Positional identification of hypertension susceptibility genes on chromosome 2.

PubWeight™: 1.25‹?› | Rank: Top 10%

🔗 View Article (PMID 14732741)

Published in Hypertension on January 19, 2004


Ruth Ann Barkley1, Aravinda Chakravarti, Richard S Cooper, R Curtis Ellison, Steven C Hunt, Michael A Province, Stephen T Turner, Alan B Weder, Eric Boerwinkle, Family Blood Pressure Program

Author Affiliations

1: Human Genetics Center and Institute of Molecular Medicine, of Texas Health Science Center at Houston, USA.

Associated clinical trials:

Family Blood Pressure Program - GenNet Network | NCT00005268

Family Blood Pressure Program - HyperGEN | NCT00005267

Family Blood Pressure Program - GENOA | NCT00005269

Articles citing this

The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters. Physiol Rev (2013) 1.50

Modular structure of sodium-coupled bicarbonate transporters. J Exp Biol (2009) 1.46

Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter. Hypertension (2012) 1.30

The SLC4 family of bicarbonate (HCO₃⁻) transporters. Mol Aspects Med (2013) 1.28

Oligomeric structure and minimal functional unit of the electrogenic sodium bicarbonate cotransporter NBCe1-A. J Biol Chem (2008) 1.21

Interactions between metallopeptidase 3 polymorphism rs679620 and BMI in predicting blood pressure in African-American women with hypertension. J Hypertens (2008) 1.16

Genetic and environmental risks for high blood pressure among African American mothers and daughters. Biol Res Nurs (2009) 1.04

Genetics of hypertension: from experimental animals to humans. Biochim Biophys Acta (2009) 1.00

Genetic and BMI risks for predicting blood pressure in three generations of West African Dogon women. Biol Res Nurs (2011) 0.97

Complexity in the genetic architecture of leukoaraiosis in hypertensive sibships from the GENOA Study. BMC Med Genomics (2009) 0.93

Cation-coupled bicarbonate transporters. Compr Physiol (2014) 0.89

Genomics of heart failure. Heart Fail Clin (2010) 0.87

Investigating the complex genetic architecture of ankle-brachial index, a measure of peripheral arterial disease, in non-Hispanic whites. BMC Med Genomics (2008) 0.86

Gene-environment effects of SLC4A5 and skin color on blood pressure among African American women. Ethn Dis (2012) 0.86

Functional identification of the promoter of SLC4A5, a gene associated with cardiovascular and metabolic phenotypes in the HERITAGE Family Study. Eur J Hum Genet (2009) 0.84

SNP-SNP interactions dominate the genetic architecture of candidate genes associated with left ventricular mass in African-Americans of the GENOA study. BMC Med Genet (2010) 0.83

Association of regions on chromosomes 6 and 7 with blood pressure in Nigerian families. Circ Cardiovasc Genet (2009) 0.83

Effects of parity on blood pressure among West African Dogon women. Ethn Dis (2012) 0.82

The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study (InterGEN): Design and Methods for Recruitment and Psychological Measures. Nurs Res (2016) 0.81

Direct Estimates of the Genomic Contributions to Blood Pressure Heritability within a Population-Based Cohort (ARIC). PLoS One (2015) 0.81

Disturbed acid-base transport: an emerging cause of hypertension. Front Physiol (2013) 0.81

Structure and Function of SLC4 Family [Formula: see text] Transporters. Front Physiol (2015) 0.80

Na(+) dependent acid-base transporters in the choroid plexus; insights from slc4 and slc9 gene deletion studies. Front Physiol (2013) 0.80

Genetically hypertensive Brown Norway congenic rat strains suggest intermediate traits underlying genetic hypertension. Croat Med J (2008) 0.79

The Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) Study: Design and Methods for Complex DNA Analysis. Biol Res Nurs (2016) 0.79

Interactions between the adducin 2 gene and antihypertensive drug therapies in determining blood pressure in people with hypertension. BMC Med Genet (2007) 0.79

Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency. Hypertension (2015) 0.78

Microsatellites and SNPs linkage analysis in a Sardinian genetic isolate confirms several essential hypertension loci previously identified in different populations. BMC Med Genet (2009) 0.77

Genetic architecture of complex traits predisposing to nephropathy: hypertension. Semin Nephrol (2010) 0.76

Deficient acid handling with distal RTA in the NBCe2 knockout mouse. Am J Physiol Renal Physiol (2015) 0.76

The sodium-bicarbonate cotransporter NBCe2 (slc4a5) expressed in human renal proximal tubules shows increased apical expression under high-salt conditions. Am J Physiol Regul Integr Comp Physiol (2015) 0.75

Attitudes toward Genetic Testing for Hypertension among African American Women and Girls. Nurs Res Pract (2013) 0.75

The Pharmacogenomics of Anti-Hypertensive Therapy. Pharmaceuticals (Basel) (2010) 0.75

Articles by these authors

A second generation human haplotype map of over 3.1 million SNPs. Nature (2007) 85.39

Finding the missing heritability of complex diseases. Nature (2009) 67.95

Somatic mutations affect key pathways in lung adenocarcinoma. Nature (2008) 30.02

Biological, clinical and population relevance of 95 loci for blood lipids. Nature (2010) 28.21

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med (2006) 23.83

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

A common allele on chromosome 9 associated with coronary heart disease. Science (2007) 20.37

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med (2008) 19.71

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Genome-wide detection and characterization of positive selection in human populations. Nature (2007) 17.27

Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science (2012) 17.12

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96

Characterizing the cancer genome in lung adenocarcinoma. Nature (2007) 16.48

Replicating genotype-phenotype associations. Nature (2007) 16.11

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99

Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. Nat Genet (2007) 13.78

Patterns and rates of exonic de novo mutations in autism spectrum disorders. Nature (2012) 13.71

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet (2011) 13.25

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Genome-wide association study of blood pressure and hypertension. Nat Genet (2009) 11.54

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet (2008) 10.87

Long-term mortality after gastric bypass surgery. N Engl J Med (2007) 10.75

The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. Am J Cardiol (2004) 9.43

Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA (2003) 9.06

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation (2003) 8.61

Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57

Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet (2009) 8.42

Subclinical thyroid disease: scientific review and guidelines for diagnosis and management. JAMA (2004) 8.12

Haplotype inference in random population samples. Am J Hum Genet (2002) 8.07

Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94

A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet (2006) 7.89

Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59

Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16

dbNSFP: a lightweight database of human nonsynonymous SNPs and their functional predictions. Hum Mutat (2011) 6.97

Admixture mapping for hypertension loci with genome-scan markers. Nat Genet (2005) 6.78

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet (2010) 6.66

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39

Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet (2008) 5.89

Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol (2010) 5.79

Exhaustive allelic transmission disequilibrium tests as a new approach to genome-wide association studies. Nat Genet (2004) 5.78

Hypertension treatment and control in five European countries, Canada, and the United States. Hypertension (2003) 5.63

New loci associated with kidney function and chronic kidney disease. Nat Genet (2010) 5.58

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47

Genomewide association studies of stroke. N Engl J Med (2009) 5.29

A common genetic variant in the neurexin superfamily member CNTNAP2 increases familial risk of autism. Am J Hum Genet (2008) 5.28

dbNSFP v2.0: a database of human non-synonymous SNVs and their functional predictions and annotations. Hum Mutat (2013) 5.11

Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans. J Clin Invest (2008) 5.05

Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94

A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk. Nature (2005) 4.92

Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet (2009) 4.78

Cardiac troponin T measured by a highly sensitive assay predicts coronary heart disease, heart failure, and mortality in the Atherosclerosis Risk in Communities Study. Circulation (2011) 4.78

A genome-wide linkage and association scan reveals novel loci for autism. Nature (2009) 4.76

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

Physical activity does not influence obesity risk: time to clarify the public health message. Int J Epidemiol (2013) 4.71

Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita. Proc Natl Acad Sci U S A (2005) 4.64

Generalized T2 test for genome association studies. Am J Hum Genet (2002) 4.55

Clan genomics and the complex architecture of human disease. Cell (2011) 4.53

Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51

Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun (2010) 4.39

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nat Genet (2009) 4.28

An assessment of incremental coronary risk prediction using C-reactive protein and other novel risk markers: the atherosclerosis risk in communities study. Arch Intern Med (2006) 4.23

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Common variants at ten loci modulate the QT interval duration in the QTSCD Study. Nat Genet (2009) 4.10

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97

Association mapping, using a mixture model for complex traits. Genet Epidemiol (2002) 3.95

From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part II. Circulation (2003) 3.94

Genomic alterations in cultured human embryonic stem cells. Nat Genet (2005) 3.89

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80

Genome-wide association study of PR interval. Nat Genet (2010) 3.73

Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71

Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation (2011) 3.68

Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet (2009) 3.60

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55