Published in Am J Hum Genet on October 20, 2003
A haplotype map of the human genome. Nature (2005) 105.70
A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. Am J Hum Genet (2006) 28.32
Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am J Hum Genet (2007) 24.68
Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet (2005) 14.09
A comparison of phasing algorithms for trios and unrelated individuals. Am J Hum Genet (2006) 12.45
Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet (2004) 11.90
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Detection of sharing by descent, long-range phasing and haplotype imputation. Nat Genet (2008) 9.69
Whole-genome molecular haplotyping of single cells. Nat Biotechnol (2010) 6.77
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science (2012) 5.34
Coalescent-based association mapping and fine mapping of complex trait loci. Genetics (2004) 5.26
Multilocus association mapping using variable-length Markov chains. Am J Hum Genet (2006) 5.13
Validating, augmenting and refining genome-wide association signals. Nat Rev Genet (2009) 4.56
Linkage disequilibrium mapping via cladistic analysis of single-nucleotide polymorphism haplotypes. Am J Hum Genet (2004) 4.44
GERBIL: Genotype resolution and block identification using likelihood. Proc Natl Acad Sci U S A (2004) 4.36
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet (2006) 4.22
Pattern of sequence variation across 213 environmental response genes. Genome Res (2004) 3.93
Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations. Am J Hum Genet (2004) 3.91
A new approach for using genome scans to detect recent positive selection in the human genome. PLoS Biol (2007) 3.71
Missing data imputation and haplotype phase inference for genome-wide association studies. Hum Genet (2008) 3.65
Analyses and comparison of accuracy of different genotype imputation methods. PLoS One (2008) 3.41
JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms. Nat Genet (2009) 3.21
Microsatellite variation and evolution of human lactase persistence. Hum Genet (2005) 3.20
Comparison of the accuracy of methods of computational haplotype inference using a large empirical dataset. BMC Genet (2004) 3.15
Spread of an inactive form of caspase-12 in humans is due to recent positive selection. Am J Hum Genet (2006) 3.00
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups. Blood (2010) 2.93
Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice. J Clin Invest (2010) 2.87
Antiretroelement activity of APOBEC3H was lost twice in recent human evolution. Cell Host Microbe (2008) 2.85
Population stratification of a common APOBEC gene deletion polymorphism. PLoS Genet (2007) 2.85
Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nat Genet (2010) 2.74
Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet (2005) 2.71
Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet (2004) 2.71
Chromosomal rearrangements maintain a polymorphic supergene controlling butterfly mimicry. Nature (2011) 2.65
A genome-wide survey of the prevalence and evolutionary forces acting on human nonsense SNPs. Am J Hum Genet (2009) 2.62
Adaptive evolution of UGT2B17 copy-number variation. Am J Hum Genet (2008) 2.58
An MCMC algorithm for haplotype assembly from whole-genome sequence data. Genome Res (2008) 2.45
A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol (2005) 2.42
A general approach for haplotype phasing across the full spectrum of relatedness. PLoS Genet (2014) 2.38
Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense. PLoS Genet (2009) 2.35
Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture. Am J Hum Genet (2008) 2.28
Absence of the TAP2 human recombination hotspot in chimpanzees. PLoS Biol (2004) 2.22
Direct determination of molecular haplotypes by chromosome microdissection. Nat Methods (2010) 2.21
Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol (2008) 2.20
Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'. BMC Bioinformatics (2007) 2.15
Haplotype sorting using human fosmid clone end-sequence pairs. Genome Res (2008) 2.10
Little loss of information due to unknown phase for fine-scale linkage-disequilibrium mapping with single-nucleotide-polymorphism genotype data. Am J Hum Genet (2004) 2.06
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Am J Hum Genet (2005) 2.04
Methods to impute missing genotypes for population data. Hum Genet (2007) 1.98
Inferring the history of speciation in house mice from autosomal, X-linked, Y-linked and mitochondrial genes. Mol Ecol (2008) 1.96
Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proc Natl Acad Sci U S A (2009) 1.96
Genetic evidence for a second domestication of barley (Hordeum vulgare) east of the Fertile Crescent. Proc Natl Acad Sci U S A (2007) 1.95
Association between two mu-opioid receptor gene (OPRM1) haplotype blocks and drug or alcohol dependence. Hum Mol Genet (2006) 1.93
The molecular basis of high-altitude adaptation in deer mice. PLoS Genet (2007) 1.91
Association studies for next-generation sequencing. Genome Res (2011) 1.89
Understanding the accuracy of statistical haplotype inference with sequence data of known phase. Genet Epidemiol (2007) 1.87
A novel DNA sequence database for analyzing human demographic history. Genome Res (2008) 1.85
A comprehensive literature review of haplotyping software and methods for use with unrelated individuals. Hum Genomics (2005) 1.84
A comprehensively molecular haplotype-resolved genome of a European individual. Genome Res (2011) 1.83
MHC haplotype matching for unrelated hematopoietic cell transplantation. PLoS Med (2007) 1.83
The case for selection at CCR5-Delta32. PLoS Biol (2005) 1.83
Recent speciation associated with the evolution of selfing in Capsella. Proc Natl Acad Sci U S A (2009) 1.83
Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Am J Hum Genet (2006) 1.82
Paraoxonase polymorphisms, haplotypes, and enzyme activity in Latino mothers and newborns. Environ Health Perspect (2006) 1.81
Linkage disequilibrium and demographic history of wild and domestic canids. Genetics (2009) 1.79
A susceptibility locus for papillary thyroid carcinoma on chromosome 8q24. Cancer Res (2009) 1.77
Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry. Am J Hum Genet (2006) 1.76
A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations. Am J Hum Genet (2005) 1.75
Genetic variation in soluble epoxide hydrolase (EPHX2) and risk of coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) study. Hum Mol Genet (2006) 1.74
Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15. Hum Mutat (2010) 1.73
Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria. Hum Mol Genet (2007) 1.72
A flexible Bayesian framework for modeling haplotype association with disease, allowing for dominance effects of the underlying causative variants. Am J Hum Genet (2006) 1.70
Haplotype and missing data inference in nuclear families. Genome Res (2004) 1.69
Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology (2010) 1.68
Bayesian species delimitation in West African forest geckos (Hemidactylus fasciatus). Proc Biol Sci (2010) 1.66
Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. Am J Med Genet B Neuropsychiatr Genet (2006) 1.64
Rare BRCA1 haplotypes including 3'UTR SNPs associated with breast cancer risk. Cell Cycle (2011) 1.64
Patterns of polymorphism and demographic history in natural populations of Arabidopsis lyrata. PLoS One (2008) 1.63
Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes. Environ Health Perspect (2010) 1.62
Finding haplotype tagging SNPs by use of principal components analysis. Am J Hum Genet (2004) 1.61
Association of PDCD1 genetic variation with risk and clinical manifestations of systemic lupus erythematosus in a multiethnic cohort. Genes Immun (2007) 1.60
A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation. PLoS Med (2010) 1.60
Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. Proc Natl Acad Sci U S A (2011) 1.60
Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet (2008) 1.60
Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots. Genetics (2004) 1.59
Chromosomal haplotypes by genetic phasing of human families. Am J Hum Genet (2011) 1.58
Association of genetic variation in the MET proto-oncogene with schizophrenia and general cognitive ability. Am J Psychiatry (2010) 1.58
IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. Cancer Epidemiol Biomarkers Prev (2009) 1.58
Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A (2012) 1.58
Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS One (2007) 1.57
The IGF1 small dog haplotype is derived from Middle Eastern grey wolves. BMC Biol (2010) 1.57
Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants. Am J Hum Genet (2005) 1.55
Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage. Proc Natl Acad Sci U S A (2006) 1.54
Localization of candidate regions maintaining a common polymorphic inversion (2La) in Anopheles gambiae. PLoS Genet (2007) 1.53
Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect (2010) 1.53
The effect of polymorphisms in the enhancer of split gene complex on bristle number variation in a large wild-caught cohort of Drosophila melanogaster. Genetics (2005) 1.52
Exploring the distribution of genetic markers of pharmacogenomics relevance in Brazilian and Mexican populations. PLoS One (2014) 1.51
Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes. Hum Mol Genet (2009) 1.50
Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet (2006) 1.50
Developmentally restricted genetic determinants of human arsenic metabolism: association between urinary methylated arsenic and CYT19 polymorphisms in children. Environ Health Perspect (2005) 1.49
Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. Neuropsychopharmacology (2007) 1.48
A new statistical method for haplotype reconstruction from population data. Am J Hum Genet (2001) 59.30
Identification of the cystic fibrosis gene: genetic analysis. Science (1989) 33.61
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol (1995) 30.55
Inference of haplotypes from PCR-amplified samples of diploid populations. Mol Biol Evol (1990) 16.18
Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. Am J Hum Genet (2001) 10.48
Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A (2000) 10.27
Sequence variation in the human angiotensin converting enzyme. Nat Genet (1999) 10.12
Partition-ligation-expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms. Am J Hum Genet (2002) 10.12
Haplotype inference in random population samples. Am J Hum Genet (2002) 8.07
A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39
A new multipoint method for genome-wide association studies by imputation of genotypes. Nat Genet (2007) 52.68
A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PLoS Genet (2009) 30.09
A fine-scale map of recombination rates and hotspots across the human genome. Science (2005) 26.82
Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27
The fine-scale structure of recombination rate variation in the human genome. Science (2004) 17.05
Replicating genotype-phenotype associations. Nature (2007) 16.11
The effects of human population structure on large genetic association studies. Nat Genet (2004) 14.88
Genome-wide strategies for detecting multiple loci that influence complex diseases. Nat Genet (2005) 14.88
Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am J Hum Genet (2005) 14.09
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
A comparison of phasing algorithms for trios and unrelated individuals. Am J Hum Genet (2006) 12.45
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
A common sequence motif associated with recombination hot spots and genome instability in humans. Nat Genet (2008) 8.64
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet (2010) 8.48
Comparison of fine-scale recombination rates in humans and chimpanzees. Science (2005) 7.86
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Drive against hotspot motifs in primates implicates the PRDM9 gene in meiotic recombination. Science (2009) 7.35
Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet (2009) 6.61
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. Nat Genet (2012) 6.25
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
Accessibility, sustainability, excellence: how to expand access to research publications. Executive summary. Int Microbiol (2013) 4.66
A statistical method for predicting classical HLA alleles from SNP data. Am J Hum Genet (2008) 4.65
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet (2009) 4.61
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nat Genet (2010) 4.42
Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30
The influence of recombination on human genetic diversity. PLoS Genet (2006) 4.04
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nat Genet (2012) 3.40
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21. Hum Mol Genet (2010) 3.34
Human recombination hot spots hidden in regions of strong marker association. Nat Genet (2005) 3.33
Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease. Proc Natl Acad Sci U S A (2012) 3.29
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet (2013) 2.87
A fine-scale chimpanzee genetic map from population sequencing. Science (2012) 2.83
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
HAPGEN2: simulation of multiple disease SNPs. Bioinformatics (2011) 2.58
Multiple instances of ancient balancing selection shared between humans and chimpanzees. Science (2013) 2.32
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. PLoS Genet (2011) 1.83
Is mate choice in humans MHC-dependent? PLoS Genet (2008) 1.66
Including known covariates can reduce power to detect genetic effects in case-control studies. Nat Genet (2012) 1.66
Recombination and population structure in Salmonella enterica. PLoS Genet (2011) 1.61
Human metabolic profiles are stably controlled by genetic and environmental variation. Mol Syst Biol (2011) 1.60
Application of coalescent methods to reveal fine-scale rate variation and recombination hotspots. Genetics (2004) 1.59
People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. Eur J Hum Genet (2011) 1.58
Gang membership, violence, and psychiatric morbidity. Am J Psychiatry (2013) 1.54
Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus. Nat Genet (2012) 1.52
Pneumococcal genome sequencing tracks a vaccine escape variant formed through a multi-fragment recombination event. Nat Genet (2012) 1.43
Presynaptic NMDARs in the hippocampus facilitate transmitter release at theta frequency. Neuron (2010) 1.33
Quantifying the underestimation of relative risks from genome-wide association studies. PLoS Genet (2011) 1.30
High recombination rate in herpes simplex virus type 1 natural populations suggests significant co-infection. Infect Genet Evol (2004) 1.23
A robust clustering algorithm for identifying problematic samples in genome-wide association studies. Bioinformatics (2011) 1.19
Congenital myasthenic syndromes due to mutations in ALG2 and ALG14. Brain (2013) 1.18
Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Nat Genet (2013) 1.15
Disease model distortion in association studies. Genet Epidemiol (2011) 1.14
Recessive mutations in SPTBN2 implicate β-III spectrin in both cognitive and motor development. PLoS Genet (2012) 1.14
Economic instruments for obesity prevention: results of a scoping review and modified Delphi survey. Int J Behav Nutr Phys Act (2011) 1.05
A model-based approach to capture genetic variation for future association studies. Genome Res (2006) 1.05
Genomic tools for evolution and conservation in the chimpanzee: Pan troglodytes ellioti is a genetically distinct population. PLoS Genet (2012) 1.00
Gene-gene interactions in breast cancer susceptibility. Hum Mol Genet (2011) 0.97
Homozygous mutations in a predicted endonuclease are a novel cause of congenital dyserythropoietic anemia type I. Haematologica (2013) 0.95
Bayesian hierarchical mixture modeling to assign copy number from a targeted CNV array. Genet Epidemiol (2011) 0.93
Patterns of Eurasian HSV-1 molecular diversity and inferences of human migrations. Infect Genet Evol (2005) 0.90
Fatal hemorrhagic pneumonia caused by infection due to Kytococcus sedentarius--a pathogen or passenger? Ann Hematol (2003) 0.88
A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation. Biol Psychiatry (2013) 0.87
Systematic review of validity testing in colonoscopy simulation. Surg Endosc (2012) 0.86
The antimicrobial effect of Iseganan HCl oral solution in patients receiving stomatotoxic chemotherapy: analysis from a multicenter, double-blind, placebo-controlled, randomized, phase III clinical trial. J Oral Pathol Med (2011) 0.85
Effectiveness of an educational video on concussion knowledge in minor league hockey players: a cluster randomised controlled trial. Br J Sports Med (2013) 0.84
Options for early breast cancer follow-up in primary and secondary care - a systematic review. BMC Cancer (2012) 0.84
Experiments with the site frequency spectrum. Bull Math Biol (2010) 0.81
Assessing association between protein truncating variants and quantitative traits. Bioinformatics (2013) 0.78
The role of ATM in response to metformin treatment and activation of AMPK. Nat Genet (2012) 0.77
Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people. Cochrane Database Syst Rev (2015) 0.77
Differences in UK health care after devolution. BMJ (2010) 0.75
Software process improvement for the medical industry. Stud Health Technol Inform (2005) 0.75
Polymerase chain reaction blood tests for the diagnosis of invasive aspergillosis in immunocompromised people. Cochrane Database Syst Rev (2015) 0.75
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A review of quality assessment of the methodology used in guidelines and systematic reviews on oral mucositis. J Clin Nurs (2009) 0.75