Published in Pediatrics on January 01, 2004
Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood (2008) 1.94
Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis. J Perinatol (2008) 1.21
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates. Blood (2007) 1.12
Why are clinicians not embracing the results from pivotal clinical trials in severe sepsis? A bayesian analysis. PLoS One (2008) 1.08
Activated protein C action in inflammation. Br J Haematol (2009) 0.98
Clinical trials in severe sepsis with drotrecogin alfa (activated). Crit Care (2007) 0.88
Protein S modulates the anticoagulant action of recombinant human activated protein C: a comparison between neonates and adults. Br J Pharmacol (2005) 0.80
Activation and degradation of protein C by primary rabbit pleural mesothelial cells. Lung (2006) 0.77
Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis. Pediatrics (2004) 0.75
Matrix Metalloproteinase-8 Augments Bacterial Clearance in a Juvenile Sepsis Model. Mol Med (2016) 0.75
Protective Effect of N-Acetyl-Cysteine (NAC) in Lipopolysaccharide (LPS)-Associated Inflammatory Response in Rat Neonates. Rambam Maimonides Med J (2017) 0.75
Mortality after fluid bolus in African children with severe infection. N Engl J Med (2011) 10.99
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. N Engl J Med (2005) 8.55
Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med (2009) 7.55
Clinical recognition of meningococcal disease in children and adolescents. Lancet (2006) 6.27
Drotrecogin alfa (activated) in children with severe sepsis: a multicentre phase III randomised controlled trial. Lancet (2007) 5.23
Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med (2015) 4.90
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med (2012) 4.65
Early changes in organ function predict eventual survival in severe sepsis. Crit Care Med (2005) 3.97
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78
Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med (2008) 3.67
Guidelines on critical care services and personnel: Recommendations based on a system of categorization of three levels of care. Crit Care Med (2003) 3.37
Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). Am J Respir Crit Care Med (2007) 3.34
Drotrecogin alfa (activated) administration across clinically important subgroups of patients with severe sepsis. Crit Care Med (2003) 3.18
Multicenter cohort study of out-of-hospital pediatric cardiac arrest. Crit Care Med (2011) 3.05
Clinical features of dominant and recessive interferon gamma receptor 1 deficiencies. Lancet (2004) 2.90
Multicenter cohort study of in-hospital pediatric cardiac arrest. Pediatr Crit Care Med (2009) 2.81
Fluid overload at 48 hours is associated with respiratory morbidity but not mortality in a general PICU: retrospective cohort study. Pediatr Crit Care Med (2015) 2.73
In-hospital versus out-of-hospital pediatric cardiac arrest: a multicenter cohort study. Crit Care Med (2009) 2.70
Decreasing PICU catheter-associated bloodstream infections: NACHRI's quality transformation efforts. Pediatrics (2010) 2.60
The clinical evaluation committee in a large multicenter phase 3 trial of drotrecogin alfa (activated) in patients with severe sepsis (PROWESS): role, methodology, and results. Crit Care Med (2003) 2.54
The role of healthcare delivery in the outcome of meningococcal disease in children: case-control study of fatal and non-fatal cases. BMJ (2005) 2.52
A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. PLoS Genet (2009) 2.45
Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever. J Infect Dis (2007) 2.44
Response to volume resuscitation in children with severe malaria. Pediatr Crit Care Med (2003) 2.39
Revisiting human IL-12Rβ1 deficiency: a survey of 141 patients from 30 countries. Medicine (Baltimore) (2010) 2.33
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. Nat Genet (2010) 2.32
Pediatric brain death. Crit Care Med (2011) 2.22
Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes. Circulation (2009) 2.20
ENHANCE: results of a global open-label trial of drotrecogin alfa (activated) in children with severe sepsis. Pediatr Crit Care Med (2006) 2.19
Point: Efficacy of extracorporeal membrane oxygenation in 2009 influenza A(H1N1): sufficient evidence? Chest (2010) 2.13
Diagnosis of childhood tuberculosis and host RNA expression in Africa. N Engl J Med (2014) 2.12
Dynamic evolution of coagulopathy in the first day of severe sepsis: relationship with mortality and organ failure. Crit Care Med (2005) 2.12
Assessing the prediction potential of an in silico computer model of intracranial pressure dynamics. Crit Care Med (2009) 2.11
A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration. Chem Biol (2011) 2.07
Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma. J Clin Invest (2005) 2.06
Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intensive Care Med (2003) 2.05
Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One (2009) 2.03
WHO guidelines on fluid resuscitation in children: missing the FEAST data. BMJ (2014) 2.00
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet (2011) 1.97
Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: a case-control study. PLoS Med (2013) 1.91
Bioelectric controls of cell proliferation: ion channels, membrane voltage and the cell cycle. Cell Cycle (2009) 1.88
Cerebral hyperemia and impaired cerebral autoregulation associated with diabetic ketoacidosis in critically ill children. Crit Care Med (2006) 1.84
West Nile virus-associated encephalitis in recipients of renal and pancreas transplants: case series and literature review. Clin Infect Dis (2004) 1.84
Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med (2008) 1.82
Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A (2003) 1.78
Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality. J Infect Dis (2007) 1.78
Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects. Pharmacotherapy (2008) 1.77
Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory inhospital pediatric cardiac arrest: a report from the National Registry of Cardiopulmonary Resuscitation. Pediatr Crit Care Med (2010) 1.76
The Pediatric Multiple Organ Dysfunction Score (P-MODS): development and validation of an objective scale to measure the severity of multiple organ dysfunction in critically ill children. Crit Care Med (2005) 1.73
A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation. Am Heart J (2007) 1.73
Coagulation abnormalities in dengue hemorrhagic Fever: serial investigations in 167 Vietnamese children with Dengue shock syndrome. Clin Infect Dis (2002) 1.73
Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction. Crit Care Med (2005) 1.73
Dissecting interferon-induced transcriptional programs in human peripheral blood cells. PLoS One (2010) 1.73
Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing. Am J Respir Crit Care Med (2006) 1.72
Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study. BMJ (2006) 1.69
Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. Development (2006) 1.68
Pediatric Regional Anesthesia Network (PRAN): a multi-institutional study of the use and incidence of complications of pediatric regional anesthesia. Anesth Analg (2012) 1.68
Platelet and soluble CD40L in meningococcal sepsis. Intensive Care Med (2006) 1.67
Neuropsychologic function three to six months following admission to the PICU with meningoencephalitis, sepsis, and other disorders: a prospective study of school-aged children. Crit Care Med (2013) 1.67
H+ pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration. Development (2007) 1.67
Role of membrane potential in the regulation of cell proliferation and differentiation. Stem Cell Rev (2009) 1.66
Genomewide analysis of the host response to malaria in Kenyan children. J Infect Dis (2005) 1.66
Randomized trial of group interventions to reduce HIV/STD risk and change theoretical mediators among detained adolescents. J Consult Clin Psychol (2009) 1.65
Fresh whole blood versus reconstituted blood for pump priming in heart surgery in infants. N Engl J Med (2004) 1.63
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. Dev Biol (2009) 1.62
Complex analysis of intracranial hypertension using approximate entropy. Crit Care Med (2006) 1.62
Role of functional plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism in susceptibility, severity, and outcome of meningococcal disease in Caucasian children. Crit Care Med (2003) 1.61
Lipid formulations of amphotericin B significantly improve outcome in solid organ transplant recipients with central nervous system cryptococcosis. Clin Infect Dis (2009) 1.60
Size and charge characteristics of the protein leak in dengue shock syndrome. J Infect Dis (2004) 1.60
Open, aware, and active: contextual approaches as an emerging trend in the behavioral and cognitive therapies. Annu Rev Clin Psychol (2011) 1.59
Elevated plasma concentrations of IL-6 and elevated APACHE II score predict acute kidney injury in patients with severe sepsis. Clin J Am Soc Nephrol (2006) 1.59
Intestinal injury and endotoxemia in children undergoing surgery for congenital heart disease. Am J Respir Crit Care Med (2011) 1.57
Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the FEAST trial. BMC Med (2013) 1.57
Emergency management of meningococcal disease: eight years on. Arch Dis Child (2007) 1.57
Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet (2004) 1.56
Volume expansion with albumin compared to gelofusine in children with severe malaria: results of a controlled trial. PLoS Clin Trials (2006) 1.55
Hemolytic and thrombocytopathic characteristics of extracorporeal membrane oxygenation systems at simulated flow rate for neonates. Pediatr Crit Care Med (2012) 1.52
Apoptosis is required during early stages of tail regeneration in Xenopus laevis. Dev Biol (2006) 1.52
Extubation failure in pediatric intensive care: a multiple-center study of risk factors and outcomes. Crit Care Med (2003) 1.52
Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med (2002) 1.50
Critical Care Delivery: The Importance of Process of Care and ICU Structure to Improved Outcomes: An Update From the American College of Critical Care Medicine Task Force on Models of Critical Care. Crit Care Med (2015) 1.49
Helium/oxygen-driven albuterol nebulization in the management of children with status asthmaticus: a randomized, placebo-controlled trial. Pediatr Crit Care Med (2010) 1.48
Interactive Web sites for families and physicians of pediatric intensive care unit patients: a preliminary report. Pediatr Crit Care Med (2004) 1.47
Interscalene brachial plexus blocks under general anesthesia in children: is this safe practice?: A report from the Pediatric Regional Anesthesia Network (PRAN). Reg Anesth Pain Med (2014) 1.46