Published in Am J Epidemiol on March 01, 2004
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet (2009) 1.87
Low folate levels may protect against colorectal cancer. Gut (2006) 1.60
Evaluating predictive pharmacogenetic signatures of adverse events in colorectal cancer patients treated with fluoropyrimidines. PLoS One (2013) 1.48
Folate and cancer: how DNA damage, repair and methylation impact on colon carcinogenesis. J Inherit Metab Dis (2010) 1.40
DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer. Br J Cancer (2006) 1.36
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study. Blood (2007) 1.30
Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer. Cancer Causes Control (2010) 1.22
Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes. Nat Commun (2013) 1.18
Plasma folate, related genetic variants, and colorectal cancer risk in EPIC. Cancer Epidemiol Biomarkers Prev (2010) 1.18
Genetic variation in the folate metabolic pathway and risk of childhood leukemia. Blood (2010) 1.14
Alcohol, DNA methylation, and cancer. Alcohol Res (2013) 1.14
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification. Int J Cancer (2009) 1.14
Genetic polymorphisms in the methylenetetrahydrofolate reductase and thymidylate synthase genes and risk of hepatocellular carcinoma. Hepatology (2007) 1.08
Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. BMC Cancer (2008) 1.08
Folate pathway and nonsyndromic cleft lip and palate. Birth Defects Res A Clin Mol Teratol (2010) 1.06
Plasma vitamins B2, B6, and B12, and related genetic variants as predictors of colorectal cancer risk. Cancer Epidemiol Biomarkers Prev (2010) 1.05
Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation. Cancer Epidemiol Biomarkers Prev (2008) 1.05
Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review. Am J Epidemiol (2009) 1.05
Randomized multicenter investigation of folate plus vitamin B12 supplementation in schizophrenia. JAMA Psychiatry (2013) 1.02
Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies. PLoS One (2012) 1.01
Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer. PLoS One (2013) 0.99
The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. Hum Genet (2010) 0.99
Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. Cancer Causes Control (2007) 0.95
Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis. BMC Cancer (2006) 0.95
Genes and abdominal aortic aneurysm. Ann Vasc Surg (2010) 0.95
Folate Intake, MTHFR Polymorphisms, and the Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis. J Cancer Epidemiol (2012) 0.95
Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev (2010) 0.92
DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR. Cancer Epidemiol Biomarkers Prev (2009) 0.90
Hearing impairment risk and interaction of folate metabolism related gene polymorphisms in an aging study. BMC Med Genet (2011) 0.89
Folate and colorectal cancer prevention. Br J Cancer (2008) 0.89
Expression and alternative splicing of folate pathway genes in HapMap lymphoblastoid cell lines. Pharmacogenomics (2009) 0.89
Detection of metabolic syndrome in schizophrenia and implications for antipsychotic therapy : is there a role for folate? Mol Diagn Ther (2013) 0.88
Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia. Schizophr Bull (2011) 0.86
Comprehensive evaluation of one-carbon metabolism pathway gene variants and renal cell cancer risk. PLoS One (2011) 0.86
Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk. J Nutrigenet Nutrigenomics (2008) 0.86
Impact of the MTHFR C677T polymorphism on colorectal cancer in a population with low genetic variability. Int J Colorectal Dis (2013) 0.86
Genetic modifiers of cancer risk in Lynch syndrome: a review. Fam Cancer (2013) 0.85
MTHFR, MTR, and MTRR polymorphisms in relation to p16INK4A hypermethylation in mucosa of patients with colorectal cancer. Mol Med (2010) 0.85
SHMT1 1420 and MTHFR 677 variants are associated with rectal but not colon cancer. BMC Cancer (2010) 0.85
Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibility. Meta Gene (2015) 0.84
Polymorphisms in methylenetetrahydrofolate reductase gene (MTHFR) and the age of onset of sporadic colorectal adenocarcinoma. Int J Colorectal Dis (2006) 0.84
Role of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS gene polymorphisms in atrial fibrillation susceptibility. PLoS One (2007) 0.83
The association between the 844ins68 polymorphism in the CBS gene and breast cancer. Arch Med Sci (2014) 0.82
Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism. Genes Nutr (2014) 0.82
Genetic variation in genes involved in folate and drug metabolism in a south Indian population. Indian J Hum Genet (2011) 0.82
Combined impact of polymorphism of folate metabolism genes; glutamate carboxypeptidase, methylene tetrahydrofolate reductase and methionine synthase reductase on breast cancer susceptibility in kashmiri women. Int J Health Sci (Qassim) (2008) 0.82
Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes. Evol Med Public Health (2014) 0.81
Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma. Br J Cancer (2007) 0.80
Association of thymidylate synthase expression and clinical outcomes of gastric cancer patients treated with fluoropyrimidine-based chemotherapy: a meta-analysis. Onco Targets Ther (2016) 0.80
MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial. Cancer Epidemiol Biomarkers Prev (2008) 0.80
Folate intake and bowel cancer risk. Genes Nutr (2009) 0.80
Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India. Trans R Soc Trop Med Hyg (2016) 0.79
Association of thymidylate synthase gene with endometrial cancer risk in a Chinese population. Cancer Epidemiol Biomarkers Prev (2009) 0.79
Analysis of multiple genetic polymorphisms in aggressive-growing and slow-growing abdominal aortic aneurysms. J Vasc Surg (2014) 0.79
Genetic variation in folylpolyglutamate synthase and gamma-glutamyl hydrolase and plasma homocysteine levels in the Singapore Chinese Health Study. Mol Genet Metab (2011) 0.78
Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects. BMC Gastroenterol (2016) 0.78
C677T (RS1801133 ) MTHFR gene polymorphism frequency in a colombian population. Colomb Med (Cali) (2015) 0.78
Systemic folate status, rectal mucosal folate concentration and dietary intake in patients at differential risk of bowel cancer (The FAB2 Study). Eur J Nutr (2012) 0.78
The MTHFR C677T polymorphism and global DNA methylation in oral epithelial cells. Genet Mol Biol (2013) 0.77
Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms. Int J Mol Sci (2016) 0.77
Nutrients and genetic variation involved in one-carbon metabolism and Hodgkin lymphoma risk: a population-based case-control study. Am J Epidemiol (2011) 0.77
Regular Multivitamin Supplement Use, Single Nucleotide Polymorphisms in ATIC, SHMT2, and SLC46A1, and Risk of Ovarian Carcinoma. Front Genet (2012) 0.76
Risk factors for colon cancer in Northeastern Thailand: interaction of MTHFR codon 677 and 1298 genotypes with environmental factors. J Epidemiol (2010) 0.76
Overview of genes, diet and cancer. Genes Nutr (2007) 0.76
The A1298C Methylenetetrahydrofolate Reductase Gene Variant as a Susceptibility Gene for Non-Syndromic Conotruncal Heart Defects in an Indian Population. Pediatr Cardiol (2015) 0.76
Alcohol consumption, genetic variants in the alcohol- and folate metabolic pathways and colorectal cancer risk: the JPHC Study. Sci Rep (2016) 0.75
Involvement of Multiple Transporters-mediated Transports in Mizoribine and Methotrexate Pharmacokinetics. Pharmaceuticals (Basel) (2012) 0.75
Associations of the A66G Methionine Synthase Reductase Polymorphism in Colorectal Cancer: A Systematic Review and Meta-Analysis. Biomark Cancer (2015) 0.75
Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet. J Assist Reprod Genet (2016) 0.75
TSER polymorphism is not associated with risk of pediatric acute lymphoblastic leukemia: A meta-analysis. Medicine (Baltimore) (2017) 0.75
Interplay between 3'-UTR polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and the risk of ischemic stroke. Sci Rep (2017) 0.75
Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94
Assessment of cumulative evidence on genetic associations: interim guidelines. Int J Epidemiol (2007) 4.96
Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol (2008) 4.53
How many genes underlie the occurrence of common complex diseases in the population? Int J Epidemiol (2005) 4.46
Cleft lip and palate. Lancet (2009) 4.29
Disruption of an AP-2alpha binding site in an IRF6 enhancer is associated with cleft lip. Nat Genet (2008) 4.04
A road map for efficient and reliable human genome epidemiology. Nat Genet (2006) 3.21
Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology (2003) 2.96
On the synthesis and interpretation of consistent but weak gene-disease associations in the era of genome-wide association studies. Int J Epidemiol (2006) 2.66
Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies. Int J Epidemiol (2010) 2.44
DataSHIELD: resolving a conflict in contemporary bioscience--performing a pooled analysis of individual-level data without sharing the data. Int J Epidemiol (2010) 2.23
Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am J Epidemiol (2009) 2.15
Vitamin D status of Canadians as measured in the 2007 to 2009 Canadian Health Measures Survey. Health Rep (2010) 1.75
Systematic review: family history in risk assessment for common diseases. Ann Intern Med (2009) 1.70
The emergence of networks in human genome epidemiology: challenges and opportunities. Epidemiology (2007) 1.61
Systematic reviews of genetic association studies. Human Genome Epidemiology Network. PLoS Med (2009) 1.60
An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions. Genet Med (2004) 1.57
Occupational risk factors for low grade and high grade glioma: results from an international case control study of adult brain tumours. Int J Cancer (2005) 1.54
Citizens' values regarding research with stored samples from newborn screening in Canada. Pediatrics (2012) 1.48
Addressing the challenges of cleft lip and palate research in India. Indian J Plast Surg (2009) 1.46
Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration. J Clin Epidemiol (2011) 1.46
A network of investigator networks in human genome epidemiology. Am J Epidemiol (2005) 1.43
Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies. Int J Epidemiol (2011) 1.41
Folate intake, markers of folate status and oral clefts: is the evidence converging? Int J Epidemiol (2008) 1.37
The emergence of epidemiology in the genomics age. Int J Epidemiol (2004) 1.36
Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancer. J Natl Cancer Inst (2012) 1.30
A P3G generic access agreement for population genomic studies. Nat Biotechnol (2013) 1.28
Methods for meta-analyses of genome-wide association studies: critical assessment of empirical evidence. Am J Epidemiol (2012) 1.24
Understanding sickle cell carrier status identified through newborn screening: a qualitative study. Eur J Hum Genet (2009) 1.22
After-effects reported by women following colposcopy, cervical biopsies and LLETZ: results from the TOMBOLA trial. BJOG (2009) 1.21
Family history and improving health. Evid Rep Technol Assess (Full Rep) (2009) 1.17
Associations between two common variants C677T and A1298C in the methylenetetrahydrofolate reductase gene and measures of folate metabolism and DNA stability (strand breaks, misincorporated uracil, and DNA methylation status) in human lymphocytes in vivo. Cancer Epidemiol Biomarkers Prev (2004) 1.11
MC1R variants increased the risk of sporadic cutaneous melanoma in darker-pigmented Caucasians: a pooled-analysis from the M-SKIP project. Int J Cancer (2014) 1.10
Strengthening the reporting of Genetic RIsk Prediction Studies: the GRIPS Statement. PLoS Med (2011) 1.09
The human genome project is complete. How do we develop a handle for the pump? Am J Epidemiol (2003) 1.07
The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland. Cancer Epidemiol Biomarkers Prev (2005) 1.06
Trial of management of borderline and other low-grade abnormal smears (TOMBOLA): Trial design. Contemp Clin Trials (2006) 1.05
Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. Eur J Epidemiol (2011) 1.04
Achieving the "triple aim" for inborn errors of metabolism: a review of challenges to outcomes research and presentation of a new practice-based evidence framework. Genet Med (2012) 1.04
Turning the pump handle: evolving methods for integrating the evidence on gene-disease association. Am J Epidemiol (2007) 1.01
Variability in the clinical management of fatty acid oxidation disorders: results of a survey of Canadian metabolic physicians. J Inherit Metab Dis (2011) 1.01
Dietary flavonoid intake and colorectal cancer: a case-control study. Br J Nutr (2009) 0.99
The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer. Hum Genet (2010) 0.99
Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. Int J Epidemiol (2012) 0.99
Informing parents about expanded newborn screening: influences on provider involvement. Pediatrics (2009) 0.97
Cancer risk in children and adolescents with birth defects: a population-based cohort study. PLoS One (2013) 0.96
A qualitative study of provider perspectives of structural barriers to cervical cancer screening among first nations women. Womens Health Issues (2013) 0.95
Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention. Gut (2010) 0.95
United Kingdom cervical cancer screening and the costs of time and travel. Int J Technol Assess Health Care (2007) 0.95
Health-care providers' views on pursuing reproductive benefit through newborn screening: the case of sickle cell disorders. Eur J Hum Genet (2011) 0.95
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. Eur J Epidemiol (2011) 0.94
Fetal anticonvulsant syndromes and polymorphisms in MTHFR, MTR, and MTRR. Am J Med Genet A (2007) 0.93
The unintended consequences of cervical screening: distress in women undergoing cytologic surveillance. J Low Genit Tract Dis (2014) 0.92
Bias in the case-only design applied to studies of gene-environment and gene-gene interaction: a systematic review and meta-analysis. Int J Epidemiol (2011) 0.91
Clinical utility of cancer family history collection in primary care. Evid Rep Technol Assess (Full Rep) (2009) 0.91
Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. Eur J Clin Invest (2011) 0.91
Prevention by daily soluble aspirin of colorectal adenoma recurrence: 4-year results of the APACC randomised trial. Gut (2011) 0.90
An international case-control study of adult diet and brain tumor risk: a histology-specific analysis by food group. Ann Epidemiol (2009) 0.89
Refining the management of low-grade cervical abnormalities in the UK National Health Service and defining the potential for human papillomavirus testing: a commentary on emerging evidence. J Low Genit Tract Dis (2006) 0.88
Relation of childhood brain tumors to exposure of parents and children to tobacco smoke: the SEARCH international case-control study. Surveillance of Environmental Aspects Related to Cancer in Humans. Int J Cancer (2002) 0.87
Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. BMJ (2011) 0.87
Folate, DNA stability and colo-rectal neoplasia. Proc Nutr Soc (2004) 0.87
Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis. Birth Defects Res A Clin Mol Teratol (2013) 0.86
Expectations and values about expanded newborn screening: a public engagement study. Health Expect (2013) 0.86
Vitamin D receptor (VDR) polymorphisms and severe RSV bronchiolitis: a systematic review and meta-analysis. Pediatr Pulmonol (2013) 0.85
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. Eur J Clin Invest (2011) 0.85
Human papillomavirus infection and anxiety: analyses in women with low-grade cervical cytological abnormalities unaware of their infection status. PLoS One (2011) 0.85
Strengthening the reporting of Genetic Risk Prediction Studies: the GRIPS statement. Genet Med (2011) 0.85
Reporting of systematic reviews: the challenge of genetic association studies. PLoS Med (2007) 0.85
Breast cancer risk in relation to alcohol consumption and BRCA gene mutations--a case-only study of gene-environment interaction. Breast J (2011) 0.84
Leukaemia in young children living in the vicinity of nuclear power plants. Int J Cancer (2008) 0.84
Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancer. Curr Top Med Chem (2005) 0.83
Who defaults from colposcopy? A multi-centre, population-based, prospective cohort study of predictors of non-attendance for follow-up among women with low-grade abnormal cervical cytology. Eur J Obstet Gynecol Reprod Biol (2012) 0.83
Family cancer history and risk of brain tumors in children: results of the SEARCH international brain tumor study. Cancer Causes Control (2008) 0.83
A meta-analysis of observational studies of the association between chronic occupational exposure to lead and amyotrophic lateral sclerosis. J Occup Environ Med (2014) 0.82
Strengthening the reporting of genetic risk prediction studies: The GRIPS Statement. Ann Intern Med (2011) 0.82
Maternal medication use and the risk of brain tumors in the offspring: the SEARCH international case-control study. Int J Cancer (2006) 0.82
Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies. BMC Med Res Methodol (2012) 0.81
Prevention of orofacial clefts: does pregnancy planning have a role? Cleft Palate Craniofac J (2007) 0.81
Alcohol consumption and the risk of breast cancer among BRCA1 and BRCA2 mutation carriers. Breast (2010) 0.80
Factors associated with psychological distress following colposcopy among women with low-grade abnormal cervical cytology: a prospective study within the Trial Of Management of Borderline and Other Low-grade Abnormal smears (TOMBOLA). Psychooncology (2011) 0.80
Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration. Eur J Hum Genet (2011) 0.79
Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. Eur J Hum Genet (2011) 0.78
Assessment of systematic effects of methodological characteristics on candidate genetic associations. Hum Genet (2012) 0.77
After-effects reported by women having follow-up cervical cytology tests in primary care: a cohort study within the TOMBOLA trial. Br J Gen Pract (2011) 0.77
Reporting genetic association studies: the STREGA statement. Lancet (2009) 0.77
Editorial: Updated guidance on human genome epidemiology (HuGE) reviews and meta-analyses of genetic associations. Am J Epidemiol (2014) 0.77
Effectiveness of individual-focused interventions to prevent chronic disease. Eur J Clin Invest (2014) 0.77
Multigene panels in prostate cancer risk assessment. Evid Rep Technol Assess (Full Rep) (2012) 0.76
Modes of delivery in preventive intervention studies: a rapid review. Eur J Clin Invest (2014) 0.76
Polymorphisms of adrenergic receptors and the risk of heart failure. N Engl J Med (2003) 0.75
Measuring the psychosocial burden in women with low-grade abnormal cervical cytology in the TOMBOLA trial: psychometric properties of the Process and Outcome Specific Measure (POSM). Health Qual Life Outcomes (2014) 0.75
Study protocol: the empirical investigation of methods to correct for measurement error in biobanks with dietary assessment. BMC Med Res Methodol (2011) 0.75
Metabolic Clinic Atlas: Organization of Care for Children with Inherited Metabolic Disease in Canada. JIMD Rep (2015) 0.75
Characterization of IGF-II isoforms in binge eating disorder and its group psychological treatment. PLoS One (2013) 0.75
Primary care role in expanded newborn screening: After the heel prick test. Can Fam Physician (2013) 0.75
Strengthening the reporting of genetic risk prediction studies: the GRIPS statement. Genome Med (2011) 0.75
Genetic Interactions in Nonsyndromic Orofacial Clefts in Europe-EUROCRAN Study. Cleft Palate Craniofac J (2016) 0.75
Segregation analysis of cleft lip with or without cleft palate in the First Nations (Amerindian) people of British Columbia and review of isolated cleft palate etiologies. Birth Defects Res A Clin Mol Teratol (2009) 0.75