Published in Nature on November 20, 2003
Small silencing RNAs: an expanding universe. Nat Rev Genet (2009) 13.88
Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome. PLoS Biol (2004) 6.67
Transposable elements and the evolution of regulatory networks. Nat Rev Genet (2008) 6.11
A pathway for the biogenesis of trans-acting siRNAs in Arabidopsis. Genes Dev (2005) 6.04
Endogenous RNA interference provides a somatic defense against Drosophila transposons. Curr Biol (2008) 5.22
DNA transposons and the evolution of eukaryotic genomes. Annu Rev Genet (2007) 4.99
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes. Genes Dev (2006) 4.97
The CRISPR system: small RNA-guided defense in bacteria and archaea. Mol Cell (2010) 4.60
Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 3.80
Crystal structure of a PIWI protein suggests mechanisms for siRNA recognition and slicer activity. EMBO J (2004) 3.57
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell (2009) 3.43
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
Hidden layers of human small RNAs. BMC Genomics (2008) 3.31
Editor meets silencer: crosstalk between RNA editing and RNA interference. Nat Rev Mol Cell Biol (2006) 3.31
zucchini and squash encode two putative nucleases required for rasiRNA production in the Drosophila germline. Dev Cell (2007) 3.29
Argonaute proteins: functional insights and emerging roles. Nat Rev Genet (2013) 3.09
Endogenous small interfering RNAs in animals. Nat Rev Mol Cell Biol (2008) 3.00
RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production. Proc Natl Acad Sci U S A (2004) 2.88
A novel repeat-associated small interfering RNA-mediated silencing pathway downregulates complementary sense gypsy transcripts in somatic cells of the Drosophila ovary. J Virol (2006) 2.87
Interacting endogenous and exogenous RNAi pathways in Caenorhabditis elegans. RNA (2006) 2.78
Conserved themes in small-RNA-mediated transposon control. Trends Cell Biol (2008) 2.67
Dynamic interactions between transposable elements and their hosts. Nat Rev Genet (2011) 2.61
The Ebola virus VP35 protein is a suppressor of RNA silencing. PLoS Pathog (2007) 2.48
The evolution of RNAi as a defence against viruses and transposable elements. Philos Trans R Soc Lond B Biol Sci (2009) 2.35
Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Nucleic Acids Res (2005) 2.26
Identification and characterization of endogenous small interfering RNAs from rice. Nucleic Acids Res (2005) 2.18
Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes Dev (2005) 2.16
Accelerated probabilistic inference of RNA structure evolution. BMC Bioinformatics (2005) 2.16
Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline. Genes Dev (2006) 2.09
Initiation, establishment, and maintenance of heritable MuDR transposon silencing in maize are mediated by distinct factors. PLoS Biol (2006) 2.08
Two classes of endogenous small RNAs in Tetrahymena thermophila. Genes Dev (2005) 2.08
HIV-1 nef suppression by virally encoded microRNA. Retrovirology (2004) 2.05
Comparison of dot chromosome sequences from D. melanogaster and D. virilis reveals an enrichment of DNA transposon sequences in heterochromatic domains. Genome Biol (2006) 1.98
Promiscuous DNA: horizontal transfer of transposable elements and why it matters for eukaryotic evolution. Trends Ecol Evol (2010) 1.95
EGO-1, a C. elegans RdRP, modulates gene expression via production of mRNA-templated short antisense RNAs. Curr Biol (2011) 1.95
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev (2005) 1.94
Stalled spliceosomes are a signal for RNAi-mediated genome defense. Cell (2013) 1.94
QIP, a putative exonuclease, interacts with the Neurospora Argonaute protein and facilitates conversion of duplex siRNA into single strands. Genes Dev (2007) 1.88
Disclosing hidden transcripts: mouse natural sense-antisense transcripts tend to be poly(A) negative and nuclear localized. Genome Res (2005) 1.85
Element 1360 and RNAi components contribute to HP1-dependent silencing of a pericentric reporter. Curr Biol (2006) 1.85
Dual coding of siRNAs and miRNAs by plant transposable elements. RNA (2008) 1.76
The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends. Mol Cell Biol (2007) 1.74
Evidence for maternally transmitted small interfering RNA in the repression of transposition in Drosophila virilis. Proc Natl Acad Sci U S A (2005) 1.72
The 3'-to-5' exoribonuclease Nibbler shapes the 3' ends of microRNAs bound to Drosophila Argonaute1. Curr Biol (2011) 1.66
Deep small RNA sequencing from the nematode Ascaris reveals conservation, functional diversification, and novel developmental profiles. Genome Res (2011) 1.57
Effects of length and location on the cellular response to double-stranded RNA. Microbiol Mol Biol Rev (2004) 1.57
The initiation of epigenetic silencing of active transposable elements is triggered by RDR6 and 21-22 nucleotide small interfering RNAs. Plant Physiol (2013) 1.56
An RIG-I-Like RNA helicase mediates antiviral RNAi downstream of viral siRNA biogenesis in Caenorhabditis elegans. PLoS Pathog (2009) 1.49
Functional mapping of a trypanosome centromere by chromosome fragmentation identifies a 16-kb GC-rich transcriptional "strand-switch" domain as a major feature. Genome Res (2005) 1.47
The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa. Nucleic Acids Res (2005) 1.40
Chromodomains direct integration of retrotransposons to heterochromatin. Genome Res (2008) 1.39
The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs. Cell Cycle (2008) 1.38
RNAi-dependent and RNAi-independent mechanisms contribute to the silencing of RIPed sequences in Neurospora crassa. Nucleic Acids Res (2004) 1.38
RB1, development, and cancer. Curr Top Dev Biol (2011) 1.37
Patterns of molecular evolution in Caenorhabditis preclude ancient origins of selfing. Genetics (2008) 1.37
Computational analysis of mouse piRNA sequence and biogenesis. PLoS Comput Biol (2007) 1.36
A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon. Nucleic Acids Res (2005) 1.34
Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA (2011) 1.31
A double-stranded-RNA response program important for RNA interference efficiency. Mol Cell Biol (2007) 1.29
Exploration of small RNAs. PLoS Genet (2008) 1.29
DNA transposons: nature and applications in genomics. Curr Genomics (2010) 1.25
Characterization of Mos1-mediated mutagenesis in Caenorhabditis elegans: a method for the rapid identification of mutated genes. Genetics (2005) 1.24
Evolution of susceptibility to ingested double-stranded RNAs in Caenorhabditis nematodes. PLoS One (2012) 1.23
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 1.23
aubergine mutations in Drosophila melanogaster impair P cytotype determination by telomeric P elements inserted in heterochromatin. Mol Genet Genomics (2004) 1.21
rasiRNA pathway controls antisense expression of Drosophila telomeric retrotransposons in the nucleus. Nucleic Acids Res (2008) 1.19
Small sense and antisense RNAs derived from a telomeric retroposon family in Giardia intestinalis. Eukaryot Cell (2005) 1.17
Early intermediates of mariner transposition: catalysis without synapsis of the transposon ends suggests a novel architecture of the synaptic complex. Mol Cell Biol (2004) 1.15
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet (2011) 1.13
Silencing of a gene adjacent to the breakpoint of a widespread Drosophila inversion by a transposon-induced antisense RNA. Proc Natl Acad Sci U S A (2004) 1.12
Epigenetic regulation of the rice retrotransposon Tos17. Mol Genet Genomics (2006) 1.09
Diversification of the core RNA interference machinery in Chlamydomonas reinhardtii and the role of DCL1 in transposon silencing. Genetics (2008) 1.04
The RNA silencing pathway: the bits and pieces that matter. PLoS Comput Biol (2005) 1.04
Anti-viral RNA silencing: do we look like plants? Retrovirology (2006) 1.03
Shielding of sleeping beauty DNA transposon-delivered transgene cassettes by heterologous insulators in early embryonal cells. Mol Ther (2008) 1.02
Polymerase Θ is a key driver of genome evolution and of CRISPR/Cas9-mediated mutagenesis. Nat Commun (2015) 1.02
"siRNAs and miRNAs": a meeting report on RNA silencing. RNA (2004) 1.02
The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A. Nucleic Acids Res (2007) 1.01
Transcribed Tc1-like transposons in salmonid fish. BMC Genomics (2005) 1.00
Natural epigenetic protection against the I-factor, a Drosophila LINE retrotransposon, by remnants of ancestral invasions. PLoS One (2007) 1.00
Hallmarks of RNA silencing are found in the smut fungus Ustilago hordei but not in its close relative Ustilago maydis. Curr Genet (2007) 1.00
Untangling the web: the diverse functions of the PIWI/piRNA pathway. Mol Reprod Dev (2013) 0.98
RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. J Biol Chem (2012) 0.98
Genome-wide target profiling of piggyBac and Tol2 in HEK 293: pros and cons for gene discovery and gene therapy. BMC Biotechnol (2011) 0.98
L1 retrotransposons, cancer stem cells and oncogenesis. FEBS J (2013) 0.97
A genome-wide transcriptional activity survey of rice transposable element-related genes. Genome Biol (2007) 0.96
A single transgene locus triggers both transcriptional and post-transcriptional silencing through double-stranded RNA production. Planta (2006) 0.95
Survey sequencing reveals elevated DNA transposon activity, novel elements, and variation in repetitive landscapes among vesper bats. Genome Biol Evol (2012) 0.94
Insights from the worm: the C. elegans model for innate immunity. Semin Immunol (2014) 0.94
Expression site silencing and life-cycle progression appear normal in Argonaute1-deficient Trypanosoma brucei. Mol Biochem Parasitol (2006) 0.93
Differential epigenetic regulation within an Arabidopsis retroposon family. Genetics (2007) 0.93
Learning to live together: mutualism between self-splicing introns and their hosts. BMC Biol (2011) 0.93
Chromatin remodeling by the small RNA machinery in mammalian cells. Epigenetics (2013) 0.92
MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer. Open Biol (2013) 0.91
Molecular characterization of embryonic gonads by gene expression profiling in Drosophila melanogaster. Proc Natl Acad Sci U S A (2006) 0.90
Functional diversity of RNAi-associated sRNAs in fungi. Int J Mol Sci (2013) 0.90
Evidence for small RNAs homologous to effector-encoding genes and transposable elements in the oomycete Phytophthora infestans. PLoS One (2012) 0.89
DNA transposon-based gene vehicles - scenes from an evolutionary drive. J Biomed Sci (2013) 0.89
The Dictyostelium discoideum RNA-dependent RNA polymerase RrpC silences the centromeric retrotransposon DIRS-1 post-transcriptionally and is required for the spreading of RNA silencing signals. Nucleic Acids Res (2013) 0.89
Functional complementation of RNA interference mutants in trypanosomes. BMC Biotechnol (2005) 0.89
The diverse functions of microRNAs in animal development and disease. Dev Cell (2006) 15.62
MicroRNA expression in zebrafish embryonic development. Science (2005) 15.52
Processing of primary microRNAs by the Microprocessor complex. Nature (2004) 14.59
Phylogenetic shadowing and computational identification of human microRNA genes. Cell (2005) 13.24
The zebrafish reference genome sequence and its relationship to the human genome. Nature (2013) 8.52
MicroRNA function in animal development. FEBS Lett (2005) 6.93
In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes. Nat Methods (2006) 6.67
Diversity of microRNAs in human and chimpanzee brain. Nat Genet (2006) 6.57
A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell (2007) 6.31
Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol (2002) 5.66
Secondary siRNAs result from unprimed RNA synthesis and form a distinct class. Science (2006) 5.49
Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions. PLoS Biol (2003) 5.07
The microRNA-producing enzyme Dicer1 is essential for zebrafish development. Nat Genet (2003) 4.97
RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA (2005) 4.91
Concern Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic Acids Res (2004) 4.50
Approaches to microRNA discovery. Nat Genet (2006) 4.32
A micrococcal nuclease homologue in RNAi effector complexes. Nature (2003) 3.67
Efficient target-selected mutagenesis in zebrafish. Genome Res (2003) 3.61
Mapping determinants of gene expression plasticity by genetical genomics in C. elegans. PLoS Genet (2006) 3.39
Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev (2004) 3.21
MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system. Genome Biol (2007) 3.05
Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. PLoS Biol (2007) 3.04
Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proc Natl Acad Sci U S A (2004) 2.89
The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89
Identification of genes that protect the C. elegans genome against mutations by genome-wide RNAi. Genes Dev (2003) 2.76
Target-selected inactivation of the zebrafish rag1 gene. Science (2002) 2.60
Cloning and expression of new microRNAs from zebrafish. Nucleic Acids Res (2006) 2.58
Differences in vertebrate microRNA expression. Proc Natl Acad Sci U S A (2006) 2.45
Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nat Biotechnol (2003) 2.37
Gene expression: long-term gene silencing by RNAi. Nature (2006) 2.27
Genetic variation in the zebrafish. Genome Res (2006) 2.22
Camels and zebrafish, viruses and cancer: a microRNA update. Hum Mol Genet (2005) 2.18
Dicers at RISC; the mechanism of RNAi. Cell (2004) 2.14
Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. Mol Cell Biol (2003) 2.13
The genetics of RNA silencing. Annu Rev Genet (2002) 2.10
Homologous gene targeting in Caenorhabditis elegans by biolistic transformation. Nucleic Acids Res (2004) 2.06
C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. PLoS Genet (2008) 2.03
Mouse microRNA profiles determined with a new and sensitive cloning method. Nucleic Acids Res (2006) 1.94
Chromatin and RNAi factors protect the C. elegans germline against repetitive sequences. Genes Dev (2005) 1.94
A genome-wide screen identifies 27 genes involved in transposon silencing in C. elegans. Curr Biol (2003) 1.92
RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs. Science (2002) 1.91
PPW-1, a PAZ/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans. Curr Biol (2002) 1.91
Structural features of small RNA precursors determine Argonaute loading in Caenorhabditis elegans. Nat Struct Mol Biol (2007) 1.84
LPIN2 is associated with type 2 diabetes, glucose metabolism, and body composition. Diabetes (2007) 1.83
Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway. Genes Dev (2007) 1.74
Generation of gene knockouts and mutant models in the laboratory rat by ENU-driven target-selected mutagenesis. Pharmacogenet Genomics (2006) 1.60
Genes required for systemic RNA interference in Caenorhabditis elegans. Curr Biol (2004) 1.59
CONREAL: conserved regulatory elements anchored alignment algorithm for identification of transcription factor binding sites by phylogenetic footprinting. Genome Res (2003) 1.57
Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans. EMBO J (2004) 1.56
RNAi protects the Caenorhabditis elegans germline against transposition. Trends Genet (2004) 1.48
Single nucleotide polymorphisms associated with rat expressed sequences. Genome Res (2004) 1.43
A Caenorhabditis elegans wild type defies the temperature-size rule owing to a single nucleotide polymorphism in tra-3. PLoS Genet (2007) 1.41
Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. Curr Biol (2006) 1.35
Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol (2006) 1.30
Target-selected mutagenesis of the rat. Genomics (2004) 1.26
GENOTRACE: cDNA-based local GENOme assembly from TRACE archives. Bioinformatics (2002) 1.25
Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality. Proc Natl Acad Sci U S A (2004) 1.21
Efficient target-selected mutagenesis in Caenorhabditis elegans: toward a knockout for every gene. Genome Res (2007) 1.20
Target-selected gene inactivation in zebrafish. Methods Cell Biol (2004) 1.16
The G-protein gamma subunit gpc-1 of the nematode C.elegans is involved in taste adaptation. EMBO J (2002) 1.16
Frequent germline mutations and somatic repeat instability in DNA mismatch-repair-deficient Caenorhabditis elegans. Genetics (2002) 1.11
RDE-2 interacts with MUT-7 to mediate RNA interference in Caenorhabditis elegans. Nucleic Acids Res (2005) 1.10
Continuous exchange of sequence information between dispersed Tc1 transposons in the Caenorhabditis elegans genome. Genetics (2003) 1.06
RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. EMBO J (2007) 1.04
Genetic variation in coding regions between and within commonly used inbred rat strains. Genome Res (2004) 1.01
RNA interference spreading in C. elegans. Methods Enzymol (2005) 0.99
A position-dependent organisation of retinoid response elements is conserved in the vertebrate Hox clusters. Trends Genet (2003) 0.98
Identification of a rat model for usher syndrome type 1B by N-ethyl-N-nitrosourea mutagenesis-driven forward genetics. Genetics (2005) 0.92
Proteins interacting with Caenorhabditis elegans Galpha subunits. Comp Funct Genomics (2003) 0.91
Hyperactivation of the G12-mediated signaling pathway in Caenorhabditis elegans induces a developmental growth arrest via protein kinase C. Curr Biol (2003) 0.89
Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Genetics (2003) 0.89
Isolation of RNA from C. elegans. CSH Protoc (2006) 0.88
Functional characterization of the adenylyl cyclase gene sgs-1 by analysis of a mutational spectrum in Caenorhabditis elegans. Genetics (2002) 0.88
Genomic instability and cancer: scanning the Caenorhabditis elegans genome for tumor suppressors. Oncogene (2004) 0.81
Shotgun cloning of transposon insertions in the genome of Caenorhabditis elegans. Comp Funct Genomics (2004) 0.80
Cosuppression in C. elegans. CSH Protoc (2006) 0.76
X-ray absorption spectroscopic studies of zinc in the N-terminal domain of HIV-2 integrase and model compounds. J Synchrotron Radiat (2002) 0.76
Knocking out the Argonautes. Cell (2006) 0.76
What's new about RNAi? Meeting on siRNAs and miRNAs. EMBO Rep (2004) 0.75
Introduction of Double-Stranded RNA in C. elegans by Injection. CSH Protoc (2006) 0.75
Detection of siRNA in C. elegans Using RNase Protection. CSH Protoc (2006) 0.75
Ronald H.A. Plasterk. Interview by Suzanne Berry. Trends Biotechnol (2002) 0.75
Introduction of Double-Stranded RNA in C. elegans by Feeding. CSH Protoc (2006) 0.75
Introduction of Double-Stranded RNA in C. elegans by Soaking. CSH Protoc (2006) 0.75
Detection of si/miRNA in C. elegans by Northern Blot. CSH Protoc (2006) 0.75