The glycophorin A transmembrane domain dimer: sequence-specific propensity for a right-handed supercoil of helices.

PubWeight™: 1.57‹?› | Rank: Top 4%

🔗 View Article (PMID 1463744)

Published in Biochemistry on December 29, 1992

Authors

H R Treutlein1, M A Lemmon, D M Engelman, A T Brünger

Author Affiliations

1: Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06511.

Articles citing this

Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel. EMBO J (1994) 1.52

Effect of detergents on the association of the glycophorin a transmembrane helix. Biophys J (2003) 1.51

A Transmembrane Domain GGxxG Motif in CD4 Contributes to Its Lck-Independent Function but Does Not Mediate CD4 Dimerization. PLoS One (2015) 1.41

Parallel helix bundles and ion channels: molecular modeling via simulated annealing and restrained molecular dynamics. Biophys J (1994) 1.41

How do helix-helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo-oligomeric helical bundles. Protein Sci (2003) 1.38

The pore domain of the nicotinic acetylcholine receptor: molecular modeling, pore dimensions, and electrostatics. Biophys J (1996) 1.34

Transmembrane helix dimerization: beyond the search for sequence motifs. Biochim Biophys Acta (2011) 1.26

Cloning and characterization of gp36, a human mucin-type glycoprotein preferentially expressed in vascular endothelium. Biochem J (1999) 1.21

Interaction and conformational dynamics of membrane-spanning protein helices. Protein Sci (2009) 1.19

Ala-insertion scanning mutagenesis of the glycophorin A transmembrane helix: a rapid way to map helix-helix interactions in integral membrane proteins. Protein Sci (1996) 1.15

Determination of helix-helix interactions in membranes by rotational resonance NMR. Proc Natl Acad Sci U S A (1995) 1.13

Molecular dynamics of individual alpha-helices of bacteriorhodopsin in dimyristol phosphatidylocholine. I. Structure and dynamics. Biophys J (1997) 1.10

Mapping the energy surface of transmembrane helix-helix interactions. Biophys J (2001) 1.03

Molecular dynamics simulations of individual alpha-helices of bacteriorhodopsin in dimyristoylphosphatidylcholine. II. Interaction energy analysis. Biophys J (1998) 1.02

Lipid-modulated sequence-specific association of glycophorin A in membranes. Biophys J (2010) 1.01

Modeling the structure of the respiratory syncytial virus small hydrophobic protein by silent-mutation analysis of global searching molecular dynamics. Protein Sci (2003) 1.00

Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer. J Mol Biol (2009) 1.00

TMKink: a method to predict transmembrane helix kinks. Protein Sci (2011) 0.98

Association of a model transmembrane peptide containing gly in a heptad sequence motif. Biophys J (2004) 0.98

Substitution rates in alpha-helical transmembrane proteins. Protein Sci (2001) 0.98

Activation of the erythropoietin receptor by the gp55-P viral envelope protein is determined by a single amino acid in its transmembrane domain. EMBO J (1999) 0.95

Seven-helix bundles: molecular modeling via restrained molecular dynamics. Biophys J (1995) 0.94

Insulin receptor activation with transmembrane domain ligands. J Biol Chem (2014) 0.94

Contribution of energy values to the analysis of global searching molecular dynamics simulations of transmembrane helical bundles. Biophys J (2002) 0.93

Dimerization of the polymeric immunoglobulin receptor controls its transcytotic trafficking. Mol Biol Cell (1998) 0.93

Multiple transmembrane amino acid requirements suggest a highly specific interaction between the bovine papillomavirus E5 oncoprotein and the platelet-derived growth factor beta receptor. J Virol (2002) 0.92

Transmembrane domain sequence requirements for activation of the p185c-neu receptor tyrosine kinase. J Cell Biol (1997) 0.88

Specificity for homooligomer versus heterooligomer formation in integrin transmembrane helices. J Mol Biol (2010) 0.84

Primary and secondary dimer interfaces of the fibroblast growth factor receptor 3 transmembrane domain: characterization via multiscale molecular dynamics simulations. Biochemistry (2014) 0.83

Beyond anchoring: the expanding role of the hendra virus fusion protein transmembrane domain in protein folding, stability, and function. J Virol (2012) 0.83

Association of transmembrane helices: what determines assembling of a dimer? J Comput Aided Mol Des (2006) 0.83

Using experimental information to produce a model of the transmembrane domain of the ion channel phospholamban. Biophys J (1998) 0.83

The association of polar residues in the DAP12 homodimer: TOXCAT and molecular dynamics simulation studies. Biophys J (2013) 0.81

Molecular dynamics simulation approach for the prediction of transmembrane helix-helix heterodimers assembly. Eur Biophys J (2007) 0.79

Molecular dynamics simulations of the E1/E2 transmembrane domain of the Semliki Forest virus. Biophys J (2003) 0.79

Distinct protein interfaces in transmembrane domains suggest an in vivo folding model. Protein Sci (2004) 0.78

Contribution of charged and polar residues for the formation of the E1-E2 heterodimer from Hepatitis C Virus. J Mol Model (2010) 0.78

A photon-free approach to transmembrane protein structure determination. J Mol Biol (2011) 0.78

New user-friendly approach to obtain an Eisenberg plot and its use as a practical tool in protein sequence analysis. Int J Mol Sci (2011) 0.77

Convergence and Sampling in Determining Free Energy Landscapes for Membrane Protein Association. J Phys Chem B (2016) 0.77

Orientation and dynamics of synthetic transbilayer polypeptides containing GpATM dimerization motifs. Biophys J (2011) 0.77

Articles by these authors

Crystallographic R factor refinement by molecular dynamics. Science (1987) 15.90

Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins. Annu Rev Biophys Biophys Chem (1986) 11.00

The spontaneous insertion of proteins into and across membranes: the helical hairpin hypothesis. Cell (1981) 7.77

New parameters for the refinement of nucleic acid-containing structures. Acta Crystallogr D Biol Crystallogr (1996) 6.92

Lipid bilayer thickness varies linearly with acyl chain length in fluid phosphatidylcholine vesicles. J Mol Biol (1983) 6.67

A transmembrane helix dimer: structure and implications. Science (1997) 6.46

The GxxxG motif: a framework for transmembrane helix-helix association. J Mol Biol (2000) 5.09

Membrane protein folding and oligomerization: the two-stage model. Biochemistry (1990) 4.86

Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures. J Mol Biol (1994) 4.77

Path of the polypeptide in bacteriorhodopsin. Proc Natl Acad Sci U S A (1980) 4.76

Sequence specificity in the dimerization of transmembrane alpha-helices. Biochemistry (1992) 4.19

Bilayer structure in membranes. Nat New Biol (1971) 4.12

Statistical analysis of amino acid patterns in transmembrane helices: the GxxxG motif occurs frequently and in association with beta-branched residues at neighboring positions. J Mol Biol (2000) 3.95

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell (1995) 3.65

Cross-validated maximum likelihood enhances crystallographic simulated annealing refinement. Proc Natl Acad Sci U S A (1997) 3.64

Helical membrane protein folding, stability, and evolution. Annu Rev Biochem (2000) 3.63

Glycophorin A dimerization is driven by specific interactions between transmembrane alpha-helices. J Biol Chem (1992) 3.52

Current models for the structure of biological membranes. J Cell Biol (1969) 3.47

Checking your imagination: applications of the free R value. Structure (1996) 3.40

Conformational variability in the refined structure of the chaperonin GroEL at 2.8 A resolution. Nat Struct Biol (1995) 3.36

X-ray diffraction studies of phase transitions in the membrane of Mycoplasma laidlawii. J Mol Biol (1970) 3.31

The effect of point mutations on the free energy of transmembrane alpha-helix dimerization. J Mol Biol (1997) 3.16

Interhelical hydrogen bonding drives strong interactions in membrane proteins. Nat Struct Biol (2000) 3.12

Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting. EMBO J (1998) 3.09

Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem (1998) 3.07

The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc Natl Acad Sci U S A (2001) 2.97

Structural changes are associated with soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor complex formation. J Biol Chem (1997) 2.96

Torsion angle dynamics: reduced variable conformational sampling enhances crystallographic structure refinement. Proteins (1994) 2.94

Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. Mol Cell (2000) 2.86

A dimerization motif for transmembrane alpha-helices. Nat Struct Biol (1994) 2.82

Lipid bilayer structure in the membrane of Mycoplasma laidlawii. J Mol Biol (1971) 2.81

TOXCAT: a measure of transmembrane helix association in a biological membrane. Proc Natl Acad Sci U S A (1999) 2.76

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J (1998) 2.75

Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2. Protein Eng (1988) 2.74

Bacteriorhodopsin is an inside-out protein. Proc Natl Acad Sci U S A (1980) 2.72

Direct observation of protein solvation and discrete disorder with experimental crystallographic phases. Science (1996) 2.65

The planar organization of lecithin-cholesterol bilayers. J Biol Chem (1972) 2.62

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Cell (1994) 2.61

Refinement of the influenza virus hemagglutinin by simulated annealing. J Mol Biol (1990) 2.61

Polar residues drive association of polyleucine transmembrane helices. Proc Natl Acad Sci U S A (2001) 2.47

A complete mapping of the proteins in the small ribosomal subunit of Escherichia coli. Science (1987) 2.43

Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin. Cell (1994) 2.41

Torsion-angle molecular dynamics as a new efficient tool for NMR structure calculation. J Magn Reson (1997) 2.31

Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly. Biochemistry (1998) 2.28

Identification of the binding site for acidic phospholipids on the pH domain of dynamin: implications for stimulation of GTPase activity. J Mol Biol (1996) 2.23

Refolding of bacteriorhodopsin in lipid bilayers. A thermodynamically controlled two-stage process. J Mol Biol (1987) 2.23

Phase improvement by cross-validated density modification. Acta Crystallogr D Biol Crystallogr (1995) 2.18

Two EGF molecules contribute additively to stabilization of the EGFR dimer. EMBO J (1997) 2.16

Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban. Nat Struct Biol (1995) 2.15

Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry (1997) 2.11

A single amino acid in the SH3 domain of Hck determines its high affinity and specificity in binding to HIV-1 Nef protein. EMBO J (1995) 2.10

Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. Proc Natl Acad Sci U S A (1995) 2.08

Bacteriorhodopsin remains dispersed in fluid phospholipid bilayers over a wide range of bilayer thicknesses. J Mol Biol (1983) 2.07

Structure of the ATP-dependent oligomerization domain of N-ethylmaleimide sensitive factor complexed with ATP. Nat Struct Biol (1998) 2.05

The length of the flexible SNAREpin juxtamembrane region is a critical determinant of SNARE-dependent fusion. Mol Cell (1999) 1.99

All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. J Biol Chem (2001) 1.96

Detergents modulate dimerization, but not helicity, of the glycophorin A transmembrane domain. J Mol Biol (1999) 1.94

Characterization of the plasma membrane of Mycoplasma laidlawii. I. Sodium dodecyl sulfate solubilization. Biochim Biophys Acta (1967) 1.90

Glycophorin A helical transmembrane domains dimerize in phospholipid bilayers: a resonance energy transfer study. Biochemistry (1994) 1.87

Characterization of the plasma membrane of Mycoplasma laidlawii. II. Modes of aggregation of solubilized membrane components. Biochim Biophys Acta (1967) 1.85

Molecular mechanism for the interaction of phospholipid with cholesterol. Nat New Biol (1972) 1.81

Specificity and promiscuity in membrane helix interactions. Q Rev Biophys (1994) 1.79

Specificity in transmembrane helix-helix interactions can define a hierarchy of stability for sequence variants. Proc Natl Acad Sci U S A (2001) 1.77

Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching. Proteins (1996) 1.75

The pleckstrin homology domains of dynamin isoforms require oligomerization for high affinity phosphoinositide binding. J Biol Chem (1998) 1.75

Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition. Nat Struct Biol (1998) 1.74

Phosphatidylinositol-4,5-bisphosphate is required for endocytic coated vesicle formation. Curr Biol (1999) 1.72

Truncated staphylococcal nuclease is compact but disordered. Proc Natl Acad Sci U S A (1992) 1.72

A structural change occurs upon binding of syntaxin to SNAP-25. J Biol Chem (1997) 1.72

Mutations can cause large changes in the conformation of a denatured protein. Biochemistry (1993) 1.69

Active site dynamics of ribonuclease. Proc Natl Acad Sci U S A (1985) 1.65

Surface area per lipid molecule in the intact membrane of the human red cell. Nature (1969) 1.65

Structural model of the phospholamban ion channel complex in phospholipid membranes. J Mol Biol (1995) 1.62

Analysis of a yeast SNARE complex reveals remarkable similarity to the neuronal SNARE complex and a novel function for the C terminus of the SNAP-25 homolog, Sec9. J Biol Chem (1997) 1.61

Structure-based prediction of the stability of transmembrane helix-helix interactions: the sequence dependence of glycophorin A dimerization. Proc Natl Acad Sci U S A (1998) 1.56

Extracellular domains drive homo- but not hetero-dimerization of erbB receptors. EMBO J (2000) 1.55

A neutron scattering study of the distribution of protein and RNA in the 30 S ribosomal subunit of Escherichia coli. J Mol Biol (1975) 1.54

Pair distribution functions of bacteriorhodopsin and rhodopsin in model bilayers. Biophys J (1983) 1.54

A zinc-binding domain involved in the dimerization of RAG1. J Mol Biol (1996) 1.53

Structural organization of the pentameric transmembrane alpha-helices of phospholamban, a cardiac ion channel. EMBO J (1994) 1.52

Three-dimensional structure of proteins determined by molecular dynamics with interproton distance restraints: application to crambin. Proc Natl Acad Sci U S A (1986) 1.52

Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation. Oncogene (1997) 1.52

The three-dimensional structure of alpha1-purothionin in solution: combined use of nuclear magnetic resonance, distance geometry and restrained molecular dynamics. EMBO J (1986) 1.50

Positions of S2, S13, S16, S17, S19 and S21 in the 30 S ribosomal subunit of Escherichia coli. J Mol Biol (1988) 1.50

Inelastic neutron scattering analysis of hexokinase dynamics and its modification on binding of glucose. Nature (1982) 1.45

Sampling and efficiency of metric matrix distance geometry: a novel partial metrization algorithm. J Biomol NMR (1992) 1.43

Amphipols: polymeric surfactants for membrane biology research. Cell Mol Life Sci (2003) 1.42

Chromophore-protein interactions and the function of the photosynthetic reaction center: a molecular dynamics study. Proc Natl Acad Sci U S A (1992) 1.40

Modulation of glycophorin A transmembrane helix interactions by lipid bilayers: molecular dynamics calculations. J Mol Biol (2000) 1.35

A biophysical study of integral membrane protein folding. Biochemistry (1997) 1.35

Characterization of the plasma membrane of Mycoplasma laidlawii. IV. Structure and composition of membrane and aggregated components. Biochim Biophys Acta (1968) 1.33

High-affinity binding of a FYVE domain to phosphatidylinositol 3-phosphate requires intact phospholipid but not FYVE domain oligomerization. Biochemistry (2001) 1.32

Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond. J Biol Chem (1994) 1.32

Positions of proteins S6, S11 and S15 in the 30 S ribosomal subunit of Escherichia coli. J Mol Biol (1981) 1.31