Published in Proc Natl Acad Sci U S A on October 15, 1992
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest (1996) 2.07
Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia. Biochim Biophys Acta (2009) 1.54
Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proc Natl Acad Sci U S A (2003) 1.50
Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc Natl Acad Sci U S A (2010) 1.44
Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proc Natl Acad Sci U S A (1994) 1.27
Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains. J Biol Chem (2005) 1.19
Human extracellular superoxide dismutase is a tetramer composed of two disulphide-linked dimers: a simplified, high-yield purification of extracellular superoxide dismutase. Biochem J (1996) 1.13
Decreased pulmonary extracellular superoxide dismutase during systemic inflammation. Free Radic Biol Med (2008) 1.02
Nitric oxide as a mediator of oxidant lung injury due to paraquat. Proc Natl Acad Sci U S A (1994) 0.99
The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ Health Perspect (1998) 0.98
Dual gene therapy with extracellular superoxide dismutase and catalase attenuates experimental optic neuritis. Mol Vis (2007) 0.98
Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases. Proc Natl Acad Sci U S A (1995) 0.94
Relation between delayed impairment of cerebral energy metabolism and infarction following transient focal hypoxia-ischaemia in the developing brain. Exp Brain Res (1997) 0.93
Oxidative stress and adult neurogenesis--effects of radiation and superoxide dismutase deficiency. Semin Cell Dev Biol (2012) 0.92
Endogenous enzymes (NOX and ECSOD) regulate smoke-induced oxidative stress. Free Radic Biol Med (2010) 0.90
A common polymorphism in extracellular superoxide dismutase affects cardiopulmonary disease risk by altering protein distribution. Circ Cardiovasc Genet (2014) 0.84
Role of EC-SOD overexpression in preserving pulmonary angiogenesis inhibited by oxidative stress. PLoS One (2012) 0.83
A new mouse model for temporal- and tissue-specific control of extracellular superoxide dismutase. Genesis (2009) 0.82
Endothelial nitric oxide synthase expression is progressively increased in primary cerebral microvascular endothelial cells during hyperbaric oxygen exposure. Oxid Med Cell Longev (2010) 0.81
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. Physiol Rev (2016) 0.81
A nitric oxide-releasing reagent, S-nitroso-N-acetylpenicillamine, enhances the expression of superoxide dismutases mRNA in the murine macrophage cell line RAW264-7. Immunology (1997) 0.79
Alpha-tocopherol and ascorbic acid administration prevents the impairment of brain energy metabolism of hyperargininemic rats. Cell Mol Neurobiol (2006) 0.78
Neuroprotective effect of gui zhi (ramulus cinnamomi) on ma huang- (herb ephedra-) induced toxicity in rats treated with a ma huang-gui zhi herb pair. Evid Based Complement Alternat Med (2015) 0.78
Overexpression of extracellular superoxide dismutase protects against brain injury induced by chronic hypoxia. PLoS One (2014) 0.76
Recovery from central nervous system oxygen toxicity in the rat at oxygen pressures between 100 and 300 kPa. Eur J Appl Physiol (2008) 0.76
Nitric oxide-mediated central sympathetic excitation promotes CNS and pulmonary O₂ toxicity. J Appl Physiol (1985) (2012) 0.76
Subcellular Energetics and Metabolism: Potential Therapeutic Applications. Anesth Analg (2017) 0.75
Metallothionein-induced zinc partitioning exacerbates hyperoxic acute lung injury. Am J Physiol Lung Cell Mol Physiol (2012) 0.75
IFNγ-mediated inhibition of cell proliferation through increased PKCδ-induced overexpression of EC-SOD. BMB Rep (2012) 0.75
Is glucose-6-phosphate dehydrogenase deficiency a risk factor for hyperbaric oxygen exposure? Eur J Appl Physiol (2011) 0.75
Lactobacillus rhamnosus GG conditioned media modulates acute reactive oxygen species and nitric oxide in J774 murine macrophages. Biochem Biophys Rep (2016) 0.75
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A (1990) 16.34
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature (1986) 9.93
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci U S A (1991) 5.70
Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol (1986) 4.88
Human copper-containing superoxide dismutase of high molecular weight. Proc Natl Acad Sci U S A (1982) 3.45
Preparation and assay of superoxide dismutases. Methods Enzymol (1978) 3.21
Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled. Proc Natl Acad Sci U S A (1988) 2.84
Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible. J Clin Invest (1986) 2.76
A requirement for the intercellular messenger nitric oxide in long-term potentiation. Science (1991) 2.68
The antioxidants of human extracellular fluids. Arch Biochem Biophys (1990) 2.62
Sites of inhibition of mitochondrial electron transport in macrophage-injured neoplastic cells. J Cell Biol (1982) 2.54
Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem J (1992) 2.51
Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad Sci U S A (1991) 2.49
Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle. Am J Physiol (1986) 2.42
Does superoxide underlie the pathogenesis of hypertension? Proc Natl Acad Sci U S A (1991) 2.39
Extracellular superoxide dismutase in human tissues and human cell lines. J Clin Invest (1984) 2.39
Superoxide dismutase in extracellular fluids. Clin Chim Acta (1982) 2.32
In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate. J Biol Chem (1976) 2.21
Isolation and sequence of complementary DNA encoding human extracellular superoxide dismutase. Proc Natl Acad Sci U S A (1987) 2.20
Injury of neoplastic cells by murine macrophages leads to inhibition of mitochondrial respiration. J Clin Invest (1980) 1.82
Effect of exogenous and endogenous nitric oxide on mitochondrial respiration of rat hepatocytes. Am J Physiol (1991) 1.54
Expression of human extracellular superoxide dismutase in Chinese hamster ovary cells and characterization of the product. Proc Natl Acad Sci U S A (1987) 1.43
Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. Am J Physiol (1992) 1.41
Mitochondrial iron loss from leukemia cells injured by macrophages. A possible mechanism for electron transport chain defects. J Immunol (1988) 1.41
Extracellular superoxide dismutase in the vascular system of mammals. Biochem J (1988) 1.41
Mechanism for the potentiation of oxygen toxicity by disulfiram. J Pharmacol Exp Ther (1980) 1.40
Superoxide, iron, vascular endothelium and reperfusion injury. Free Radic Res Commun (1989) 0.99
Platelet inhibition by endothelium-derived relaxing factor from the rabbit perfused aorta. Br J Pharmacol (1988) 0.96
Regional localization of human extracellular superoxide dismutase gene to 4pter-q21. Genomics (1990) 0.89
Effect of diethyldithiocarbamate on oxygen toxicity and lung enzyme activity in immature and adult rats. Biochem Pharmacol (1978) 0.86
Prevention of H2O2 generation by monoamine oxidase protects against CNS O2 toxicity. J Appl Physiol (1985) (1991) 0.86
Protection with disulfiram from central and pulmonary oxygen toxicity. Biochem Pharmacol (1971) 0.80
[Interactions between oxygen under high pressure and drugs (author's transl)]. Wien Klin Wochenschr (1977) 0.78
Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists. Can J Physiol Pharmacol (1985) 0.78
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell (1982) 9.27
Biology of disease: free radicals and tissue injury. Lab Invest (1982) 6.09
Blood flow regulation by S-nitrosohemoglobin in the physiological oxygen gradient. Science (1997) 4.29
The use of pKc30 and its derivatives for controlled expression of genes. Methods Enzymol (1983) 3.90
A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat Genet (1998) 3.41
Preparation and assay of superoxide dismutases. Methods Enzymol (1978) 3.21
Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am Rev Respir Dis (1980) 3.08
Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol (1992) 3.07
Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal (1997) 2.77
Maximizing gene expression from plasmid vectors containing the lambda PL promoter: strategies for overproducing transcription termination factor rho. Proc Natl Acad Sci U S A (1985) 2.70
Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem (1981) 2.60
Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis (1982) 2.54
Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. Am J Physiol Heart Circ Physiol (2001) 2.38
The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch Biochem Biophys (1982) 2.37
Prognosis of patients with cirrhosis and chronic liver disease admitted to the medical intensive care unit. Crit Care Med (1988) 2.33
Morphologic changes in pulmonary oxygen toxicity. Annu Rev Physiol (1986) 2.25
Red cells from glutathione peroxidase-1-deficient mice have nearly normal defenses against exogenous peroxides. Blood (2000) 2.19
Human Mn-superoxide dismutase in pulmonary epithelial cells of transgenic mice confers protection from oxygen injury. J Biol Chem (1992) 2.18
Bacteriophage lambda protein cII binds promoters on the opposite face of the DNA helix from RNA polymerase. Nature (1983) 2.13
The protective role of manganese superoxide dismutase against adriamycin-induced acute cardiac toxicity in transgenic mice. J Clin Invest (1996) 2.07
Warehouse workers' headache. Carbon monoxide poisoning from propane-fueled forklifts. J Occup Med (1992) 2.06
Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys (1997) 2.03
Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide. Radiat Res (1997) 2.02
Isolation of type 5 adenovirus mutants with a cold-sensitive host range phenotype: genetic evidence of an adenovirus transformation maintenance function. Virology (1982) 1.99
Superoxide dismutase and pulmonary oxygen toxicity. Am J Physiol (1974) 1.99
Detection of catalase in rat heart mitochondria. J Biol Chem (1991) 1.90
Cell number and distribution in human and rat airways. Am J Respir Cell Mol Biol (1994) 1.86
Requirement for superoxide in excitotoxic cell death. Neuron (1996) 1.80
Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice. J Mol Cell Cardiol (1998) 1.72
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro. J Pharmacol Exp Ther (1995) 1.70
Molecular immunocytochemistry of the CuZn superoxide dismutase in rat hepatocytes. J Cell Biol (1988) 1.68
Regulation of sodium-calcium exchange and mitochondrial energetics by Bcl-2 in the heart of transgenic mice. J Mol Cell Cardiol (2001) 1.65
Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Invest (1994) 1.62
Extracellular superoxide dismutase in vessels and airways of humans and baboons. Free Radic Biol Med (1996) 1.56
The differential degradation of two cytosolic proteins as a tool to monitor autophagy in hepatocytes by immunocytochemistry. J Cell Biol (1993) 1.55
Cellular and connective tissue changes in alveolar septal walls in emphysema. Am J Respir Crit Care Med (1999) 1.55
Effects of prolonged exposure to low doses of nitric oxide or nitrogen dioxide on the alveolar septa of the adult rat lung. Lab Invest (1995) 1.54
Mitochondrial superoxide production in kainate-induced hippocampal damage. Neuroscience (2000) 1.53
Hyperoxia increases H2O2 release by lung mitochondria and microsomes. Arch Biochem Biophys (1982) 1.51
In vivo binding of carbon monoxide to cytochrome c oxidase in rat brain. J Appl Physiol (1985) (1990) 1.50
Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene. Genomics (1994) 1.49
Left atrial ball thrombus in nonrheumatic atrial fibrillation diagnosed by transesophageal echocardiography. Am Heart J (1992) 1.46
Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability. Lab Invest (1996) 1.46
Morphometric characteristics of cells in the alveolar region of mammalian lungs. Am Rev Respir Dis (1983) 1.44
EMPHYSEMA QUANTIFICATION IN A MULTI-SCANNER HRCT COHORT USING LOCAL INTENSITY DISTRIBUTIONS. Proc IEEE Int Symp Biomed Imaging (2012) 1.42
Near-infrared spectroscopy for monitoring muscle oxygenation. Acta Physiol Scand (2000) 1.41
Near infrared monitoring of human skeletal muscle oxygenation during forearm ischemia. J Appl Physiol (1985) (1988) 1.41
Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. J Clin Invest (1992) 1.40
Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J Assoc Res Otolaryngol (2000) 1.39
Attenuation of bleomycin-induced pulmonary fibrosis by a catalytic antioxidant metalloporphyrin. Am J Respir Cell Mol Biol (2001) 1.39
Coagulation blockade prevents sepsis-induced respiratory and renal failure in baboons. Am J Respir Crit Care Med (2001) 1.39
Neuroprotection from delayed postischemic administration of a metalloporphyrin catalytic antioxidant. J Neurosci (2001) 1.38
Pathologic changes in the lungs of oxygen-adapted rats: a morphometric analysis. Lab Invest (1978) 1.38
Induction of arginase isoforms in the lung during hyperoxia. Am J Physiol (1998) 1.36
Alveolar septal structure in different species. J Appl Physiol (1985) (1994) 1.35
Transgenic models for the study of lung antioxidant defense: enhanced manganese-containing superoxide dismutase activity gives partial protection to B6C3 hybrid mice exposed to hyperoxia. Am J Respir Cell Mol Biol (1998) 1.33
Three-dimensional reconstruction of the rat acinus. J Appl Physiol (1985) (1987) 1.31
Composition of lung lavage in pulmonary alveolar microlithiasis. Respiration (1996) 1.31
Distribution of lung cell numbers and volumes between alveolar and nonalveolar tissue. Am Rev Respir Dis (1992) 1.31
Selective O-desulfation produces nonanticoagulant heparin that retains pharmacological activity in the lung. J Pharmacol Exp Ther (1997) 1.30
Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. J Clin Invest (1984) 1.30
Pulmonary macrophage accumulation and asbestos-induced lesions at sites of fiber deposition. Am Rev Respir Dis (1984) 1.30
Release of cytochrome c from liver mitochondria during permeability transition. Biochem Biophys Res Commun (1997) 1.30
Factors related to the survival of papillary and follicular thyroid carcinoma patients with distant metastases. Thyroid (1999) 1.30
L&H variants of Reed-Sternberg cells express sialylated Leu M1 antigen. Am J Pathol (1986) 1.29
Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice. Invest Ophthalmol Vis Sci (2001) 1.29
Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series. J Oral Maxillofac Surg (2007) 1.28
Liposome-mediated augmentation of superoxide dismutase in endothelial cells prevents oxygen injury. J Biol Chem (1983) 1.28
Metalloporphyrins are potent inhibitors of lipid peroxidation. Free Radic Biol Med (1999) 1.27
Intracellular localization of the copper-zinc and manganese superoxide dismutases in rat liver parenchymal cells. Lab Invest (1986) 1.25
Three-dimensional reconstruction of alveoli in the rat lung for pressure-volume relationships. J Appl Physiol (1985) (1987) 1.25
Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. FEBS Lett (1987) 1.25
Targeted disruption of the mouse Sod I gene makes the hearts vulnerable to ischemic reperfusion injury. Circ Res (2000) 1.24
Purification and characterization of extracellular superoxide dismutase in mouse lung. Biochem Biophys Res Commun (2000) 1.23
Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress. Hepatology (1999) 1.23
Removal of Cr(VI) from aqueous solutions using agricultural waste 'maize bran'. J Hazard Mater (2007) 1.23
In vivo aminoacylation of human and Xenopus suppressor tRNAs constructed by site-specific mutagenesis. Proc Natl Acad Sci U S A (1987) 1.22
Mouse extracellular superoxide dismutase: primary structure, tissue-specific gene expression, chromosomal localization, and lung in situ hybridization. Am J Respir Cell Mol Biol (1997) 1.21
Should hyperbaric oxygen be used to treat the pregnant patient for acute carbon monoxide poisoning? A case report and literature review. JAMA (1989) 1.21
H(mox-1) constitutes an adaptive response to effect antioxidant cardioprotection: A study with transgenic mice heterozygous for targeted disruption of the Heme oxygenase-1 gene. Circulation (2001) 1.20
Cellular glutathione peroxidase knockout mice express normal levels of selenium-dependent plasma and phospholipid hydroperoxide glutathione peroxidases in various tissues. J Nutr (1997) 1.20
Reactive oxygen species produced by liver mitochondria of rats in sepsis. Arch Biochem Biophys (1995) 1.20
Characterization of a third, cII-dependent, coordinately activated promoter on phage lambda involved in lysogenic development. J Biol Chem (1985) 1.20
Hyperoxia increases H2O2 production by brain in vivo. J Appl Physiol (1985) (1987) 1.20
cDNA and deduced amino acid sequence of rat copper-zinc-containing superoxide dismutase. Nucleic Acids Res (1987) 1.19
Cell number and cell characteristics of the normal human lung. Am Rev Respir Dis (1982) 1.19
Pulmonary morphology in a multihospital collaborative extracorporeal membrane oxygenation project. I. Light microscopy. Am J Pathol (1979) 1.19
Oxidative stress-associated impairment of proteasome activity during ischemia-reperfusion injury. J Cereb Blood Flow Metab (2000) 1.18
Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide. J Biol Chem (1993) 1.18
Progressive lung cell reactions and extracellular matrix production after a brief exposure to asbestos. Am J Pathol (1988) 1.18
Spatial distribution of collagen and elastin fibers in the lungs. J Appl Physiol (1985) (1990) 1.18
Transgenic mice overexpressing glutathione peroxidase are resistant to myocardial ischemia reperfusion injury. J Mol Cell Cardiol (1996) 1.17
Structural and biochemical adaptive changes in rat lungs after exposure to hypoxia. Lab Invest (1983) 1.17
Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice. J Nutr (1998) 1.16
Hyperoxia increases oxygen radical production in rat lung homogenates. Arch Biochem Biophys (1982) 1.16
Morphologic changes in the lung during the lifespan of Fischer 344 rats. Am J Anat (1982) 1.16
Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury. Osteoarthritis Cartilage (2008) 1.16
Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells. Am J Physiol (1997) 1.16