Published in J Biol Chem on April 01, 1962
A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1970) 23.79
Radioimmunoassay for the measurement of adenosine 3',5'-cyclic phosphate. Proc Natl Acad Sci U S A (1969) 7.81
The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood. Surg Gynecol Obstet (1973) 3.84
Pseudohypoparathyroidism: defective excretion of 3',5'-AMP in response to parathyroid hormone. J Clin Invest (1969) 3.41
Differentiation of T cells induced by preparations from thymus and by nonthymic agents. J Exp Med (1973) 3.12
D-myoinositol 1:2-cyclic phosphate 2-phosphohydrolase. Biochem J (1972) 3.05
Parathyroid function and the renal excretion of 3'5'-adenylic acid. Proc Natl Acad Sci U S A (1967) 2.81
Cyclic adenosine 3',5'-monophosphate and morphogenesis in Mucor racemosus. J Bacteriol (1974) 2.67
Adenosine receptors and behavioral actions of methylxanthines. Proc Natl Acad Sci U S A (1981) 2.66
Inhibition of rabbit intestine mediated by alpha- and beta-adrenoceptors. Br J Pharmacol (1970) 2.64
Cyclic adenosine 3':5'-monophosphate-stimulated phosphorylation of isolated neurotubule subunits. Proc Natl Acad Sci U S A (1970) 2.56
A possible role for the adenylcyclase system in insulin secretion. J Clin Invest (1967) 2.54
The role of [Ca2+]i and [Ca2+] sensitization in the caffeine contracture of rat myocytes: measurement of [Ca2+]i and [caffeine]i. J Physiol (1990) 2.48
Cyclic adenosine monophosphate, CA++, and membranes. Proc Natl Acad Sci U S A (1968) 2.46
The inhibition of plant and animal adenosine 3':5'-cyclic monophosphate phosphodiesterases by a cell-division-promoting substance from tissues of higher plant species. Proc Natl Acad Sci U S A (1972) 2.36
Evidence for a role of cyclic AMP in neuromuscular transmission. Proc Natl Acad Sci U S A (1969) 2.32
THE MEASUREMENT OF CYCLIC ADENYLATE IN TISSUES. Proc Natl Acad Sci U S A (1964) 2.28
Isolation of adenyl cyclase from Escherichia coli. Proc Natl Acad Sci U S A (1969) 2.23
PDE4 inhibitors: current status. Br J Pharmacol (2008) 2.23
Stimulated formation of adenosine 3',5'-cyclic phosphate in cerebral cortex: synergism between electrical activity and biogenic amines. Proc Natl Acad Sci U S A (1970) 2.19
Kinetic parameters and renal clearances of plasma adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in man. J Clin Invest (1970) 2.18
Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol (1983) 2.10
Effect of adenosine 3'-5'-cyclic monophosphate on cell proliferation. J Cell Biol (1972) 2.00
A non-adrenergic inhibitory nervous pathway in guinea-pig trachea. Br J Pharmacol (1974) 1.97
The modulating influence of cyclic nucleotides upon lymphocyte-mediated cytotoxicity. J Exp Med (1973) 1.92
Adenosine 3',5'-monophosphate in rat uterus: acute elevation by estrogen. Proc Natl Acad Sci U S A (1967) 1.87
ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine. J Invest Dermatol (2009) 1.86
Effects of parathyroid hormone on plasma and urinary adenosine 3',5'-monophosphate in man. J Clin Invest (1970) 1.86
Pentitols and insulin release by isolated rat islets of Langerhans. Biochem J (1968) 1.82
Adenine nucleotides and synaptic transmission in the in vitro rat hippocampus. Br J Pharmacol (1980) 1.78
Enzyme secretion in mouse pancreas mediated by adenosine-3'5'-cyclic phosphate and inhibited by adenosine-3'-phosphate. Proc Natl Acad Sci U S A (1968) 1.77
The effect of substances releasing intracellular calcium ions on sodium-dependent calcium efflux from guinea-pig auricles. J Physiol (1975) 1.74
Caffeine inhibits inositol trisphosphate-mediated liberation of intracellular calcium in Xenopus oocytes. J Physiol (1991) 1.74
Regulation of adenosine 3',5'-cyclic monophosphate phosphodiesterase activity in fibroblasts by intracellular concentrations of cyclic adenosine monophosphate (3T3-dibutyryl cyclic AMP-SV40-transformed cells-michaelis constants-L cells-prostaglandin E 1 ). Proc Natl Acad Sci U S A (1972) 1.72
Role of Vibrio cholerae neuraminidase in the function of cholera toxin. Infect Immun (1992) 1.72
Phosphodiesterase inhibitors. Br J Pharmacol (2006) 1.72
Turnover of protein-bound phosphorylserine in membrane preparations from ox brain catalysed by intrinsic kinase and phosphatase activity. Biochem J (1971) 1.68
Adenosine 3':5'-cyclic monophosphate as a regulator of bacterial transformation. Proc Natl Acad Sci U S A (1973) 1.67
The effect of adrenaline on the adenosine otriphosphate and creatine phosphate content of intestinal smooth muscle. J Physiol (1967) 1.64
Cyclic 3', 5'-adenosine monophosphate phosphodiesterase mutants of Salmonella typhimurium. J Bacteriol (1975) 1.58
Application of imidazole as a selective inhibitor thromboxane synthetase in human platelets. Proc Natl Acad Sci U S A (1977) 1.56
Interaction between isoprenaline and aminophylline in asthma. Thorax (1977) 1.52
Effects of glucagon on adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in human plasma and urine. J Clin Invest (1970) 1.49
Metabolism of adenosine 3',5'-cyclic monophosphate and induction of fruiting bodies in Coprinus macrorhizus. J Bacteriol (1973) 1.41
Independent action of antidiuretic hormone, theophylline and cyclic 3',5'-adenosine monophosphate on cell membrane permeability in frog skin. J Physiol (1968) 1.41
The specific interaction of cibacron and related dyes with cyclic nucleotide phosphodiesterase and lactate dehydrogenase. Biochem J (1978) 1.41
A new enzymatic assay for guanosine 3':5'-cyclic monophosphate and its application to the ductus deferens of the rat. Proc Natl Acad Sci U S A (1973) 1.37
Correlation between pinocytosis and hydroosmosis induced by neurohypophyseal hormones and mediated by adenosine 3',5'-cyclic monophosphate. J Cell Biol (1971) 1.33
Norepinephrine induces glial-specific enzyme activity in cultured plasma glioma cells. Proc Natl Acad Sci U S A (1977) 1.33
A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors. Biochem J (1982) 1.32
Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem J (2006) 1.31
Enterotoxin and cytotoxin production by enteroinvasive Escherichia coli. Infect Immun (1990) 1.30
Caffeine-induced inhibition of inositol(1,4,5)-trisphosphate-gated calcium channels from cerebellum. Mol Biol Cell (1994) 1.29
Rhythmic potassium flux in albizzia: effect of aminophylline, cations, and inhibitors of respiration and protein synthesis. Plant Physiol (1974) 1.27
Effects of phosphodiesterase inhibitors on spontaneous electrical activity (slow waves) in the guinea-pig gastric muscle. J Physiol (1995) 1.25
Effects of catecholamines and adenosine derivatives given into the brain of fowls. Br J Pharmacol (1972) 1.23
The actions of dibutyryl cyclic adenosine 3',5'-monophosphate and methyl xanthines on pancreatic exocrine secretion. J Physiol (1972) 1.23
Regulation of nucleoside cyclic 3':5'-monophosphate phosphodiesterase activity from rat brain by a modulator and Ca2+. Proc Natl Acad Sci U S A (1973) 1.20
Changes of intracellular [Ca2+] during refilling of sarcoplasmic reticulum in rat ventricular and vascular smooth muscle. J Physiol (1993) 1.18
The influence of free calcium on the maximum speed of shortening in skinned frog muscle fibres. J Physiol (1986) 1.16
Caffeine-induced release and reuptake of Ca2+ by Ca2+ stores in myocytes from guinea-pig urinary bladder. J Physiol (1992) 1.16
Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem J (1983) 1.14
Structure-activity relations for caffeine: a comparative study of the inotropic effects of the methylxanthines, imidazoles and related compounds on the frog's heart. J Physiol (1974) 1.14
Cyclic adenosine 3',5'-monophosphate concentration in the pancreas following stimulation by secretin, cholecystokinin-pancreozymin and acetylcholine. J Physiol (1972) 1.14
Psychostimulants and cognition: a continuum of behavioral and cognitive activation. Pharmacol Rev (2013) 1.13
Regulation of adenosine 3':5'-cyclic monophosphate concentration in cultured human astrocytoma cells by catecholamines and histamine. Proc Natl Acad Sci U S A (1971) 1.12
Formation of adenosine cyclic 3',5'-phosphate by nonproliferating cells and cell-free extract of Brevibacterium liquefaciens. J Bacteriol (1967) 1.11
The significance of adenosine cyclic 3',5'-monophosphate for the contraction of smooth muscle. J Physiol (1967) 1.11
Abnormal regulation of adenosine 3',5'-monophosphate and corticosterone formation in an adrenocortical carcinoma. J Clin Invest (1969) 1.11
Evaluation of the reproductive and developmental risks of caffeine. Birth Defects Res B Dev Reprod Toxicol (2011) 1.10
Multiple cyclic nucleotide phosphodiesterase activities from rat tissues and occurrence of a calcium-plus-magnesium-ion-dependent phosphodiesterase and its protein activator. Biochem J (1975) 1.10
Prostaglandins, nonsteroidal anti-inflammatory agents and eye disease. Trans Am Ophthalmol Soc (1976) 1.09
Effects of phosphodiesterase inhibitors on normal and chemically-skinned isolated airway smooth muscle. Br J Pharmacol (1987) 1.08
Effect of administration of the fructose on the glycogenolytic action of glucagon. An investigation of the pathogeny of hereditary fructose intolerance. Biochem J (1973) 1.08
THE EFFECTS OF ADRENALINE AND OTHER DRUGS AFFECTING CARBOHYDRATE METABOLISM ON CONTRACTIONS OF THE RAT DIAPHRAGM. Br J Pharmacol Chemother (1964) 1.08
The effect of posture on the sympathoadrenal response to theophylline infusion. Br J Clin Pharmacol (1983) 1.08
Adenosine 3':5'-Cyclic Monophosphate in Chlamydomonas reinhardtii: Isolation and Characterization. Proc Natl Acad Sci U S A (1973) 1.07
Plasma clearance rates and renal clearance of 3H-labeled cyclic AMP and 3H-labeled cyclic GMP in the dog. J Clin Invest (1974) 1.07
The ability of denbufylline to inhibit cyclic nucleotide phosphodiesterase and its affinity for adenosine receptors and the adenosine re-uptake site. Br J Pharmacol (1989) 1.06
Specific antagonism of adenosine-induced bronchoconstriction in asthma by oral theophylline. Br J Clin Pharmacol (1985) 1.06
Basal Ca2+ and the oscillation of Ca2+ in caffeine-treated bullfrog sympathetic neurones. J Physiol (1992) 1.05
Specificities of afferents reinnervating cat muscle spindles after nerve section. J Physiol (1989) 1.05
Inhibitory effects of caffeine on contractions and calcium movement in vascular and intestinal smooth muscle. Br J Pharmacol (1988) 1.05
Caffeine's Vascular Mechanisms of Action. Int J Vasc Med (2010) 1.05
3':5'-cyclic adenosine monophosphate phosphodiesterase: negative cooperativity. Proc Natl Acad Sci U S A (1972) 1.05
Buffering of calcium influx by sarcoplasmic reticulum during the action potential in guinea-pig ventricular myocytes. J Physiol (1993) 1.05
Influence of glucose on the transmembrane action potential of papillary muscle. Effects of concentration, phlorizin and insulin, nonmetabolizable sugars, and stimulators of glycolysis. J Gen Physiol (1969) 1.04
Threshold and receptor reserve in the action of neurohypophyseal peptides. A study of synergists and antagonists of the hydroosmotic response of the toad urinary bladder. J Gen Physiol (1970) 1.04
Anti-platelet therapy: phosphodiesterase inhibitors. Br J Clin Pharmacol (2011) 1.03
Mechanisms of caffeine-induced contraction and relaxation of rat aortic smooth muscle. J Physiol (1992) 1.02
Potentiation of isoprenaline-induced plasma cyclic AMP response by aminophylline in normal and asthmatic subjects. Br J Clin Pharmacol (1978) 1.02
Investigation into the mode of action of histamine on the isolated rabbit heart. Br J Pharmacol Chemother (1968) 1.01
Acidification in the rat proximal jejunum. J Physiol (1975) 1.01
Failure to Detect Cyclic 3', 5'-Adenosine Monophosphate in Healthy and Crown Gall Tumorous Tissues of Vicia faba. Plant Physiol (1974) 1.01
Adenosine 5'-triphosphate modulates membrane potassium conductance in guinea-pig myenteric neurones. J Physiol (1989) 1.01
Genome-wide screen of genes required for caffeine tolerance in fission yeast. PLoS One (2009) 1.00
Effects of cyclic AMP- and cyclic GMP- phosphodiesterase inhibitors on immunological release of histamine and on lung contraction. Br J Pharmacol (1981) 1.00
Major difference between rat and guinea-pig ureter in the ability of agonists and caffeine to release Ca2+ and influence force. J Physiol (1995) 1.00
ADENOSINE 3',5'-PHOSPHATE IN ESCHERICHIA COLI. J Biol Chem (1965) 11.04
Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem (1958) 4.17
Adenyl cylase. I. Distribution, preparation, and properties. J Biol Chem (1962) 3.69
THE ACTION OF EPINEPHRINE AND THE ROLE OF THE ADENYL CYCLASE SYSTEM IN HORMONE ACTION. Recent Prog Horm Res (1965) 3.51
Formation of a cyclic adenine ribonucleotide by tissue particles. J Biol Chem (1958) 3.33
The relationship of epinephrine and glucagon to liver phosphorylase. IV. Effect of epinephrine and glucagon on the reactivation of phosphorylase in liver homogenates. J Biol Chem (1957) 2.83
Adenyl cyclase. III. The effect of catecholamines and choline esters on the formation of adenosine 3',5'-phosphate by preparations from cardiac muscle and liver. J Biol Chem (1962) 2.77
Effect of hyperglycemic-glycogenolytic factor and epinephrine on liver phosphorylase. J Biol Chem (1951) 2.44
Derivatives of cyclic 3',5'-adenosine monophosphate. Biochim Biophys Acta (1962) 2.20
Adenyl cyclase. IV. The effects of neurohormones on the formation of adenosine 3',5'-phosphate by preparations from brain and other tissues. J Biol Chem (1962) 1.77
USE OF LIVER ADENYL CYCLASE FOR ASSAY OF GLUCAGON IN HUMAN GASTRO-INTESTINAL TRACT AND PANCREAS. Endocrinology (1964) 1.66
The relationship of epinephrine and glucagon to liver phosphorylase. I. Liver phosphorylase; preparation and properties. J Biol Chem (1956) 1.60
THE EFFECT OF L-EPINEPHRINE AND OTHER AGENTS ON THE SYNTHESIS AND RELEASE OF ADENOSINE 3',5'-PHOSPHATE BY WHOLE PIGEON ERYTHROCYTES. J Biol Chem (1963) 1.46
THE CELLULAR LOCATION OF ADENYL CYCLASE IN THE PIGEON ERYTHROCYTE. J Biol Chem (1963) 1.44
Immunological differences of phosphorylases. J Biol Chem (1957) 1.41
The relationship of epinephrine and glucagon to liver phosphorylase. III. Reactivation of liver phosphorylase in slices and in extracts. J Biol Chem (1956) 1.40
Adenyl cyclase. II. The enzymatically catalyzed formation of adenosine 3',5'-phosphate and inorganic pyrophosphate from adenosine triphosphate. J Biol Chem (1962) 1.34
The effect of the hyperglycemic factor and epinephrine on enzyme systems of liver and muscle. Ann N Y Acad Sci (1951) 1.33
Purification of the hyperglycemic-glycogenolytic factor from insulin and from gastric mucosa. J Biol Chem (1949) 1.25
The regulatory role of adenosine-3', 5'-phosphate. Cold Spring Harb Symp Quant Biol (1961) 1.24
The role of cyclic adenylic acid in hormone action. Recent Prog Horm Res (1960) 1.21
Mechanism of the phosphoglyceric mutase reaction. J Biol Chem (1949) 1.13
The relationship of epinephrine and glucagon to liver phosphorylase. II. Enzymatic inactivation of liver phosphorylase. J Biol Chem (1956) 1.13
The effect of serotonin (5-hydroxytryptamine) on the formation of adenosine 3',5'-phosphate by tissue particles from the liver fluke, Fasciola hepatica. J Biol Chem (1960) 0.97
Inactivation and activation of liver phosphorylase. Nature (1955) 0.95
The assay of glucagon and epinephrine with use of liver homogenates. J Biol Chem (1957) 0.92
Presence of a glucagon-like material in blood of man and dog. J Biol Chem (1958) 0.89
Formation of adenosine-3,5-phosphate (cyclic adenylate) and its relation to the action of several neurohormones or hormones. Acta Endocrinol Suppl (Copenh) (1960) 0.85
Origin and distribution of the hyperglycemic-glycogenolytic factor of the pancreas. J Biol Chem (1948) 0.85
Observations on the action of certain sulfonylurea derivatives. Metabolism (1956) 0.83
The mechanism of action of phosphoglucomutase and phosphoglyceric acid mutase. J Biol Chem (1949) 0.83
Influence of insulin preparations on glycogenolysis in liver slices. J Biol Chem (1948) 0.80
Action of epinephrine and norepinephrine in broken cell preparations. Pharmacol Rev (1959) 0.78
The interconversion of phosphorylase a and phosphorylase b from dog heart muscle. Biochim Biophys Acta (1956) 0.75
The mechanism of the phosphoglucomutase reaction. J Biol Chem (1949) 0.75
The effect of the hyperglycemic factor of the pancreas and of the epinephrine on glycogenolys. Omnia Med (1951) 0.75
Influence of insulin on glycogen synthesis and breakdown in liver slices. Fed Proc (1947) 0.75
The mortality of acute appendicitis treated surgically in a small general hospital; a fifteen year review. Mo Med (1953) 0.75
Experiences in the culture of algae. J R Microsc Soc (1951) 0.75
Activation of phosphoglucomutase by metal-binding agents. J Biol Chem (1949) 0.75
A glycogenolytic factor from pancreas. Fed Proc (1948) 0.75