Published in Science on November 22, 1957
The pharmacological actions of 3,4-dihydroxyphenyl-alpha-methylalanine (alpha-methyldopa), an inhibitor of 5-hydroxytryptophan decarboxylase. Br J Pharmacol Chemother (1960) 0.94
Monoamine oxidase in the pineal gland, neurohypophysis and brain of the albino rat. J Anat (1963) 0.78
A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem (1952) 18.27
A method for the fluorometric assay of histamine in tissues. J Pharmacol Exp Ther (1959) 16.61
The physiological disposition and metabolic fate of hydrocortisone in man. J Clin Invest (1955) 6.74
Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation. J Biol Chem (1954) 5.08
Identification and assay of serotonin in brain. J Pharmacol Exp Ther (1956) 4.17
The gastric secretion of drugs: a pH partition hypothesis. J Pharmacol Exp Ther (1957) 3.99
Studies in detoxication. 67. The biosynthesis of the glucuronides of umbelliferone and 4-methylumbelliferone and their use in fluorimetric determination of beta-glucuronidase. Biochem J (1955) 3.97
The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material. J Pharmacol Exp Ther (1953) 3.60
A chemical method for the determination of free choline in plasma. J Biol Chem (1953) 3.57
ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART. J Pharmacol Exp Ther (1965) 3.45
Norepinephrine depletion as a possible mechanism of action of guanethidine (SU 5864), a new hypotensive agent. Proc Soc Exp Biol Med (1960) 3.26
On the mechanism of intestinal absorption of drugs. J Pharmacol Exp Ther (1959) 3.16
Some physico-chemical factors in drug action. J Pharm Pharmacol (1957) 3.13
The fate of antipyrine in man. J Pharmacol Exp Ther (1950) 3.05
Serotonin release as a possible mechanism of reserpine action. Science (1955) 3.03
The direct determination of phosphatidyl ethanolamine and phosphatidyl serine in plasma and red blood cells. J Biol Chem (1953) 2.98
BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE. J Pharmacol Exp Ther (1965) 2.82
Ascorbic acid in aromatic hydroxylation. II. Products formed by reaction of substrates with ascorbic acid, ferrous ion, and oxygen. J Biol Chem (1954) 2.78
INTERACTION OF GUANETHIDINE WITH ADRENERGIC NEURONS. J Pharmacol Exp Ther (1965) 2.77
A concept for a role of serotonin and norepinephrine as chemical mediators in the brain. Ann N Y Acad Sci (1957) 2.71
Absorption of drugs from the rat small intestine. J Pharmacol Exp Ther (1958) 2.62
The fate of aminopyrine (pyramidon) in man and methods for the estimation of aminopyrine and its metabolites in biological material. J Pharmacol Exp Ther (1950) 2.54
The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen. J Pharmacol Exp Ther (1957) 2.46
The fate of pentobarbital in man and dog and a method for its estimation in biological material. J Pharmacol Exp Ther (1953) 2.38
Identification and chemical assay of norepinephrine in brain and other tissues. J Pharmacol Exp Ther (1958) 2.37
Enzymatic metabolism of drugs and other foreign compounds. Annu Rev Biochem (1958) 2.36
Serotonin as a mediator of reserpine action in brain. J Pharmacol Exp Ther (1956) 2.26
A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671. J Pharmacol Exp Ther (1957) 2.20
Detoxication of drugs and other foreign compounds by liver microsomes. Science (1955) 2.20
Estimation of intracellular water in man. Am J Physiol (1950) 2.14
Evidence that serotonin has a role in brain function. Science (1955) 2.13
Pharmacological consequences of the selective release of peripheral norepinephrine by syrosingopine (Su 3118). J Pharmacol Exp Ther (1960) 2.10
The fate of thiopental in man and a method for its estimation in biological material. J Pharmacol Exp Ther (1950) 2.10
Studies in detoxication. 71. The metabolism of hydroxycoumarins. Biochem J (1958) 2.06
Interaction of reserpine, serotonin, and lysergic acid diethylamide in brain. Science (1955) 1.99
Possible role of pleuropneumonia-like organisms in etiology of disease in childhood. AMA Am J Dis Child (1951) 1.94
Absorption of drugs from the stomach. I. The rat. J Pharmacol Exp Ther (1957) 1.86
Absorption of drugs from the stomach. II. The human. J Pharmacol Exp Ther (1957) 1.85
STUDIES ON PULMONARY SECRETIONS. I. THE OVER-ALL CHEMICAL COMPOSITION OF PULMONARY SECRETIONS FROM PATIENTS WITH CYSTIC FIBROSIS, BRONCHIECTASIS, AND LARYNGECTOMY. Am Rev Respir Dis (1963) 1.81
Mechanism of the potentiating action of beta-diethylaminoethyl diphenylpropylacetate. J Pharmacol Exp Ther (1954) 1.78
Enzymatic dealkylation of aminopyrine (pyramidon) and other alkylamines. J Biol Chem (1955) 1.77
The metabolic fate of phenylbutazone (butazolidin) in man. J Pharmacol Exp Ther (1955) 1.76
A 5 YEAR CLINICAL EVALUATION OF A THERAPEUTIC PROGRAM FOR PATIENTS WITH CYSTIC FIBROSIS. J Pediatr (1964) 1.66
Biochemical and pharmacological studies of RO 1-9569 (tetrabenazine), a nonindole tranquilizing agent with reserpine-like effects. J Pharmacol Exp Ther (1959) 1.63
The physiological disposition and metabolic fate of cortisone in man. J Clin Invest (1957) 1.62
On the mechanism of drug potentiation by iproniazid (2-isopropyl-1-isonicotinyl hydrazine). J Pharmacol Exp Ther (1956) 1.61
Physiological disposition and fate of chlorpromazine and a method for its estimation in biological material. J Pharmacol Exp Ther (1956) 1.59
Studies in detoxication. 72. The metabolism of coumarin and of o-coumaric acid. Biochem J (1958) 1.58
BINDING AND RELEASE OF METARAMINOL: MECHANISM OF NOREPINEPHRINE DEPLETION BY ALPHA-METHYL-M-TYROSINE AND RELATED AGENTS. J Pharmacol Exp Ther (1964) 1.56
The enzymatic metabolism of hexobarbital (evipal). J Pharmacol Exp Ther (1955) 1.56
Possible interrelationship between release of brain norepinephrine and serotonin by reserpine. Science (1957) 1.54
Release of serotonin and catecholamines by drugs. Pharmacol Rev (1962) 1.53
Use of I131 - labeled protein in the study of protein digestion and absorption in children with and without cystic fibrosis of the pancreas. Pediatrics (1952) 1.51
Total body water in man. Am J Physiol (1950) 1.50
Inhibitory effects of beta-diethylaminoethyl diphenylpropylacetate on a variety of drug metabolic pathways in vitro. J Pharmacol Exp Ther (1954) 1.49
The importance of dissociaton constant and lipid-solubility in influencing the passage of drugs into the cerebrospinal fluid. J Pharmacol Exp Ther (1960) 1.47
RECENT VIEWS ON MECHANISMS FOR LOWERING SYMPATHETIC TONE. Circulation (1963) 1.44
On the mechanism of antidepressant action of imipraminelike drugs. Ann N Y Acad Sci (1962) 1.42
The use of procaine amide in cardiac arrhythmias. Circulation (1951) 1.42
Biochemical and pharmacological effects of the monoamine oxidase inhibitors, iproniazid, 1-phenyl-2-hydrazinopropane (JB 516) and 1-phenyl-3-hydrazinobutane (JB 835). J Pharmacol Exp Ther (1960) 1.41
Pathways of drug metabolism. J Pharm Pharmacol (1956) 1.41
The mechanism of serotonin and catecholamine uptake by platelets. J Pharmacol Exp Ther (1959) 1.40
Role of brain serotonin in reserpine action. Ann N Y Acad Sci (1957) 1.40
Structural requirements for bretylium and guanethidine-like activity. Life Sci (1962) 1.39
Release of serotonin from blood platelets by reserpine in vitro. J Pharmacol Exp Ther (1957) 1.39
The enzymatic reduction of chloramphenicol, p-nitrobenzoic acid and other aromatic nitro compounds in mammals. J Pharmacol Exp Ther (1957) 1.38
Metabolism of drugs in subjects with Laennec's cirrhosis. Med Exp Int J Exp Med (1959) 1.38
Postoperative pain; its use in the comparative evaluation of analgesics. Surgery (1952) 1.38
Assay of serotonin and related metabolites, enzymes, and drugs. Methods Biochem Anal (1958) 1.37
Microanalytical procedures for fluorometric assay of brain DOPA-5HTP decarboxylase, norepinephrine and serotonin, and a detailed mapping of decarboxylase activity in brain. J Neurochem (1961) 1.35
The physiological disposition and biotransformation of dibenamine and a method for its estimation in biological tissues. J Pharmacol Exp Ther (1952) 1.35
Fluorimetric determination of beta-glucuronidase. Biochem J (1954) 1.35
RELEASE OF METARAMINOL (ARAMINE) FROM THE HEART BY SYMPATHETIC NERVE STIMULATION. Science (1964) 1.33
The role of body fat in limiting the duration of action of thiopental. J Pharmacol Exp Ther (1952) 1.32
On the nature of the chemical mediators involved in anaphylactic reactions in mice. Br J Pharmacol Chemother (1963) 1.30
MECHANISM OF ACTION OF RESERPINE AND INSULIN ON GASTRIC AMINES AND GASTRIC ACID SECRETION, AND THE EFFECT OF MONOAMINE OXIDASE INHIBITION. J Pharmacol Exp Ther (1963) 1.28
Reserpine and guanethidine action on peripheral stores of catecholamines. Life Sci (1962) 1.27
FOLIC ACID ANTAGONIST. EFFECTS ON THE CELL AND THE PATIENT. COMBINED CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTH. Ann Intern Med (1963) 1.25
Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone. Am J Med (1954) 1.22
Effects of reserpine and cold-exposure on pituitary-adrenocortical function in rats. J Pharmacol Exp Ther (1961) 1.21
THE ACTIONS OF RESERPINE, GUANETHIDINE AND METARAMINOL ON CARDIAC CATECHOLAMINE STORES. Life Sci (1964) 1.18
Enzymatic reduction of prontosil and other azo dyes. J Pharmacol Exp Ther (1957) 1.17
The physiological disposition of dicumarol in man. J Pharmacol Exp Ther (1950) 1.17
Interaction of monoamine oxidase inhibitors with physiological and biochemical mechanisms in brain. Ann N Y Acad Sci (1959) 1.17