Published in Immunol Rev on December 01, 2003
Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest (2008) 1.66
Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant (2007) 1.64
In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response. Nat Med (2010) 1.63
Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure. Am J Transplant (2011) 1.30
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol (2006) 1.19
Human inhibitory receptor immunoglobulin-like transcript 2 amplifies CD11b+Gr1+ myeloid-derived suppressor cells that promote long-term survival of allografts. Transplantation (2008) 1.17
Composite tissue allotransplantation immunology. Arch Plast Surg (2013) 0.97
A novel clinically relevant approach to tip the balance toward regulation in stringent transplant model. Transplantation (2010) 0.94
T regulatory cells and transplantation tolerance. Transplant Rev (Orlando) (2010) 0.90
Combined administration of a mutant TGF-beta1/Fc and rapamycin promotes induction of regulatory T cells and islet allograft tolerance. J Immunol (2010) 0.88
Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol (2011) 0.87
Prolonged, low-dose anti-thymocyte globulin, combined with CTLA4-Ig, promotes engraftment in a stringent transplant model. PLoS One (2013) 0.83
Mixed chimerism and split tolerance: mechanisms and clinical correlations. Chimerism (2012) 0.83
The molecular mechanisms of regulatory T cell immunosuppression. Front Immunol (2011) 0.81
Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study. PLoS One (2014) 0.80
Regulatory T cells in lung transplantation--an emerging concept. Semin Immunopathol (2011) 0.79
Influence of combined treatment of low dose rapamycin and cyclosporin A on corneal allograft survival. Graefes Arch Clin Exp Ophthalmol (2010) 0.78
Mesenchymal stem cells in regenerative rehabilitation. J Phys Ther Sci (2016) 0.77
Proceedings: Immune Tolerance and Stem Cell Transplantation: A CIRM Mini-Symposium and Workshop Report. Stem Cells Transl Med (2014) 0.75
Rejuvenation: an integrated approach to regenerative medicine. Regen Med Res (2013) 0.75
Are we ready for the use of foxp3(+) regulatory T cells for immunodiagnosis and immunotherapy in kidney transplantation? J Transplant (2012) 0.75
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 46.36
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 10.00
The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol (2005) 7.80
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med (2007) 7.73
IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol (2008) 6.41
Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature (2006) 5.49
Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol (2003) 5.07
Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol (2003) 4.66
Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol (2003) 3.86
TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol (2005) 3.00
Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity (2003) 2.80
In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature (2011) 2.44
T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res (2009) 2.43
Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol (2004) 2.40
TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol (2009) 2.00
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A (2008) 1.83
Upregulation of miR-142-3p in peripheral blood mononuclear cells of operationally tolerant patients with a renal transplant. J Am Soc Nephrol (2012) 1.81
Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells. Eur J Immunol (2007) 1.70
CD39 and control of cellular immune responses. Purinergic Signal (2007) 1.68
Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest (2008) 1.66
Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med (2005) 1.63
In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response. Nat Med (2010) 1.63
TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol (2008) 1.58
Role of the programmed death-1 pathway in regulation of alloimmune responses in vivo. J Immunol (2005) 1.58
Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood (2003) 1.57
Tracking the immunoregulatory mechanisms active during allograft tolerance. J Immunol (2002) 1.50
Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol (2008) 1.41
Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology (2010) 1.39
Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival. Transplantation (2003) 1.38
Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol (2008) 1.36
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A (2007) 1.35
Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle (2009) 1.34
Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol (2004) 1.33
CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance. Transplantation (2003) 1.19
Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol (2006) 1.19
Critical role of OX40 in CD28 and CD154-independent rejection. J Immunol (2004) 1.19
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest (2012) 1.15
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest (2002) 1.12
Human CD4 memory T cells can become CD4+IL-9+ T cells. PLoS One (2010) 1.12
Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size. J Immunol (2002) 1.12
Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery. Mol Pharm (2010) 1.11
Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells. FASEB J (2005) 1.10
Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol. J Immunol (2005) 1.08
On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes. J Am Soc Nephrol (2005) 1.07
Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens. Immunology (2009) 1.04
Immunosuppression minimization vs. complete drug withdrawal in liver transplantation. J Hepatol (2013) 0.99
Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci U S A (2012) 0.98
Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood (2012) 0.98
Regulation of T cell dependent immune responses by TIM family members. Philos Trans R Soc Lond B Biol Sci (2005) 0.96
Requirements for induction and maintenance of peripheral tolerance in stringent allograft models. Proc Natl Acad Sci U S A (2005) 0.96
Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. J Immunol (2009) 0.96
Routes to transplant tolerance versus rejection; the role of cytokines. Immunity (2004) 0.95
Expression of protective genes in human renal allografts: a regulatory response to injury associated with graft rejection. Transplantation (2002) 0.95
TIM family proteins promote the lysosomal degradation of the nuclear receptor NUR77. Sci Signal (2012) 0.94
Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis. J Am Soc Nephrol (2012) 0.92
Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation. Transpl Int (2007) 0.92
Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells. Eur J Immunol (2014) 0.91
Activated intrarenal transcription of CTL-effectors and TGF-beta1 in children with focal segmental glomerulosclerosis. Kidney Int (2002) 0.90
Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes. J Biol Chem (2004) 0.90
Mechanisms of tolerance induced by donor-specific transfusion and ICOS-B7h blockade in a model of CD4+ T-cell-mediated allograft rejection. Am J Transplant (2005) 0.89
The Tor Vergata weaning off immunosuppression protocol in stable HCV liver transplant patients: the updated follow up at 78 months. Transpl Immunol (2008) 0.89
Fragile TIM-4-expressing tissue resident macrophages are migratory and immunoregulatory. J Clin Invest (2014) 0.88
The role of TNF-α in mice with type 1- and 2- diabetes. PLoS One (2012) 0.87
An antagonist mutant IL-15/Fc promotes transplant tolerance. Transplantation (2006) 0.87
On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response. J Immunol (2002) 0.86
Acute rejection in vascularized composite allotransplantation. Curr Opin Organ Transplant (2014) 0.86
Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int Immunol (2004) 0.85
Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label. PLoS One (2013) 0.84
CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein. Transplantation (2006) 0.84
Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms. J Immunol (2003) 0.84
The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression. Transplantation (2002) 0.84
Immunological tolerance and liver transplantation. J Hepatol (2004) 0.82
Gene expression profiling of the donor kidney at the time of transplantation predicts clinical outcomes 2 years after transplantation. Hum Immunol (2010) 0.82
Innate immunity for better or worse govern the allograft response. Curr Opin Organ Transplant (2015) 0.81
Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance. Int Immunol (2006) 0.80
Osteoprotegerin and parathyroid hormone as markers of high-turnover osteodystrophy and decreased bone mineralization in hemodialysis patients. Am J Kidney Dis (2002) 0.80
In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3. Transpl Int (2008) 0.79
Proteomic analysis of the allograft response. Transplantation (2006) 0.79
Rapamycin generates graft-homing murine suppressor CD8(+) T cells that confer donor-specific graft protection. Cell Transplant (2011) 0.79
Cytokines in the treatment and prevention of autoimmune responses-a role of IL-15. Adv Exp Med Biol (2003) 0.79
Hepatitis B vaccination after liver transplantation. Hepatology (2002) 0.78
Hand transplants and the mandate for tolerance. Curr Opin Organ Transplant (2014) 0.78
A20--a biomarker of allograft outcome: a showcase in kidney transplantation. Adv Exp Med Biol (2014) 0.78
Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins. Transplantation (2007) 0.78
Anticoagulation with prostaglandins and unfractionated heparin during continuous venovenous haemofiltration: a randomized controlled trial. Wien Klin Wochenschr (2002) 0.78
TIM-1: a new player in transplant immunity. Transplantation (2009) 0.77
Th1 to Th2 immune deviation facilitates, but does not cause, islet allograft tolerance in mice. Cytokine (2010) 0.77
Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates. J Heart Lung Transplant (2012) 0.77
Direct pathway T-cell alloactivation is more rapid than indirect pathway alloactivation. Transplantation (2011) 0.77
T-cell-directed treatment strategies for Type 1 diabetes and the confounding role of inflammation. Immunotherapy (2010) 0.77