Published in Oncogene on January 29, 2004
Susceptibility pathways in Fanconi's anemia and breast cancer. N Engl J Med (2010) 2.79
DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer (2012) 2.70
Modeling cancer progression via pathway dependencies. PLoS Comput Biol (2008) 2.12
Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation. J Clin Invest (2009) 1.95
Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma. Carcinogenesis (2009) 1.94
BRCA1: a novel prognostic factor in resected non-small-cell lung cancer. PLoS One (2007) 1.86
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated. J Clin Invest (2007) 1.80
The ubiquitin system, disease, and drug discovery. BMC Biochem (2008) 1.73
Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer. Br J Cancer (2012) 1.64
DNA methyltransferases, DNA damage repair, and cancer. Adv Exp Med Biol (2013) 1.57
Biomarkers in early-stage non-small-cell lung cancer: current concepts and future directions. J Thorac Oncol (2014) 1.56
The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells. Blood (2005) 1.43
CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer (2009) 1.42
Epigenetics of cervical cancer. An overview and therapeutic perspectives. Mol Cancer (2005) 1.40
Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression. PLoS One (2009) 1.36
The potential of exploiting DNA-repair defects for optimizing lung cancer treatment. Nat Rev Clin Oncol (2012) 1.23
Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proc Natl Acad Sci U S A (2010) 1.20
Coordinate regulation of Fanconi anemia gene expression occurs through the Rb/E2F pathway. Oncogene (2008) 1.18
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. Mol Cancer (2004) 1.14
The Fanconi anemia pathway and ubiquitin. BMC Biochem (2007) 1.10
Epigenetic changes of DNA repair genes in cancer. J Mol Cell Biol (2011) 1.08
TGFβ signaling in head and neck squamous cell carcinoma. Oncogene (2010) 1.08
Basic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer. Cancer J (2013) 1.00
Fanconi anemia proteins, DNA interstrand crosslink repair pathways, and cancer therapy. Curr Cancer Drug Targets (2009) 1.00
Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell Cycle (2010) 0.98
Molecular cross-talk among chromosome fragility syndromes. Genes Dev (2004) 0.96
Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1. Oncogene (2010) 0.96
The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma. Mutat Res (2013) 0.95
Identification of an epigenetic profile classifier that is associated with survival in head and neck cancer. Cancer Res (2012) 0.94
Components of a Fanconi-like pathway control Pso2-independent DNA interstrand crosslink repair in yeast. PLoS Genet (2012) 0.93
Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer. Br J Cancer (2008) 0.91
Detection of impaired homologous recombination repair in NSCLC cells and tissues. J Thorac Oncol (2013) 0.89
Oral squamous cell carcinoma in relation to field precancerisation: pathobiology. Cancer Cell Int (2013) 0.87
Gene silencing of FANCF potentiates the sensitivity to mitoxantrone through activation of JNK and p38 signal pathways in breast cancer cells. PLoS One (2012) 0.87
Genetic inactivation of the Fanconi anemia gene FANCC identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents. Mol Cancer (2010) 0.86
A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma. Sci Rep (2014) 0.85
Advances in the understanding of the Fanconi anemia tumor suppressor pathway. Cancer Biol Ther (2013) 0.85
Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers. ORL J Otorhinolaryngol Relat Spec (2010) 0.85
Smad4: gatekeeper gene in head and neck squamous cell carcinoma. J Clin Invest (2009) 0.83
Functional analyses of ATM, ATR and Fanconi anemia proteins in lung carcinoma : ATM, ATR and FA in lung carcinoma. BMC Cancer (2015) 0.81
Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research. DNA Repair (Amst) (2014) 0.81
Assessing the function of homologous recombination DNA repair in malignant pleural effusion (MPE) samples. Br J Cancer (2014) 0.80
FANCA safeguards interphase and mitosis during hematopoiesis in vivo. Exp Hematol (2015) 0.80
Differential expression analysis for individual cancer samples based on robust within-sample relative gene expression orderings across multiple profiling platforms. Oncotarget (2016) 0.79
Genome stability pathways in head and neck cancers. Int J Genomics (2013) 0.79
Inhibitory effects of marine-derived DNA-binding anti-tumour tetrahydroisoquinolines on the Fanconi anaemia pathway. Br J Pharmacol (2013) 0.78
RAD51C--a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC). Oral Oncol (2013) 0.78
Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome. Clin Epigenetics (2014) 0.78
Cell-based high-throughput screens for the discovery of chemotherapeutic agents. Oncotarget (2012) 0.77
Repairing of N-mustard derivative BO-1055 induced DNA damage requires NER, HR, and MGMT-dependent DNA repair mechanisms. Oncotarget (2015) 0.77
Subpathway Analysis based on Signaling-Pathway Impact Analysis of Signaling Pathway. PLoS One (2015) 0.77
Celastrol induces proteasomal degradation of FANCD2 to sensitize lung cancer cells to DNA crosslinking agents. Cancer Sci (2015) 0.76
[Epigenetic aspects in carcinomas of the head and neck]. HNO (2008) 0.76
Mitomycin C and Vinorelbine for second-line chemotherapy in NSCLC--a phase II trial. Br J Cancer (2007) 0.76
Fanconi anemia genes in lung adenocarcinoma- a pathway-wide study on cancer susceptibility. J Biomed Sci (2016) 0.76
Oxidative Stress in Cancer-Prone Genetic Diseases in Pediatric Age: The Role of Mitochondrial Dysfunction. Oxid Med Cell Longev (2016) 0.76
Inactivation of BRCA2 in human cancer cells identifies a subset of tumors with enhanced sensitivity towards death receptormediated apoptosis. Oncotarget (2016) 0.75
RNAi-mediated knockdown of FANCF suppresses cell proliferation, migration, invasion, and drug resistance potential of breast cancer cells. Braz J Med Biol Res (2013) 0.75
Hawaii natural compounds are promising to reduce ovarian cancer deaths. Cancer Biol Ther (2016) 0.75
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst (2005) 13.00
DNA methylation arrays as surrogate measures of cell mixture distribution. BMC Bioinformatics (2012) 9.31
Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. PLoS Genet (2009) 7.07
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol (2002) 5.39
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res (2005) 4.25
New common variants affecting susceptibility to basal cell carcinoma. Nat Genet (2009) 4.15
Global DNA methylation level in whole blood as a biomarker in head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev (2007) 4.01
Model-based clustering of DNA methylation array data: a recursive-partitioning algorithm for high-dimensional data arising as a mixture of beta distributions. BMC Bioinformatics (2008) 3.89
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial. Lancet Oncol (2013) 3.50
PIK3CA mutations and copy number gains in human lung cancers. Cancer Res (2008) 3.42
Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium. J Natl Cancer Inst (2010) 3.18
MicroRNA responses to cellular stress. Cancer Res (2006) 3.13
Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res (2007) 2.93
TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol (2008) 2.88
DNA methylation, isocitrate dehydrogenase mutation, and survival in glioma. J Natl Cancer Inst (2010) 2.87
A study of machine-learning-based approaches to extract clinical entities and their assertions from discharge summaries. J Am Med Inform Assoc (2011) 2.70
The OsTB1 gene negatively regulates lateral branching in rice. Plant J (2003) 2.69
Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J Natl Cancer Inst (2007) 2.68
Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. J Natl Cancer Inst (2006) 2.40
A case-control study of smoking and bladder cancer risk: emergent patterns over time. J Natl Cancer Inst (2009) 2.40
Herceptin in patients with advanced or metastatic salivary gland carcinomas. A phase II study. Oral Oncol (2003) 2.38
Prediction of protein-protein interactions using random decision forest framework. Bioinformatics (2005) 2.30
Extensive somatic L1 retrotransposition in colorectal tumors. Genome Res (2012) 2.29
A let-7 microRNA-binding site polymorphism in the KRAS 3' UTR is associated with reduced survival in oral cancers. Carcinogenesis (2009) 2.28
2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3. J Neurosci (2004) 2.27
Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci (2005) 2.21
Human papillomavirus type 16 and squamous cell carcinoma of the head and neck. Clin Cancer Res (2002) 2.20
Recommendations for the design and analysis of epigenome-wide association studies. Nat Methods (2013) 2.19
P38 MAP kinase is activated at early stages in Alzheimer's disease brain. Exp Neurol (2003) 2.14
pH sensing by intracellular Salmonella induces effector translocation. Science (2010) 2.13
MicroRNA expression ratio is predictive of head and neck squamous cell carcinoma. Clin Cancer Res (2009) 2.13
Retracted Aberrant methylation of Reprimo in human malignancies. Int J Cancer (2005) 2.13
Implications of LINE1 methylation for bladder cancer risk in women. Clin Cancer Res (2010) 2.10
Concordance of multiple analytical approaches demonstrates a complex relationship between DNA repair gene SNPs, smoking and bladder cancer susceptibility. Carcinogenesis (2005) 2.08
Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate. Arthritis Care Res (Hoboken) (2011) 2.06
Exploring the impact of climate on human longevity. Exp Gerontol (2012) 2.03
Nightshift work and genome-wide DNA methylation. Chronobiol Int (2014) 2.01
Impaired osmotic sensation in mice lacking TRPV4. Am J Physiol Cell Physiol (2003) 2.00
SseL, a Salmonella deubiquitinase required for macrophage killing and virulence. Proc Natl Acad Sci U S A (2007) 1.99
Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma. Carcinogenesis (2009) 1.94
Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol (2010) 1.94
Assessment of epidermal growth factor receptor mutation by endobronchial ultrasound-guided transbronchial needle aspiration. Chest (2007) 1.93
DNA methylation array analysis identifies profiles of blood-derived DNA methylation associated with bladder cancer. J Clin Oncol (2011) 1.92
BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A (2009) 1.90
TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem (2004) 1.88
Dynamics of intracellular bacterial replication at the single cell level. Proc Natl Acad Sci U S A (2010) 1.83
Toxicity testing in the 21st century: a vision and a strategy. J Toxicol Environ Health B Crit Rev (2010) 1.81
Blood-based profiles of DNA methylation predict the underlying distribution of cell types: a validation analysis. Epigenetics (2013) 1.79
Human papillomavirus 16 and head and neck squamous cell carcinoma. Int J Cancer (2007) 1.78
Biomarkers of HPV in head and neck squamous cell carcinoma. Cancer Res (2012) 1.76
TRPV4-mediated endothelial Ca2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol (2009) 1.76
Peripheral blood immune cell methylation profiles are associated with nonhematopoietic cancers. Cancer Epidemiol Biomarkers Prev (2012) 1.76
Breast cancer DNA methylation profiles are associated with tumor size and alcohol and folate intake. PLoS Genet (2010) 1.74
Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer. Cancer Res (2004) 1.74
Clinical implications of an implantable cardioverter-defibrillator in patients with vasospastic angina and lethal ventricular arrhythmia. J Am Coll Cardiol (2012) 1.73
Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome. Cancer Res (2009) 1.73
Siblings of Okinawan centenarians share lifelong mortality advantages. J Gerontol A Biol Sci Med Sci (2006) 1.73
Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Int J Epidemiol (2009) 1.70
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet (2011) 1.68
PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration. Hum Pathol (2005) 1.67
The Salmonella kinase SteC targets the MAP kinase MEK to regulate the host actin cytoskeleton. Cell Host Microbe (2012) 1.66
Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein. Cell Res (2012) 1.64
The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. Cancer Epidemiol Biomarkers Prev (2005) 1.64
Semi-supervised recursively partitioned mixture models for identifying cancer subtypes. Bioinformatics (2010) 1.63
Development and validation of a lung cancer risk prediction model for African-Americans. Cancer Prev Res (Phila) (2008) 1.63
A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction. Genet Epidemiol (2009) 1.61
Minimal alteration of pulmonary function after lobectomy in lung cancer patients with chronic obstructive pulmonary disease. Ann Thorac Surg (2003) 1.61
Association of chronic obstructive pulmonary disease and tumor recurrence in patients with stage IA lung cancer after complete resection. Ann Thorac Surg (2007) 1.60
Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation. Nat Cell Biol (2012) 1.60
Narrow band imaging with high-resolution bronchovideoscopy: a new approach for visualizing angiogenesis in squamous cell carcinoma of the lung. Lung Cancer (2010) 1.58
Lymph node staging by endobronchial ultrasound-guided transbronchial needle aspiration in patients with small cell lung cancer. Ann Thorac Surg (2010) 1.58
Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer. Ann Thorac Surg (2006) 1.56
LINE-1 hypomethylation is associated with bladder cancer risk among nonsmoking Chinese. Int J Cancer (2011) 1.56
High-risk HPV types and head and neck cancer. Int J Cancer (2014) 1.56
Carcinogen exposure and gene promoter hypermethylation in bladder cancer. Carcinogenesis (2005) 1.55
Caloric restriction, the traditional Okinawan diet, and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and life span. Ann N Y Acad Sci (2007) 1.55
SpvC is a Salmonella effector with phosphothreonine lyase activity on host mitogen-activated protein kinases. Mol Microbiol (2008) 1.55