Published in Free Radic Biol Med on December 01, 2003
Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Invest (2014) 1.77
Doxorubicin pathways: pharmacodynamics and adverse effects. Pharmacogenet Genomics (2011) 1.53
Oxidative stress, redox signaling, and metal chelation in anthracycline cardiotoxicity and pharmacological cardioprotection. Antioxid Redox Signal (2012) 1.37
Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil. Transl Res (2006) 1.16
A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity. BMC Pharmacol Toxicol (2014) 1.05
Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone. Br J Pharmacol (2008) 0.91
Dihydromyricetin prevents cardiotoxicity and enhances anticancer activity induced by adriamycin. Oncotarget (2015) 0.90
Dietary inorganic nitrate alleviates doxorubicin cardiotoxicity: mechanisms and implications. Nitric Oxide (2012) 0.85
Cardiovascular toxicities from systemic breast cancer therapy. Front Oncol (2014) 0.81
Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both topoisomerase II isoforms. BMC Cancer (2014) 0.78
A boronate prochelator built on a triazole framework for peroxide-triggered tridentate metal binding. Inorganica Chim Acta (2012) 0.78
Effect of Remote Ischaemic Conditioning in Oncology Patients Undergoing Chemotherapy: Rationale and Design of the ERIC-ONC Study-A Single-Center, Blinded, Randomized Controlled Trial. Clin Cardiol (2016) 0.76
Visnagin-a new protectant against doxorubicin cardiotoxicity? Inhibition of mitochondrial malate dehydrogenase 2 (MDH2) and beyond. Ann Transl Med (2016) 0.76
Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells. PLoS One (2016) 0.75
High Throughput Screening Identifies a Novel Compound Protecting Cardiomyocytes from Doxorubicin-Induced Damage. Oxid Med Cell Longev (2015) 0.75
Stimulus-Responsive Prochelators for Manipulating Cellular Metals. Acc Chem Res (2016) 0.75
Anthracycline Chemotherapy and Cardiotoxicity. Cardiovasc Drugs Ther (2017) 0.75
Effects and Clinical Characteristics of Intracranial Pressure Monitoring-Targeted Management for Subsets of Traumatic Brain Injury: An Observational Multicenter Study. Crit Care Med (2015) 2.06
Immunogenicity and safety of an enterovirus 71 vaccine in healthy Chinese children and infants: a randomised, double-blind, placebo-controlled phase 2 clinical trial. Lancet (2013) 1.87
Direct, nonoxidative conversion of methane to ethylene, aromatics, and hydrogen. Science (2014) 1.71
Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China. J Med Virol (2002) 1.43
Application of lower fluence rate for less microvasculature damage and greater cell-killing during photodynamic therapy. Lasers Med Sci (2004) 1.39
Regulation of vascular smooth muscle cell phenotype by cyclic GMP and cyclic GMP-dependent protein kinase. Front Biosci (2006) 1.34
Molecular determinants of enterovirus 71 viral entry: cleft around GLN-172 on VP1 protein interacts with variable region on scavenge receptor B 2. J Biol Chem (2012) 1.33
The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro. Toxicol Appl Pharmacol (2010) 1.19
The viral E4 protein is required for the completion of the cottontail rabbit papillomavirus productive cycle in vivo. J Virol (2004) 1.18
Mechanisms of myocyte cytotoxicity induced by the multiple receptor tyrosine kinase inhibitor sunitinib. Mol Pharmacol (2008) 1.12
Progress on the research and development of inactivated EV71 whole-virus vaccines. Hum Vaccin Immunother (2013) 1.12
Low expression of Beclin 1, associated with high Bcl-xL, predicts a malignant phenotype and poor prognosis of gastric cancer. Autophagy (2012) 1.11
Biochemical and proteomics approaches to characterize topoisomerase IIalpha cysteines and DNA as targets responsible for cisplatin-induced inhibition of topoisomerase IIalpha. Mol Pharmacol (2004) 1.07
Kinamycins A and C, bacterial metabolites that contain an unusual diazo group, as potential new anticancer agents: antiproliferative and cell cycle effects. Anticancer Drugs (2006) 1.04
Dual-targeted antitumor effects against brainstem glioma by intravenous delivery of tumor necrosis factor-related, apoptosis-inducing, ligand-engineered human mesenchymal stem cells. Neurosurgery (2009) 1.04
Chemokines mediate mesenchymal stem cell migration toward gliomas in vitro. Oncol Rep (2010) 1.02
Aurora-A identifies early recurrence and poor prognosis and promises a potential therapeutic target in triple negative breast cancer. PLoS One (2013) 1.01
Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity. Diabetes (2003) 1.00
Immunogenicity, safety, and immune persistence of a novel inactivated human enterovirus 71 vaccine: a phase II, Randomized, double-blind, placebo-controlled Trial. J Infect Dis (2013) 0.99
Dexrazoxane (ICRF-187) protects cardiac myocytes against doxorubicin by preventing damage to mitochondria. Cardiovasc Toxicol (2003) 0.98
Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells. J Transl Med (2011) 0.97
Aberrant upregulation of 14-3-3ơ expression serves as an inferior prognostic biomarker for gastric cancer. BMC Cancer (2011) 0.97
Layer-by-layer thinning of MoS2 by plasma. ACS Nano (2013) 0.97
MR imaging of tumor angiogenesis using sterically stabilized Gd-DTPA liposomes targeted to CD105. Eur J Radiol (2008) 0.96
Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F. Free Radic Biol Med (2007) 0.96
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6. J Biol Chem (2010) 0.95
Synthesis and characterization of the biological activity of the cisplatin analogs, cis-PtCl(2)(dexrazoxane) and cis-PtCl(2)(levrazoxane), of the topoisomerase II inhibitors dexrazoxane (ICRF-187) and levrazoxane (ICRF-186). J Inorg Biochem (2004) 0.94
The combination of carotid and lower extremity ultrasonography increases the detection of atherosclerosis in type 2 diabetes patients. J Diabetes Complications (2012) 0.93
A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors. Mol Pharmacol (2007) 0.92
Prevalence and clinical characteristics of carotid atherosclerosis in newly diagnosed patients with ketosis-onset diabetes: a cross-sectional study. Cardiovasc Diabetol (2013) 0.92
Top-down fabrication of sub-nanometre semiconducting nanoribbons derived from molybdenum disulfide sheets. Nat Commun (2013) 0.92
Alpha-lipoic acid pre- and post-treatments provide protection against in vitro ischemia-reperfusion injury in cerebral endothelial cells via Akt/mTOR signaling. Brain Res (2012) 0.91
Carbon microbelt aerogel prepared by waste paper: an efficient and recyclable sorbent for oils and organic solvents. Small (2014) 0.91
VEGF promotes proliferation of human glioblastoma multiforme stem-like cells through VEGF receptor 2. ScientificWorldJournal (2013) 0.91
A structure-based 3D-QSAR study of anthrapyrazole analogues of the anticancer agents losoxantrone and piroxantrone. J Chem Inf Model (2006) 0.91
The interacting domains of hCdt1 and hMcm6 involved in the chromatin loading of the MCM complex in human cells. Cell Cycle (2010) 0.90
Reactogenicity and immunogenicity of an enterovirus 71 vaccine in Chinese healthy children and infants. Pediatr Infect Dis J (2012) 0.89
Validating the incidence of coagulopathy and disseminated intravascular coagulation in patients with traumatic brain injury--analysis of 242 cases. Br J Neurosurg (2011) 0.88
The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity. Mol Pharmacol (2003) 0.88
Removal of arsenic from water by supported nano zero-valent iron on activated carbon. J Hazard Mater (2009) 0.88
The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II. Biochem Pharmacol (2012) 0.87
Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II. Cancer Chemother Pharmacol (2005) 0.87
Impact of intracranial pressure monitoring on mortality in patients with traumatic brain injury: a systematic review and meta-analysis. J Neurosurg (2014) 0.87
Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents. Bioorg Med Chem (2010) 0.87
The self and its resting state in consciousness: an investigation of the vegetative state. Hum Brain Mapp (2013) 0.85
Affinity, lateral mobility, and clustering contribute independently to beta 2-integrin-mediated adhesion. Am J Physiol Cell Physiol (2010) 0.85
Tracking induced pluripotent stem cells-derived neural stem cells in the central nervous system of rats and monkeys. Cell Reprogram (2013) 0.84
The cytotoxicity of celecoxib towards cardiac myocytes is cyclooxygenase-2 independent. Cardiovasc Toxicol (2007) 0.84
Is Intracranial Pressure Monitoring of Patients With Diffuse Traumatic Brain Injury Valuable? An Observational Multicenter Study. Neurosurgery (2016) 0.84
A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II. Bioorg Med Chem (2009) 0.83
Pioglitazone prevents hyperglycemia induced decrease of AdipoR1 and AdipoR2 in coronary arteries and coronary VSMCs. Mol Cell Endocrinol (2012) 0.83
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds. Bioorg Med Chem (2008) 0.82
A novel family (QnrAS) of plasmid-mediated quinolone resistance determinant. Int J Antimicrob Agents (2010) 0.82
MH1 domain of SMAD4 binds N-terminal residues of the homeodomain of Hoxc9. Biochim Biophys Acta (2008) 0.82
Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents. Bioorg Med Chem (2011) 0.82
The iron chelator Dp44mT does not protect myocytes against doxorubicin. J Inorg Biochem (2009) 0.82
The structure-based design, synthesis, and biological evaluation of DNA-binding amide linked bisintercalating bisanthrapyrazole anticancer compounds. Bioorg Med Chem (2009) 0.82
Mechanisms of myocyte cytotoxicity induced by the multikinase inhibitor sorafenib. Cardiovasc Toxicol (2010) 0.81
Iron-ion radiation accelerates atherosclerosis in apolipoprotein E-deficient mice. Radiat Res (2011) 0.81
Determination of pentapeptide repeat units in Qnr proteins by the structure-based alignment approach. Antimicrob Agents Chemother (2011) 0.81
Intensive management and prognosis of 127 cases with traumatic bilateral frontal contusions. World Neurosurg (2013) 0.81
Characteristics of acute treatment costs of traumatic brain injury in Eastern China--a multi-centre prospective observational study. Injury (2012) 0.81
Predictive value of initial intracranial pressure for refractory intracranial hypertension in persons with traumatic brain injury: a prospective observational study. Brain Inj (2013) 0.81
Outcomes, and factors affecting outcomes, following shoulder hemiarthroplasty for proximal humeral fracture repair. J Orthop Sci (2011) 0.81
A Hybrid Constructive Algorithm for Single-Layer Feedforward Networks Learning. IEEE Trans Neural Netw Learn Syst (2014) 0.80
Continuous measurement of the cumulative amplitude and duration of hyperglycemia best predicts outcome after traumatic brain injury. Neurocrit Care (2014) 0.80
Documentation of impaired coronary blood flow by TIMI frame count method in patients with atrial fibrillation. Int J Cardiol (2012) 0.80
Detection of neural stem cells function in rats with traumatic brain injury by manganese-enhanced magnetic resonance imaging. Chin Med J (Engl) (2011) 0.80
Role of NADPH cytochrome P450 reductase in activation of RH1. Cancer Chemother Pharmacol (2007) 0.79
Total synthesis of isoprekinamycin: structural evidence for enhanced diazonium ion character and growth inhibitory activity toward cancer cells. Org Lett (2007) 0.79
The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα. Biochem Pharmacol (2012) 0.79
The dual-targeted HER1/HER2 tyrosine kinase inhibitor lapatinib strongly potentiates the cardiac myocyte-damaging effects of doxorubicin. Cardiovasc Toxicol (2013) 0.78
Risk factors of gene-resistant mutations in different nucleosides. Hepatogastroenterology (2012) 0.78
The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites. Drug Metab Dispos (2008) 0.77
Direct, real-time PCR (MethyLight) assay for methylation of O6-methylguanine-DNA methyltransferase promoter in glioma. Chin Med J (Engl) (2009) 0.77
[Abdominal random single pedicled flap of three leaves for the treatment of multiple finger skin defects]. Zhongguo Gu Shang (2012) 0.77
Tunable electroluminescence in planar graphene/SiO(2) memristors. Adv Mater (2013) 0.77
Operative versus conservative treatment for patellar dislocation: a meta-analysis of 7 randomized controlled trials. Diagn Pathol (2014) 0.77
Evaluation of renal ischemia-reperfusion injury in rabbits using microbubbles targeted to activated neutrophils. Clin Imaging (2008) 0.77
Increased Rho kinase activity predicts worse cardiovascular outcome in ST-segment elevation myocardial infarction patients. Cardiol J (2016) 0.76
Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II). J Inorg Biochem (2013) 0.76
The iron chelating cardioprotective prodrug dexrazoxane does not affect the cell growth inhibitory effects of bleomycin. J Inorg Biochem (2004) 0.76
Erratum to: A Stable Human-Cell System Overexpressing Cystic Fibrosis Transmembrane Conductance Regulator Recombinant Protein at the Cell Surface. Mol Biotechnol (2015) 0.76
Bioavailability of cadmium adsorbed on various oxides minerals to wetland plant species Phragmites australis. J Hazard Mater (2009) 0.75
Crystallization and preliminary diffraction studies of SFC-1, a carbapenemase conferring antibiotic resistance. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.75
Type I interferon related genes are common genes on the early stage after vaccination by meta-analysis of microarray data. Hum Vaccin Immunother (2015) 0.75
Protective effect of an improved immunization practice of mother-to-infant transmission of hepatitis B virus and risk factors associated with immunoprophylaxis failure. Medicine (Baltimore) (2016) 0.75
Application of lower fluence rate for less microvasculature damage and greater cell-killing during photodynamic therapy. Lasers Med Sci (2005) 0.75
Correction: Evaluation of Commercial Diagnostic Assays for the Specific Detection of Avian Influenza A (H7N9) Virus RNA Using a Quality-Control Panel and Clinical Specimens in China. PLoS One (2015) 0.75
Authors' reply. Drug Des Devel Ther (2015) 0.75
Localized subacute thyroiditis presenting as a painful hot nodule. BMC Endocr Disord (2014) 0.75
[Studies on the molecular diagnosis and prenatal diagnosis of the spinal muscular atrophy carriers by multiplex ligation-dependent probe]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2010) 0.75
Dynamic investigation of interface atom migration during heterostructure nanojoining. Nanoscale (2013) 0.75
Crystallization and preliminary X-ray crystallographic analysis of CTX-M-15, an extended-spectrum β-lactamase conferring worldwide emerging antibiotic resistance. Protein Pept Lett (2011) 0.75
[Epidemiology of hepatitis E in clinical patients in Dongtai, Jiangsu province]. Zhonghua Liu Xing Bing Xue Za Zhi (2010) 0.75