Published in N Engl J Med on March 04, 2004
Oestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial. Lancet (2009) 5.22
The effects of tibolone in older postmenopausal women. N Engl J Med (2008) 3.96
Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA (2005) 3.88
Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. Am J Epidemiol (2009) 3.33
Insulin, insulin-like growth factor-I, endogenous estradiol, and risk of colorectal cancer in postmenopausal women. Cancer Res (2008) 2.24
The payoff time: a flexible framework to help clinicians decide when patients with comorbid disease are not likely to benefit from practice guidelines. Med Care (2009) 2.10
Pleiotropic actions of estrogen: a mitochondrial matter. Physiol Genomics (2012) 2.07
Unifying roles for regulatory T cells and inflammation in cancer. Int J Cancer (2010) 1.98
Estrogen and progestogen use in postmenopausal women: July 2008 position statement of The North American Menopause Society. Menopause (2008) 1.74
Helicobacter pylori infection increases the risk of colorectal adenoma and adenocarcinoma, especially in women. J Gastroenterol (2005) 1.71
Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones. Proc Natl Acad Sci U S A (2014) 1.63
Risk of colorectal cancer in men on long-term androgen deprivation therapy for prostate cancer. J Natl Cancer Inst (2010) 1.63
Role of estrogen receptor beta in colonic epithelium. Proc Natl Acad Sci U S A (2006) 1.49
Colorectal cancer screening and prevention in women. Dig Dis Sci (2015) 1.46
Increasing trend of colorectal cancer incidence in Korea, 1999-2009. Cancer Res Treat (2012) 1.43
Gender disparities in metastatic colorectal cancer survival. Clin Cancer Res (2009) 1.43
Conjugated equine estrogens and colorectal cancer incidence and survival: the Women's Health Initiative randomized clinical trial. Cancer Epidemiol Biomarkers Prev (2008) 1.42
Colorectal cancer incidence trends in the United States and United kingdom: evidence of right- to left-sided biological gradients with implications for screening. Cancer Res (2010) 1.42
Adiposity and cancer risk: new mechanistic insights from epidemiology. Nat Rev Cancer (2015) 1.32
Lung cancer among postmenopausal women treated with estrogen alone in the women's health initiative randomized trial. J Natl Cancer Inst (2010) 1.31
Colorectal cancer in relation to postmenopausal estrogen and estrogen plus progestin in the Women's Health Initiative clinical trial and observational study. Cancer Epidemiol Biomarkers Prev (2009) 1.29
American Society of Clinical Oncology policy statement: the role of the oncologist in cancer prevention and risk assessment. J Clin Oncol (2008) 1.29
Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers Prev (2010) 1.26
Use of electronic medical records in oncology outcomes research. Clinicoecon Outcomes Res (2010) 1.21
Reproductive history and risk of colorectal cancer in postmenopausal women. J Natl Cancer Inst (2011) 1.16
Specialty supplements and breast cancer risk in the VITamins And Lifestyle (VITAL) Cohort. Cancer Epidemiol Biomarkers Prev (2010) 1.15
A case-control study of levothyroxine and the risk of colorectal cancer. J Natl Cancer Inst (2010) 1.14
Molecular pathways: Estrogen pathway in colorectal cancer. Clin Cancer Res (2013) 1.13
Use of hormone replacement therapy and the risk of colorectal cancer. J Clin Oncol (2009) 1.11
Association between sex hormones and colorectal cancer risk in men and women. Clin Gastroenterol Hepatol (2012) 1.09
Gender, anthropometric factors and risk of colorectal cancer with particular reference to tumour location and TNM stage: a cohort study. Biol Sex Differ (2012) 1.09
Menopausal hormone therapy and risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev (2009) 1.07
Prospective cohort study of soy food intake and colorectal cancer risk in women. Am J Clin Nutr (2008) 1.05
The association of menstrual and reproductive factors with upper gastrointestinal tract cancers in the NIH-AARP cohort. Cancer (2010) 1.05
Sex differences in colorectal cancer survival: population-based analysis of 164,996 colorectal cancer patients in Germany. PLoS One (2013) 1.05
Endogenous estrogen exposure in relation to distribution of histological type and estrogen receptors in gastric adenocarcinoma. Gastric Cancer (2008) 1.04
Comparison of screen-detected and interval colorectal cancers in the Bowel Cancer Screening Programme. Br J Cancer (2012) 1.04
Association of vegetable, fruit, and grain intakes with colorectal cancer: the Multiethnic Cohort Study. Am J Clin Nutr (2008) 1.00
Estrogen plus progestin and colorectal cancer incidence and mortality. J Clin Oncol (2012) 1.00
Scientific rationale for postmenopause delay in the use of conjugated equine estrogens among postmenopausal women that causes reduction in breast cancer incidence and mortality. Menopause (2013) 1.00
Modeling hot flushes and quality of life in breast cancer survivors. Climacteric (2010) 1.00
Risk of second primary colorectal cancer among colorectal cancer cases: a population-based analysis. J Carcinog (2011) 1.00
Cardiovascular medication use and risk for colorectal cancer. Cancer Epidemiol Biomarkers Prev (2008) 0.99
Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study. Cancer Res (2014) 0.98
Pre-diagnostic NSAID use but not hormone therapy is associated with improved colorectal cancer survival in women. Br J Cancer (2011) 0.98
Risk factors for serrated polyps of the colorectum. Dig Dis Sci (2014) 0.96
Sex hormones and colorectal cancer: what have we learned so far? J Natl Cancer Inst (2010) 0.96
Relationship between higher estradiol levels and 9-year mortality in older women: the Invecchiare in Chianti study. J Am Geriatr Soc (2009) 0.95
Novel female sex-dependent actions of oestrogen in the intestine. J Physiol (2009) 0.95
Adenoma detection rate in 41,010 patients from Southwest China. Oncol Lett (2015) 0.93
Optical measurement of rectal microvasculature as an adjunct to flexible sigmoidosocopy: gender-specific implications. Cancer Prev Res (Phila) (2010) 0.93
Reversibility of aberrant global DNA and estrogen receptor-alpha gene methylation distinguishes colorectal precancer from cancer. Int J Clin Exp Pathol (2008) 0.93
Menopausal hormone therapy use and risk of invasive colon cancer: the California Teachers Study. Am J Epidemiol (2010) 0.92
Cancer of the colon and rectum: potential effects of sex-age interactions on incidence and outcome. Med Sci Monit (2013) 0.92
Hormone therapy, DNA methylation and colon cancer. Carcinogenesis (2010) 0.91
Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells. Exp Mol Med (2012) 0.90
Differences in colon adenomas and carcinomas among women and men: potential clinical implications. JAMA (2009) 0.90
Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma. Br J Cancer (2006) 0.90
A pilot randomized, single-blind, placebo-controlled trial of traditional acupuncture for vasomotor symptoms and mechanistic pathways of menopause. Menopause (2012) 0.90
Colorectal Chemoprevention Pilot Study (SWOG-9041), randomized and placebo controlled: the importance of multiple luminal lesions. Clin Colorectal Cancer (2011) 0.90
Bone mass density, subsequent risk of colon cancer and survival in postmenopausal women. Eur J Epidemiol (2008) 0.89
Variation in the CYP19A1 gene and risk of colon and rectal cancer. Cancer Causes Control (2011) 0.89
Racial differences in colorectal cancer incidence and mortality in the Women's Health Initiative. Cancer Epidemiol Biomarkers Prev (2011) 0.89
Oestrogen and colorectal cancer: mechanisms and controversies. Int J Colorectal Dis (2013) 0.87
Colon cancer and the elderly: from screening to treatment in management of GI disease in the elderly. Best Pract Res Clin Gastroenterol (2009) 0.87
Perceived control and hot flashes in treatment-seeking breast cancer survivors and menopausal women. Cancer Nurs (2012) 0.87
Birth size and colorectal cancer risk: a prospective population based study. Gut (2005) 0.87
Functional polymorphisms to modulate luminal lipid exposure and risk of colorectal cancer. Cancer Epidemiol (2010) 0.86
Common single-nucleotide polymorphisms in the estrogen receptor β promoter are associated with colorectal cancer survival in postmenopausal women. Cancer Res (2012) 0.86
Primary prevention of colorectal cancer: myth or reality? World J Gastroenterol (2014) 0.86
Hormone replacement therapy, body mass, and the risk of colorectal cancer among postmenopausal women from Germany. Br J Cancer (2007) 0.86
The association between NSAID use and colorectal cancer mortality: results from the women's health initiative. Cancer Epidemiol Biomarkers Prev (2012) 0.86
Association of estrogen receptor beta variants and serum levels of estradiol with risk of colorectal cancer: a case control study. BMC Cancer (2012) 0.86
Estrogen receptors and their implications in colorectal carcinogenesis. Front Oncol (2015) 0.86
Dietary fatty acids, luminal modifiers, and risk of colorectal cancer. Int J Cancer (2010) 0.85
Increased risk of colon cancer in men in the pre-diabetes phase. PLoS One (2013) 0.85
Estrogen and progesterone-related gene variants and colorectal cancer risk in women. BMC Med Genet (2011) 0.85
JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells. J Biomed Sci (2011) 0.84
Postmenopausal hormone therapy is associated with a reduced risk of colorectal cancer lacking CDKN1A expression. Cancer Res (2012) 0.84
Translational approaches to addressing complex genetic pathways in colorectal cancer. Transl Res (2007) 0.84
A large prospective study of risk factors for adenocarcinomas and malignant carcinoid tumors of the small intestine. Cancer Causes Control (2013) 0.84
Estrogen, male dominance and esophageal adenocarcinoma: is there a link? World J Gastroenterol (2012) 0.84
Probing the link between oestrogen receptors and oesophageal cancer. World J Surg Oncol (2010) 0.84
Recurrence and surveillance of colorectal adenoma after polypectomy in a southern Chinese population. J Gastroenterol (2010) 0.84
Estrogen receptor α or β loss in the colon of Min/+ mice promotes crypt expansion and impairs TGFβ and HNF3β signaling. Carcinogenesis (2013) 0.83
Postmenopausal hormone therapy and the risks of coronary heart disease, breast cancer, and stroke. Semin Reprod Med (2014) 0.82
Menopausal hormone therapy and cancer: changing clinical observations of target site specificity. Steroids (2014) 0.82
Hormone therapy in relation to survival from large bowel cancer. Cancer Causes Control (2008) 0.82
Decreased expression of 17β-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon. BMC Cancer (2011) 0.82
Oral contraceptive use and colorectal cancer in the Nurses' Health Study I and II. Cancer Epidemiol Biomarkers Prev (2015) 0.82
The p53-estrogen receptor loop in cancer. Curr Mol Med (2013) 0.82
Daidzein-estrogen interaction in the rat uterus and its effect on human breast cancer cell growth. J Med Food (2012) 0.81
Long-term status and change of body fat distribution, and risk of colorectal cancer: a prospective cohort study. Int J Epidemiol (2015) 0.81
Family history of hormonal cancers and colorectal cancer risk: a case-control study conducted in Ontario. Int J Cancer (2009) 0.81
Menopausal hormone therapy and sleep-disordered breathing: evidence for a healthy user bias. Ann Epidemiol (2015) 0.81
Downregulation of DLC-1 gene by promoter methylation during primary colorectal cancer progression. Biomed Res Int (2012) 0.80
Strategies for colon cancer prevention. EPMA J (2010) 0.80
Dietary Inflammatory Index and Risk of Colorectal Cancer: A Case-Control Study in Korea. Nutrients (2016) 0.80
Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women's Health Initiative randomized controlled trial. JAMA (2004) 23.69
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Low-fat dietary pattern and risk of cardiovascular disease: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 12.44
Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med (2006) 12.09
Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. JAMA (2003) 10.61
Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med (2003) 10.06
Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med (2006) 8.73
The Women's Health Initiative recruitment methods and results. Ann Epidemiol (2003) 8.42
Exemestane for breast-cancer prevention in postmenopausal women. N Engl J Med (2011) 8.19
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing. Nat Biotechnol (2013) 7.97
The Women's Health Initiative Observational Study: baseline characteristics of participants and reliability of baseline measures. Ann Epidemiol (2003) 7.49
Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA (2010) 7.12
Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med (2012) 6.77
Calcium/vitamin D supplementation and cardiovascular events. Circulation (2007) 6.63
Low-fat dietary pattern and risk of invasive breast cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 6.51
Statin use and risk of diabetes mellitus in postmenopausal women in the Women's Health Initiative. Arch Intern Med (2012) 6.46
Lung cancer susceptibility locus at 5p15.33. Nat Genet (2008) 5.99
Low-fat dietary pattern and weight change over 7 years: the Women's Health Initiative Dietary Modification Trial. JAMA (2006) 5.75
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am J Hum Genet (2009) 5.62
Ethnicity and breast cancer: factors influencing differences in incidence and outcome. J Natl Cancer Inst (2005) 5.52
Oestrogen plus progestin and lung cancer in postmenopausal women (Women's Health Initiative trial): a post-hoc analysis of a randomised controlled trial. Lancet (2009) 5.22
Prospective breast cancer risk prediction model for women undergoing screening mammography. J Natl Cancer Inst (2006) 5.17
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89
Effects of estrogen plus progestin on health-related quality of life. N Engl J Med (2003) 4.83
Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women's Health Initiative Cohort Study. JAMA (2003) 4.72
Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J Natl Cancer Inst (2007) 4.55
Combined postmenopausal hormone therapy and cardiovascular disease: toward resolving the discrepancy between observational studies and the Women's Health Initiative clinical trial. Am J Epidemiol (2005) 4.55
Common variants at 19p13 are associated with susceptibility to ovarian cancer. Nat Genet (2010) 4.51
Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study. Arch Intern Med (2005) 4.24
Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA (2003) 4.07
Conjugated equine estrogens and coronary heart disease: the Women's Health Initiative. Arch Intern Med (2006) 3.91
Health outcomes after stopping conjugated equine estrogens among postmenopausal women with prior hysterectomy: a randomized controlled trial. JAMA (2011) 3.85
Detectable clonal mosaicism and its relationship to aging and cancer. Nat Genet (2012) 3.69
Calcium plus vitamin D supplementation and the risk of breast cancer. J Natl Cancer Inst (2008) 3.60
Conjugated equine oestrogen and breast cancer incidence and mortality in postmenopausal women with hysterectomy: extended follow-up of the Women's Health Initiative randomised placebo-controlled trial. Lancet Oncol (2012) 3.56
Diabetes, metformin, and breast cancer in postmenopausal women. J Clin Oncol (2012) 3.47
Estrogen plus progestin and risk of venous thrombosis. JAMA (2004) 3.46
A randomized trial of the effect of a plant-based dietary pattern on additional breast cancer events and survival: the Women's Healthy Eating and Living (WHEL) Study. Control Clin Trials (2002) 3.41
Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev (2009) 3.33
Benefits and risks of postmenopausal hormone therapy when it is initiated soon after menopause. Am J Epidemiol (2009) 3.33
Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy. JAMA (2006) 3.29
Obesity, body size, and risk of postmenopausal breast cancer: the Women's Health Initiative (United States). Cancer Causes Control (2002) 3.27
Oral bisphosphonate use and breast cancer incidence in postmenopausal women. J Clin Oncol (2010) 3.17
Hormone replacement therapy in relation to breast cancer. JAMA (2002) 3.14
Reproductive factors, hormonal contraception, and risk of uterine leiomyomata in African-American women: a prospective study. Am J Epidemiol (2004) 3.07
Conjugated equine estrogens and breast cancer risk in the Women's Health Initiative clinical trial and observational study. Am J Epidemiol (2008) 3.05
Oophorectomy vs ovarian conservation with hysterectomy: cardiovascular disease, hip fracture, and cancer in the Women's Health Initiative Observational Study. Arch Intern Med (2011) 3.00
Height as an explanatory factor for sex differences in human cancer. J Natl Cancer Inst (2013) 2.99
Low-fat dietary pattern and risk of colorectal cancer: the Women's Health Initiative Randomized Controlled Dietary Modification Trial. JAMA (2006) 2.97
Researching complementary and alternative treatments--the gatekeepers are not at home. BMC Med Res Methodol (2007) 2.96
Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: the Women's Health Initiative randomized trial. JAMA (2003) 2.90
Lung cancer occurrence in never-smokers: an analysis of 13 cohorts and 22 cancer registry studies. PLoS Med (2008) 2.90
Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer. Nat Genet (2009) 2.85
Factors contributing to mammography failure in women aged 40-49 years. J Natl Cancer Inst (2004) 2.84
Reproductive history and oral contraceptive use in relation to risk of triple-negative breast cancer. J Natl Cancer Inst (2011) 2.84
Factors associated with 5-year risk of hip fracture in postmenopausal women. JAMA (2007) 2.81
Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: the Women's Health Initiative. J Womens Health (Larchmt) (2013) 2.81
Association of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective cohort study. BMJ (2011) 2.80
Estrogen plus progestin therapy and breast cancer in recently postmenopausal women. Am J Epidemiol (2008) 2.79
Calcium plus vitamin D supplementation and the risk of incident diabetes in the Women's Health Initiative. Diabetes Care (2008) 2.76
Physical activity and survival in postmenopausal women with breast cancer: results from the women's health initiative. Cancer Prev Res (Phila) (2011) 2.73
Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA (2008) 2.73
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (2012) 2.57
Long-term use of supplemental multivitamins, vitamin C, vitamin E, and folate does not reduce the risk of lung cancer. Am J Respir Crit Care Med (2007) 2.55
Prehypertension and cardiovascular disease risk in the Women's Health Initiative. Circulation (2007) 2.50
Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative. Cancer Res (2003) 2.49
Estrogen plus progestin and breast cancer incidence and mortality in the Women's Health Initiative Observational Study. J Natl Cancer Inst (2013) 2.45
Effect of calcium and vitamin D supplementation on blood pressure: the Women's Health Initiative Randomized Trial. Hypertension (2008) 2.44
Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med (2008) 2.44
Low-fat dietary pattern and change in body-composition traits in the Women's Health Initiative Dietary Modification Trial. Am J Clin Nutr (2010) 2.43
Reliability and validity of self-report of vitamin and mineral supplement use in the vitamins and lifestyle study. Am J Epidemiol (2003) 2.38
Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med (2013) 2.38