994) 4.23

A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med (1987) 3.89

Guidelines for the initial management of adults with community-acquired pneumonia: diagnosis, assessment of severity, and initial antimicrobial therapy. American Thoracic Society. Medical Section of the American Lung Association. Am Rev Respir Dis (1993) 3.68

Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. JAMA (1995) 3.45

Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group. Crit Care Med (1989) 3.41

The relation of pneumothorax and other air leaks to mortality in the acute respiratory distress syndrome. N Engl J Med (1998) 3.40

Do advance directives provide instructions that direct care? SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. J Am Geriatr Soc (1997) 3.37

Prognosis in acute organ-system failure. Ann Surg (1985) 3.26

A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group. JAMA (1991) 3.25

Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA (1993) 3.23

Practice parameters for intravenous analgesia and sedation for adult patients in the intensive care unit: an executive summary. Society of Critical Care Medicine. Crit Care Med (1995) 3.19

Magnitude and duration of the effect of sepsis on survival. Department of Veterans Affairs Systemic Sepsis Cooperative Studies Group. JAMA (1997) 3.11

Influence of an anti-tumor necrosis factor monoclonal antibody on cytokine levels in patients with sepsis. The CB0006 Sepsis Syndrome Study Group. Crit Care Med (1993) 2.84

Advance directives for seriously ill hospitalized patients: effectiveness with the patient self-determination act and the SUPPORT intervention. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. J Am Geriatr Soc (1997) 2.84

Sepsis: a new hypothesis for pathogenesis of the disease process. Chest (1997) 2.84

Multiple organ failure syndrome in the 1990s. Systemic inflammatory response and organ dysfunction. JAMA (1994) 2.71

Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion. Lancet (1979) 2.71

Definitions for sepsis and organ failure. Crit Care Med (1992) 2.69

Sedation in the intensive care unit: a systematic review. JAMA (2000) 2.65

Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Crit Care Med (1995) 2.63

A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. Crit Care Med (1995) 2.48

Peripheral nerve function in sepsis and multiple organ failure. Chest (1991) 2.46

Evaluation of acute physiology and chronic health evaluation III predictions of hospital mortality in an independent database. Crit Care Med (1998) 2.44

Older age, aggressiveness of care, and survival for seriously ill, hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. Ann Intern Med (1999) 2.34

The use of intensive care: a comparison of a university and community hospital. Health Care Financ Rev (1981) 2.33

Elastolytic activity in pulmonary lavage fluid from patients with adult respiratory-distress syndrome. N Engl J Med (1981) 2.32

High-dose corticosteroids in patients with the adult respiratory distress syndrome. N Engl J Med (1987) 2.32

Nitrogen oxide levels in patients after trauma and during sepsis. Ann Surg (1991) 2.24

Initial development of a system-wide maternal-fetal outcomes assessment program. Am J Obstet Gynecol (2000) 2.24

The laboratory-clinical interface: point-of-care testing. Chest (1999) 2.23

Preoperative optimization of cardiovascular hemodynamics improves outcome in peripheral vascular surgery. A prospective, randomized clinical trial. Ann Surg (1991) 2.21

Physician fee patterns under medicare: a descriptive analysis. N Engl J Med (1976) 2.15

Polyneuropathy in critically ill patients. J Neurol Neurosurg Psychiatry (1984) 2.14

E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. JAMA (2000) 2.07

Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. Crit Care Med (1990) 2.04

A "closed" medical intensive care unit (MICU) improves resource utilization when compared with an "open" MICU. Am J Respir Crit Care Med (1998) 2.03

Patients readmitted to the intensive care unit during the same hospitalization: clinical features and outcomes. Crit Care Med (1998) 2.00

Undergraduate education in critical care medicine. Crit Care Med (1992) 1.99

Improving intensive care: observations based on organizational case studies in nine intensive care units: a prospective, multicenter study. Crit Care Med (1993) 1.97

Effect of noninvasive positive pressure ventilation on mortality in patients admitted with acute respiratory failure: a meta-analysis. Crit Care Med (1997) 1.95

Critically ill polyneuropathy: electrophysiological studies and differentiation from Guillain-Barré syndrome. J Neurol Neurosurg Psychiatry (1986) 1.95

Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats. Crit Care Med (1997) 1.91

Introducing Critical Appraisal to studies of animal models investigating novel therapies in sepsis. Crit Care Med (1996) 1.89

The Southwestern Ontario Joint Replacement Pilot Project: electronic point-of-care data collection. Southwestern Ontario Study Group. Can J Surg (2001) 1.82

An initial comparison of intensive care in Japan and the United States. Crit Care Med (1992) 1.79

Predicting outcome in critical care: the current status of the APACHE prognostic scoring system. Can J Anaesth (1991) 1.77

Variations in the use of do-not-resuscitate orders in ICUS. Findings from a national study. Chest (1996) 1.77

Clostridium difficile infection as a cause of severe sepsis. Intensive Care Med (1996) 1.75

Albumin versus hydroxyethyl starch in cardiopulmonary bypass surgery: a meta-analysis of postoperative bleeding. Ann Thorac Surg (2001) 1.74

Noninvasive positive pressure ventilation in the setting of severe, acute exacerbations of chronic obstructive pulmonary disease: more effective and less expensive. Crit Care Med (2000) 1.71

Factors associated with do-not-resuscitate orders: patients' preferences, prognoses, and physicians' judgments. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment. Ann Intern Med (1996) 1.69

AIDS in a bodybuilder using anabolic steroids. N Engl J Med (1984) 1.66

Withdrawal and withholding of life support in the intensive care unit: a comparison of teaching and community hospitals. The Southwestern Ontario Critical Care Research Network. Crit Care Med (1998) 1.65

Safety and potential efficacy of an aerosolized surfactant in human sepsis-induced adult respiratory distress syndrome. JAMA (1994) 1.64

Value and cost of teaching hospitals: a prospective, multicenter, inception cohort study. Crit Care Med (1993) 1.64

Utility of fiberoptic bronchoscopy in nonresolving pneumonia. Chest (1990) 1.64

Risk of right bundle-branch block and complete heart block during pulmonary artery catheterization. Crit Care Med (1989) 1.62

Changing the cause of death. JAMA (1983) 1.61

Dopexamine attenuates flow motion in ileal mucosal arterioles in normotensive sepsis. Crit Care Med (1999) 1.60

Benefits of a multidisciplinary pulmonary rehabilitation program. Improvements are independent of lung function. Chest (1991) 1.59

A predictive risk model for outcomes of ischemic stroke. Stroke (2000) 1.59

A retrospective review of a large cohort of patients undergoing the process of withholding or withdrawal of life support. Crit Care Med (1997) 1.58

Physiological and metabolic correlations in human sepsis. Invited commentary. Surgery (1979) 1.58

Interobserver variability in data collection of the APACHE II score in teaching and community hospitals. Crit Care Med (1999) 1.57

Clinical utility and cost-effectiveness of an air suspension bed in the prevention of pressure ulcers. JAMA (1993) 1.57

Does implementing pulse oximetry in a critical care unit result in substantial arterial blood gas savings? Chest (1993) 1.54

Interhospital comparisons of patient outcome from intensive care: importance of lead-time bias. Crit Care Med (1989) 1.53

Progressive necrotizing surgical infections--a unified approach. J Trauma (1981) 1.51

Pulmonary artery catheterization. Can there be an integrated strategy for guideline development and research promotion? JAMA (1993) 1.51

Pulmonary hypertension in sepsis: measurement by the pulmonary arterial diastolic-pulmonary wedge pressure gradient and the influence of passive and active factors. Chest (1978) 1.50

The range of intensive care services today. JAMA (1981) 1.49

Identification of low-risk monitor patients within a medical-surgical intensive care unit. Med Care (1983) 1.48

Endotoxin promotes adhesion of human erythrocytes to human vascular endothelial cells under conditions of flow. Crit Care Med (2000) 1.48

Changes in myocardial blood flow rates during hyperdynamic sepsis with induced changes in arterial perfusing pressures and metabolic need. Crit Care Med (1993) 1.47

Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver. Ann Surg (1994) 1.46

Nitric oxide inhibition in the treatment of septic shock. Crit Care Med (1995) 1.45

Show me the evidence: a critical appraisal of the Pulmonary Artery Catheter Consensus Conference and other musings on how critical care practitioners need to improve the way we conduct business. Crit Care Med (1997) 1.44

The use of risk predictions to identify candidates for intermediate care units. Implications for intensive care utilization and cost. Chest (1995) 1.44

Polymyxin-dextran antiendotoxin pretreatment in an ovine model of normotensive sepsis. Crit Care Med (1997) 1.44

Statistical validation of a severity of illness measure. Am J Public Health (1983) 1.44

Medical effectiveness of esophageal balloon pressure manometry in weaning patients from mechanical ventilation. Crit Care Med (1995) 1.43

Fulminant hepatic failure from a sea anemone sting. Ann Intern Med (1994) 1.43