Dicer is essential for mouse development.

Principles of microRNA-target recognition. PLoS Biol (2005) 23.70

Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell (2008) 16.38

Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17

Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88

TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature (2005) 13.44

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell (2008) 12.29

Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing. Genes Dev (2005) 12.15

Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50

Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res (2008) 10.18

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat Genet (2007) 9.25

Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med (2008) 8.77

Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A (2005) 8.33

Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell (2009) 8.33

Characterization of microRNA expression profiles in normal human tissues. BMC Genomics (2007) 8.01

Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol (2005) 7.23

Aberrant T cell differentiation in the absence of Dicer. J Exp Med (2005) 6.58

Determinants of targeting by endogenous and exogenous microRNAs and siRNAs. RNA (2007) 6.44

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med (2008) 5.91

TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep (2005) 5.82

A role for Dicer in immune regulation. J Exp Med (2006) 5.81

Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet (2007) 5.33

Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med (2005) 5.26

Dicer1 functions as a haploinsufficient tumor suppressor. Genes Dev (2009) 5.21

Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell (2010) 4.97

Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A (2006) 4.87

MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. J Clin Invest (2007) 4.76

The biology of infertility: research advances and clinical challenges. Nat Med (2008) 4.62

The role of PACT in the RNA silencing pathway. EMBO J (2006) 4.53

Cerebellar neurodegeneration in the absence of microRNAs. J Exp Med (2007) 4.48

MicroRNA-125b is a novel negative regulator of p53. Genes Dev (2009) 4.43

MicroRNAs: key regulators of stem cells. Nat Rev Mol Cell Biol (2009) 4.26

Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Dev Biol (2007) 4.16

Maternal microRNAs are essential for mouse zygotic development. Genes Dev (2007) 4.16

Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A (2008) 4.00

Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology (2009) 3.92

MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 3.90

Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. Cell (2009) 3.90

In vivo investigation of the transcription, processing, endonucleolytic activity, and functional relevance of the spatial distribution of a plant miRNA. Genes Dev (2004) 3.77

Let-7 and miR-200 microRNAs: guardians against pluripotency and cancer progression. Cell Cycle (2009) 3.68

The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol (2006) 3.64

The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med (2008) 3.45

MiRNAs and cancer. Am J Pathol (2009) 3.42

Noncoding RNA in development. Mamm Genome (2008) 3.42

Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron (2010) 3.37

Non-coding RNAs as regulators of embryogenesis. Nat Rev Genet (2011) 3.36

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J Neurosci (2008) 3.33

Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29

MicroRNA: implications for cancer. Virchows Arch (2007) 3.17

Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J Cell Biol (2010) 3.16

RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev (2007) 3.13

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A (2008) 3.10

MicroRNA control of muscle development and disease. Curr Opin Cell Biol (2009) 3.04

Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol (2007) 3.04

Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A (2008) 3.03

microRNA involvement in human cancer. Carcinogenesis (2012) 2.98

Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res (2010) 2.98

A feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination. Nat Struct Mol Biol (2009) 2.96

The developmental miRNA profiles of zebrafish as determined by small RNA cloning. Genes Dev (2005) 2.94

Retracted RNAi-dependent and independent control of LINE1 accumulation and mobility in mouse embryonic stem cells. PLoS Genet (2013) 2.91

MicroRNA biogenesis is required for mouse primordial germ cell development and spermatogenesis. PLoS One (2008) 2.82

Essential role for Dicer during skeletal muscle development. Dev Biol (2007) 2.76

Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol (2008) 2.74

Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants. Mol Cell (2011) 2.73

Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev (2009) 2.73

Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease. J Am Soc Nephrol (2008) 2.69

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis. Proc Natl Acad Sci U S A (2010) 2.67

Caspase-dependent conversion of Dicer ribonuclease into a death-promoting deoxyribonuclease. Science (2010) 2.66

Mammalian microRNAs: a small world for fine-tuning gene expression. Mamm Genome (2006) 2.64

Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci U S A (2005) 2.62

Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res (2006) 2.58

microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol (2010) 2.57

MicroRNA miR-125a controls hematopoietic stem cell number. Proc Natl Acad Sci U S A (2010) 2.53

Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci (2008) 2.50

A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev (2007) 2.48

Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44

MicroRNA regulation of cardiovascular development. Circ Res (2009) 2.42

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol (2008) 2.39

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation. Nucleic Acids Res (2011) 2.39

MicroRNAs as novel regulators of angiogenesis. Circ Res (2009) 2.33

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration. Proc Natl Acad Sci U S A (2008) 2.32

MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and disease. Int J Biochem Cell Biol (2009) 2.30

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements. Genes Dev (2008) 2.26

The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol (2011) 2.16

MicroRNA regulation of cyclooxygenase-2 during embryo implantation. Proc Natl Acad Sci U S A (2007) 2.16

Origins and evolution of eukaryotic RNA interference. Trends Ecol Evol (2008) 2.15

MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases. Transl Res (2011) 2.15

Impaired microRNA processing causes corpus luteum insufficiency and infertility in mice. J Clin Invest (2008) 2.15

Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients. Rheumatol Int (2008) 2.09

MicroRNA control of bone formation and homeostasis. Nat Rev Endocrinol (2012) 2.05

Loss of individual microRNAs causes mutant phenotypes in sensitized genetic backgrounds in C. elegans. Curr Biol (2010) 2.02

MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arterioscler Thromb Vasc Biol (2010) 2.00

MicroRNA in lung cancer. Br J Cancer (2010) 1.97

Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res (2006) 1.94

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo. Cell Death Differ (2009) 1.92

Deletion of Dicer in somatic cells of the female reproductive tract causes sterility. Mol Endocrinol (2008) 1.91

Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets. Mamm Genome (2007) 1.88

DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA (2011) 1.85

Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Br J Cancer (2009) 1.85

A microRNA polycistron as a potential human oncogene. Nature (2005) 40.21

MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet (2004) 37.83

Argonaute2 is the catalytic engine of mammalian RNAi. Science (2004) 22.86

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science (2007) 20.11

Genome-wide in situ exon capture for selective resequencing. Nat Genet (2007) 19.97

A microRNA component of the p53 tumour suppressor network. Nature (2007) 19.25

Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell (2007) 18.35

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science (2003) 18.29

The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13

Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev (2006) 15.20

Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell (2006) 12.72

Crystal structure of Argonaute and its implications for RISC slicer activity. Science (2004) 12.48

Identification of host proteins required for HIV infection through a functional genomic screen. Science (2008) 12.44

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol (2005) 12.12

The DNA damage response: ten years after. Mol Cell (2007) 11.80

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40

Principles of cancer therapy: oncogene and non-oncogene addiction. Cell (2009) 10.96

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature (2008) 10.71

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells. Genes Dev (2002) 10.71

A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A (2008) 10.07

A germline-specific class of small RNAs binds mammalian Piwi proteins. Nature (2006) 9.88

The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36

Sorting of small RNAs into Arabidopsis argonaute complexes is directed by the 5' terminal nucleotide. Cell (2008) 9.02

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nat Genet (2005) 8.99

Small RNAs as guardians of the genome. Cell (2009) 8.88

The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell (2009) 8.64

Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature (2003) 8.38

Characterization of Dicer-deficient murine embryonic stem cells. Proc Natl Acad Sci U S A (2005) 8.35

Second-generation shRNA libraries covering the mouse and human genomes. Nat Genet (2005) 8.23

An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88

The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell (2009) 7.88

Developmentally regulated piRNA clusters implicate MILI in transposon control. Science (2007) 7.68

MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev Cell (2007) 7.66

The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev (2002) 7.61

Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC. Nat Methods (2007) 7.56

A role for the P-body component GW182 in microRNA function. Nat Cell Biol (2005) 7.54

The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexes. Nat Struct Biol (2003) 6.90

MDC1 is a mediator of the mammalian DNA damage checkpoint. Nature (2003) 6.81

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77

Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68

Purified Argonaute2 and an siRNA form recombinant human RISC. Nat Struct Mol Biol (2005) 6.64

Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev (2002) 6.43

p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev (2004) 6.40

Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary. Cell (2009) 6.39

A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature (2010) 6.37

A resource for large-scale RNA-interference-based screens in mammals. Nature (2004) 6.36

A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell (2008) 6.35

A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31

Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A (2005) 5.87

A novel miRNA processing pathway independent of Dicer requires Argonaute2 catalytic activity. Science (2010) 5.84

An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet (2003) 5.82

Genome analysis of the platypus reveals unique signatures of evolution. Nature (2008) 5.74

Alta-Cyclic: a self-optimizing base caller for next-generation sequencing. Nat Methods (2008) 5.70

A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008) 5.47

Cancer proliferation gene discovery through functional genomics. Science (2008) 5.41

Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell (2009) 5.41

microRNAs join the p53 network--another piece in the tumour-suppression puzzle. Nat Rev Cancer (2007) 5.38

The graded response to Sonic Hedgehog depends on cilia architecture. Dev Cell (2007) 5.35

RNA interference in adult mice. Nature (2002) 5.33

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells. Proc Natl Acad Sci U S A (2005) 5.29

A biochemical approach to identifying microRNA targets. Proc Natl Acad Sci U S A (2007) 5.16

Stable suppression of gene expression by RNAi in mammalian cells. Proc Natl Acad Sci U S A (2002) 5.05

An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05

53BP1, a mediator of the DNA damage checkpoint. Science (2002) 5.00

miR-19 is a key oncogenic component of mir-17-92. Genes Dev (2009) 4.95

A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii. Genes Dev (2007) 4.95

RNA interference screen for human genes associated with West Nile virus infection. Nature (2008) 4.93

CHD5 is a tumor suppressor at human 1p36. Cell (2007) 4.90

Cilia and developmental signaling. Annu Rev Cell Dev Biol (2007) 4.88

The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair. Science (2009) 4.85

Silencing of microRNA families by seed-targeting tiny LNAs. Nat Genet (2011) 4.81

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature (2003) 4.79

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A (2007) 4.75

Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev (2004) 4.68

Distinct catalytic and non-catalytic roles of ARGONAUTE4 in RNA-directed DNA methylation. Nature (2006) 4.68

The CRISPR system: small RNA-guided defense in bacteria and archaea. Mol Cell (2010) 4.60

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev (2002) 4.58

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell (2009) 4.57

Profiling essential genes in human mammary cells by multiplex RNAi screening. Science (2008) 4.51

Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila. Science (2002) 4.47

Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing. Nat Protoc (2009) 4.45

Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28

Small RNA sorting: matchmaking for Argonautes. Nat Rev Genet (2010) 4.27