Published in J Biol Chem on November 24, 2003
Analysis of tissue specimens by matrix-assisted laser desorption/ionization imaging mass spectrometry in biological and clinical research. Chem Rev (2013) 1.80
Targeted single-cell microchemical analysis: MS-based peptidomics of individual paraformaldehyde-fixed and immunolabeled neurons. Chem Biol (2012) 1.51
Nanoparticle-detained toxins for safe and effective vaccination. Nat Nanotechnol (2013) 1.50
Postmortem MRI of human brain hemispheres: T2 relaxation times during formaldehyde fixation. Magn Reson Med (2009) 1.33
Structural characterization of formaldehyde-induced cross-links between amino acids and deoxynucleosides and their oligomers. J Am Chem Soc (2010) 1.28
Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates. Nat Protoc (2011) 1.24
Revealing novel telomere proteins using in vivo cross-linking, tandem affinity purification, and label-free quantitative LC-FTICR-MS. Mol Cell Proteomics (2010) 1.22
Propionate oxidation by and methanol inhibition of anaerobic ammonium-oxidizing bacteria. Appl Environ Microbiol (2005) 1.17
Cytoplasmic membrane protonmotive force energizes periplasmic interactions between ExbD and TonB. Mol Microbiol (2009) 1.17
Critical comparison of sample preparation strategies for shotgun proteomic analysis of formalin-fixed, paraffin-embedded samples: insights from liver tissue. Clin Proteomics (2014) 1.14
DNA mediated chromatin pull-down for the study of chromatin replication. Sci Rep (2011) 1.10
Special symposium: fixation and tissue processing models. Biotech Histochem (2009) 1.09
Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma. J Proteomics Bioinform (2013) 1.07
ChIP-exo signal associated with DNA-binding motifs provides insight into the genomic binding of the glucocorticoid receptor and cooperating transcription factors. Genome Res (2015) 1.05
Optimal use of tandem biotin and V5 tags in ChIP assays. BMC Mol Biol (2009) 1.02
In vivo T-box transcription factor profiling reveals joint regulation of embryonic neuromesodermal bipotency. Cell Rep (2013) 1.00
Imaging mass spectrometry of intact proteins from alcohol-preserved tissue specimens: bypassing formalin fixation. J Proteome Res (2008) 0.96
Complete solubilization of formalin-fixed, paraffin-embedded tissue may improve proteomic studies. Proteomics Clin Appl (2013) 0.95
Formaldehyde Crosslinking: A Tool for the Study of Chromatin Complexes. J Biol Chem (2015) 0.94
Precision of multiple reaction monitoring mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue. J Proteome Res (2012) 0.94
Antigen retrieval causes protein unfolding: evidence for a linear epitope model of recovered immunoreactivity. J Histochem Cytochem (2011) 0.92
Sorbin and SH3 domain-containing protein 2 is released from infarcted heart in the very early phase: proteomic analysis of cardiac tissues from patients. J Am Heart Assoc (2013) 0.92
Elucidation of sigma factor-associated networks in Pseudomonas aeruginosa reveals a modular architecture with limited and function-specific crosstalk. PLoS Pathog (2015) 0.91
Elevated Pressure Improves the Rate of Formalin Penetration while Preserving Tissue Morphology. J Cancer (2010) 0.90
Structural Studies of Medicago truncatula Histidinol Phosphate Phosphatase from Inositol Monophosphatase Superfamily Reveal Details of Penultimate Step of Histidine Biosynthesis in Plants. J Biol Chem (2016) 0.90
Bivalent recombinant vaccine for botulinum neurotoxin types A and B based on a polypeptide comprising their effector and translocation domains that is protective against the predominant A and B subtypes. Infect Immun (2009) 0.89
Use of LC-MS/MS and stable isotopes to differentiate hydroxymethyl and methyl DNA adducts from formaldehyde and nitrosodimethylamine. Chem Res Toxicol (2012) 0.89
Reactions of beta-propiolactone with nucleobase analogues, nucleosides, and peptides: implications for the inactivation of viruses. J Biol Chem (2011) 0.89
The effect of antigen retrieval on cells fixed in 10% neutral buffered formalin followed by transfer to 70% ethanol. PLoS One (2013) 0.86
Rational design and evaluation of FRET experiments to measure protein proximities in cells. Curr Protoc Cell Biol (2006) 0.86
Current approaches on viral infection: proteomics and functional validations. Front Microbiol (2012) 0.85
Proteomic identification of immunoproteasome accumulation in formalin-fixed rodent spinal cords with experimental autoimmune encephalomyelitis. J Proteome Res (2012) 0.85
Exploring DNA-binding proteins with in vivo chemical cross-linking and mass spectrometry. J Proteome Res (2009) 0.85
The molecular basis of the specificity and cross-reactivity of the NeuN epitope of the neuron-specific splicing regulator, Rbfox3. Histochem Cell Biol (2013) 0.85
Preservation of immunorecognition by transferring cells from 10% neutral buffered formalin to 70% ethanol. Biotech Histochem (2013) 0.84
A method for investigating protein-protein interactions related to salmonella typhimurium pathogenesis. J Proteome Res (2009) 0.83
Plasmodium falciparum-derived uric acid precipitates induce maturation of dendritic cells. PLoS One (2013) 0.83
The non-coding B2 RNA binds to the DNA cleft and active-site region of RNA polymerase II. J Mol Biol (2013) 0.83
Elevated pressure improves the extraction and identification of proteins recovered from formalin-fixed, paraffin-embedded tissue surrogates. PLoS One (2010) 0.83
Validation of a robust proteomic analysis carried out on formalin-fixed paraffin-embedded tissues of the pancreas obtained from mouse and human. Proteomics (2012) 0.83
Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope prediction. J Virol (2014) 0.82
MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev (2016) 0.82
Taurolidine antiadhesive properties on interaction with E. coli; its transformation in biological environment and interaction with bacteria cell wall. PLoS One (2010) 0.81
Rationalisation and Validation of an Acrylamide-Free Procedure in Three-Dimensional Histological Imaging. PLoS One (2016) 0.81
Engineered nanoparticles mimicking cell membranes for toxin neutralization. Adv Drug Deliv Rev (2015) 0.81
Surface modifications of influenza proteins upon virus inactivation by β-propiolactone. Proteomics (2013) 0.81
Novel protein extraction approach using micro-sized chamber for evaluation of proteins eluted from formalin-fixed paraffin-embedded tissue sections. Proteome Sci (2012) 0.81
Beyond laser microdissection technology: follow the yellow brick road for cancer research. Am J Cancer Res (2014) 0.81
Identification and functional characterization of the nascent RNA contacting residues of the hepatitis C virus RNA-dependent RNA polymerase. RNA (2012) 0.81
Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers. Bioconjug Chem (2015) 0.80
Characterization of new formalin-detoxified botulinum neurotoxin toxoids. Clin Vaccine Immunol (2008) 0.80
Critical analysis of compositions and protective efficacies of oral killed cholera vaccines. Clin Vaccine Immunol (2014) 0.79
Mechanism of acetaldehyde-induced deactivation of microbial lipases. BMC Biochem (2011) 0.79
A high throughput combinatorial library technique for identifying formalin-sensitive epitopes. J Immunol Methods (2006) 0.79
The mechanism of a formaldehyde-sensing transcriptional regulator. Sci Rep (2016) 0.78
Formaldehyde Stress Responses in Bacterial Pathogens. Front Microbiol (2016) 0.78
Evidence that the folate-dependent proteins YgfZ and MnmEG have opposing effects on growth and on activity of the iron-sulfur enzyme MiaB. J Bacteriol (2011) 0.78
Formalin Inactivation of Japanese Encephalitis Virus Vaccine Alters the Antigenicity and Immunogenicity of a Neutralization Epitope in Envelope Protein Domain III. PLoS Negl Trop Dis (2015) 0.78
Improving the Proteomic Analysis of Archival Tissue by Using Pressure-Assisted Protein Extraction: A Mechanistic Approach. J Proteomics Bioinform (2014) 0.78
Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney, one-clip hypertensive rats. Nephrol Dial Transplant (2014) 0.78
Moniliform deformation of retinal ganglion cells by formaldehyde-based fixatives. J Comp Neurol (2014) 0.77
Serum biomarkers of Burkholderia mallei infection elucidated by proteomic imaging of skin and lung abscesses. Clin Proteomics (2015) 0.77
Commentary: mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma. Environ Health (2009) 0.77
On methylene-bridged cysteine and lysine residues in proteins. Protein Sci (2016) 0.76
Effect of selenium on neurotoxicity in adult male mice exposed to formaldehyde. Electron Physician (2014) 0.76
Protein coated microcrystals formulated with model antigens and modified with calcium phosphate exhibit enhanced phagocytosis and immunogenicity. Vaccine (2013) 0.76
Recombinant antigens based on toxins A and B of Clostridium difficile that evoke a potent toxin-neutralising immune response. Vaccine (2013) 0.76
Effect of the achondroplasia mutation on FGFR3 dimerization and FGFR3 structural response to fgf1 and fgf2: A quantitative FRET study in osmotically derived plasma membrane vesicles. Biochim Biophys Acta (2016) 0.76
Formaldehyde scavengers function as novel antigen retrieval agents. Sci Rep (2015) 0.75
Confocal microscopy study of pertussis toxin and toxoids on CHO-cells. Hum Vaccin Immunother (2013) 0.75
Genome-wide snapshot of chromatin regulators and states in Xenopus embryos by ChIP-Seq. J Vis Exp (2015) 0.75
A Method for Whole Brain Ex Vivo Magnetic Resonance Imaging with Minimal Susceptibility Artifacts. Front Neurol (2016) 0.75
Evidence for Conversion of Methanol to Formaldehyde in Nonhuman Primate Brain. Anal Cell Pathol (Amst) (2016) 0.75
Cell Membrane-Coated Nanoparticles As an Emerging Antibacterial Vaccine Platform. Vaccines (Basel) (2015) 0.75
Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen. Hum Vaccin Immunother (2016) 0.75
Beta-Propiolactone Inactivation of Coxsackievirus A16 Induces Structural Alteration and Surface Modification of Viral Capsids. J Virol (2017) 0.75
Verification of the Cross Immunoreactivity of A60, a Mouse Monoclonal Antibody against Neuronal Nuclear Protein. Front Neuroanat (2016) 0.75
Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB). Front Microbiol (2016) 0.75
Protocol for HER2 FISH determination on PAXgene-fixed and paraffin-embedded tissue in breast cancer. Int J Exp Pathol (2016) 0.75
MSFragger: ultrafast and comprehensive peptide identification in mass spectrometry-based proteomics. Nat Methods (2017) 0.75
Using lysine adducts of human serum albumin to investigate the disposition of exogenous formaldehyde in human blood. Toxicol Lett (2017) 0.75
Evaluation of Lumazine Synthase from Bacillus anthracis as a Presentation Platform for Polyvalent Antigen Display. Protein Sci (2017) 0.75
Cell membrane-derived nanoparticles: emerging clinical opportunities for targeted drug delivery. Nanomedicine (Lond) (2017) 0.75
Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res (2010) 3.40
Extrinsic fluorescent dyes as tools for protein characterization. Pharm Res (2008) 2.63
Structure-immunogenicity relationships of therapeutic proteins. Pharm Res (2004) 2.39
Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. J Control Release (2011) 2.37
Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. J Pharm Sci (2009) 2.36
ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity. J Bacteriol (2007) 2.31
Sheddable coatings for long-circulating nanoparticles. Pharm Res (2007) 2.15
Eprex-associated pure red cell aplasia and leachates. Nat Biotechnol (2006) 1.98
Theranostic nanomedicine. Acc Chem Res (2011) 1.84
Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharm Res (2010) 1.83
Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination. J Control Release (2009) 1.81
Reduction-sensitive polymers and bioconjugates for biomedical applications. Biomaterials (2009) 1.70
Biodegradable polymers as non-viral carriers for plasmid DNA delivery. J Control Release (2007) 1.64
Nanotheranostics and image-guided drug delivery: current concepts and future directions. Mol Pharm (2010) 1.60
A Neisserial autotransporter NalP modulating the processing of other autotransporters. Mol Microbiol (2003) 1.56
Novel bioreducible poly(amido amine)s for highly efficient gene delivery. Bioconjug Chem (2007) 1.56
25th anniversary article: Engineering hydrogels for biofabrication. Adv Mater (2013) 1.54
Artificial viruses: a nanotechnological approach to gene delivery. Nat Rev Drug Discov (2006) 1.52
Microneedle technologies for (trans)dermal drug and vaccine delivery. J Control Release (2012) 1.49
Quality of original and biosimilar epoetin products. Pharm Res (2010) 1.46
Hydrogels for protein delivery. Chem Rev (2012) 1.44
Intratumoral administration of holmium-166 acetylacetonate microspheres: antitumor efficacy and feasibility of multimodality imaging in renal cancer. PLoS One (2013) 1.42
Hydrogels as extracellular matrices for skeletal tissue engineering: state-of-the-art and novel application in organ printing. Tissue Eng (2007) 1.42
In situ gelling hydrogels for pharmaceutical and biomedical applications. Int J Pharm (2008) 1.41
The effect of photopolymerization on stem cells embedded in hydrogels. Biomaterials (2008) 1.39
Passive versus active tumor targeting using RGD- and NGR-modified polymeric nanomedicines. Nano Lett (2014) 1.37
Identification of formaldehyde-induced modifications in proteins: reactions with insulin. Bioconjug Chem (2006) 1.37
Strategies for the assessment of protein aggregates in pharmaceutical biotech product development. Pharm Res (2010) 1.35
Micelle-associated protein in epoetin formulations: aA risk factor for immunogenicity? Pharm Res (2003) 1.34
Cyclodextrin-based polymeric materials: synthesis, properties, and pharmaceutical/biomedical applications. Biomacromolecules (2009) 1.33
Antibody response to aggregated human interferon alpha2b in wild-type and transgenic immune tolerant mice depends on type and level of aggregation. J Pharm Sci (2006) 1.32
Structural characterization and immunogenicity in wild-type and immune tolerant mice of degraded recombinant human interferon alpha2b. Pharm Res (2005) 1.32
Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies. Biomaterials (2007) 1.30
Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties. J Control Release (2006) 1.26
Organ printing: the future of bone regeneration? Trends Biotechnol (2011) 1.26
Chitosan-based delivery systems for protein therapeutics and antigens. Adv Drug Deliv Rev (2009) 1.26
Effect of cationic carriers on the pharmacokinetics and tumor localization of nucleic acids after intravenous administration. Int J Pharm (2006) 1.25
Synthesis and characterization of hyperbranched polyglycerol hydrogels. Biomaterials (2006) 1.24
The immunogenicity of polyethylene glycol: facts and fiction. Pharm Res (2013) 1.24
Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers. Biomaterials (2009) 1.24
Adjuvant effect of cationic liposomes and CpG depends on administration route. J Control Release (2011) 1.24
Structural properties of monoclonal antibody aggregates induced by freeze-thawing and thermal stress. Eur J Pharm Sci (2009) 1.23
Immunological mechanism underlying the immune response to recombinant human protein therapeutics. Trends Pharmacol Sci (2009) 1.23
Immunogenicity of therapeutic proteins: the use of animal models. Pharm Res (2011) 1.22
Bioreducible poly(amido amine)s with oligoamine side chains: synthesis, characterization, and structural effects on gene delivery. J Control Release (2007) 1.21
The therapeutic equivalence of complex drugs. Regul Toxicol Pharmacol (2010) 1.20
Administration routes affect the quality of immune responses: A cross-sectional evaluation of particulate antigen-delivery systems. J Control Release (2010) 1.20
A role for protein misfolding in immunogenicity of biopharmaceuticals. J Biol Chem (2006) 1.19
Nonnatural amino acids for site-specific protein conjugation. Bioconjug Chem (2009) 1.18
Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants. Nat Med (2006) 1.17
Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin. Biomaterials (2010) 1.17
How to screen non-viral gene delivery systems in vitro? J Control Release (2011) 1.17
Forced degradation of therapeutic proteins. J Pharm Sci (2011) 1.16
Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products. J Pharm Sci (2010) 1.16
A versatile family of degradable non-viral gene carriers based on hyperbranched poly(ester amine)s. J Control Release (2005) 1.16
Pulsed in vitro release and in vivo behavior of exploding microcapsules. J Control Release (2009) 1.15
Advances in transcutaneous vaccine delivery: do all ways lead to Rome? J Control Release (2010) 1.13
Preparation and characterization of protein-loaded N-trimethyl chitosan nanoparticles as nasal delivery system. J Control Release (2005) 1.13
Endosomal escape of polymeric gene delivery complexes is not always enhanced by polymers buffering at low pH. Biomacromolecules (2004) 1.09
The nuclear pore complex: the gateway to successful nonviral gene delivery. Pharm Res (2006) 1.07
Degradable-brushed pHEMA-pDMAEMA synthesized via ATRP and click chemistry for gene delivery. Bioconjug Chem (2007) 1.06
Aggregated recombinant human interferon Beta induces antibodies but no memory in immune-tolerant transgenic mice. Pharm Res (2010) 1.05
Hydrogels for protein delivery in tissue engineering. J Control Release (2012) 1.04
Towards tailored vaccine delivery: needs, challenges and perspectives. J Control Release (2012) 1.03
Isolation and structural characterization of epilancin 15X, a novel lantibiotic from a clinical strain of Staphylococcus epidermidis. FEBS Lett (2005) 1.03
Interaction of dendritic cells with antigen-containing liposomes: effect of bilayer composition. Vaccine (2004) 1.03
Functional characterization of an endosome-disruptive peptide and its application in cytosolic delivery of immunoliposome-entrapped proteins. J Biol Chem (2002) 1.02
Self-assembly of recombinant amphiphilic oligopeptides into vesicles. Biomacromolecules (2007) 1.02
Human CD8(+) T cell responses against five newly identified respiratory syncytial virus-derived epitopes. J Gen Virol (2004) 1.02
Challenges for the effective molecular imprinting of proteins. Biomaterials (2011) 1.02
Sensitive spectroscopic detection of large and denatured protein aggregates in solution by use of the fluorescent dye Nile red. J Fluoresc (2007) 1.02
Inactivated polio vaccine development for technology transfer using attenuated Sabin poliovirus strains to shift from Salk-IPV to Sabin-IPV. Vaccine (2011) 1.02
Rational design of nasal vaccines. J Drug Target (2008) 1.02
Shifting paradigms: biopharmaceuticals versus low molecular weight drugs. Int J Pharm (2003) 1.02
Characterization of the CD8+ T cell responses directed against respiratory syncytial virus during primary and secondary infection in C57BL/6 mice. Virology (2006) 1.02