Published in Hum Hered on January 01, 2003
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Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma. Blood (2007) 2.31
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Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet (2011) 2.02
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Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes (2007) 1.68
Finding haplotype tagging SNPs by use of principal components analysis. Am J Hum Genet (2004) 1.61
Identification of risk-related haplotypes with the use of multiple SNPs from nuclear families. Am J Hum Genet (2007) 1.59
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An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. PLoS Genet (2006) 1.47
Application of association mapping to understanding the genetic diversity of plant germplasm resources. Int J Plant Genomics (2008) 1.40
Use of weighted reference panels based on empirical estimates of ancestry for capturing untyped variation. Hum Genet (2009) 1.37
Picking single-nucleotide polymorphisms in forests. BMC Proc (2007) 1.36
A constrained-likelihood approach to marker-trait association studies. Am J Hum Genet (2005) 1.32
Simple methods for assessing haplotype-environment interactions in case-only and case-control studies. Genet Epidemiol (2007) 1.29
Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies. Genet Epidemiol (2011) 1.29
Linkage disequilibrium mapping of CHEK2: common variation and breast cancer risk. PLoS Med (2006) 1.23
Single-marker and two-marker association tests for unphased case-control genotype data, with a power comparison. Genet Epidemiol (2010) 1.22
Intra- and interpopulation genotype reconstruction from tagging SNPs. Genome Res (2006) 1.21
The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice. J Clin Immunol (2008) 1.19
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An ensemble learning approach jointly modeling main and interaction effects in genetic association studies. Genet Epidemiol (2008) 1.17
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Vitamin D related genes, CYP24A1 and CYP27B1, and colon cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.13
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A role for XRCC2 gene polymorphisms in breast cancer risk and survival. J Med Genet (2011) 1.10
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Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity. J Hum Genet (2008) 1.09
Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics. Hum Genomics (2004) 1.08
Incorporating single-locus tests into haplotype cladistic analysis in case-control studies. PLoS Genet (2007) 1.08
A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma. Carcinogenesis (2008) 1.08
Vitamin D pathway gene variants and prostate cancer risk. Cancer Epidemiol Biomarkers Prev (2009) 1.07
Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS. Intensive Care Med (2009) 1.07
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Assessing methods for assigning SNPs to genes in gene-based tests of association using common variants. PLoS One (2013) 1.06
A model-based approach to capture genetic variation for future association studies. Genome Res (2006) 1.05
A simple method for assessing the strength of evidence for association at the level of the whole gene. Adv Appl Bioinform Chem (2008) 1.04
Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes. PLoS One (2013) 1.04
Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. Hum Genet (2006) 1.03
ESR1 and EGF genetic variation in relation to breast cancer risk and survival. Breast Cancer Res (2008) 1.00
One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia. Hum Genet (2007) 0.98
Analysis of Case-Control Association Studies: SNPs, Imputation and Haplotypes. Stat Sci (2009) 0.96
No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes. Am J Hum Genet (2005) 0.96
Variation at the Calpain 3 gene is associated with meat tenderness in zebu and composite breeds of cattle. BMC Genet (2008) 0.96
A new association test to test multiple-marker association. Genet Epidemiol (2009) 0.95
Comparison of artificial neural network analysis with other multimarker methods for detecting genetic association. BMC Genet (2007) 0.95
The effect of genetic variation of the retinoic acid receptor-related orphan receptor C gene on fatness in cattle. Genetics (2006) 0.95
Selenium, selenoenzymes, oxidative stress and risk of neoplastic progression from Barrett's esophagus: results from biomarkers and genetic variants. PLoS One (2012) 0.94
A comparison of five methods for selecting tagging single-nucleotide polymorphisms. BMC Genet (2005) 0.94
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Comprehensive analysis of the ATM, CHEK2 and ERBB2 genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study. Breast Cancer Res (2006) 0.93
Association of polymorphisms in NOS3 with the ankle-brachial index in hypertensive adults. Atherosclerosis (2007) 0.92
JEPEG: a summary statistics based tool for gene-level joint testing of functional variants. Bioinformatics (2014) 0.91
Predicting signatures of "synthetic associations" and "natural associations" from empirical patterns of human genetic variation. PLoS Comput Biol (2012) 0.90
Detecting susceptibility genes for rheumatoid arthritis based on a novel sliding-window approach. BMC Proc (2009) 0.90
Efficacy assessment of SNP sets for genome-wide disease association studies. Nucleic Acids Res (2007) 0.90
HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes. Immunogenetics (2006) 0.89
A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels. Am J Hum Genet (2010) 0.89
A pathway analysis applied to Genetic Analysis Workshop 16 genome-wide rheumatoid arthritis data. BMC Proc (2009) 0.89
Population structure, differential bias and genomic control in a large-scale, case-control association study. Nat Genet (2005) 25.34
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet (2007) 19.04
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (2009) 16.35
A high-resolution HLA and SNP haplotype map for disease association studies in the extended human MHC. Nat Genet (2006) 15.63
Genome-wide association studies: theoretical and practical concerns. Nat Rev Genet (2005) 14.30
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature (2003) 13.00
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants. Nat Genet (2007) 12.62
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature (2010) 12.27
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. Nat Genet (2006) 8.65
A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am J Hum Genet (2001) 8.47
Control of confounding of genetic associations in stratified populations. Am J Hum Genet (2003) 7.99
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci. Nat Genet (2008) 7.71
Shared and distinct genetic variants in type 1 diabetes and celiac disease. N Engl J Med (2008) 7.66
Genetically distinct subsets within ANCA-associated vasculitis. N Engl J Med (2012) 6.93
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A. Nature (2007) 6.67
Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med (2007) 6.47
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes. Nat Genet (2007) 6.11
Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet (2007) 5.68
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94
Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus. Diabetes (2004) 4.81
A method to address differential bias in genotyping in large-scale association studies. PLoS Genet (2007) 4.51
Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet (2011) 4.42
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms. Am J Hum Genet (2005) 4.36
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet (2009) 3.59
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing. Hum Mol Genet (2010) 3.50
Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. Genet Epidemiol (2004) 3.39
Betting odds and genetic associations. J Natl Cancer Inst (2004) 3.39
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Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat Genet (2012) 3.31
T1DBase: integration and presentation of complex data for type 1 diabetes research. Nucleic Acids Res (2006) 3.25
Association of the interleukin-2 receptor alpha (IL-2Ralpha)/CD25 gene region with Graves' disease using a multilocus test and tag SNPs. Clin Endocrinol (Oxf) (2007) 3.17
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature (2010) 2.88
Type 1 diabetes: evidence for susceptibility loci from four genome-wide linkage scans in 1,435 multiplex families. Diabetes (2005) 2.85
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes. Diabetes (2008) 2.74
Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med (2013) 2.73
Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer. Nature (2012) 2.66
A human type 1 diabetes susceptibility locus maps to chromosome 21q22.3. Diabetes (2008) 2.51
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes. Nat Genet (2009) 2.38
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30
Extreme clonality in lymphoblastoid cell lines with implications for allele specific expression analyses. PLoS One (2008) 2.28
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. PLoS Genet (2011) 2.25
The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci (2006) 2.22
Genome-wide scan for linkage to type 1 diabetes in 2,496 multiplex families from the Type 1 Diabetes Genetics Consortium. Diabetes (2009) 2.02
Remapping the insulin gene/IDDM2 locus in type 1 diabetes. Diabetes (2004) 2.02
Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping. Am J Hum Genet (2006) 2.01
Metagenomics and personalized medicine. Cell (2011) 2.00
Parameters for reliable results in genetic association studies in common disease. Nat Genet (2002) 2.00
Genetics of type 1 diabetes: what's next? Diabetes (2010) 1.80
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability. Nature (2013) 1.79
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol (2006) 1.79
Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes (2011) 1.78
Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13. Biostatistics (2008) 1.72
Experimental aspects of copy number variant assays at CCL3L1. Nat Med (2009) 1.71
Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes. Genome Res (2002) 1.68
Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes (2007) 1.68
Absolute risk of childhood-onset type 1 diabetes defined by human leukocyte antigen class II genotype: a population-based study in the United Kingdom. J Clin Endocrinol Metab (2004) 1.60
Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. J Immunol (2004) 1.59
Seven newly identified loci for autoimmune thyroid disease. Hum Mol Genet (2012) 1.57
Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest Ophthalmol Vis Sci (2006) 1.56
Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene. Hum Mol Genet (2004) 1.48