Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress.

PubWeight™: 1.39‹?› | Rank: Top 5%

🔗 View Article (PMC 1892360)

Published in Am J Pathol on December 01, 2003

Authors

Hui-Ching Wang1, Han-Chieh Wu, Chien-Fu Chen, Nelson Fausto, Huan-Yao Lei, Ih-Jen Su

Author Affiliations

1: Graduate Institutes of Basic Medical Sciences, Molecular Medicine, and Immunology and Microbiology, National Cheng Kung University College of Medicine, Tainan, Taiwan.

Associated clinical trials:

Efficacy of HBV Vaccine in Consolidation of Nucleos(t)Ide Analogues Therapy | NCT02505009

Articles citing this

Subversion of cellular autophagy machinery by hepatitis B virus for viral envelopment. J Virol (2011) 1.41

Intersection of the unfolded protein response and hepatic lipid metabolism. Cell Mol Life Sci (2009) 1.24

Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B. J Infect Dis (2011) 1.11

Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus. J Virol (2006) 1.05

Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation. PLoS One (2012) 1.04

Coinfection of hepatic cell lines with human immunodeficiency virus and hepatitis B virus leads to an increase in intracellular hepatitis B surface antigen. J Virol (2010) 0.97

Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in Qidong, China. PLoS One (2014) 0.95

Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma. Mol Med (2012) 0.94

Unfolded protein response in hepatitis C virus infection. Front Microbiol (2014) 0.92

Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells. PLoS One (2011) 0.92

Coexistence of hepatitis B virus quasispecies enhances viral replication and the ability to induce host antibody and cellular immune responses. J Virol (2014) 0.90

Modulation of the unfolded protein response by the human hepatitis B virus. Front Microbiol (2014) 0.90

Therapeutic strategies for a functional cure of chronic hepatitis B virus infection. Acta Pharm Sin B (2014) 0.89

Hepatitis B virus genetic variants: biological properties and clinical implications. Emerg Microbes Infect (2013) 0.88

Molecular biology of hepatitis B virus: effect of nucleotide substitutions on the clinical features of chronic hepatitis B. Med Mol Morphol (2006) 0.87

Overview of hepatitis B viral replication and genetic variability. J Hepatol (2016) 0.87

The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis. J Biomed Sci (2014) 0.86

Tissue- and Serum-Associated Biomarkers of Hepatocellular Carcinoma. Biomark Cancer (2016) 0.85

A pre-S gene chip to detect pre-S deletions in hepatitis B virus large surface antigen as a predictive marker for hepatoma risk in chronic hepatitis B virus carriers. J Biomed Sci (2009) 0.84

The N-Glycosylation Modification of LHBs (Large Surface Proteins of HBV) Effects on Endoplasmic Reticulum Stress, Cell Proliferation and its Secretion. Hepat Mon (2013) 0.83

Pre-s mutation is a significant risk factor for hepatocellular carcinoma development: a long-term retrospective cohort study. Dig Dis Sci (2012) 0.83

mTOR in viral hepatitis and hepatocellular carcinoma: function and treatment. Biomed Res Int (2014) 0.82

Increased expression of Gp96 by HBx-induced NF-κB activation feedback enhances hepatitis B virus production. PLoS One (2013) 0.82

In vitro replication phenotype of a novel (-1G) hepatitis B virus variant associated with HIV co-infection. J Med Virol (2012) 0.81

Functional analysis of hepatitis B virus pre-s deletion variants associated with hepatocellular carcinoma. J Biomed Sci (2012) 0.81

Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection. ISRN Gastroenterol (2013) 0.80

Hepatocellular carcinoma and hepatitis B surface protein. World J Gastroenterol (2016) 0.79

Association of preS/S Mutations with Occult Hepatitis B Virus (HBV) Infection in South Korea: Transmission Potential of Distinct Occult HBV Variants. Int J Mol Sci (2015) 0.79

Resistance of ground glass hepatocytes to oral antivirals in chronic hepatitis B patients and implication for the development of hepatocellular carcinoma. Oncotarget (2016) 0.78

Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics. World J Hepatol (2015) 0.78

Hepatitis B virus PreS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability. Oncotarget (2016) 0.78

HBsAg inhibits the translocation of JTB into mitochondria in HepG2 cells and potentially plays a role in HCC progression. PLoS One (2012) 0.78

Zinc-dependent interaction between JAB1 and pre-S2 mutant large surface antigen of hepatitis B virus and its implications for viral hepatocarcinogenesis. J Virol (2013) 0.77

A ubiquitin independent degradation pathway utilized by a hepatitis B virus envelope protein to limit antigen presentation. PLoS One (2011) 0.77

Clinical significance and evolution of hepatic HBsAg expression in HBeAg-positive patients receiving interferon therapy. J Gastroenterol (2013) 0.77

Significance of viral status on occurrence of hepatitis B-related hepatocellular carcinoma. World J Gastroenterol (2014) 0.77

Different pre-S deletion patterns and their association with hepatitis B virus genotypes. World J Gastroenterol (2016) 0.76

Activation of ATP citrate lyase by mTOR signal induces disturbed lipid metabolism in hepatitis B virus pre-S2 mutant tumorigenesis. J Virol (2014) 0.76

Induction of apurinic endonuclease 1 overexpression by endoplasmic reticulum stress in hepatoma cells. Int J Mol Sci (2014) 0.75

Hepatitis B Virus-Related Hepatocellular Carcinoma: Pathogenic Mechanisms and Novel Therapeutic Interventions. Gastrointest Tumors (2014) 0.75

Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo. Infect Agent Cancer (2016) 0.75

Screening of hepatocyte proteins binding with C‑terminally truncated surface antigen middle protein of hepatitis B virus (MHBst167) by a yeast two‑hybrid system. Mol Med Rep (2014) 0.75

Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver. Sci Rep (2016) 0.75

LHBs can elevate the expression of MDR1 through HIF-1α in patients with CHB infection: a comparative proteomic study. Oncotarget (2017) 0.75

HBV DNA Integration: Molecular Mechanisms and Clinical Implications. Viruses (2017) 0.75

Articles cited by this

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature (1999) 16.97

Hepatitis B virus infection. N Engl J Med (1997) 14.50

Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature (2000) 13.45

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell (1993) 9.84

Hepatitis B virus immunopathogenesis. Annu Rev Immunol (1995) 8.62

Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer (1988) 7.05

Large surface proteins of hepatitis B virus containing the pre-s sequence. J Virol (1984) 6.90

Vaccine-induced escape mutant of hepatitis B virus. Lancet (1990) 5.31

Viral strategies of immune evasion. Science (1998) 4.48

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell (1989) 3.60

HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection. J Immunol (1993) 3.42

Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. Science (1986) 3.01

Pattern of core and surface expression in liver tissue reflects state of specific immune response in hepatitis B. Lab Invest (1975) 2.97

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol (1986) 2.94

HLA-A31- and HLA-Aw68-restricted cytotoxic T cell responses to a single hepatitis B virus nucleocapsid epitope during acute viral hepatitis. J Exp Med (1993) 2.49

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. EMBO J (1995) 2.31

Signal transduction from the endoplasmic reticulum to the cell nucleus. Physiol Rev (1999) 2.16

Infection process of the hepatitis B virus depends on the presence of a defined sequence in the pre-S1 domain. J Virol (1999) 2.09

Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection. J Clin Invest (1996) 2.04

The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. Crit Rev Eukaryot Gene Expr (1994) 2.00

Naturally occurring variants of hepatitis B virus. Adv Virus Res (1999) 1.72

Cytoplasmic hepatitis B antigen in "ground-glass" hepatocytes of carriers. Arch Pathol (1973) 1.65

Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein. J Virol (1987) 1.64

Activation of transcription factor NF-kappaB by the adenovirus E3/19K protein requires its ER retention. J Cell Biol (1996) 1.62

Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol (1997) 1.56

Prevalence and significance of hepatitis B virus (HBV) pre-S mutants in serum and liver at different replicative stages of chronic HBV infection. Hepatology (2001) 1.54

Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96. Curr Opin Immunol (1998) 1.36

The hepatitis B virus large surface protein (LHBs) is a transcriptional activator. Virology (1996) 1.32

The PreS2 activator MHBs(t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice. EMBO J (2002) 1.27

Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles. J Virol (1996) 1.25

Properties of hepatitis B virus pre-S1 deletion mutants. Virology (1994) 1.15

Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice. Hepatology (1995) 1.09

Identification of a pre-S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection. J Gastroenterol Hepatol (2000) 1.08

Australia antigen in liver tissue--an immunofluorescent and immunoelectron microscopic study. Jpn J Exp Med (1973) 1.06

The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted. J Virol (1997) 1.05

Concentration of dilute protein for gel electrophoresis. Anal Biochem (1995) 1.04

Hepatic expression patterns of the large and middle hepatitis B virus surface proteins in viremic and nonviremic chronic hepatitis B. Gastroenterology (1990) 1.01

Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor. J Virol (1992) 0.99

The PreS2 activators of the hepatitis B virus: activators of tumour promoter pathways. Recent Results Cancer Res (1998) 0.99

Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen. J Virol (1997) 0.96

Activation of the hepatitis B virus S promoter by transcription factor NF-Y via a CCAAT element. Virology (1996) 0.92

Correlation of hepatocyte HBsAg expression with virus replication and liver pathology. Hepatology (1988) 0.90

The pre-S region determines the intracellular localization and appearance of hepatitis B virus. Hepatology (1999) 0.90

The ground glass hepatocyte as a diagnostic hint. Hum Pathol (1975) 0.87

Diverse virological, histopathological and prognostic implications of seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. J Hepatol (1986) 0.84

Demonstration of pre-S polypeptides of hepatitis B virus in infected livers. Hepatology (1987) 0.83

Liver biopsy interpretation in hepatitis. Part I. Presentation of critical morphologic features used in diagnosis (glossary). Pathol Res Pract (1983) 0.81

Activation of promoters for cellular lipogenic genes by hepatitis B virus large surface protein. Virology (2000) 0.80

Hepatocyte hepatitis B surface antigen. Diagnostic evaluation of patients with clinically acute hepatitis B surface antigen-positive hepatitis. Arch Pathol Lab Med (1985) 0.78

Articles by these authors

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92

Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08

Integration with the human genome of peptide sequences obtained by high-throughput mass spectrometry. Genome Biol (2004) 4.91

Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development (2006) 4.88

Milrinone therapy for enterovirus 71-induced pulmonary edema and/or neurogenic shock in children: a randomized controlled trial. Crit Care Med (2013) 2.88

CLEC5A is critical for dengue-virus-induced lethal disease. Nature (2008) 2.79

Waning immunity to plasma-derived hepatitis B vaccine and the need for boosters 15 years after neonatal vaccination. Hepatology (2004) 2.74

Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis. J Bacteriol (2009) 2.64

Change of major genotype of enterovirus 71 in outbreaks of hand-foot-and-mouth disease in Taiwan between 1998 and 2000. J Clin Microbiol (2002) 2.64

A revisit of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in non-Hodgkin's lymphoma: a randomized trial. Hepatology (2008) 2.55

Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis (2004) 2.43

Reemergence of enterovirus 71 in 2008 in taiwan: dynamics of genetic and antigenic evolution from 1998 to 2008. J Clin Microbiol (2009) 2.40

Pathogenesis of enterovirus 71 brainstem encephalitis in pediatric patients: roles of cytokines and cellular immune activation in patients with pulmonary edema. J Infect Dis (2003) 2.36

Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma. Proc Natl Acad Sci U S A (2005) 2.28

Autophagic machinery activated by dengue virus enhances virus replication. Virology (2008) 2.23

Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes. Am J Pathol (2007) 2.18

Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model. Hepatology (2007) 2.16

Steroid-free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma. Hepatology (2003) 2.15

Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes. Arterioscler Thromb Vasc Biol (2006) 2.13

A mouse-adapted enterovirus 71 strain causes neurological disease in mice after oral infection. J Virol (2004) 2.10

Immature dengue virus: a veiled pathogen? PLoS Pathog (2010) 2.04

SARS in healthcare facilities, Toronto and Taiwan. Emerg Infect Dis (2004) 1.95

The dual-specific binding of dengue virus and target cells for the antibody-dependent enhancement of dengue virus infection. J Immunol (2006) 1.93

Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase. J Biol Chem (2004) 1.86

The autophagic induction in Helicobacter pylori-infected macrophage. Exp Biol Med (Maywood) (2008) 1.83

An interferon-gamma-related cytokine storm in SARS patients. J Med Virol (2005) 1.83

Establishing a nationwide emergency department-based syndromic surveillance system for better public health responses in Taiwan. BMC Public Health (2008) 1.81

Hepatitis C virus and liver disease: global transcriptional profiling and identification of potential markers. Hepatology (2003) 1.80

Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone resistance and extended-spectrum-beta-lactamase activity in a clinical Klebsiella pneumoniae isolate. Antimicrob Agents Chemother (2006) 1.76

Antibodies from dengue patient sera cross-react with endothelial cells and induce damage. J Med Virol (2003) 1.72

Epidemiological survey of enterovirus infections occurring in Taiwan between 2000 and 2005: analysis of sentinel physician surveillance data. J Med Virol (2007) 1.69

Sensitive and quantitative detection of severe acute respiratory syndrome coronavirus infection by real-time nested polymerase chain reaction. Clin Infect Dis (2003) 1.68

Pre-S mutant surface antigens in chronic hepatitis B virus infection induce oxidative stress and DNA damage. Carcinogenesis (2004) 1.67

Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: molecular epidemiology and genome evolution. Proc Natl Acad Sci U S A (2004) 1.66

Hepatitis B virus pre-S mutants, endoplasmic reticulum stress and hepatocarcinogenesis. Cancer Sci (2006) 1.64

MCP-1, a highly expressed chemokine in dengue haemorrhagic fever/dengue shock syndrome patients, may cause permeability change, possibly through reduced tight junctions of vascular endothelium cells. J Gen Virol (2006) 1.63

Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. J Exp Med (2007) 1.62

Pre-S2 deletion mutants of hepatitis B virus could have an important role in hepatocarcinogenesis in Asian children. Cancer Sci (2009) 1.61

Retrograde axonal transport: a major transmission route of enterovirus 71 in mice. J Virol (2007) 1.61

Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. Am J Trop Med Hyg (2006) 1.61

Molecular epidemiology and evolutionary genetics of Mycobacterium tuberculosis in Taipei. BMC Infect Dis (2008) 1.59

All chronic rejection failures of kidney transplants were preceded by the development of HLA antibodies. Transplantation (2002) 1.58

Establishment, characterization, and long-term maintenance of cultures of human fetal hepatocytes. Hepatology (2003) 1.58

Distinct cellular responses differentiating alcohol- and hepatitis C virus-induced liver cirrhosis. Virol J (2006) 1.58

Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest (2002) 1.58

Type I interferons protect mice against enterovirus 71 infection. J Gen Virol (2005) 1.57

Gene expression profiling of the cellular transcriptional network regulated by alpha/beta interferon and its partial attenuation by the hepatitis C virus nonstructural 5A protein. J Virol (2003) 1.56

New concepts in liver regeneration. J Gastroenterol Hepatol (2011) 1.55

Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle. Mol Cell Biol (2011) 1.55

Effect of type 2 diabetes mellitus on the clinical severity and treatment outcome in patients with pulmonary tuberculosis: a potential role in the emergence of multidrug-resistance. J Formos Med Assoc (2011) 1.53

Transforming growth factor-beta differentially regulates oval cell and hepatocyte proliferation. Hepatology (2007) 1.50

A murine oral enterovirus 71 infection model with central nervous system involvement. J Gen Virol (2004) 1.49

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity. J Hepatol (2008) 1.44

Heparin-binding epidermal growth factor-like growth factor links hepatocyte priming with cell cycle progression during liver regeneration. J Biol Chem (2004) 1.44

Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization. J Infect Dis (2008) 1.43

Endothelial cell apoptosis induced by antibodies against dengue virus nonstructural protein 1 via production of nitric oxide. J Immunol (2002) 1.40

Identification of novel tumor markers in hepatitis C virus-associated hepatocellular carcinoma. Cancer Res (2003) 1.40

Modulation of cytokine production by intravenous immunoglobulin in patients with enterovirus 71-associated brainstem encephalitis. J Clin Virol (2006) 1.39

Gene expression patterns that correlate with hepatitis C and early progression to fibrosis in liver transplant recipients. Gastroenterology (2006) 1.38

Long-term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma. J Natl Cancer Inst (2005) 1.35

Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes. Hepatology (2005) 1.35

Interleukin-17-producing cell infiltration in the breast cancer tumour microenvironment is a poor prognostic factor. Histopathology (2013) 1.35

Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. Am J Trop Med Hyg (2005) 1.34

Autoimmune pathogenesis in dengue virus infection. Viral Immunol (2006) 1.32

Intracellular localization and determination of a nuclear localization signal of the core protein of dengue virus. J Gen Virol (2002) 1.32

Challenges to licensure of enterovirus 71 vaccines. PLoS Negl Trop Dis (2012) 1.31

Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. Antimicrob Agents Chemother (2007) 1.28

Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis. J Infect Dis (2008) 1.28

Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan. J Clin Microbiol (2005) 1.26

Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1. J Immunol (2005) 1.26

Virus replication and cytokine production in dengue virus-infected human B lymphocytes. J Virol (2002) 1.25

Proinflammatory cytokine production in liver regeneration is Myd88-dependent, but independent of Cd14, Tlr2, and Tlr4. J Immunol (2006) 1.25

Inhibition of RIP2/RIck/CARDIAK activity by pyridinyl imidazole inhibitors of p38 MAPK. Mol Cell Biochem (2005) 1.22

Heparin inhibits dengue-2 virus infection of five human liver cell lines. Antiviral Res (2002) 1.21

Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan. Hum Pathol (2005) 1.21

Dengue viruses can infect human primary lung epithelia as well as lung carcinoma cells, and can also induce the secretion of IL-6 and RANTES. Virus Res (2007) 1.20

Association of NRAMP 1 gene polymorphism with susceptibility to tuberculosis in Taiwanese aboriginals. J Formos Med Assoc (2006) 1.20

Extracellular matrix dynamics in hepatocarcinogenesis: a comparative proteomics study of PDGFC transgenic and Pten null mouse models. PLoS Genet (2011) 1.20

Neutrophils and macrophages promote angiogenesis in the early stage of endometriosis in a mouse model. Endocrinology (2005) 1.20

Treatment outcome and pattern of failure in 77 patients with sinonasal natural killer/T-cell or T-cell lymphoma. Cancer (2004) 1.19

Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma. Cancer Lett (2006) 1.19

TGFbeta1-induced suppression of glutathione antioxidant defenses in hepatocytes: caspase-dependent post-translational and caspase-independent transcriptional regulatory mechanisms. FASEB J (2003) 1.18

Appearance of intratypic recombination of enterovirus 71 in Taiwan from 2002 to 2005. Virus Res (2007) 1.18

Genetic diversity of multidrug-resistant Mycobacterium tuberculosis isolates and identification of 11 novel rpoB alleles in Taiwan. J Clin Microbiol (2005) 1.18

Epidermal growth factor receptor transactivation mediates tumor necrosis factor-induced hepatocyte replication. J Biol Chem (2004) 1.17

Enhanced expression of vascular endothelial growth factor-A in ground glass hepatocytes and its implication in hepatitis B virus hepatocarcinogenesis. Hepatology (2009) 1.16