Published in PLoS Biol on October 13, 2003
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MicroRNA targets in Drosophila. Genome Biol (2003) 23.59
Specificity of microRNA target selection in translational repression. Genes Dev (2004) 21.14
Fast and effective prediction of microRNA/target duplexes. RNA (2004) 18.10
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures. Nature (2007) 11.66
A combined computational-experimental approach predicts human microRNA targets. Genes Dev (2004) 9.82
Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs. Genome Res (2007) 9.61
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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity. RNA (2006) 7.06
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MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol (2007) 6.41
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MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev (2006) 6.30
MicroRNA control of PHABULOSA in leaf development: importance of pairing to the microRNA 5' region. EMBO J (2004) 6.27
Structural insights into mRNA recognition from a PIWI domain-siRNA guide complex. Nature (2005) 6.23
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The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev Cell (2005) 5.90
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A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain. Genome Res (2004) 5.77
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Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1. Cell (2007) 5.26
A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence. Proc Natl Acad Sci U S A (2008) 5.11
The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs. Nature (2008) 5.05
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The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution. Nat Struct Mol Biol (2008) 4.88
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MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One (2006) 4.29
Systematic discovery and characterization of fly microRNAs using 12 Drosophila genomes. Genome Res (2007) 4.28
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov (2010) 4.25
A microRNA imparts robustness against environmental fluctuation during development. Cell (2009) 4.08
MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Genes Dev (2007) 4.01
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Prediction and identification of Arabidopsis thaliana microRNAs and their mRNA targets. Genome Biol (2004) 3.66
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Target mRNA abundance dilutes microRNA and siRNA activity. Mol Syst Biol (2010) 3.37
Systematic identification of microRNA functions by combining target prediction and expression profiling. Nucleic Acids Res (2006) 3.29
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Experimental strategies for microRNA target identification. Nucleic Acids Res (2011) 3.00
Widespread regulatory activity of vertebrate microRNA* species. RNA (2010) 2.97
Target prediction for small, noncoding RNAs in bacteria. Nucleic Acids Res (2006) 2.90
MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics (2010) 2.80
Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development. Proc Natl Acad Sci U S A (2005) 2.62
Predicting and validating microRNA targets. Genome Biol (2004) 2.54
Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab (2007) 2.52
Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr Biol (2006) 2.51
Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression. Genome Biol (2006) 2.49
Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. Nucleic Acids Res (2007) 2.48
MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation. Exp Cell Res (2008) 2.46
A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Genes Dev (2008) 2.45
Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci. Genes Dev (2008) 2.35
Enhancement of the seed-target recognition step in RNA silencing by a PIWI/MID domain protein. Mol Cell (2009) 2.27
Current tools for the identification of miRNA genes and their targets. Nucleic Acids Res (2009) 2.12
Temporal regulation of metamorphic processes in Drosophila by the let-7 and miR-125 heterochronic microRNAs. Curr Biol (2008) 2.11
miTarget: microRNA target gene prediction using a support vector machine. BMC Bioinformatics (2006) 2.08
Revealing posttranscriptional regulatory elements through network-level conservation. PLoS Comput Biol (2005) 2.04
A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A (2006) 2.04
The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings. Genes Dev (2005) 2.04
MicroRNAs in the Drosophila bithorax complex. Genes Dev (2008) 1.99
Relative contribution of sequence and structure features to the mRNA binding of Argonaute/EIF2C-miRNA complexes and the degradation of miRNA targets. Genome Res (2009) 1.98
PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Nat Struct Mol Biol (2012) 1.91
MicroRNA regulation of human protein protein interaction network. RNA (2007) 1.82
NAViGaTing the micronome--using multiple microRNA prediction databases to identify signalling pathway-associated microRNAs. PLoS One (2011) 1.80
microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Genes Dev (2007) 1.80
MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila. Mol Cell (2010) 1.78
The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One (2008) 1.78
Evolution under canalization and the dual roles of microRNAs: a hypothesis. Genome Res (2009) 1.72
MicroRNA-repressed mRNAs contain 40S but not 60S components. Proc Natl Acad Sci U S A (2008) 1.71
Deep sequencing of small RNA libraries reveals dynamic regulation of conserved and novel microRNAs and microRNA-stars during silkworm development. BMC Genomics (2010) 1.68
A novel computational framework for simultaneous integration of multiple types of genomic data to identify microRNA-gene regulatory modules. Bioinformatics (2011) 1.68
Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res (2009) 1.64
Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes. RNA (2004) 1.63
IGF-II is regulated by microRNA-125b in skeletal myogenesis. J Cell Biol (2011) 1.62
Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity. RNA (2007) 1.61
miROrtho: computational survey of microRNA genes. Nucleic Acids Res (2008) 1.60
Identification of microRNAs expressed in two mosquito vectors, Aedes albopictus and Culex quinquefasciatus. BMC Genomics (2010) 1.59
Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. Nucleic Acids Res (2006) 1.58
MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism. J Lipid Res (2010) 1.56
Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A (2007) 1.53
High-resolution profiling and discovery of planarian small RNAs. Proc Natl Acad Sci U S A (2009) 1.53
Plant and animal microRNAs: similarities and differences. Funct Integr Genomics (2005) 1.51
Anopheles gambiae miRNAs as actors of defence reaction against Plasmodium invasion. Nucleic Acids Res (2007) 1.51
Pre-miRNA loop nucleotides control the distinct activities of mir-181a-1 and mir-181c in early T cell development. PLoS One (2008) 1.51
The evolution and functional diversification of animal microRNA genes. Cell Res (2008) 1.49
Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology. PLoS One (2008) 1.49
Impact of microRNA regulation on variation in human gene expression. Genome Res (2012) 1.49
Got target? Computational methods for microRNA target prediction and their extension. Exp Mol Med (2010) 1.49
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An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16
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The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature (2000) 39.31
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Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell (1993) 33.79
A microRNA in a multiple-turnover RNAi enzyme complex. Science (2002) 23.36
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell (2003) 22.14
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Control of leaf morphogenesis by microRNAs. Nature (2003) 11.36
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The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol (2003) 11.23
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The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell (2003) 6.86
The C elegans hunchback homolog, hbl-1, controls temporal patterning and is a probable microRNA target. Dev Cell (2003) 6.74
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The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science (2007) 9.36
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An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
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Drosophila's insulin/PI3-kinase pathway coordinates cellular metabolism with nutritional conditions. Dev Cell (2002) 4.85
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The conserved microRNA miR-8 tunes atrophin levels to prevent neurodegeneration in Drosophila. Cell (2007) 4.00
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Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature (2008) 2.54
An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J (2010) 2.51
MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev (2010) 2.51
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A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands. Genes Dev (2008) 2.45
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Ten thousand interactions for the molecular biologist. Nat Biotechnol (2004) 2.30
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev (2005) 2.28
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DILIMOT: discovery of linear motifs in proteins. Nucleic Acids Res (2006) 2.17
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HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient. Dev Cell (2002) 2.03
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microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila. Genes Dev (2007) 1.80
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Wingless and Notch signaling provide cell survival cues and control cell proliferation during wing development. Development (2003) 1.72
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The bantam gene regulates Drosophila growth. Genetics (2002) 1.62
MicroRNAs in neurodegeneration. Curr Opin Neurobiol (2008) 1.62
Transportin2 functions as importin and mediates nuclear import of HuR. Proc Natl Acad Sci U S A (2004) 1.61
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Drosophila Melted modulates FOXO and TOR activity. Dev Cell (2005) 1.59
A systematic analysis of Drosophila TUDOR domain-containing proteins identifies Vreteno and the Tdrd12 family as essential primary piRNA pathway factors. EMBO J (2011) 1.58
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (2009) 1.57
Short-range cell interactions and cell survival in the Drosophila wing. Dev Cell (2002) 1.57
Towards a complete description of the microRNA complement of animal genomes. Genome Biol (2003) 1.49
A more complete, complexed and structured interactome. Curr Opin Struct Biol (2007) 1.48
Accurate prediction of peptide binding sites on protein surfaces. PLoS Comput Biol (2009) 1.48
Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium. Mol Syst Biol (2012) 1.44
Protein complexes: structure prediction challenges for the 21st century. Curr Opin Struct Biol (2005) 1.43
A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Mol Syst Biol (2010) 1.43
The third dimension for protein interactions and complexes. Trends Biochem Sci (2002) 1.41
A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains. Mol Cell (2002) 1.40
Peptide-mediated interactions in biological systems: new discoveries and applications. Curr Opin Biotechnol (2008) 1.39
Subunit architecture of intact protein complexes from mass spectrometry and homology modeling. Acc Chem Res (2008) 1.38
Slik Sterile-20 kinase regulates Moesin activity to promote epithelial integrity during tissue growth. Genes Dev (2004) 1.38
The genetic makeup of the Drosophila piRNA pathway. Mol Cell (2013) 1.35
The cochaperone shutdown defines a group of biogenesis factors essential for all piRNA populations in Drosophila. Mol Cell (2012) 1.34
Identification of novel Drosophila melanogaster microRNAs. PLoS One (2007) 1.28
Fast fitting of atomic structures to low-resolution electron density maps by surface overlap maximization. J Mol Biol (2004) 1.27
Recombinase-mediated cassette exchange provides a versatile platform for gene targeting: knockout of miR-31b. Genetics (2009) 1.26
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. Proc Natl Acad Sci U S A (2009) 1.26
Drosophila microRNAs 263a/b confer robustness during development by protecting nascent sense organs from apoptosis. PLoS Biol (2010) 1.26
Drosophila Gtsf1 is an essential component of the Piwi-mediated transcriptional silencing complex. Genes Dev (2013) 1.25
MAP4K3 regulates body size and metabolism in Drosophila. Dev Biol (2010) 1.24
Content disputes in Wikipedia reflect geopolitical instability. PLoS One (2011) 1.23
Illuminating drug discovery with biological pathways. FEBS Lett (2005) 1.22
A complex prediction: three-dimensional model of the yeast exosome. EMBO Rep (2002) 1.18
On the role of glypicans in the process of morphogen gradient formation. Dev Biol (2006) 1.18