Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation.

PubWeight™: 1.34‹?› | Rank: Top 10%

🔗 View Article (PMC 314282)

Published in Genes Dev on January 01, 2004

Authors

Karin G Wirth1, Romeo Ricci, Juan F Giménez-Abián, Shahryar Taghybeeglu, Nobuaki R Kudo, Wolfram Jochum, Mireille Vasseur-Cognet, Kim Nasmyth

Author Affiliations

1: Research Institute of Molecular Pathology (IMP), A-1030 Vienna, Austria.

Articles citing this

Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell (2008) 4.33

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell (2011) 2.73

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol (2006) 1.80

Mechanisms controlling cell cycle exit upon terminal differentiation. Curr Opin Cell Biol (2007) 1.70

The function of APC/CCdh1 in cell cycle and beyond. Cell Div (2009) 1.35

The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression. Oncogene (2009) 1.35

PIASgamma is required for faithful chromosome segregation in human cells. PLoS One (2006) 1.21

Downregulation of the anaphase-promoting complex (APC)7 in invasive ductal carcinomas of the breast and its clinicopathologic relationships. Breast Cancer Res (2005) 1.20

APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. J Cell Sci (2010) 1.18

Cdh1: a master G0/G1 regulator. Nat Cell Biol (2008) 1.16

Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans. Genetics (2006) 1.12

The viral protein Apoptin associates with the anaphase-promoting complex to induce G2/M arrest and apoptosis in the absence of p53. Genes Dev (2004) 1.11

Constitutive turnover of cyclin E by Cul3 maintains quiescence. Mol Cell Biol (2007) 1.10

Cell and tissue engineering for liver disease. Sci Transl Med (2014) 1.08

APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity. Cell Cycle (2010) 1.06

State of the APC/C: organization, function, and structure. Crit Rev Biochem Mol Biol (2011) 1.02

The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis. Front Oncol (2012) 1.01

Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochim Biophys Acta (2014) 1.00

Development of a multipurpose GATEWAY-based lentiviral tetracycline-regulated conditional RNAi system (GLTR). PLoS One (2014) 0.87

A minimal anaphase promoting complex/cyclosome (APC/C) in Trypanosoma brucei. PLoS One (2013) 0.85

The molecular chaperone Hsp90 is required for cell cycle exit in Drosophila melanogaster. PLoS Genet (2013) 0.82

Oligosyndactylism mice have an inversion of chromosome 8. Genetics (2004) 0.78

FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia. Blood (2017) 0.75

Suppression of APC/CCdh1 has subtype specific biological effects in acute myeloid leukemia. Oncotarget (2016) 0.75

APC/C(CDC20) and APC/C play pivotal roles in the process of embryonic development in Artemia sinica. Sci Rep (2016) 0.75

APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Rep (2016) 0.75

Hard clam extracts induce atypical apoptosis in human gastric cancer cells. Exp Ther Med (2017) 0.75

APC/C is essential for hematopoiesis and impaired in aplastic anemia. Oncotarget (2017) 0.75

Articles cited by this

T-Coffee: A novel method for fast and accurate multiple sequence alignment. J Mol Biol (2000) 57.88

Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements. Nucleic Acids Res (2001) 22.33

Inducible gene targeting in mice. Science (1995) 21.22

SEAVIEW and PHYLO_WIN: two graphic tools for sequence alignment and molecular phylogeny. Comput Appl Biosci (1996) 20.45

Mechanisms underlying ubiquitination. Annu Rev Biochem (2001) 18.87

Clustering of highly homologous sequences to reduce the size of large protein databases. Bioinformatics (2001) 9.11

A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell (1995) 8.34

CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science (1997) 8.00

The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev (2000) 6.43

Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res (1999) 6.35

The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol Cell (2002) 6.26

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell (1995) 6.23

Genes involved in sister chromatid separation are needed for B-type cyclin proteolysis in budding yeast. Cell (1995) 5.85

Closing the cell cycle circle in yeast: G2 cyclin proteolysis initiated at mitosis persists until the activation of G1 cyclins in the next cycle. Cell (1994) 5.05

Control of cyclin ubiquitination by CDK-regulated binding of Hct1 to the anaphase promoting complex. Science (1998) 4.57

The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol (2000) 4.53

Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci U S A (2001) 4.51

CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Cell (1995) 4.13

APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature (1999) 4.05

The anaphase-promoting complex: it's not just for mitosis any more. Genes Dev (2002) 3.89

Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles. Cell (1997) 3.83

Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell (2001) 3.43

Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Science (1998) 3.38

Identification of subunits of the anaphase-promoting complex of Saccharomyces cerevisiae. Science (1996) 3.26

The proteolysis of mitotic cyclins in mammalian cells persists from the end of mitosis until the onset of S phase. EMBO J (1996) 3.12

Emerging roles of ubiquitin in transcription regulation. Science (2002) 2.92

Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev (2001) 2.66

Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science (1998) 2.61

Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC. EMBO J (2001) 2.55

Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. Proc Natl Acad Sci U S A (1999) 2.54

Identification of BIME as a subunit of the anaphase-promoting complex. Science (1996) 2.33

Regulatory functions of ubiquitination in the immune system. Nat Immunol (2002) 2.26

Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev (2001) 1.91

The APC11 RING-H2 finger mediates E2-dependent ubiquitination. Mol Biol Cell (2000) 1.89

Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells. EMBO J (2001) 1.88

The anaphase inhibitor Pds1 binds to the APC/C-associated protein Cdc20 in a destruction box-dependent manner. Curr Biol (2001) 1.88

The anaphase-promoting complex is required in G1 arrested yeast cells to inhibit B-type cyclin accumulation and to prevent uncontrolled entry into S-phase. J Cell Sci (1997) 1.83

The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. Proc Natl Acad Sci U S A (2000) 1.82

The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Mol Cell (2001) 1.76

Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans. J Cell Biol (2000) 1.63

APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex. Mol Biol Cell (2001) 1.59

EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. Mol Biol Cell (2000) 1.52

A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver. Hepatology (2002) 1.26

Apc10 and Ste9/Srw1, two regulators of the APC-cyclosome, as well as the CDK inhibitor Rum1 are required for G1 cell-cycle arrest in fission yeast. EMBO J (1998) 1.16

Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities. Proc Natl Acad Sci U S A (2001) 1.09

A transgene-induced mitotic arrest mutation in the mouse allelic with Oligosyndactylism. Genetics (1996) 0.81

Taxonomy workbench. Bioinformatics (2001) 0.77

Articles by these authors

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections. Cell (2002) 6.59

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat Methods (2008) 6.51

Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors. Nature (2007) 5.39

Molecular architecture of SMC proteins and the yeast cohesin complex. Mol Cell (2002) 5.36

Un ménage à quatre: the molecular biology of chromosome segregation in meiosis. Cell (2003) 4.82

Systematic analysis of human protein complexes identifies chromosome segregation proteins. Science (2010) 4.69

Chromosomal cohesin forms a ring. Cell (2003) 4.38

Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepatocellular carcinomas. Hepatology (2009) 4.03

Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell (2003) 3.92

Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Nature (2006) 3.81

Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med (2005) 3.59

The cohesin ring concatenates sister DNA molecules. Nature (2008) 3.58

Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. PLoS Biol (2005) 3.33

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity. Mol Cell (2009) 3.33

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles. Curr Biol (2004) 3.29

Platelet-derived serotonin mediates liver regeneration. Science (2006) 2.98

Polo-like kinase Cdc5 promotes chiasmata formation and cosegregation of sister centromeres at meiosis I. Nat Cell Biol (2003) 2.94

Osteoclasts are essential for TNF-alpha-mediated joint destruction. J Clin Invest (2002) 2.85

Cell-type-specific TEV protease cleavage reveals cohesin functions in Drosophila neurons. Dev Cell (2008) 2.82

Structure and stability of cohesin's Smc1-kleisin interaction. Mol Cell (2004) 2.81

Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1. Cell (2006) 2.70

ATP hydrolysis is required for cohesin's association with chromosomes. Curr Biol (2003) 2.69

Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle. Nature (2004) 2.64

Evidence that loading of cohesin onto chromosomes involves opening of its SMC hinge. Cell (2006) 2.58

A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58

Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis. Cell (2009) 2.57

Use of severely steatotic grafts in liver transplantation: a matched case-control study. Ann Surg (2007) 2.53

A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann Surg (2003) 2.48

Apc tumor suppressor gene is the "zonation-keeper" of mouse liver. Dev Cell (2006) 2.45

A topological interaction between cohesin rings and a circular minichromosome. Cell (2005) 2.35

Two fission yeast homologs of Drosophila Mei-S332 are required for chromosome segregation during meiosis I and II. Curr Biol (2004) 2.28

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27

An Smc3 acetylation cycle is essential for establishment of sister chromatid cohesion. Mol Cell (2010) 2.23

Kinetochore recruitment of two nucleolar proteins is required for homolog segregation in meiosis I. Dev Cell (2003) 2.17

Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science (2004) 2.14

JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet (2002) 2.07

Dendritic cell-induced autoimmune heart failure requires cooperation between adaptive and innate immunity. Nat Med (2003) 2.04

Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. Curr Biol (2006) 2.04

Eco1 is a novel acetyltransferase that can acetylate proteins involved in cohesion. Curr Biol (2002) 2.04

Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes. Genes Dev (2010) 2.04

A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Dev Cell (2007) 1.98

Resolution of chiasmata in oocytes requires separase-mediated proteolysis. Cell (2006) 1.96

Maintenance of cohesin at centromeres after meiosis I in budding yeast requires a kinetochore-associated protein related to MEI-S332. Curr Biol (2004) 1.93

Cohesin's concatenation of sister DNAs maintains their intertwining. Mol Cell (2011) 1.91

Impact of integrated positron emission tomography and computed tomography on staging and management of gallbladder cancer and cholangiocarcinoma. J Hepatol (2006) 1.87

Regulation of human separase by securin binding and autocleavage. Curr Biol (2002) 1.86

A direct role for cohesin in gene regulation and ecdysone response in Drosophila salivary glands. Curr Biol (2010) 1.86

Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners. Mol Cell (2003) 1.85

c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev (2006) 1.84

Separase: a universal trigger for sister chromatid disjunction but not chromosome cycle progression. J Cell Biol (2006) 1.80

Novel genes required for meiotic chromosome segregation are identified by a high-throughput knockout screen in fission yeast. Curr Biol (2005) 1.76

Regulation of APC/C activity in oocytes by a Bub1-dependent spindle assembly checkpoint. Curr Biol (2009) 1.76

Cohesin's DNA exit gate is distinct from its entrance gate and is regulated by acetylation. Cell (2012) 1.75

Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. Nat Cell Biol (2010) 1.74

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res (2007) 1.74

Rhabdomyosarcoma development in mice lacking Trp53 and Fos: tumor suppression by the Fos protooncogene. Cancer Cell (2003) 1.71

Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion. Cell Stem Cell (2008) 1.67

Serotonin reverts age-related capillarization and failure of regeneration in the liver through a VEGF-dependent pathway. Proc Natl Acad Sci U S A (2011) 1.66

Structure and function of the PP2A-shugoshin interaction. Mol Cell (2009) 1.66

Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis. Dev Cell (2010) 1.61

Building and breaking bridges between sister chromatids. Bioessays (2003) 1.61

Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer. Proc Natl Acad Sci U S A (2011) 1.59

Assessment of hepatic steatosis by expert pathologists: the end of a gold standard. Ann Surg (2009) 1.56

Reproducibility of immunohistochemical scoring for epidermal growth factor receptor expression in non-small cell lung cancer: round robin test. Arch Pathol Lab Med (2012) 1.53

Sister-chromatid cohesion mediated by the alternative RF-CCtf18/Dcc1/Ctf8, the helicase Chl1 and the polymerase-alpha-associated protein Ctf4 is essential for chromatid disjunction during meiosis II. J Cell Sci (2004) 1.51

Division of the nucleolus and its release of CDC14 during anaphase of meiosis I depends on separase, SPO12, and SLK19. Dev Cell (2003) 1.48

Ex vivo evaluation of coronary atherosclerotic plaques: characterization with dual-source CT in comparison with histopathology. J Cardiovasc Comput Tomogr (2010) 1.47

Dearterialization of the liver causes intrahepatic cholestasis due to reduced bile transporter expression. Transplantation (2008) 1.43

Rare PIK3CA hotspot mutations in carcinomas of the biliary tract. Genes Chromosomes Cancer (2008) 1.43

Hepatic steatosis is a risk factor for postoperative complications after major hepatectomy: a matched case-control study. Ann Surg (2007) 1.42

A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping for major liver resection. Ann Surg (2006) 1.39

Retroperitoneal perforation of the colon caused by colonic tuberculosis: report of a case. Dis Colon Rectum (2004) 1.38

A physical assay for sister chromatid cohesion in vitro. Mol Cell (2007) 1.35

The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation. Curr Biol (2007) 1.33

Spo13 facilitates monopolin recruitment to kinetochores and regulates maintenance of centromeric cohesion during yeast meiosis. Curr Biol (2004) 1.33

Construction of conditional analog-sensitive kinase alleles in the fission yeast Schizosaccharomyces pombe. Nat Protoc (2007) 1.32

Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit. Curr Biol (2006) 1.32

MAPK signalling in cellular metabolism: stress or wellness? EMBO Rep (2010) 1.32

Control of Shugoshin function during fission-yeast meiosis. Curr Biol (2005) 1.31

The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta. Mol Cell Biol (2002) 1.30

High-throughput knockout screen in fission yeast. Nat Protoc (2006) 1.30

The transcription factor encyclopedia. Genome Biol (2012) 1.28

A randomized controlled trial on pharmacological preconditioning in liver surgery using a volatile anesthetic. Ann Surg (2008) 1.28

Rere controls retinoic acid signalling and somite bilateral symmetry. Nature (2010) 1.27

A tamoxifen-inducible chimeric Cre recombinase specifically effective in the fetal and adult mouse liver. Hepatology (2002) 1.26

Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Cell Stem Cell (2009) 1.25

Role of cleavage by separase of the Rec8 kleisin subunit of cohesin during mammalian meiosis I. J Cell Sci (2009) 1.24

Mice humanised for the EGF receptor display hypomorphic phenotypes in skin, bone and heart. Development (2003) 1.24

Chromosome cohesion - rings, knots, orcs and fellowship. J Cell Sci (2008) 1.21

PIASgamma is required for faithful chromosome segregation in human cells. PLoS One (2006) 1.21

Cohesin cleavage is insufficient for centriole disengagement in Drosophila. Curr Biol (2013) 1.21

Carcinoma of the collecting ducts of Bellini and renal medullary carcinoma: clinicopathologic analysis of 52 cases of rare aggressive subtypes of renal cell carcinoma with a focus on their interrelationship. Am J Surg Pathol (2012) 1.21

Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis. J Hepatol (2005) 1.19