Inhibition of liver, kidney, and intestine regeneration by rapamycin.

PubWeight™: 1.00‹?› | Rank: Top 15%

🔗 View Article (PMC 2979306)

Published in Transplantation on February 01, 1992

Authors

A Francavilla1, T E Starzl, C Scotti, G Carrieri, A Azzarone, Q H Zeng, K A Porter, S L Schreiber

Author Affiliations

1: Department of Surgery, University of Pittsburgh, PA 15213.

Articles citing this

A fresh look at augmenter of liver regeneration in rats. Hepatology (1999) 1.32

Effects of rapamycin on cultured hepatocyte proliferation and gene expression. Hepatology (1992) 1.06

The in vivo effect of hepatotrophic factors augmenter of liver regeneration, hepatocyte growth factor, and insulin-like growth factor-II on liver natural killer cell functions. Hepatology (1997) 1.04

The physiology and pathophysiology of rapamycin resistance: implications for cancer. Cell Cycle (2011) 0.91

Portacaval shunt causes apoptosis and liver atrophy in rats despite increases in endogenous levels of major hepatic growth factors. J Hepatol (2002) 0.88

mTOR signaling in liver regeneration: Rapamycin combined with growth factor treatment. World J Transplant (2013) 0.87

Amphiregulin stimulates liver regeneration after small-for-size mouse liver transplantation. Am J Transplant (2012) 0.83

Oral administration of rapamycin and cyclosporine differentially alter intestinal function in rabbits. Dig Dis Sci (1998) 0.82

Rapamycin Inhibition of mTOR Reduces Levels of the Na+/H+ Exchanger 3 in Intestines of Mice and Humans, Leading to Diarrhea. Gastroenterology (2015) 0.80

Effects on in vivo and in vitro hepatocyte proliferation of methylprednisolone, azathioprine, mycophenolic acid, mizoribine, and prostaglandin E1. Transplant Proc (1992) 0.78

Intestinal Epithelial-Specific mTORC1 Activation Enhances Intestinal Adaptation After Small Bowel Resection. Cell Mol Gastroenterol Hepatol (2016) 0.75

Hepatic growth effects of methylprednisolone, azathioprine, mycophenolic acid, and mizoribine. Transplantation (1993) 0.75

8-pCPT-cGMP prevents mitochondrial depolarization and improves the outcome of steatotic partial liver transplantation. Int J Physiol Pathophysiol Pharmacol (2017) 0.75

Articles cited by this

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins. Nature (1989) 8.48

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature (1989) 7.02

Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science (1991) 6.80

Abdominal organ cluster transplantation for the treatment of upper abdominal malignancies. Ann Surg (1989) 5.78

A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature (1989) 5.53

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci U S A (1990) 3.70

Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin. J Immunol (1990) 3.29

Hepatotrophic effects of FK506 in dogs. Transplantation (1991) 2.39

The hepatotropic influence of cyclosporine. Surgery (1990) 2.27

Augmentation of rat liver regeneration by FK 506 compared with cyclosporin. Lancet (1989) 2.01

The refolding of urea-denatured ribonuclease A is catalyzed by peptidyl-prolyl cis-trans isomerase. Biochim Biophys Acta (1985) 1.75

Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding. Nature (1990) 1.74

Transplantation. JAMA (1990) 1.71

Cyclosporine A augments the regenerative response after partial hepatectomy in the rat. Transplant Proc (1988) 1.64

Cyclosporin A stimulates proliferation of the liver cells after partial hepatectomy in rats. Surg Gynecol Obstet (1988) 1.60

EFFECT OF CYCLOSPORIN ON HEPATIC REGENERATION. Surg Forum (1986) 1.59

Activity of rapamycin (AY-22,989) against transplanted tumors. J Antibiot (Tokyo) (1984) 1.44

Cyclosporin A hepatotoxicity in 66 renal allograft recipients. Transplantation (1981) 1.38

FK 506 as a growth control factor. Transplant Proc (1990) 1.36

Human brain tumor xenografts in nude mice as a chemotherapy model. Eur J Cancer Clin Oncol (1983) 1.32

Studies on mechanisms of augmentation of liver regeneration by cyclosporine and FK 506. Hepatology (1991) 1.13

Distribution of the cyclosporine binding protein cyclophilin in human tissues. Immunology (1991) 1.13

Cyclosporin A inhibits degranulation of rat basophilic leukemia cells and human basophils. Inhibition of mediator release without affecting PI hydrolysis or Ca2+ fluxes. J Immunol (1990) 1.05

Hepatotrophic properties in dogs of human FKBP, the binding protein for FK506 and rapamycin. Transplantation (1991) 1.01

In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts. Cancer Treat Rev (1990) 0.95

The immunochemical distribution of cyclophilin in normal mammalian tissues. Transplantation (1991) 0.87

Articles by these authors

Evolution of liver transplantation. Hepatology (1982) 19.54

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell (1991) 15.76

A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (1996) 12.64

Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (1999) 12.52

A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature (1994) 11.50

Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin. J Mol Biol (1993) 11.24

Printing proteins as microarrays for high-throughput function determination. Science (2000) 10.77

A flexible procedure for multiple cadaveric organ procurement. Surg Gynecol Obstet (1984) 10.33

Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Cell (1997) 8.99

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science (1995) 8.58

Orthotopic liver transplantation in ninety-three patients. Surg Gynecol Obstet (1976) 8.11

The use of cyclosporin A and prednisone in cadaver kidney transplantation. Surg Gynecol Obstet (1980) 7.40

The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation. Surg Gynecol Obstet (1967) 7.24

Fifteen years of clinical liver transplantation. Gastroenterology (1979) 7.19

Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature (1995) 7.05

Venous bypass in clinical liver transplantation. Ann Surg (1984) 7.04

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. Nature (1989) 7.02

Liver transplantation with use of cyclosporin a and prednisone. N Engl J Med (1981) 6.95

Controlling signal transduction with synthetic ligands. Science (1993) 6.70

Orthotopic homotransplantation of the human liver. Ann Surg (1968) 6.64

Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A (1999) 6.50

Structural basis for the binding of proline-rich peptides to SH3 domains. Cell (1994) 6.34

Histone deacetylase activity is required for full transcriptional repression by mSin3A. Cell (1997) 6.27

Vascular homografts from cadaveric organ donors. Surg Gynecol Obstet (1979) 6.23

Long survival in rats after multivisceral versus isolated small-bowel allotransplantation under FK 506. Surgery (1991) 5.92

Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science (1996) 5.92

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins. Proc Natl Acad Sci U S A (1999) 5.89

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature (1998) 5.84

Infections after liver transplantation. An analysis of 101 consecutive cases. Medicine (Baltimore) (1988) 5.77

Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporin-steroid therapy. Lancet (1984) 5.74

Refinements in the surgical technique of liver transplantation. Semin Liver Dis (1985) 5.70

Progress in and deterrents to orthotopic liver transplantation, with special reference to survival, resistance to hyperacute rejection, and biliary duct reconstruction. Transplant Proc (1974) 5.53

Extended survival in 3 cases of orthotopic homotransplantation of the human liver. Surgery (1968) 5.44

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J (1998) 5.25

Cyclophosphamide and whole organ transplantation in human beings. Surg Gynecol Obstet (1971) 5.24

Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization. Proc Natl Acad Sci U S A (2000) 5.18

Alternative methods of arterialization of the hepatic graft. Surg Gynecol Obstet (1984) 5.16

Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction. Surgery (1988) 5.03

Liver, kidney, and thoracic organ transplantation under FK 506. Ann Surg (1990) 5.01

Conversion from cyclosporine to FK 506 in liver allograft recipients with cyclosporine-related complications. Transplant Proc (1990) 4.90

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions. Science (1994) 4.57

PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science (1995) 4.51

Pancreaticoduodenal transplantation in humans. Surg Gynecol Obstet (1984) 4.49

Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology (1994) 4.32

A simplified technique for revascularization of homografts of the liver with a variant right hepatic artery from the superior mesenteric artery. Surg Gynecol Obstet (1985) 4.29

Heterotopic heart transplantation in the rat receiving FK-506 alone or with cyclosporine. Transplant Proc (1987) 4.21

Pancreatic islet transplantation after upper abdominal exenteration and liver replacement. Lancet (1990) 4.18

Experience in hepatic resection for metastatic colorectal cancer: analysis of clinical and pathologic risk factors. Surgery (1994) 4.16

Orthotopic liver transplantation with preservation of the inferior vena cava. Ann Surg (1989) 4.12

Malignant lymphomas in transplantation patients. Transplant Proc (1969) 4.12

Role of liver transplantation in cancer therapy. Ann Surg (1985) 4.08

Biliary complications after liver transplantation: with special reference to the biliary cast syndrome and techniques of secondary duct repair. Surgery (1977) 4.08

Shwartzman reaction after human renal homotransplantation. N Engl J Med (1968) 4.05

Extended preservation of human liver grafts with UW solution. JAMA (1989) 3.99

Canine and human liver preservation for 6 to 18 hr by cold infusion. Transplantation (1977) 3.99

Clinical presentation of hepatic artery thrombosis after liver transplantation in the cyclosporine era. Transplantation (1985) 3.91

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue. Proc Natl Acad Sci U S A (1995) 3.87

The preparation and testing of horse antidog and antihuman antilymphoid plasma or serum and its protein fractions. Surg Gynecol Obstet (1967) 3.86

Replacement of donor lymphoid tissue in small-bowel transplants. Lancet (1991) 3.85

A role for histone deacetylase activity in HDAC1-mediated transcriptional repression. Proc Natl Acad Sci U S A (1998) 3.85

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet (1973) 3.84

Effects of insulin, glucagon, and insuling/glucagon infusions on liver morphology and cell division after complete portacaval shunt in dogs. Lancet (1976) 3.74

Immunosuppressive effect of FK-506 on in vitro lymphocyte alloactivation: synergism with cyclosporine A. Transplant Proc (1987) 3.73

Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol (1999) 3.72

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci U S A (1990) 3.70

CoREST is an integral component of the CoREST- human histone deacetylase complex. Proc Natl Acad Sci U S A (2001) 3.66

Hepatic trisegmentectomy and other liver resections. Surg Gynecol Obstet (1975) 3.66

Right trisegmentectomy for hepatic neoplasms. Surg Gynecol Obstet (1980) 3.64

Variable chimerism, graft-versus-host disease, and tolerance after different kinds of cell and whole organ transplantation from Lewis to brown Norway rats. Transplantation (1995) 3.63

Hepatic Retransplantation. Transplant Proc (1985) 3.62

Transplantation of multiple abdominal viscera. JAMA (1989) 3.59

Hepatic resection versus transplantation for hepatocellular carcinoma. Ann Surg (1991) 3.57

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin. Cell (1995) 3.56

Canine liver transplantation under Nva2-cyclosporine versus cyclosporine. Transplantation (1986) 3.54

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc Natl Acad Sci U S A (1999) 3.49

Combination donor hepatectomy and nephrectomy and early functional results of allografts. Surg Gynecol Obstet (1982) 3.49

Cadaveric renal transplantation. An analysis of 65 cases. Lancet (1969) 3.48

Long-term survival after renal transplantation in humans: (with special reference to histocompatibility matching, thymectomy, homograft glomerulonephritis, heterologous ALG , AND RECIPIENT MALIGNANCY). Ann Surg (1970) 3.48

Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A (2000) 3.46

Selected topics on FK 506, with special references to rescue of extrahepatic whole organ grafts, transplantation of "forbidden organs," side effects, mechanisms, and practical pharmacokinetics. Transplant Proc (1991) 3.40

Nephrotoxicity of cyclosporin A in liver and kidney transplant patients. Lancet (1981) 3.38

The relation of preoperative coagulation findings to diagnosis, blood usage, and survival in adult liver transplantation. Transplantation (1985) 3.38