Published in J Mol Biol on February 06, 2004
Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. EMBO J (2006) 2.17
Muscle giants: molecular scaffolds in sarcomerogenesis. Physiol Rev (2009) 1.92
Cardiac titin: a multifunctional giant. Circulation (2010) 1.84
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. EMBO J (2007) 1.61
Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation (2011) 1.51
Titin: physiological function and role in cardiomyopathy and failure. Heart Fail Rev (2005) 1.22
The zebrafish runzel muscular dystrophy is linked to the titin gene. Dev Biol (2007) 1.20
Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy. J Clin Invest (2010) 0.99
Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle. Mol Cell Biol (2009) 0.97
Regulation and physiological roles of the calpain system in muscular disorders. Cardiovasc Res (2012) 0.97
Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy. J Gen Physiol (2014) 0.96
Mdm muscular dystrophy: interactions with calpain 3 and a novel functional role for titin's N2A domain. Hum Mol Genet (2005) 0.95
Skeletal muscle repair in a mouse model of nemaline myopathy. Hum Mol Genet (2006) 0.95
Mechanics on myocardium deficient in the N2B region of titin: the cardiac-unique spring element improves efficiency of the cardiac cycle. Biophys J (2011) 0.95
Probing muscle ankyrin-repeat protein (MARP) structure and function. Anat Rec (Hoboken) (2014) 0.84
Anchoring skeletal muscle development and disease: the role of ankyrin repeat domain containing proteins in muscle physiology. Crit Rev Biochem Mol Biol (2010) 0.84
Early mechanical dysfunction of the diaphragm in the muscular dystrophy with myositis (Ttnmdm) model. Am J Physiol Cell Physiol (2008) 0.82
nfi-I affects behavior and life-span in C. elegans but is not essential for DNA replication or survival. BMC Dev Biol (2005) 0.80
A Review of the Giant Protein Titin in Clinical Molecular Diagnostics of Cardiomyopathies. Front Cardiovasc Med (2016) 0.79
Monocular visual deprivation in macaque monkeys: a profile in the gene expression of lateral geniculate nucleus by laser capture microdissection. Mol Vis (2008) 0.76
Formation, contraction, and mechanotransduction of myofribrils in cardiac development: clues from genetics. Biochem Res Int (2012) 0.76
Multifunctional protein: cardiac ankyrin repeat protein. J Zhejiang Univ Sci B (2016) 0.75
Will you still need me (Ca(2+) , TnT, and DHPR), will you still cleave me (calpain), when I'm 64? Aging Cell (2016) 0.75
The effects of a skeletal muscle titin mutation on walking in mice. J Comp Physiol A Neuroethol Sens Neural Behav Physiol (2016) 0.75
Genetic epidemiology of titin-truncating variants in the etiology of dilated cardiomyopathy. Biophys Rev (2017) 0.75
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proc Natl Acad Sci U S A (2005) 4.34
Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet (2010) 3.91
LRP: role in vascular wall integrity and protection from atherosclerosis. Science (2003) 3.89
Striated muscle cytoarchitecture: an intricate web of form and function. Annu Rev Cell Dev Biol (2002) 3.66
The giant protein titin: a major player in myocardial mechanics, signaling, and disease. Circ Res (2004) 3.30
Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy. Circulation (2004) 3.29
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A (2002) 3.03
Neural mechanisms of a genome-wide supported psychosis variant. Science (2009) 2.88
Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy. Nat Genet (2002) 2.67
Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation (2002) 2.43
Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circ Res (2004) 2.38
Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. EMBO J (2006) 2.17
Calcium-dependent molecular spring elements in the giant protein titin. Proc Natl Acad Sci U S A (2003) 2.16
Structure, activation, and biology of calpain. Diabetes (2004) 2.16
Tibial muscular dystrophy is a titinopathy caused by mutations in TTN, the gene encoding the giant skeletal-muscle protein titin. Am J Hum Genet (2002) 2.14
MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. J Mol Biol (2005) 2.13
The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol (2003) 2.12
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nat Neurosci (2007) 2.10
Recessive truncating titin gene, TTN, mutations presenting as centronuclear myopathy. Neurology (2013) 2.09
Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy. J Mol Med (Berl) (2006) 2.05
Titin and its associated proteins: the third myofilament system of the sarcomere. Adv Protein Chem (2005) 2.00
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing. Nat Med (2012) 1.97
Brain function in carriers of a genome-wide supported bipolar disorder variant. Arch Gen Psychiatry (2010) 1.95
PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res (2009) 1.91
Nebulette mutations are associated with dilated cardiomyopathy and endocardial fibroelastosis. J Am Coll Cardiol (2010) 1.88
Cardiac titin: a multifunctional giant. Circulation (2010) 1.84
Shortening of the elastic tandem immunoglobulin segment of titin leads to diastolic dysfunction. Circulation (2013) 1.83
Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo. J Am Coll Cardiol (2009) 1.81
Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury. Circulation (2010) 1.80
Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae. J Biol Chem (2002) 1.74
Thin filament length dysregulation contributes to muscle weakness in nemaline myopathy patients with nebulin deficiency. Hum Mol Genet (2009) 1.73
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proc Natl Acad Sci U S A (2007) 1.70
Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure. Basic Res Cardiol (2009) 1.62
Dimerization of the cardiac ankyrin protein CARP: implications for MARP titin-based signaling. J Muscle Res Cell Motil (2005) 1.62
Molecular mechanics of cardiac titin's PEVK and N2B spring elements. J Biol Chem (2002) 1.61
Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. EMBO J (2007) 1.61
Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner. J Gen Physiol (2005) 1.61
Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis. Arterioscler Thromb Vasc Biol (2008) 1.58
Cardiac titin: an adjustable multi-functional spring. J Physiol (2002) 1.56
Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy. Hypertension (2012) 1.54
Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients. Am J Respir Crit Care Med (2015) 1.52
Genetic variation in titin in arrhythmogenic right ventricular cardiomyopathy-overlap syndromes. Circulation (2011) 1.51
C-terminal titin deletions cause a novel early-onset myopathy with fatal cardiomyopathy. Ann Neurol (2007) 1.47
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure. J Biol Chem (2002) 1.47
The structure of Lethocerus troponin C: insights into the mechanism of stretch activation in muscles. Structure (2007) 1.45
Nebulin: the nebulous, multifunctional giant of striated muscle. Trends Cardiovasc Med (2003) 1.44
Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality. J Cell Biol (2003) 1.44
Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway. Mol Cell Biol (2005) 1.43
Actin-related myopathy without any missense mutation in the ACTA1 gene. J Child Neurol (2004) 1.42
Nebulin alters cross-bridge cycling kinetics and increases thin filament activation: a novel mechanism for increasing tension and reducing tension cost. J Biol Chem (2009) 1.41
Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. J Mol Biol (2007) 1.41
Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle. J Physiol (2003) 1.39
Calpains: an elaborate proteolytic system. Biochim Biophys Acta (2011) 1.38
Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Genes Dev (2012) 1.38
Nebulin interacts with CapZ and regulates thin filament architecture within the Z-disc. Mol Biol Cell (2008) 1.35
Nebulin regulates actin filament lengths by a stabilization mechanism. J Cell Biol (2010) 1.35
Association of the chaperone alphaB-crystallin with titin in heart muscle. J Biol Chem (2003) 1.31