Published in Neurobiol Dis on December 01, 2003
Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia. J Neuroinflammation (2016) 0.84
Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats. ACS Chem Neurosci (2013) 0.81
Hepatic encephalopathy: an updated approach from pathogenesis to treatment. Med Sci Monit (2011) 0.81
Infliximab reduces peripheral inflammation, neuroinflammation, and extracellular GABA in the cerebellum and improves learning and motor coordination in rats with hepatic encephalopathy. J Neuroinflammation (2016) 0.77
Contributions of microdialysis to new alternative therapeutics for hepatic encephalopathy. Int J Mol Sci (2013) 0.76
Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat. J Neurochem (2008) 1.88
Brain edema and inflammatory activation in bile duct ligated rats with diet-induced hyperammonemia: A model of hepatic encephalopathy in cirrhosis. Hepatology (2006) 1.83
Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts. Hepatology (2007) 1.81
Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats. Eur J Neurosci (2007) 1.62
Activation of soluble guanylate cyclase by nitric oxide in lymphocytes correlates with minimal hepatic encephalopathy in cirrhotic patients. J Mol Med (Berl) (2007) 1.49
Experimental models of hepatic encephalopathy: ISHEN guidelines. Liver Int (2009) 1.48
Value of the critical flicker frequency in patients with minimal hepatic encephalopathy. Hepatology (2007) 1.41
Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy. Gastroenterology (2010) 1.21
Activation of NMDA receptors induces protein kinase A-mediated phosphorylation and degradation of matrin 3. Blocking these effects prevents NMDA-induced neuronal death. J Neurochem (2005) 1.11
IL-6 and IL-18 in blood may discriminate cirrhotic patients with and without minimal hepatic encephalopathy. J Clin Gastroenterol (2009) 1.07
Long-term potentiation in hippocampus involves sequential activation of soluble guanylate cyclase, cGMP-dependent protein kinase, and cGMP-degrading phosphodiesterase. J Neurosci (2002) 1.04
Oral administration of sildenafil restores learning ability in rats with hyperammonemia and with portacaval shunts. Hepatology (2005) 1.03
Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide. Neurochem Int (2003) 1.01
Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity. J Neurosci Res (2009) 0.98
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. Neurochem Int (2005) 0.97
Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying. Am J Physiol Gastrointest Liver Physiol (2002) 0.95
p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts. Gut (2011) 0.95
Glutamatergic and gabaergic neurotransmission and neuronal circuits in hepatic encephalopathy. Metab Brain Dis (2008) 0.95
Hyperammonemia increases GABAergic tone in the cerebellum but decreases it in the rat cortex. Gastroenterology (2008) 0.95
Serum metabolic signature of minimal hepatic encephalopathy by (1)H-nuclear magnetic resonance. J Proteome Res (2010) 0.94
Brain region-selective mechanisms contribute to the progression of cerebral alterations in acute liver failure in rats. Gastroenterology (2010) 0.93
[Normality tables in the Spanish population for psychometric tests used in the diagnosis of minimal hepatic encephalopathy]. Med Clin (Barc) (2006) 0.92
Modulation of NMDA receptors in the cerebellum. 1. Properties of the NMDA receptor that modulate its function. Cerebellum (2005) 0.91
Modulation of NMDA receptors in the cerebellum. II. Signaling pathways and physiological modulators regulating NMDA receptor function. Cerebellum (2005) 0.90
Sources of oxygen radicals in brain in acute ammonia intoxication in vivo. Brain Res (2003) 0.88
Chronic liver failure in rats impairs glutamatergic synaptic transmission and long-term potentiation in hippocampus and learning ability. Eur J Neurosci (2007) 0.88
Brain cholinergic impairment in liver failure. Brain (2008) 0.87
Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats. Synapse (2002) 0.87
Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties. Eur J Med Chem (2003) 0.87
Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide. Metab Brain Dis (2005) 0.87
Molecular mechanism of acute ammonia toxicity: role of NMDA receptors. Neurochem Int (2002) 0.87
Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain. Brain Res (2005) 0.87
Encapsulation of glutamine synthetase in mouse erythrocytes: a new procedure for ammonia detoxification. Biochem Cell Biol (2008) 0.86
Changes in liver and plasma acetylcholinesterase in rats with cirrhosis induced by bile duct ligation. Hepatology (2006) 0.86
Differential long-term effects of developmental exposure to polychlorinated biphenyls 52, 138 or 180 on motor activity and neurotransmission. Gender dependence and mechanisms involved. Neurochem Int (2010) 0.86
Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy. Neuroimage (2012) 0.86
Hypolocomotion in rats with chronic liver failure is due to increased glutamate and activation of metabotropic glutamate receptors in substantia nigra. J Hepatol (2006) 0.85
Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients. Hepatology (2002) 0.85
Molecular mechanisms of the alterations in NMDA receptor-dependent long-term potentiation in hyperammonemia. Metab Brain Dis (2005) 0.85
3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with liver cirrhosis. Am J Gastroenterol (2011) 0.85
Chronic hyperammonemia reduces the activity of neuronal nitric oxide synthase in cerebellum by altering its localization and increasing its phosphorylation by calcium-calmodulin kinase II. J Neurochem (2008) 0.85
Motor alterations induced by chronic lead exposure. Environ Toxicol Pharmacol (2009) 0.84
Modulation of NMDA receptors by AKT kinase. Neurochem Int (2006) 0.84
Proteome analysis of primary neurons and astrocytes from rat cerebellum. J Proteome Res (2005) 0.84
Increasing the function of the glutamate-nitric oxide-cyclic guanosine monophosphate pathway increases the ability to learn a Y-maze task. J Neurosci Res (2009) 0.83
Effects of hyperammonemia and liver failure on glutamatergic neurotransmission. Metab Brain Dis (2002) 0.83
Ebselen prevents chronic alcohol-induced rat hippocampal stress and functional impairment. Alcohol Clin Exp Res (2007) 0.83
Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease. J Biol Chem (2013) 0.83
The relationship between depression and frailty syndrome: a systematic review. Aging Ment Health (2014) 0.82
Interleukin 6 and cognitive dysfunction. Metab Brain Dis (2014) 0.82
Cyclic GMP pathways in hepatic encephalopathy. Neurological and therapeutic implications. Metab Brain Dis (2010) 0.82
NMDA receptors in hyperammonemia and hepatic encephalopathy. Metab Brain Dis (2007) 0.82
Sensitization to caffeine and cross-sensitization to amphetamine: influence of individual response to caffeine. Behav Brain Res (2006) 0.82
Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: therapeutical implications. Neurochem Int (2009) 0.82
Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants. J Pharmacol Exp Ther (2002) 0.82
Prenatal exposure to polybrominated diphenylether 99 enhances the function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and in cultured neurons. Eur J Neurosci (2007) 0.82
Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity. Bioorg Med Chem (2004) 0.82
Chronic exposure to ammonia induces isoform-selective alterations in the intracellular distribution and NMDA receptor-mediated translocation of protein kinase C in cerebellar neurons in culture. J Neurochem (2005) 0.82
Hyperammonemia alters the modulation by different neurosteroids of the glutamate-nitric oxide-cyclic GMP pathway through NMDA- GABAA - or sigma receptors in cerebellum in vivo. J Neurochem (2013) 0.82
Nephrilin peptide modulates a neuroimmune stress response in rodent models of burn trauma and sepsis. Int J Burns Trauma (2013) 0.81
Blocking NMDA receptors delays death in rats with acute liver failure by dual protective mechanisms in kidney and brain. Neuromolecular Med (2013) 0.81
Pregnenolone sulfate restores the glutamate-nitric-oxide-cGMP pathway and extracellular GABA in cerebellum and learning and motor coordination in hyperammonemic rats. ACS Chem Neurosci (2013) 0.81
Role of NMDA receptors in acute liver failure and ammonia toxicity: therapeutical implications. Neurochem Int (2009) 0.81
Correlation of nitric oxide and atrial natriuretic peptide changes with altered cGMP homeostasis in liver cirrhosis. Liver Int (2005) 0.81
Acute liver failure-induced death of rats is delayed or prevented by blocking NMDA receptors in brain. Am J Physiol Gastrointest Liver Physiol (2008) 0.81
Pharmacological manipulation of cyclic GMP levels in brain restores learning ability in animal models of hepatic encephalopathy: therapeutic implications. Neuropsychiatr Dis Treat (2006) 0.81
A novel N-methyl-D-aspartate receptor open channel blocker with in vivo neuroprotectant activity. J Pharmacol Exp Ther (2002) 0.81
The function of the glutamate-nitric oxide-cGMP pathway in brain in vivo and learning ability decrease in parallel in mature compared with young rats. Learn Mem (2007) 0.81
Chronic hyperammonemia induces tonic activation of NMDA receptors in cerebellum. J Neurochem (2009) 0.80
Developmental exposure to polychlorinated biphenyls PCB153 or PCB126 impairs learning ability in young but not in adult rats. Eur J Neurosci (2008) 0.80
An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain. J Pharmacol Exp Ther (2012) 0.80