| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Cisapride: a potential model substrate to assess cytochrome P4503A4 activity in vivo.
|
Clin Pharmacol Ther
|
2003
|
1.42
|
|
2
|
Pharmacogenetics affects dosing, efficacy, and toxicity of cytochrome P450-metabolized drugs.
|
Am J Med
|
2002
|
1.30
|
|
3
|
Combined phenotypic assessment of cytochrome p450 1A2, 2C9, 2C19, 2D6, and 3A, N-acetyltransferase-2, and xanthine oxidase activities with the "Cooperstown 5+1 cocktail".
|
Clin Pharmacol Ther
|
2003
|
1.22
|
|
4
|
Randomized study of paclitaxel and tamoxifen deposition into human brain tumors: implications for the treatment of metastatic brain tumors.
|
Clin Cancer Res
|
2006
|
1.12
|
|
5
|
Limited sampling strategy to predict AUC of the CYP3A phenotyping probe midazolam in adults: application to various assay techniques.
|
J Clin Pharmacol
|
2002
|
1.08
|
|
6
|
Comparison of midazolam and simvastatin as cytochrome P450 3A probes.
|
Clin Pharmacol Ther
|
2006
|
1.00
|
|
7
|
Poor correlation between 6beta-hydroxycortisol:cortisol molar ratios and midazolam clearance as measure of hepatic CYP3A activity.
|
Br J Clin Pharmacol
|
2006
|
0.94
|
|
8
|
Comparison of 30-min and 3-h infusion regimens for imipenem/cilastatin and for meropenem evaluated by Monte Carlo simulation.
|
Diagn Microbiol Infect Dis
|
2010
|
0.93
|
|
9
|
Maribavir pharmacokinetics and the effects of multiple-dose maribavir on cytochrome P450 (CYP) 1A2, CYP 2C9, CYP 2C19, CYP 2D6, CYP 3A, N-acetyltransferase-2, and xanthine oxidase activities in healthy adults.
|
Antimicrob Agents Chemother
|
2006
|
0.92
|
|
10
|
Single plasma concentrations of 1'-hydroxymidazolam or the ratio of 1'-hydroxymidazolam:midazolam do not predict midazolam clearance in healthy subjects.
|
J Clin Pharmacol
|
2002
|
0.92
|
|
11
|
Effect of a triphasic oral contraceptive on drug-metabolizing enzyme activity as measured by the validated Cooperstown 5+1 cocktail.
|
J Clin Pharmacol
|
2005
|
0.91
|
|
12
|
Revaccination of healthy nonresponders with hepatitis B vaccine and prediction of seroprotection response.
|
Vaccine
|
2003
|
0.91
|
|
13
|
Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients.
|
Antimicrob Agents Chemother
|
2011
|
0.91
|
|
14
|
Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation.
|
Clin Pharmacokinet
|
2010
|
0.90
|
|
15
|
Drug-metabolizing enzyme inhibition by ketoconazole does not reduce interindividual variability of CYP3A activity as measured by oral midazolam.
|
Drug Metab Dispos
|
2006
|
0.89
|
|
16
|
Evaluation of inhibitory drug interactions during drug development: genetic polymorphisms must be considered.
|
Clin Pharmacol Ther
|
2005
|
0.89
|
|
17
|
The effect of oral pleconaril on hepatic cytochrome P450 3A activity in healthy adults using intravenous midazolam as a probe.
|
J Clin Pharmacol
|
2006
|
0.87
|
|
18
|
Limited sampling models for oral midazolam: midazolam plasma concentrations, not the ratio of 1-hydroxymidazolam to midazolam plasma concentrations, accurately predicts AUC as a biomarker of CYP3A activity.
|
J Clin Pharmacol
|
2006
|
0.87
|
|
19
|
Sex differences in CYP3A activity using intravenous and oral midazolam.
|
Clin Pharmacol Ther
|
2006
|
0.84
|
|
20
|
Evaluation of the drug interaction potential of aplaviroc, a novel human immunodeficiency virus entry inhibitor, using a modified cooperstown 5 + 1 cocktail.
|
J Clin Pharmacol
|
2006
|
0.83
|
|
21
|
Cardiovascular risk factor burden has a stronger association with self-rated poor health in adults in the US than in Sweden, especially for the lower educated.
|
Scand J Public Health
|
2006
|
0.83
|
|
22
|
An evaluation of the atkins' diet.
|
Metab Syndr Relat Disord
|
2003
|
0.83
|
|
23
|
Quantitative assessment of hepatic blood flow using intravenous indocyanine green.
|
Eur J Clin Pharmacol
|
2008
|
0.82
|
|
24
|
Duration of pleconaril effect on cytochrome P450 3A activity in healthy adults using the oral biomarker midazolam.
|
Drug Metab Dispos
|
2006
|
0.82
|
|
25
|
Self-rated health does not predict 10-year weight change among middle-aged adults in a longitudinal population study.
|
BMC Public Health
|
2011
|
0.81
|
|
26
|
Effect of sex and menstrual cycle phase on cytochrome P450 2C19 activity with omeprazole used as a biomarker.
|
Clin Pharmacol Ther
|
2002
|
0.80
|
|
27
|
Over-the-counter progesterone cream produces significant drug exposure compared to a food and drug administration-approved oral progesterone product.
|
J Clin Pharmacol
|
2005
|
0.79
|
|
28
|
Lack of weight-based dose dependency and intraindividual variability of omeprazole for CYP2C19 phenotyping.
|
J Clin Pharmacol
|
2004
|
0.78
|
|
29
|
Flumazenil reduces midazolam-induced cognitive impairment without altering pharmacokinetics.
|
Clin Pharmacol Ther
|
2002
|
0.78
|
|
30
|
Limited sampling strategy of S-warfarin concentrations, but not warfarin S/R ratios, accurately predicts S-warfarin AUC during baseline and inhibition in CYP2C9 extensive metabolizers.
|
J Clin Pharmacol
|
2004
|
0.77
|
|
31
|
Lack of effect of subject posture on intravenous midazolam clearance: implications for hepatic cytochrome P450 3A phenotyping.
|
Br J Clin Pharmacol
|
2008
|
0.77
|
|
32
|
Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin.
|
Eur J Clin Pharmacol
|
2006
|
0.76
|
|
33
|
Use of omeprazole as a CYP3A probe drug: effect of sex and menstrual cycle phase on CYP3A activity in healthy Caucasian adults.
|
J Clin Pharmacol
|
2006
|
0.76
|
|
34
|
Application of Bayes theorem to aminoglycoside-associated nephrotoxicity: comparison of extended-interval dosing, individualized pharmacokinetic monitoring, and multiple-daily dosing.
|
J Clin Pharmacol
|
2004
|
0.76
|
|
35
|
Genetic polymorphisms of cytochrome P450 enzymes and the effect on interindividual, pharmacokinetic variability in extensive metabolizers.
|
J Clin Pharmacol
|
2004
|
0.76
|
|
36
|
Endogenous 4β-hydroxycholesterol-to-cholesterol ratio is not a validated biomarker for the assessment of CYP3A activity.
|
Drug Metab Dispos
|
2013
|
0.75
|
|
37
|
The not so "ideal" body weight-based dosing of Integrilin in obesity.
|
Am Heart J
|
2012
|
0.75
|
|
38
|
Validating phenotyping cocktails: more work needs to be done.
|
J Clin Pharmacol
|
2012
|
0.75
|
|
39
|
S-Warfarin Limited Sampling Models to Estimate Area Under the Concentration Versus Time Curve for Cytochrome P450 2C9 Baseline Activity and After Induction.
|
Ther Drug Monit
|
2016
|
0.75
|
|
40
|
Pharmacodynamics of uniform versus nonuniform warfarin dosages.
|
Pharmacotherapy
|
2008
|
0.75
|
|
41
|
Limitations of S-warfarin truncated area under the concentration-time curve to predict cytochrome P450 2c9 activity.
|
Drug Metab Lett
|
2012
|
0.75
|