Published in Biochem J on March 01, 2004
The Hedgehog signalling pathway regulates autophagy. Nat Commun (2012) 1.80
Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Mol Cell Biol (2006) 1.38
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal. J Biol Chem (2008) 1.23
RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling. RNA Biol (2013) 0.96
Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina. Dev Biol (2008) 0.95
Hedgehog signaling in cancer stem cells: a focus on hematological cancers. Stem Cells Cloning (2015) 0.93
Mice with a targeted mutation of patched2 are viable but develop alopecia and epidermal hyperplasia. Mol Cell Biol (2006) 0.93
Essential role for ligand-dependent feedback antagonism of vertebrate hedgehog signaling by PTCH1, PTCH2 and HHIP1 during neural patterning. Development (2013) 0.92
Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors. Cancers (Basel) (2016) 0.91
Inhibition of GLI1 gene activation by Patched1. Biochem J (2006) 0.91
Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. PLoS Genet (2012) 0.89
SHH, WNT, and NOTCH pathways in medulloblastoma: when cancer stem cells maintain self-renewal and differentiation properties. Childs Nerv Syst (2014) 0.86
SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression. J Lipid Res (2015) 0.85
Hedgehog signaling pathway is active in GBM with GLI1 mRNA expression showing a single continuous distribution rather than discrete high/low clusters. PLoS One (2015) 0.85
Ptch2 mediates the Shh response in Ptch1-/- cells. Development (2014) 0.84
Patched 1 and patched 2 redundancy has a key role in regulating epidermal differentiation. J Invest Dermatol (2014) 0.81
Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial. BMC Dev Biol (2011) 0.81
The hedgehog receptor patched1 in T cells is dispensable for adaptive immunity in mice. PLoS One (2013) 0.80
Computational prediction and experimental validation of novel Hedgehog-responsive enhancers linked to genes of the Hedgehog pathway. BMC Dev Biol (2016) 0.77
The impact of S6K1 kinase on neuroblastoma cell proliferation is independent of GLI1 signaling. BMC Cancer (2014) 0.76
Altered neural cell fates and medulloblastoma in mouse patched mutants. Science (1997) 11.44
Alternative splicing: increasing diversity in the proteomic world. Trends Genet (2001) 10.44
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature (2000) 10.04
Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science (1996) 8.06
Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell (1996) 7.86
Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science (1997) 6.66
Cholesterol modification of hedgehog signaling proteins in animal development. Science (1996) 5.66
Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev (1996) 4.94
Patched acts catalytically to suppress the activity of Smoothened. Nature (2002) 4.69
Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene. Science (1997) 4.55
Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development (2000) 3.91
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature (1999) 3.87
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists. J Biol (2002) 3.85
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med (1998) 3.75
Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion. Nature (1998) 3.34
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1. Nat Cell Biol (1999) 3.32
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell (2000) 3.10
Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem (1998) 2.95
Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol (1996) 2.59
Gli1 can rescue the in vivo function of Gli2. Development (2001) 2.43
Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell (1999) 2.33
Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Curr Biol (2002) 1.86
Conservation in hedgehog signaling: induction of a chicken patched homolog by Sonic hedgehog in the developing limb. Development (1996) 1.80
Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr Biol (2000) 1.61
Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr Biol (2001) 1.41
Receptor-mediated endocytosis of soluble and membrane-tethered Sonic hedgehog by Patched-1. Proc Natl Acad Sci U S A (2000) 1.40
Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog. Nat Genet (1998) 1.38
Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A (1998) 1.38
Ptc1 and Ptc2 transcripts provide distinct readouts of Hedgehog signaling activity during chick embryogenesis. Dev Biol (2001) 1.29
In vivo functions of the patched protein: requirement of the C terminus for target gene inactivation but not Hedgehog sequestration. Mol Cell (2000) 1.25
The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking. Curr Biol (2001) 1.20
Molecular cytogenetic analysis of adult testicular germ cell tumours and identification of regions of consensus copy number change. Br J Cancer (1998) 1.18
Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32. Hum Mol Genet (1999) 1.15
Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein. Oncogene (2002) 1.15
The sonic hedgehog receptor patched associates with caveolin-1 in cholesterol-rich microdomains of the plasma membrane. J Biol Chem (2001) 1.06
Post-transcriptional regulation of the gli1 oncogene by the expression of alternative 5' untranslated regions. J Biol Chem (2001) 1.04
Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts. J Biol Chem (2002) 1.03
PTCH2, a novel human patched gene, undergoing alternative splicing and up-regulated in basal cell carcinomas. Cancer Res (1999) 0.94
GLI1 localization in the germinal epithelial cells alternates between cytoplasm and nucleus: upregulation in transgenic mice blocks spermatogenesis in pachytene. Biol Reprod (2001) 0.91
Related membrane domains in proteins of sterol sensing and cell signaling provide a glimpse of treasures still buried within the dynamic realm of intracellular metabolic regulation. Curr Opin Lipidol (1998) 0.88
The Shh signalling pathway in early tooth development. Cell Mol Biol (Noisy-le-grand) (1999) 0.85
Gli family members are differentially expressed during the mitotic phase of spermatogenesis. Oncogene (1997) 0.84
Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs. Dev Biol (2002) 0.82
Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice. Arch Dermatol Res (2001) 0.82
Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A (2007) 4.15
Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway. Dev Cell (2006) 3.62
Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta (2010) 3.21
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle (2007) 2.16
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci U S A (2011) 1.89
Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development. J Pathol (2006) 1.83
Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene (2004) 1.82
Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem (2003) 1.72
PTCH mutations: distribution and analyses. Hum Mutat (2006) 1.68
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Dev Biol (2009) 1.52
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat Struct Mol Biol (2010) 1.49
The hair follicle-a stem cell zoo. Exp Cell Res (2010) 1.46
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing. BMC Cancer (2013) 1.31
Development of mammary tumors by conditional expression of GLI1. Cancer Res (2009) 1.30
Intergenic mRNA molecules resulting from trans-splicing. J Biol Chem (2001) 1.29
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis. J Cell Sci (2006) 1.25
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal. J Biol Chem (2008) 1.23
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. PLoS One (2011) 1.22
Hedgehog signalling in breast cancer. Carcinogenesis (2009) 1.18
Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein. Oncogene (2002) 1.15
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. Int J Cancer (2012) 1.13
Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition. Proc Natl Acad Sci U S A (2004) 1.11
Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway. Genes Cancer (2010) 1.07
Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06
The Hedgehog pathway as a drug target in cancer therapy. Curr Opin Investig Drugs (2007) 1.04
Characterization of the progressive skin disease and inflammatory cell infiltrate in mice with inhibited NF-kappaB signaling. J Invest Dermatol (2004) 1.04
Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure. J Biol Chem (2007) 1.02
Inhibition of Rel/Nuclear Factor-kappaB signaling in skin results in defective DNA damage-induced cell cycle arrest and Ha-ras- and p53-independent tumor development. Oncogene (2002) 1.01
A novel first exon of the Patched1 gene is upregulated by Hedgehog signaling resulting in a protein with pathway inhibitory functions. FEBS Lett (2004) 0.99
Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. Eur J Cell Biol (2002) 0.98
The two-faced NF-kappaB in the skin. Int Rev Immunol (2008) 0.96
RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling. RNA Biol (2013) 0.96
Tumor suppressor gene co-operativity in compound Patched1 and suppressor of fused heterozygous mutant mice. Mol Carcinog (2009) 0.95
Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation. Acta Crystallogr D Biol Crystallogr (2013) 0.95
Hedgehog signaling and pancreatic tumor development. Adv Cancer Res (2011) 0.94
Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels. Mol Pharmacol (2010) 0.94
Inhibition of GLI1 gene activation by Patched1. Biochem J (2006) 0.91
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem Cell Reports (2015) 0.89
The FU gene and its possible protein isoforms. BMC Genomics (2004) 0.89
Template switching generated during reverse transcription? FEBS Lett (2002) 0.88
Targeted expression of GLI1 in the salivary glands results in an altered differentiation program and hyperplasia. Am J Pathol (2011) 0.84
Lack of aneuploidy for chromosomes 15, 16, and 18 in placentas from small-for-gestational-age liveborn infants. Am J Obstet Gynecol (2007) 0.83
PTCH1 gene mutations in exon 17 and loss of heterozygosity on D9S180 microsatellite in sporadic and inherited human basal cell carcinomas. Int J Dermatol (2011) 0.83
Timed NF-kappaB inhibition in skin reveals dual independent effects on development of HED/EDA and chronic inflammation. J Invest Dermatol (2009) 0.82
Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. Arch Dermatol Res (2004) 0.81
Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1. BMC Mol Biol (2010) 0.81
Tumour suppressors in liver carcinogenesis. J Hepatol (2007) 0.81
Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice. Mol Carcinog (2011) 0.81
Inhibition of NF-kappaB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner. J Recept Signal Transduct Res (2009) 0.79
Hedgehog in Wnterland. Nat Genet (2008) 0.79
Novel mechanism of action on Hedgehog signaling by a suppressor of fused carboxy terminal variant. PLoS One (2012) 0.79
Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus. Gut (2012) 0.78
Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma. Acta Oncol (2012) 0.76
Smoothing out drug resistance. Cancer Cell (2013) 0.76
Meeting report of the conference on UV-Radiation-Induced Disease--Roles of UVA and UVB. J Invest Dermatol (2008) 0.75
Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth. Nat Commun (2016) 0.75