Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine: a review.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 1188458)

Published in J Psychiatry Neurosci on November 01, 1992

Authors

G B Baker1, R T Coutts, K F McKenna, R L Sherry-McKenna

Author Affiliations

1: Department of Psychiatry, University of Alberta, Edmonton, Canada.

Articles citing this

Child abuse and neglect, MAOA, and mental health outcomes: a prospective examination. Biol Psychiatry (2011) 1.01

Involvement of alpha1-adrenergic receptors in tranylcypromine enhancement of nicotine self-administration in rat. Psychopharmacology (Berl) (2007) 0.94

Acute treatment with antidepressant drugs selectively increases the expression of c-fos in the rat brain. J Psychiatry Neurosci (1995) 0.94

The effects of phenelzine and other monoamine oxidase inhibitor antidepressants on brain and liver I2 imidazoline-preferring receptors. Br J Pharmacol (1995) 0.89

The monoamine oxidase (MAO) inhibitor tranylcypromine enhances nicotine self-administration in rats through a mechanism independent of MAO inhibition. Neuropharmacology (2011) 0.87

The role of monoamine oxidase inhibitors in current psychiatric practice. J Psychiatr Pract (2004) 0.80

Age influences the effects of nicotine and monoamine oxidase inhibition on mood-related behaviors in rats. Psychopharmacology (Berl) (2010) 0.79

Neurochemical and metabolic aspects of antidepressants: an overview. J Psychiatry Neurosci (2000) 0.77

The Timing of Antidepressant Effects: A Comparison of Diverse Pharmacological and Somatic Treatments. Pharmaceuticals (Basel) (2010) 0.76

Mitigation of sensory and motor deficits by acrolein scavenger phenelzine in a rat model of spinal cord contusive injury. J Neurochem (2016) 0.76

Monoamine Oxidase-A Occupancy by Moclobemide and Phenelzine: Implications for the Development of Monoamine Oxidase Inhibitors. Int J Neuropsychopharmacol (2015) 0.75

Clonidine potentiates the effects of tranylcypromine, phenelzine and two analogues in the forced swimming test in mice. J Psychiatry Neurosci (2002) 0.75

Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6. Cell Mol Neurobiol (2004) 0.75

Articles cited by this

Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan. J Neurochem (1971) 3.34

Steric requirements for catecholamine uptake by rat brain synaptosomes: studies with rigid analogs of amphetamine. J Pharmacol Exp Ther (1972) 1.58

2-Phenylethylamine: a modulator of catecholamine transmission in the mammalian central nervous system? J Neurochem (1990) 1.29

Effect of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine and 5-hydroxytryptamine. Eur J Pharmacol (1977) 1.21

Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock. J Pharmacol Exp Ther (1985) 1.20

Evidence that deprenyl, A type B monoamine oxidase inhibitor, is an indirectly acting sympathomimetic amine. Biochem Pharmacol (1978) 1.15

A role for the serotonin system in the mechanism of action of antidepressant treatments: preclinical evidence. J Clin Psychiatry (1990) 1.12

The monoamine oxidase catalyzed degradation of phenelzine-l-14C, an irreversible inhibitor of monoamine oxidase--II. Studies in vivo. Biochem Pharmacol (1969) 1.11

The monoamine oxidase catalyzed degradation of phenelzine-l-14C, an irreversible inhibitor of monoamine oxidase--I. Studies in vitro. Biochem Pharmacol (1969) 1.10

Clinical pharmacology of monoamine oxidase inhibitors. Clin Neuropharmacol (1986) 1.08

METABOLISM OF TRANYLEYPROMINE-C14 AND DL AMPHETAMINE-C14 IN THE RAT. J Med Chem (1963) 1.06

Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by administration of antidepressants. Biochem Pharmacol (1981) 1.03

Relationship between the action of monoamine oxidase inhibitors on the noradrenaline uptake system and their antidepressant efficacy. Nature (1968) 1.01

Tranylcypromine ('Parnate') overdose: measurement of tranylcypromine concentrations and MAO inhibitory activity and identification of amphetamines in plasma. Psychol Med (1979) 0.98

Analysis of the inhibition of pethidine N-demethylation by monoamine oxidase inhibitors and some other drugs with special reference to drug interactions in man. Br J Pharmacol (1972) 0.93

Tranylcypromine: effects on norepinephrine metabolism in rat brain. Am J Psychiatry (1970) 0.91

The effect of monoamine oxidase inhibitors on some arylalkylamines in rate striatum. J Neurochem (1979) 0.90

Effects of tranylcypromine stereoisomers on monamine oxidation in man. Br J Clin Pharmacol (1980) 0.89

Effects of chronic monoamine oxidase inhibitor treatment on biogenic amine metabolism in rat brain. Neuropharmacology (1979) 0.88

Antidepressant--anxiolytic interaction: decreased density of benzodiazepine receptors in rat brain following chronic administration of antidepressants. Eur J Pharmacol (1984) 0.88

Inhibitory effect of tranylcypromine on hepatic drug metabolism in the rat. Biochem Pharmacol (1982) 0.86

Effect of monoamine oxidase inhibitors on the N-demethylation and hydrolysis of meperidine. Biochem Pharmacol (1970) 0.86

Inhibition of cytochrome P-450-dependent oxidation reactions by MAO inhibitors in rat liver microsomes. Biochem Pharmacol (1987) 0.86

Role of gamma-aminobutyric acid in antipanic drug efficacy. Am J Psychiatry (1989) 0.85

The effects of tranylcypromine isomers on norepinephrine-H3 metabolism in rat brain. Psychopharmacology (Berl) (1980) 0.83

Benzodiazepine and GABAA receptors in rat brain following chronic antidepressant drug administration. Biochem Pharmacol (1987) 0.83

Some effects of monoamine oxidase inhibitors on the metabolism of gamma-aminobutyric acid in rat brain. J Neurochem (1969) 0.83

Pharmacokinetics of tranylcypromine in patients who are depressed: relationship to cardiovascular effects. Clin Pharmacol Ther (1986) 0.82

Neurochemical and neuropharmacological properties of 4-fluorotranylcypromine. Cell Mol Neurobiol (1987) 0.82

Effects of the antidepressant phenelzine on brain levels of gamma-aminobutyric acid (GABA). J Affect Disord (1991) 0.82

Implications of chirality and geometric isomerism in some psychoactive drugs and their metabolites. Chirality (1989) 0.82

Antidepressant treatments, including sibutramine hydrochloride and electroconvulsive shock, decrease beta 1- but not beta 2-adrenoceptors in rat cortex. J Neurochem (1989) 0.82

Inhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by acute administration of small doses of antidepressants. Br J Pharmacol (1982) 0.80

Inhibitory effect of phenelzine on oxidative microsomal enzyme systems of rat liver. Can J Physiol Pharmacol (1983) 0.80

Pharmacotherapy of the panic disorders. J Clin Psychiatry (1986) 0.80

Sustained drug-induced elevation of brain GABA in the rat. J Neurochem (1973) 0.80

High dose tranylcypromine therapy for refractory depression. Pharmacopsychiatry (1989) 0.80

Chronic administration of the antidepressant-antipanic drug phenelzine and its N-acetylated analogue: effects on monoamine oxidase, biogenic amines, and alpha 2-adrenoreceptor function. J Pharm Sci (1992) 0.79

Metabolism and pharmacokinetics of phenelzine: lack of evidence for acetylation pathway in humans. J Clin Psychopharmacol (1985) 0.79

Preferential reduction of binding of 125I-iodopindolol to beta-1 adrenoceptors in the amygdala of rat after antidepressant treatments. J Pharmacol Exp Ther (1991) 0.79

Use of tryptophan in combination with other antidepressant treatments: a review. J Psychiatry Neurosci (1991) 0.79

High-dosage tranylcypromine in refractory depression. J Clin Psychiatry (1987) 0.78

Refractory depression treated with high doses of monoamine oxidase inhibitor. J Clin Psychiatry (1987) 0.78

Differential effects of chronic antidepressants in behavioural tests of beta-adrenergic and GABAB receptor function. Psychopharmacology (Berl) (1991) 0.78

Monoamine oxidase inhibitors: a review. J Clin Psychiatry (1983) 0.78

The behavioural effects of phenelzine and phenylethylamine may be due to amine release. Brain Res Bull (1984) 0.78

Metabolic acetylation of phenelzine in rats. Res Commun Chem Pathol Pharmacol (1988) 0.78

Tissue levels and some pharmacological properties of an acetylated metabolite of phenelzine in the rat. J Pharm Sci (1991) 0.78

Recent studies on the MAO inhibitor phenelzine and its possible metabolites. J Neural Transm Suppl (1990) 0.78

N2-acetylphenelzine: effects on rat brain GABA, alanine and biogenic amines. Naunyn Schmiedebergs Arch Pharmacol (1991) 0.78

Formation of beta-phenylethylamine from the antidepressant, beta-phenylethylhydrazine. Biochem Pharmacol (1985) 0.77

Effects of tranylcypromine on the concentration of some trace amines in the diencephalon and hippocampus of the rat. Experientia (1980) 0.77

Antidepressant drugs: effects on beta-adrenergic and serotonineregic receptors. Adv Biochem Psychopharmacol (1982) 0.77

The relationship of acetylation phenotype to treatment with MAOIs: a review. J Clin Psychopharmacol (1982) 0.77

Inhibition of aromatic L-amino acid decarboxylase and tyrosine aminotransferase by the monoamine oxidase inhibitor phenelzine. J Neurochem (1986) 0.77

Long-lasting elevation of alanine in brain produced by the antidepressant phenelzine. Brain Res Bull (1990) 0.77

Effects of the antidepressant/antipanic drug phenelzine on GABA concentrations and GABA-transaminase activity in rat brain. Biochem Pharmacol (1992) 0.77

Para-hydroxytranylcypromine: presence in rat brain and heart following administration of tranylcypromine and an N-cyanoethyl analogue. Eur J Drug Metab Pharmacokinet (1988) 0.76

Chronic tranylcypromine treatment induces functional alpha 2-adrenoceptor down-regulation in rats. Eur J Pharmacol (1988) 0.76

Detection and quantitation of a ring-hydroxylated metabolite of the antidepressant drug tranylcypromine. J Neural Transm (1986) 0.76

Rapid development of brain beta-adrenoceptor down-regulation induced by phenelzine: subcellular studies. Eur J Pharmacol (1989) 0.76

Chronic effects of a monoamine oxidase-inhibiting antidepressant: decreases in functional alpha-adrenergic autoreceptors precede the decrease in norepinephrine-stimulated cyclic adenosine 3': 5'-monophosphate systems in rat brain. J Neurosci (1982) 0.76

Effects of acute and chronic administration of phenelzine on 2-phenylethylamine levels in rat brain. Proc West Pharmacol Soc (1982) 0.76

4-Methoxytranylcypromine, a monoamine oxidase inhibitor: effects on biogenic amines in rat brain following chronic administration. Biol Psychiatry (1992) 0.76

Effects of low-dose 4-fluorotranylcypromine on rat brain monoamine oxidase and neurotransmitter amines. Biol Psychiatry (1990) 0.76

Lowering of brain levels of the depressant prostaglandin D2 by the anti-depressant tranylcypromine. Biochem Pharmacol (1982) 0.76

Monoamine oxidase inhibitor-responsive depression. Psychiatry Res (1982) 0.76

A method for measurement of tranylcypromine in rat brain regions using gas chromatography with electron capture detection. Biochem Pharmacol (1981) 0.76

Effects of monoamine oxidase inhibitors on release of dopamine and 5-hydroxytryptamine from rat striatum in vitro. Cell Mol Biol Incl Cyto Enzymol (1980) 0.76

Acute cardiovascular effects of tranylcypromine: correlation with plasma drug, metabolite, norepinephrine, and MHPG levels. J Clin Psychiatry (1991) 0.76

MAO inhibitors and platelet MAO inhibition. Commun Psychopharmacol (1980) 0.76

Tranylcypromine stereoisomers, monoaminergic neurotransmission and behavior. A minireview. Pharmakopsychiatr Neuropsychopharmakol (1980) 0.76

[The anticonvulsant action of (+)- and (-)-tranylcypromine]. Pharmazie (1991) 0.76

Enzymatic N-methylation of phenelzine catalyzed by methyltransferases from adrenal and other tissues. Drug Metab Dispos (1991) 0.76

Antipyrine elimination by patients under treatment with monoamine oxidase inhibitors. Br J Clin Pharmacol (1980) 0.76

Psychoactive drug interactions. J Clin Psychiatry (1978) 0.76

Effect of some monoamine oxidase inhibitors on the thiamin status of rabbits. Br J Pharmacol (1985) 0.75

Differential effects of tranylcypromine and pargyline on indoleamines in brain. Biochem Pharmacol (1976) 0.75

Articles by these authors

Metabolism of amphetamines. Identification of N-oxygenated products by gas chromatography and mass spectrometry. J Pharm Pharmacol (1973) 1.10

Involvement of CYP3A4 and CYP2D6 in the metabolism of haloperidol. Cell Mol Neurobiol (1997) 1.01

Synthesis of N-propargylphenelzine and analogues as neuroprotective agents. Bioorg Med Chem Lett (2001) 0.97

Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives. Xenobiotica (1999) 0.94

Effects of intravenous lipid as a source of energy in parenteral nutrition associated hepatic dysfunction and lidocaine elimination: a study using isolated rat liver perfusion. Biopharm Drug Dispos (1997) 0.92

Metabolic drug interactions with selective serotonin reuptake inhibitor (SSRI) antidepressants. Neurosci Biobehav Rev (1998) 0.88

Metabolism of monoamine oxidase inhibitors. Cell Mol Neurobiol (1999) 0.87

Pharmacokinetics of ibuprofen enantiomers in humans following oral administration of tablets with different absorption rates. Pharm Res (1988) 0.87

Comparison of chemical components and antioxidants capacity of different Echinacea species. J Pharm Pharmacol (2001) 0.86

Simultaneous determination of fluoxetine and norfluoxetine enantiomers in biological samples by gas chromatography with electron-capture detection. J Chromatogr (1992) 0.85

Determination of paroxetine levels in human plasma using gas chromatography with electron-capture detection. J Chromatogr B Biomed Sci Appl (2000) 0.84

Identification of kaempferol as a monoamine oxidase inhibitor and potential Neuroprotectant in extracts of Ginkgo biloba leaves. J Pharm Pharmacol (2000) 0.83

Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry (1991) 0.83

Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine. Cell Mol Neurobiol (1999) 0.83

Stereoselective gas chromatographic analysis of etodolac enantiomers in human plasma and urine. J Chromatogr (1986) 0.83

Elucidation of individual cytochrome P450 enzymes involved in the metabolism of clozapine. Naunyn Schmiedebergs Arch Pharmacol (1998) 0.82

Dose-response relationship of doxapram in the therapy for refractory idiopathic apnea of prematurity. Pediatrics (1987) 0.82

Interactions of iprindole with fenfluramine metabolism in rat brain and liver. J Psychiatry Neurosci (1991) 0.82

Effects of the antidepressant phenelzine on brain levels of gamma-aminobutyric acid (GABA). J Affect Disord (1991) 0.82

The antidepressant drug phenelzine produces antianxiety effects in the plus-maze and increases in rat brain GABA. Psychopharmacology (Berl) (1996) 0.82

Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system. Cell Mol Neurobiol (1989) 0.81

Doxapram dosage regimen in apnea of prematurity based on pharmacokinetic data. Dev Pharmacol Ther (1988) 0.80

Metabolism in vitro of N-methylamphetamine with rat liver homogenates. Biochem Pharmacol (1977) 0.80

Urinary excretion of phenolic metabolites of N-(n-propyl)amphetamine in man. Res Commun Chem Pathol Pharmacol (1977) 0.80

Chemical and pharmacological evaluation of Hypericum perforatum extracts. Acta Pharmacol Sin (2000) 0.80

Metabolism and disposition of N-(2-cyanoethyl)amphetamine (fenproporex) and amphetamine: study in the rat brain. Can J Physiol Pharmacol (1986) 0.79

In vivo phenolic metabolites of N-alkylamphetamines in the rat. Evidence in favor of catechol formation. Drug Metab Dispos (1976) 0.79

Fungal metabolism of (-)-deprenyl and pargyline. Life Sci (1981) 0.79

In vitro metabolism of 1-phenyl-2-(n-propylamino) propane (N-propylamphetamine) by rat liver homogenates. J Pharm Pharmacol (1976) 0.79

Chronic administration of the antidepressant-antipanic drug phenelzine and its N-acetylated analogue: effects on monoamine oxidase, biogenic amines, and alpha 2-adrenoreceptor function. J Pharm Sci (1992) 0.79

N-(2-cyanoethyl)tranylcypromine, a potential prodrug of tranylcypromine: its disposition and interaction with catecholamine neurotransmitters in brain. Pharm Res (1987) 0.79

Acetylation and pentafluorobenzoylation of lidocaine metabolites in aqueous solution and identification of derivatives by combined gas chromatography/mass spectrometry. Biomed Environ Mass Spectrom (1987) 0.79

Determination of p-trifluoromethylphenol, a metabolite of fluoxetine, in tissues and body fluids using an electron-capture gas chromatographic procedure. J Chromatogr B Biomed Sci Appl (1997) 0.79

Failure to detect amphetamine or 1-amino-3-phenylpropane in humans or rats receiving the MAO inhibitor tranylcypromine. J Affect Disord (2000) 0.78

Neuropharmacological and neurochemical properties of N-(2-cyanoethyl)-2-phenylethylamine, a prodrug of 2-phenylethylamine. Br J Pharmacol (1987) 0.78

Synthesis and pharmacological evaluation of some , -disubstituted analogs of acetylcholine. J Med Chem (1972) 0.78

Electron-capture gas chromatographic analysis of beta-phenylethylamine in tissues and body fluids using pentafluorobenzenesulfonyl chloride for derivatization. J Chromatogr (1986) 0.78

Metabolic acetylation of phenelzine in rats. Res Commun Chem Pathol Pharmacol (1988) 0.78

N2-acetylphenelzine: effects on rat brain GABA, alanine and biogenic amines. Naunyn Schmiedebergs Arch Pharmacol (1991) 0.78

Recent studies on the MAO inhibitor phenelzine and its possible metabolites. J Neural Transm Suppl (1990) 0.78

Effects of intravenous infusion of lidocaine on its pharmacokinetics in conscious instrumented dogs. J Pharm Sci (1997) 0.77

Analysis of imipramine and three metabolites produced by isozyme CYP2D6 expressed in a human cell line. Xenobiotica (1993) 0.77

Long-lasting elevation of alanine in brain produced by the antidepressant phenelzine. Brain Res Bull (1990) 0.77

N-(3-chloropropyl)phenylethylamine as a possible prodrug of beta-phenylethylamine: studies in the rat brain. Prog Neuropsychopharmacol Biol Psychiatry (1987) 0.77

Biogenic amines and their metabolites in Alzheimer's disease: noradrenaline, 5-hydroxytryptamine and 5-hydroxyindole-3-acetic acid depleted in hippocampus but not in substantia innominata. Neurosci Lett (1989) 0.77

Neurochemical and metabolic aspects of antidepressants: an overview. J Psychiatry Neurosci (2000) 0.77

Effects of the antidepressant/antipanic drug phenelzine on GABA concentrations and GABA-transaminase activity in rat brain. Biochem Pharmacol (1992) 0.77

N,N-dipropargyl-2-phenylethylamine, a potential prodrug of 2-phenylethylamine: neurochemical and neuropharmacological studies in rat. Brain Res Bull (1987) 0.77

Adverse drug reactions and debrisoquine/sparteine (P450IID6) polymorphism in patients with fibromyalgia. Clin Rheumatol (1997) 0.77

A gas chromatographic procedure for separation and quantitation of the enantiomers of the antidepressant tranylcypromine. Biochem Pharmacol (1992) 0.77

Lack of a pharmacokinetic interaction between doxapram and theophylline in apnea of prematurity. Dev Pharmacol Ther (1991) 0.77

High-performance liquid chromatographic determination of the enantiomers of flecainide in human plasma and urine. J Pharm Sci (1990) 0.76

Detection and quantitation of a ring-hydroxylated metabolite of the antidepressant drug tranylcypromine. J Neural Transm (1986) 0.76

Rat brain concentrations of 5-hydroxytryptamine following acute and chronic administration of MAO-inhibiting antidepressants. Prog Neuropsychopharmacol Biol Psychiatry (1984) 0.76

Metabolism of antidepressants: urinary metabolites of trimipramine in the rat. Prog Neuropsychopharmacol Biol Psychiatry (1991) 0.76

Effects of acute and chronic administration of phenelzine on 2-phenylethylamine levels in rat brain. Proc West Pharmacol Soc (1982) 0.76

Metabolism of N,N-dialkylated amphetamines, including deprenyl, by CYP2D6 expressed in a human cell line. Xenobiotica (2000) 0.76

Human CYP2D6 and metabolism of m-chlorophenylpiperazine. Biol Psychiatry (1998) 0.76

Determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, by gas chromatography with electron-capture detection. J Chromatogr B Biomed Appl (1996) 0.76

A rapid and sensitive electron-capture gas chromatographic method for the analysis of tranylcypromine in brain tissue using acetylation and pentafluorobenzoylation. J Biochem Biophys Methods (1984) 0.76

Analysis of amines in the central nervous system by gas chromatography with electron-capture detection. Prog Neurobiol (1981) 0.76

A rapid electron-capture gas chromatographic method for the quantification of fluvoxamine in brain tissue. J Pharmacol Toxicol Methods (1997) 0.76

Effects of low-dose 4-fluorotranylcypromine on rat brain monoamine oxidase and neurotransmitter amines. Biol Psychiatry (1990) 0.76

Pentafluorobenzenesulfonyl chloride as a sensitive reagent for the rapid gas chromatographic analysis of tranylcypromine in tissues and body fluids. Biochem Pharmacol (1986) 0.76

Rapid analysis of beta-phenylethylamine in tissues and body fluids utilizing pentafluorobenzoylation followed by electron-capture gas chromatography. Prog Neuropsychopharmacol Biol Psychiatry (1987) 0.76

Conditioned place preferences, conditioned locomotion, and behavioral sensitization occur in rats treated with diethylpropion. Pharmacol Biochem Behav (1995) 0.76

A comparison of the neurochemical properties of the stereoisomers of tranylcypromine in the central nervous system. Cell Mol Biol (1986) 0.76

A method for measurement of tranylcypromine in rat brain regions using gas chromatography with electron capture detection. Biochem Pharmacol (1981) 0.76

Chronic tranylcypromine treatment induces functional alpha 2-adrenoceptor down-regulation in rats. Eur J Pharmacol (1988) 0.76

4-Methoxytranylcypromine, a monoamine oxidase inhibitor: effects on biogenic amines in rat brain following chronic administration. Biol Psychiatry (1992) 0.76

Displacement of serotonin from binding sites in rat cortex: the effects of biogenic "trace" amines. Prog Neuropsychopharmacol Biol Psychiatry (1984) 0.76

Effects of taurine supplementation in parenteral nutrition-associated hepatosteatosis and lidocaine metabolism. A study using isolated rat liver perfusion. Drug Metab Dispos (1996) 0.76

Para-hydroxytranylcypromine: presence in rat brain and heart following administration of tranylcypromine and an N-cyanoethyl analogue. Eur J Drug Metab Pharmacokinet (1988) 0.76

Trace amines and Tourette's syndrome. Neurochem Res (1993) 0.75

Hydralazine pharmacokinetics and interaction with food: an evaluation of the dog as an animal model. Pharm Res (1990) 0.75

Chronic administration of the antidepressant phenelzine and its N-acetyl analogue: effects on GABAergic function. J Neural Transm Suppl (1994) 0.75

Derivatization with acetic anhydride: applications to the analysis of biogenic amines and psychiatric drugs by gas chromatography and mass spectrometry. J Pharmacol Toxicol Methods (1994) 0.75

Metabolism of trimipramine in vitro by human CYP2D6 isozyme. Res Commun Chem Pathol Pharmacol (1993) 0.75

The effects of desipramine and iprindole on levels of enantiomers of fluoxetine in rat brain and urine. Chirality (1994) 0.75

Simultaneous quantification of fluoxetine, norfluoxetine, and desipramine using gas chromatography with nitrogen-phosphorus detection. J Pharmacol Toxicol Methods (1995) 0.75

A rapid, sensitive assay for gamma-aminobutyric acid in brain using electron-capture gas chromatography. Res Commun Chem Pathol Pharmacol (1990) 0.75

Metabolism of (+/-)-N-(n-propyl) amphetamine by Cunninghamella echinulata. Appl Environ Microbiol (1979) 0.75

Metabolism of monoamine oxidase inhibitors. Prog Neuropsychopharmacol Biol Psychiatry (1989) 0.75

Human metabolism of methoxyphenamine. J Chromatogr (1977) 0.75

Analysis of a monofluorinated analogue of amphetamine in brain tissue using gas chromatography with electron-capture detection. Prog Neuropsychopharmacol Biol Psychiatry (1982) 0.75

Selected ion mass spectrometric identification of chlorophenol residues in human urine. J Assoc Off Anal Chem (1983) 0.75

Amphetamine in rat brain and urine after administration of pheniprazine. Proc West Pharmacol Soc (1982) 0.75

Studies on isometheptene metabolism. Identification and stereochemistry of a major metabolite isolated from rat urine. Drug Metab Dispos (1978) 0.75

Interaction of beta-carbolines with the benzodiazepine receptor. Structure-activity relationships of amide derivatives of beta-carboline and tetrahydro-beta-carboline. Prog Neuropsychopharmacol Biol Psychiatry (1982) 0.75

Metabolism of N-alkylating derivatives of amphetamine by guinea pig and rabbit liver homogenates. Proc West Pharmacol Soc (1982) 0.75

Para-chlorophenylethylamine in brains of rats treated with a monoamine oxidase inhibitor and p-chlorophenylalanine. Prog Neuropsychopharmacol Biol Psychiatry (1982) 0.75

Stereospecific metabolic reduction of ketones. J Pharm Sci (1982) 0.75

Species differences in the in vitro metabolic reduction of the amphetamine metabolite, 1-phenyl-2-propanone. J Pharm Pharmacol (1978) 0.75

N-ethyl-alpha-methyl-alpha-(m-trifluoromethylbenzyl)nitrone--the major in vitro metabolic product of fenfluramine in guinea-pig liver microsomal fractions. J Pharm Pharmacol (1973) 0.75