Published in Mol Cell Biol on January 01, 2004
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. Mol Cell Biol (2004) 6.55
H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell (2008) 5.23
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell (2011) 4.90
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer Cell (2011) 4.56
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev (2007) 4.07
The COMPASS family of histone H3K4 methylases: mechanisms of regulation in development and disease pathogenesis. Annu Rev Biochem (2012) 3.61
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood (2007) 3.60
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol (2012) 3.15
HOXA9 is required for survival in human MLL-rearranged acute leukemias. Blood (2008) 3.12
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
Solution structure of the nonmethyl-CpG-binding CXXC domain of the leukaemia-associated MLL histone methyltransferase. EMBO J (2006) 2.89
MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A (2005) 2.87
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis. PLoS Genet (2006) 2.62
The molecular biology of mixed lineage leukemia. Haematologica (2009) 2.58
Misguided transcriptional elongation causes mixed lineage leukemia. PLoS Biol (2009) 2.44
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Dev (2011) 2.38
Cross-platform analysis of cancer microarray data improves gene expression based classification of phenotypes. BMC Bioinformatics (2005) 2.36
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. Blood (2011) 1.99
Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L. Nat Cell Biol (2006) 1.97
The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol (2011) 1.95
MicroRNA-126 regulates HOXA9 by binding to the homeobox. Mol Cell Biol (2008) 1.95
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. Blood (2011) 1.74
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A (2006) 1.67
c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Blood (2006) 1.64
Identification and characterization of Hoxa9 binding sites in hematopoietic cells. Blood (2011) 1.63
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell (2012) 1.61
The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest (2007) 1.61
Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias. J Biol Chem (2010) 1.56
A role for MEIS1 in MLL-fusion gene leukemia. Blood (2008) 1.52
MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proc Natl Acad Sci U S A (2008) 1.50
miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia. Nat Commun (2012) 1.49
The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia. Oncogene (2012) 1.46
Aberrant overexpression and function of the miR-17-92 cluster in MLL-rearranged acute leukemia. Proc Natl Acad Sci U S A (2010) 1.43
Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes. Mol Cell Biol (2006) 1.36
Therapeutic targeting of MLL. Blood (2009) 1.36
A murine Mll-AF4 knock-in model results in lymphoid and myeloid deregulation and hematologic malignancy. Blood (2006) 1.35
PBX3 is an important cofactor of HOXA9 in leukemogenesis. Blood (2012) 1.30
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Proc Natl Acad Sci U S A (2005) 1.29
Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex. Cancer Cell (2011) 1.25
HOX expression patterns identify a common signature for favorable AML. Leukemia (2008) 1.24
Novel human bronchial epithelial cell lines for cystic fibrosis research. Am J Physiol Lung Cell Mol Physiol (2008) 1.24
miR-10a is aberrantly overexpressed in Nucleophosmin1 mutated acute myeloid leukaemia and its suppression induces cell death. Mol Cancer (2012) 1.21
TET1 plays an essential oncogenic role in MLL-rearranged leukemia. Proc Natl Acad Sci U S A (2013) 1.19
The PHD fingers of MLL block MLL fusion protein-mediated transformation. Blood (2008) 1.18
HOXA9 modulates its oncogenic partner Meis1 to influence normal hematopoiesis. Mol Cell Biol (2009) 1.18
Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood (2009) 1.15
HOX proteins and leukemia. Int J Clin Exp Pathol (2008) 1.14
Initiation of MLL-rearranged AML is dependent on C/EBPα. J Exp Med (2013) 1.13
Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes. PLoS One (2007) 1.10
MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia. Proc Natl Acad Sci U S A (2012) 1.09
Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia. Cell Stem Cell (2015) 1.09
Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization. Cancer Res (2008) 1.04
Requirement of c-Myb for p210(BCR/ABL)-dependent transformation of hematopoietic progenitors and leukemogenesis. Blood (2008) 1.04
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia. Cell Death Discov (2015) 1.02
miR-9 is an essential oncogenic microRNA specifically overexpressed in mixed lineage leukemia-rearranged leukemia. Proc Natl Acad Sci U S A (2013) 1.01
Oncogenic RAS enables DNA damage- and p53-dependent differentiation of acute myeloid leukemia cells in response to chemotherapy. PLoS One (2009) 1.01
Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets. Oncogene (2015) 0.99
ALL1 fusion proteins induce deregulation of EphA7 and ERK phosphorylation in human acute leukemias. Proc Natl Acad Sci U S A (2007) 0.97
Hoxa9 regulates Flt3 in lymphohematopoietic progenitors. J Immunol (2010) 0.96
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell (2016) 0.96
PBX3 is targeted by multiple miRNAs and is essential for liver tumour-initiating cells. Nat Commun (2015) 0.94
Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem (2011) 0.94
PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. Leukemia (2013) 0.93
Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in acute myeloid leukemia. Mol Cancer (2009) 0.93
Genome-wide analysis of transcriptional reprogramming in mouse models of acute myeloid leukaemia. PLoS One (2011) 0.91
Transposon activation mutagenesis as a screening tool for identifying resistance to cancer therapeutics. BMC Cancer (2013) 0.91
PAFc, a key player in MLL-rearranged leukemogenesis. Oncotarget (2010) 0.89
Direct physical and functional interaction of the NuA4 complex components Yaf9p and Swc4p. Eukaryot Cell (2004) 0.88
Homeodomain transcription factor Meis1 is a critical regulator of adult bone marrow hematopoiesis. PLoS One (2014) 0.88
Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation. Blood (2012) 0.87
Regulation of MEIS1 by distal enhancer elements in acute leukemia. Leukemia (2013) 0.87
The trithorax protein partner menin acts in tandem with EZH2 to suppress C/EBPα and differentiation in MLL-AF9 leukemia. Haematologica (2013) 0.86
Menin as a hub controlling mixed lineage leukemia. Bioessays (2012) 0.85
Murine models of acute leukemia: important tools in current pediatric leukemia research. Front Oncol (2014) 0.84
DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. Oncogene (2015) 0.84
Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. Blood (2008) 0.84
Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis. Cancers (Basel) (2012) 0.83
Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signaling. Haematologica (2011) 0.83
Challenges and strategies for generating therapeutic patient-specific hemangioblasts and hematopoietic stem cells from human pluripotent stem cells. Int J Dev Biol (2010) 0.83
Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells. Blood Cancer J (2012) 0.83
Efficacy of cyclin-dependent-kinase 9 inhibitors in a murine model of mixed-lineage leukemia. Leukemia (2014) 0.81
MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. Blood (2015) 0.81
The deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis. PLoS One (2014) 0.80
p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia. Mol Oncol (2013) 0.80
MLL-AF9- and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C. J Clin Invest (2016) 0.80
RE-IIBP Methylates H3K79 and Induces MEIS1-mediated Apoptosis via H2BK120 Ubiquitination by RNF20. Sci Rep (2015) 0.80
TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia. Leukemia (2014) 0.79
Challenges and opportunities in targeting the menin-MLL interaction. Future Med Chem (2014) 0.79
Dangerous liaisons: cooperation between Pbx3, Meis1 and Hoxa9 in leukemia. Haematologica (2015) 0.79
MLL1/WDR5 complex in leukemogenesis and epigenetic regulation. Chin J Cancer (2011) 0.78
The role of HTS in drug discovery at the University of Michigan. Comb Chem High Throughput Screen (2014) 0.78
Two isoforms of HOXA9 function differently but work synergistically in human MLL-rearranged leukemia. Blood Cells Mol Dis (2012) 0.77
Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase. Biochemistry (2015) 0.77
Differential requirement for wild-type Flt3 in leukemia initiation among mouse models of human leukemia. Exp Hematol (2013) 0.77
Epigenetics of hematopoiesis and hematological malignancies. Genes Dev (2016) 0.77
Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation. Leukemia (2014) 0.76
Characterization of Leukemia-Inducing Genes Using a Proto-Oncogene/Homeobox Gene Retroviral Human cDNA Library in a Mouse In Vivo Model. PLoS One (2015) 0.76
Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia. Cancer Lett (2016) 0.76
PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged Disease. Cancer Res (2016) 0.76
MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet (2001) 13.79
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell (2002) 11.83
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res (1995) 7.95
ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell (2002) 6.72
Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell (2002) 6.64
Altered Hox expression and segmental identity in Mll-mutant mice. Nature (1995) 6.60
The roles of FLT3 in hematopoiesis and leukemia. Blood (2002) 6.14
Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell (1992) 6.11
The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell (1992) 5.39
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J (1998) 5.21
Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene (2001) 4.70
A movable and regulable inactivation function within the steroid binding domain of the glucocorticoid receptor. Cell (1988) 4.15
Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J (1997) 4.03
Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell (2003) 3.75
A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet (1992) 3.43
Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Proc Natl Acad Sci U S A (1991) 3.25
Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer (2002) 3.18
Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol Cell Biol (1995) 2.89
Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol Cell Biol (2001) 2.80
Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nat Genet (1996) 2.78
Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci U S A (1999) 2.76
11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene. Proc Natl Acad Sci U S A (1994) 2.67
Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Mol Cell Biol (2003) 2.66
MLL, a mammalian trithorax-group gene, functions as a transcriptional maintenance factor in morphogenesis. Proc Natl Acad Sci U S A (1998) 2.65
MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol Cell Biol (2001) 2.58
The C-terminal SET domains of ALL-1 and TRITHORAX interact with the INI1 and SNR1 proteins, components of the SWI/SNF complex. Proc Natl Acad Sci U S A (1998) 2.52
The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. Mol Cell Biol (1998) 2.48
Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood (2002) 2.48
The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation. Nucleic Acids Res (2002) 2.43
Defects in yolk sac hematopoiesis in Mll-null embryos. Blood (1997) 2.06
Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Blood (1998) 2.06
HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells. Mol Cell Biol (1999) 2.06
HOX and non-HOX homeobox genes in leukemic hematopoiesis. Stem Cells (2002) 1.94
Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia. EMBO J (2000) 1.87
Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood (2002) 1.79
Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell (2003) 1.79
Mll rearrangements in haematological malignancies: lessons from clinical and biological studies. Br J Haematol (1999) 1.78
The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood (2002) 1.64
Translocations of the RARalpha gene in acute promyelocytic leukemia. Oncogene (2001) 1.59
The role of MLL in hematopoiesis and leukemia. Curr Opin Hematol (2002) 1.42
The elongation domain of ELL is dispensable but its ELL-associated factor 1 interaction domain is essential for MLL-ELL-induced leukemogenesis. Mol Cell Biol (2001) 1.40
Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood (2002) 1.37
Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia. Proc Natl Acad Sci U S A (2001) 1.36
The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures. Blood (1997) 1.33
MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol (2002) 1.29
Transcriptional activation is a key function encoded by MLL fusion partners. Leukemia (2003) 1.28
Frequent co-expression of HoxA9 and Meis1 genes in infant acute lymphoblastic leukaemia with MLL rearrangement. Br J Haematol (2002) 1.22
Analysis of the hormone-dependent regulation of a JunD-estrogen receptor chimera. J Biol Chem (1995) 1.11
MLL-ENL causes a reversible and myc-dependent block of myelomonocytic cell differentiation. Cancer Res (2001) 1.10
The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator. Leukemia (1999) 1.09
A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A (2004) 44.81
A mammalian microRNA expression atlas based on small RNA library sequencing. Cell (2007) 34.03
High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer (2004) 11.79
New microRNAs from mouse and human. RNA (2003) 10.35
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest (2008) 9.42
Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell (2008) 8.41
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell (2004) 6.08
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis. Nature (2006) 5.52
Human host factors required for influenza virus replication. Nature (2010) 5.28
Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog (2009) 4.24
Global landscape of HIV-human protein complexes. Nature (2011) 3.70
Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome. Lancet (2008) 3.69
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification. Blood (2007) 3.60
Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling. PLoS One (2008) 3.59
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37
A probability-based approach for the analysis of large-scale RNAi screens. Nat Methods (2007) 3.34
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2. Genes Dev (2003) 3.32
Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol (2012) 3.15
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A (2005) 2.87
A human MAP kinase interactome. Nat Methods (2010) 2.62
The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell (2010) 2.50
Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis. RNA (2007) 2.48
RNA targets of wild-type and mutant FET family proteins. Nat Struct Mol Biol (2011) 2.46
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications. Cancer Res (2005) 2.45
Host switch leads to emergence of Plasmodium vivax malaria in humans. Mol Biol Evol (2005) 2.45
Misguided transcriptional elongation causes mixed lineage leukemia. PLoS Biol (2009) 2.44
The MT domain of the proto-oncoprotein MLL binds to CpG-containing DNA and discriminates against methylation. Nucleic Acids Res (2002) 2.43
Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms. Mol Biochem Parasitol (2006) 2.39
Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31
Intronic CA-repeat and CA-rich elements: a new class of regulators of mammalian alternative splicing. EMBO J (2005) 2.30
Molecular basis of the spectral expression of CIAS1 mutations associated with phagocytic cell-mediated autoinflammatory disorders CINCA/NOMID, MWS, and FCU. Blood (2003) 2.11
Prognostic value of minimal residual disease quantification before allogeneic stem-cell transplantation in relapsed childhood acute lymphoblastic leukemia: the ALL-REZ BFM Study Group. J Clin Oncol (2008) 2.08
Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing. Nat Genet (2012) 2.07
The state of general practice--not all for the better. BMJ (2008) 2.05
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell (2011) 2.01
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2. PLoS Pathog (2011) 2.00
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. Blood (2011) 1.99
The pathogenesis of mixed-lineage leukemia. Annu Rev Pathol (2011) 1.95
Orbital dirofilariasis. Clin Experiment Ophthalmol (2002) 1.92
Loss-of-function Additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia. Blood (2009) 1.90
p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. EMBO J (2002) 1.86
Determining the distribution of probes between different subcellular locations through automated unmixing of subcellular patterns. Proc Natl Acad Sci U S A (2010) 1.82
Interaction of MLL amino terminal sequences with menin is required for transformation. Cancer Res (2007) 1.82
Human Cep192 is required for mitotic centrosome and spindle assembly. Curr Biol (2007) 1.81
Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. EMBO J (2005) 1.79
Dimerization of MLL fusion proteins immortalizes hematopoietic cells. Cancer Cell (2003) 1.79
Phase II window study on rituximab in newly diagnosed pediatric mature B-cell non-Hodgkin's lymphoma and Burkitt leukemia. J Clin Oncol (2010) 1.79
An immunodeficiency disease with RAG mutations and granulomas. N Engl J Med (2008) 1.71
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proc Natl Acad Sci U S A (2006) 1.67
c-Myb is an essential downstream target for homeobox-mediated transformation of hematopoietic cells. Blood (2006) 1.64
Identification of mitochondrial carriers in Saccharomyces cerevisiae by transport assay of reconstituted recombinant proteins. Biochim Biophys Acta (2006) 1.64
The eleven-nineteen-leukemia protein ENL connects nuclear MLL fusion partners with chromatin. Oncogene (2005) 1.64
Identification and characterization of Hoxa9 binding sites in hematopoietic cells. Blood (2011) 1.63
Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood (2005) 1.61
Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia. Cancer Cell (2012) 1.61
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol (2004) 1.60
Identification of novel mammalian growth regulatory factors by genome-scale quantitative image analysis. Genome Res (2005) 1.59
The Thr224Asn mutation in the VPS45 gene is associated with the congenital neutropenia and primary myelofibrosis of infancy. Blood (2013) 1.55
Girls homozygous for an IL-2-inducible T cell kinase mutation that leads to protein deficiency develop fatal EBV-associated lymphoproliferation. J Clin Invest (2009) 1.49
Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol (2010) 1.48
Identification of p53 regulators by genome-wide functional analysis. Proc Natl Acad Sci U S A (2004) 1.48
Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat Cell Biol (2010) 1.47
Murine gammaherpesvirus 68 infection is associated with lymphoproliferative disease and lymphoma in BALB beta2 microglobulin-deficient mice. J Virol (2005) 1.46
Residential mobility and severe mental illness: a population-based analysis. Adm Policy Ment Health (2006) 1.46
Whole genome functional analysis identifies novel components required for mitotic spindle integrity in human cells. Genome Biol (2008) 1.46
Killing of leukemic cells with a BCR/ABL fusion gene by RNA interference (RNAi). Oncogene (2002) 1.45
Current status of veterinary vaccines. Clin Microbiol Rev (2007) 1.44
Evaluation of the ICT malaria P.f/P.v and the OptiMal rapid diagnostic tests for malaria in febrile returned travellers. J Clin Microbiol (2002) 1.42
Beta1 integrins control the formation of cell chains in the adult rostral migratory stream. J Neurosci (2007) 1.42
Auto- and cross-regulation of the hnRNP L proteins by alternative splicing. Mol Cell Biol (2009) 1.41
Leukemogenic transformation by HOXA cluster genes. Blood (2010) 1.41
The advent of targeted therapeutics and implications for pathologists. Am J Clin Pathol (2002) 1.38
Small interfering RNAs: a revolutionary tool for the analysis of gene function and gene therapy. Mol Interv (2002) 1.36
Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map). Cell Microbiol (2006) 1.35
MLL-AF9 and MLL-ENL alter the dynamic association of transcriptional regulators with genes critical for leukemia. Exp Hematol (2010) 1.35
MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription. Mol Cell Biol (2009) 1.33
Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus. PLoS Pathog (2007) 1.32
Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells. J Exp Med (2006) 1.29
Mitochondrial DNA mutations in patients with postlingual, nonsyndromic hearing impairment. Eur J Hum Genet (2005) 1.27
Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia. Int J Hematol (2007) 1.26
Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells. Proc Natl Acad Sci U S A (2007) 1.26