Published in Nucleic Acids Res on February 11, 2004
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell (2009) 8.69
Epigenetics in cancer. Carcinogenesis (2009) 7.49
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet (2012) 5.28
Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli. Mol Cell Proteomics (2008) 4.36
CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature (2011) 3.72
Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell (2012) 3.65
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression. Proc Natl Acad Sci U S A (2007) 3.32
Simple decision rules for classifying human cancers from gene expression profiles. Bioinformatics (2005) 3.24
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Interplay between the cancer genome and epigenome. Cell (2013) 3.05
A list of candidate cancer biomarkers for targeted proteomics. Biomark Insights (2007) 2.39
Involvement of human MOF in ATM function. Mol Cell Biol (2005) 2.30
The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. Mol Cell (2012) 2.20
Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes. Mol Cell Biol (2008) 1.89
Regulation of replication licensing by acetyltransferase Hbo1. Mol Cell Biol (2006) 1.86
STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. Mol Cell Biol (2007) 1.78
The targets of curcumin. Curr Drug Targets (2011) 1.76
Monocytic leukemia zinc finger protein is essential for the development of long-term reconstituting hematopoietic stem cells. Genes Dev (2006) 1.61
Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization. Cell Cycle (2009) 1.49
Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture. Mol Cell Biol (2008) 1.48
The epigenetics of autoimmunity. Cell Mol Immunol (2011) 1.47
Nonhistone protein acetylation as cancer therapy targets. Expert Rev Anticancer Ther (2010) 1.45
Bacterial protein acetylation: the dawning of a new age. Mol Microbiol (2010) 1.45
Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice. J Clin Invest (2011) 1.39
ATAC-king the complexity of SAGA during evolution. Genes Dev (2012) 1.36
Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J Cell Biochem (2010) 1.32
The landscape of somatic mutations in Down syndrome-related myeloid disorders. Nat Genet (2013) 1.31
BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression. Arch Biochem Biophys (2005) 1.30
Epigenetic aberrations and cancer. Mol Cancer (2006) 1.29
The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide. Proteins (2008) 1.27
Acetylation regulates the stability of a bacterial protein: growth stage-dependent modification of RNase R. Mol Cell (2011) 1.24
Prediction of Nepsilon-acetylation on internal lysines implemented in Bayesian Discriminant Method. Biochem Biophys Res Commun (2006) 1.24
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5. Nucleic Acids Res (2008) 1.23
Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. J Biol Chem (2010) 1.23
Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function. Curr Opin Immunol (2010) 1.23
Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription. Mol Cell Biol (2005) 1.22
BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity. J Biol Chem (2010) 1.22
Molecular dynamics simulations of the Cx26 hemichannel: evaluation of structural models with Brownian dynamics. J Gen Physiol (2011) 1.19
The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching. J Proteome Res (2011) 1.17
Epigenetics and airways disease. Respir Res (2006) 1.16
Hbo1 Links p53-dependent stress signaling to DNA replication licensing. Mol Cell Biol (2007) 1.16
Stalling of spliceosome assembly at distinct stages by small-molecule inhibitors of protein acetylation and deacetylation. RNA (2008) 1.16
Histone modifications and cancer: biomarkers of prognosis? Am J Cancer Res (2012) 1.15
Alcohol-induced protein hyperacetylation: mechanisms and consequences. World J Gastroenterol (2009) 1.15
Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes. Mol Microbiol (2008) 1.15
SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60. Mol Cell Biol (2012) 1.15
Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription. Mol Cell Biol (2008) 1.15
Identification of transient hub proteins and the possible structural basis for their multiple interactions. Protein Sci (2008) 1.14
p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. Nucleic Acids Res (2006) 1.12
Interactions between epigenetics and metabolism in cancers. Front Oncol (2012) 1.11
CPLA 1.0: an integrated database of protein lysine acetylation. Nucleic Acids Res (2010) 1.08
MYST family histone acetyltransferases in the protozoan parasite Toxoplasma gondii. Eukaryot Cell (2005) 1.07
Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. J Biol Chem (2013) 1.06
Histone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancers. Gene (2009) 1.05
Chromatin-modifying enzymes as therapeutic targets--Part 1. Expert Opin Ther Targets (2008) 1.04
Epigenetics: an emerging player in gastric cancer. World J Gastroenterol (2014) 1.01
Inhibition of histone acetyltransferase by glycosaminoglycans. J Cell Biochem (2008) 1.00
Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity. Nucleic Acids Res (2007) 1.00
MYSTs mark chromatin for chromosomal functions. Curr Opin Cell Biol (2008) 0.99
The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression. Mol Cell Biol (2010) 0.99
CPLM: a database of protein lysine modifications. Nucleic Acids Res (2013) 0.98
Epigenetic regulation of high glucose-induced proinflammatory cytokine production in monocytes by curcumin. J Nutr Biochem (2010) 0.97
Protein acetylation in metabolism - metabolites and cofactors. Nat Rev Endocrinol (2015) 0.97
Function of the active site lysine autoacetylation in Tip60 catalysis. PLoS One (2012) 0.97
6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site. Eur J Med Chem (2011) 0.95
Metabolism, cytoskeleton and cellular signalling in the grip of protein Nepsilon - and O-acetylation. EMBO Rep (2007) 0.94
GCN5 is a positive regulator of origins of DNA replication in Saccharomyces cerevisiae. PLoS One (2010) 0.94
Deacetylation by SIRT1 Reprograms Inflammation and Cancer. Genes Cancer (2013) 0.92
MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol (2005) 0.92
Investigation of MYST4 histone acetyltransferase and its involvement in mammalian gametogenesis. BMC Dev Biol (2007) 0.92
Gcn5p plays an important role in centromere kinetochore function in budding yeast. Mol Cell Biol (2007) 0.91
Evaluating epigenetic landmarks in the brain of multiple sclerosis patients: a contribution to the current debate on disease pathogenesis. Prog Neurobiol (2008) 0.91
Crosstalk between epigenetic readers regulates the MOZ/MORF HAT complexes. Epigenetics (2013) 0.91
Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Cell Rep (2014) 0.91
Is Runx a linchpin for developmental signaling in metazoans? J Cell Biochem (2009) 0.90
New molecular bridge between RelA/p65 and NF-κB target genes via histone acetyltransferase TIP60 cofactor. J Biol Chem (2012) 0.90
Deacetylase inhibitors - focus on non-histone targets and effects. World J Biol Chem (2010) 0.90
The Role of Histone Acetyltransferases in Normal and Malignant Hematopoiesis. Front Oncol (2015) 0.89
The MYST family histone acetyltransferase regulates gene expression and cell cycle in malaria parasite Plasmodium falciparum. Mol Microbiol (2010) 0.88
Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii. Mol Biosyst (2013) 0.88
Labeling lysine acetyltransferase substrates with engineered enzymes and functionalized cofactor surrogates. J Am Chem Soc (2013) 0.87
GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Nat Commun (2013) 0.86
Histone acetyltransferase inhibitor II induces apoptosis in glioma cell lines via the p53 signaling pathway. J Exp Clin Cancer Res (2014) 0.86
Genetic similarity between cancers and comorbid Mendelian diseases identifies candidate driver genes. Nat Commun (2015) 0.86
Chemoproteomic profiling of lysine acetyltransferases highlights an expanded landscape of catalytic acetylation. J Am Chem Soc (2014) 0.86
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Oncotarget (2012) 0.86
Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias. Curr Med Chem (2008) 0.85
Photoaffinity labeling in target- and binding-site identification. Future Med Chem (2015) 0.84
The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. J Biol Chem (2009) 0.84
The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis. Int J Mol Sci (2016) 0.83
Histone acetyltransferase Enok regulates oocyte polarization by promoting expression of the actin nucleation factor spire. Genes Dev (2014) 0.83
Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell Cycle (2013) 0.83
Digging deep into "dirty" drugs - modulation of the methylation machinery. Drug Metab Rev (2015) 0.83
Reversible acetylation on Lys501 regulates the activity of RNase II. Nucleic Acids Res (2016) 0.83
Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Sci Rep (2014) 0.82
Acetylation of the RhoA GEF Net1A controls its subcellular localization and activity. J Cell Sci (2015) 0.81
Histone acetyltransferases in rice (Oryza sativa L.): phylogenetic analysis, subcellular localization and expression. BMC Plant Biol (2012) 0.81
An intelligent system for identifying acetylated lysine on histones and nonhistone proteins. Biomed Res Int (2014) 0.80
Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS. BMC Cell Biol (2008) 0.80
The language of covalent histone modifications. Nature (2000) 44.92
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain. Nature (2001) 19.54
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell (1997) 16.79
The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell (1996) 16.57
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science (2001) 13.55
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science (1996) 12.64
The CBP co-activator is a histone acetyltransferase. Nature (1997) 10.91
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature (1996) 10.81
CBP/p300 in cell growth, transformation, and development. Genes Dev (2000) 10.76
Assembly of cell regulatory systems through protein interaction domains. Science (2003) 10.59
Structure and ligand of a histone acetyltransferase bromodomain. Nature (1999) 10.08
Histone acetyltransferases. Annu Rev Biochem (2001) 10.00
ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS. Proc Natl Acad Sci U S A (1964) 9.91
Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation. Cell (1996) 9.86
Acetylation of histones and transcription-related factors. Microbiol Mol Biol Rev (2000) 9.36
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell (1997) 8.72
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev (1997) 8.35
Structure and function of a human TAFII250 double bromodomain module. Science (2000) 8.00
Acetylation: a regulatory modification to rival phosphorylation? EMBO J (2000) 7.35
Cellular memory and the histone code. Cell (2002) 7.30
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature (1995) 7.11
Function and selectivity of bromodomains in anchoring chromatin-modifying complexes to promoter nucleosomes. Cell (2002) 7.10
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science (2001) 7.03
The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci (1995) 6.97
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature (2001) 6.76
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. Cell (1998) 6.73
Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell (2000) 6.70
Steroid receptor coactivator-1 is a histone acetyltransferase. Nature (1997) 6.15
Histone acetylation and deacetylation in yeast. Nat Rev Mol Cell Biol (2003) 5.92
Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4. Cell (1996) 5.77
p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J Cell Sci (2001) 5.74
Histone-like TAFs within the PCAF histone acetylase complex. Cell (1998) 5.26
Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell (1999) 5.23
The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell (1996) 5.20
Global histone acetylation and deacetylation in yeast. Nature (2000) 5.16
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell (2002) 5.15
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8. Genes Dev (2003) 5.13
Bromodomain: an acetyl-lysine binding domain. FEBS Lett (2002) 5.03
The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p. EMBO J (2000) 4.82
Crystal structure of globular domain of histone H5 and its implications for nucleosome binding. Nature (1993) 4.81
Class II histone deacetylases: versatile regulators. Trends Genet (2003) 4.63
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine. Science (2002) 4.61
The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet (1996) 4.59
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell (1998) 4.52
Sir2p and Sas2p opposingly regulate acetylation of yeast histone H4 lysine16 and spreading of heterochromatin. Nat Genet (2002) 4.36
Acetylation of general transcription factors by histone acetyltransferases. Curr Biol (1997) 4.22
Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair. Nature (2002) 4.18
Heterochromatin: new possibilities for the inheritance of structure. Curr Opin Genet Dev (2002) 4.14
NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J (1999) 4.14
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (2001) 4.13
mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J (1997) 4.05
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev (2003) 4.00
Activation of transcription through histone H4 acetylation by MOF, an acetyltransferase essential for dosage compensation in Drosophila. Mol Cell (2000) 3.98
A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell (2003) 3.96
The osteoblast: a sophisticated fibroblast under central surveillance. Science (2000) 3.93
Chromosomal gradient of histone acetylation established by Sas2p and Sir2p functions as a shield against gene silencing. Nat Genet (2002) 3.91
GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. Trends Biochem Sci (1997) 3.87
The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc. Mol Cell Biol (2000) 3.86
ACF consists of two subunits, Acf1 and ISWI, that function cooperatively in the ATP-dependent catalysis of chromatin assembly. Genes Dev (1999) 3.85
A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme. Mol Cell (1999) 3.80
Coordinate regulation of yeast ribosomal protein genes is associated with targeted recruitment of Esa1 histone acetylase. Mol Cell (2000) 3.80
HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell (2002) 3.70
P300 transcriptional repression is mediated by SUMO modification. Mol Cell (2003) 3.67
Deacetylase enzymes: biological functions and the use of small-molecule inhibitors. Chem Biol (2002) 3.66
Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol (1999) 3.57
The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins. Nucleic Acids Res (1992) 3.57
Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functions. Annu Rev Biophys Biomol Struct (2001) 3.51
The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell (1996) 3.40
p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2. EMBO J (2001) 3.37
The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell (2003) 3.36
A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity. Cell (1999) 3.36
Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell (2003) 3.35
The diverse functions of histone acetyltransferase complexes. Trends Genet (2003) 3.35
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Mol Cell Biol (2001) 3.31
Chromodomains are protein-RNA interaction modules. Nature (2000) 3.30
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell (2002) 3.28
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. Genes Dev (2000) 3.24
MYC recruits the TIP60 histone acetyltransferase complex to chromatin. EMBO Rep (2003) 3.24
ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc Natl Acad Sci U S A (1998) 3.19
Core-binding factors in haematopoiesis and leukaemia. Nat Rev Cancer (2002) 3.18
HIV-1 tat transcriptional activity is regulated by acetylation. EMBO J (1999) 3.10
The p400 complex is an essential E1A transformation target. Cell (2001) 3.05
Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet (1996) 3.02
The bromodomain revisited. Trends Biochem Sci (1997) 2.95
Histone deacetylase inhibitors as new cancer drugs. Curr Opin Oncol (2001) 2.91
Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell (1999) 2.90
Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries. Mol Cell (2003) 2.88
The human histone deacetylase family. Exp Cell Res (2001) 2.86
Mutations truncating the EP300 acetylase in human cancers. Nat Genet (2000) 2.84
Calf and pea histone IV. II. The complete amino acid sequence of calf thymus histone IV; presence of epsilon-N-acetyllysine. J Biol Chem (1969) 2.83
Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription. EMBO J (1992) 2.81
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem (2001) 2.80
Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Nucleic Acids Res (2002) 2.79
Functional significance of histone deacetylase diversity. Curr Opin Genet Dev (2001) 2.79
The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev (2000) 2.77
Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation. Mol Cell (2003) 2.74
Small molecule modulators of histone acetyltransferase p300. J Biol Chem (2003) 2.74
Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69